Cited by 22Coenzyme Q10 studies and effectsParkinson's Disease Mechanisms and TreatmentsNeurological diseases and metabolism

Increase of oxidized/total coenzyme Q-10 ratio in cerebrospinal fluid in patients with Parkinson’s disease

Isobe, Chiaki, Murata, Takahiko, Sato, Chigumi, Terayama, Yasuo·2007·Journal of Clinical Neuroscience

Abstract

The concentrations of oxidized coenzyme Q-10 (CoQ-10) and reduced CoQ-10 in the cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) was examined in order to determine whether the balance in oxidized and reduced CoQ-10 is related to the pathogenesis of PD. The percentage of oxidized/total CoQ-10 (%CoQ-10) in the CSF was significantly higher in the untreated PD group (80.3+/-17.9%) compared to the normal control group (68.2+/-20.4%) (p<0.05). The %CoQ-10 in the CSF of PD patients showed significant negative correlation with the duration of illness. These findings in living patients provide in vivo evidence for a possible role for %CoQ-10 in the pathogenesis in the early stages of PD development.

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Crossref · 10.1016/j.jocn.2005.12.023

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  • The ratio of reduced to oxidized CoQ10 is significantly reduced in the platelets and cerebrospinal fluid of PD patients and in plasma of ALS patients.

    “The ratio of reduced to oxidized CoQ10 is significantly reduced in the platelets and cerebrospinal fluid (CSF) of PD patients156, 157 and in plasma of ALS patients158.”

    From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [157]

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Authors
Isobe, C., Murata, T., Sato, C., & Terayama, Y.
Affiliations
Iwate Medical University (JP)
Corresponding author
Isobe, Chiaki
Venue
Journal of Clinical Neuroscience
Publisher
Elsevier BV
Published
2007-04
Volume
14
Issue
4
Pages
340-343
ISSN
0967-5868 (ISSN-L)
OpenAlex
W2044885461
Cited by
22
References
21
Citations by year
2025: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2012: 1
FWCI
1.36
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Clinical Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Education, Culture, Sports, Science and Technology
  • Ministry of Health, Labour and Welfare
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords
Parkinson's disease, coenzyme Q10, cerebrospinal fluid, oxidative stress, pathogenesis, disease duration, biomarkers
MeSH terms
Aged, Female, Humans, Male, Middle Aged, Parkinson Disease, Reference Values, Ubiquinone, Biomarkers, Case-Control Studies, Matched-Pair Analysis, Oxidative Stress, Statistics, Nonparametric

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