Increase of oxidized/total coenzyme Q-10 ratio in cerebrospinal fluid in patients with Parkinson’s disease
Abstract
The concentrations of oxidized coenzyme Q-10 (CoQ-10) and reduced CoQ-10 in the cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) was examined in order to determine whether the balance in oxidized and reduced CoQ-10 is related to the pathogenesis of PD. The percentage of oxidized/total CoQ-10 (%CoQ-10) in the CSF was significantly higher in the untreated PD group (80.3+/-17.9%) compared to the normal control group (68.2+/-20.4%) (p<0.05). The %CoQ-10 in the CSF of PD patients showed significant negative correlation with the duration of illness. These findings in living patients provide in vivo evidence for a possible role for %CoQ-10 in the pathogenesis in the early stages of PD development.
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The ratio of reduced to oxidized CoQ10 is significantly reduced in the platelets and cerebrospinal fluid of PD patients and in plasma of ALS patients.
“The ratio of reduced to oxidized CoQ10 is significantly reduced in the platelets and cerebrospinal fluid (CSF) of PD patients156, 157 and in plasma of ALS patients158.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [157]
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- Authors
- Isobe, C., Murata, T., Sato, C., & Terayama, Y.
- Affiliations
- Iwate Medical University (JP)
- Corresponding author
- Isobe, Chiaki
- ORCID
- Terayama, Yasuo
- Venue
- Journal of Clinical Neuroscience
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 14
- Issue
- 4
- Pages
- 340-343
- ISSN
- 0967-5868 (ISSN-L)
- OpenAlex
- W2044885461
- Cited by
- 22
- References
- 21
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2012: 1
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labour and Welfare
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- Parkinson's disease, coenzyme Q10, cerebrospinal fluid, oxidative stress, pathogenesis, disease duration, biomarkers
- MeSH terms
- Aged, Female, Humans, Male, Middle Aged, Parkinson Disease, Reference Values, Ubiquinone, Biomarkers, Case-Control Studies, Matched-Pair Analysis, Oxidative Stress, Statistics, Nonparametric
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