Cited by 143Coenzyme Q10 studies and effectsParkinson's Disease Mechanisms and TreatmentsAntioxidant Activity and Oxidative Stress

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Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease

Sohmiya, Makoto, Tanaka, Makoto, Wei Tak, Nyou, Yanagisawa, Makoto, Tanino, Yutaka, Suzuki, Yoko, Okamoto, Koichi, Yamamoto, Yorihiro·2004·Journal of the Neurological Sciences

DOI 10.1016/j.jns.2004.05.007

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Abstract

Oxidative stress is suggested to play an important role in the pathogenesis of Parkinson's disease (PD). However, no elevation of plasma oxidative stress marker has been reported. We measured percent content of the oxidized form of coenzyme Q10 in total coenzyme Q10 (%CoQ-10) because %CoQ-10 has been shown to be a sensitive marker of oxidative stress. A slight but significant elevation in %CoQ-10 was observed in PD patients when compared with age/gender-matched normal subjects, suggesting elevated systemic oxidative stress in PD patients.

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Authors: Sohmiya, M., Tanaka, M., Wei Tak, N., Yanagisawa, M., Tanino, Y., Suzuki, Y., Okamoto, K., & Yamamoto, Y.
Affiliations: Gunma University (JP)
The University of Tokyo (JP)
Tokyo University of Technology (JP)
Corresponding author: Sohmiya, Makoto
ORCID: Okamoto, Koichi
Venue: Journal of the Neurological Sciences
Publisher: Elsevier BV
Published: 2004-08
Volume: 223
Issue: 2
Pages: 161-166
ISSN: 0022-510X (ISSN-L)
DOI: 10.1016/j.jns.2004.05.007
OpenAlex: W2117733672
Cited by: 143
References: 52
Citations by year: 2026: 3 · 2025: 2 · 2024: 2 · 2023: 10 · 2022: 5 · 2021: 7 · 2020: 14 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 7 · 2015: 7 · 2014: 4 · 2013: 8 · 2012: 6
FWCI: 2.84
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Journal of the Neurological Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: Parkinson's disease, oxidative stress, coenzyme Q10, plasma biomarkers, redox state, neurodegeneration
MeSH terms: Adult, Aged, Aged, 80 and over, Alzheimer Disease, Chromatography, High Pressure Liquid, Coenzymes, Electrochemistry, Female, Humans, Male, Middle Aged, Oxidation-Reduction, Parkinson Disease, Plasma, Ubiquinone, Case-Control Studies, Oxidative Stress, Statistics, Nonparametric

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Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease

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