Acute hepatocyte growth factor treatment induces long-term neuroprotection and stroke recovery via mechanisms involving neural precursor cell proliferation and differentiation

Mechanisms and Functional Implications of Adult Neurogenesis

Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007 · see citing works

Neuronal replacement from endogenous precursors in the adult brain after stroke

Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., & Lindvall, O. (2002) · Nature Medicine · doi:10.1038/nm747 · Cited by 2,799 · see citing works

Molecular cloning and expression of human hepatocyte growth factor

Nakamura, T., Nishizawa, T., Hagiya, M., Seki, T., Shimonishi, M., Sugimura, A., Tashiro, K., & Shimizu, S. (1989) · Nature · doi:10.1038/342440a0 · Cited by 2,158 · see citing works

VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia

Sun, Y., Jin, K., Xie, L., Childs, J., Mao, X. O., Logvinova, A., & Greenberg, D. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317977 · Cited by 1,189 · see citing works

VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia

Sun, Y., Jin, K., Xie, L., Childs, J., Mao, X. O., Logvinova, A. V., & Greenberg, D. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17977 · Cited by 1,181 · see citing works

Matrix Metalloproteinases and TIMPs Are Associated With Blood-Brain Barrier Opening After Reperfusion in Rat Brain

Rosenberg, G. A., Estrada, E. Y., & Dencoff, J. E. (1998) · Stroke · doi:10.1161/01.str.29.10.2189 · Cited by 861 · see citing works

Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats

Wang, L., Zhang, Z., Wang, Y., Zhang, R., & Chopp, M. (2004) · Stroke · doi:10.1161/01.str.0000132196.49028.a4 · Cited by 760 · see citing works

Subventricular Zone-Derived Neuroblasts Migrate and Differentiate into Mature Neurons in the Post-Stroke Adult Striatum

Yamashita, T., Ninomiya, M., Hernandez-Acosta, P., García‐Verdugo, J. M., Sunabori, T., Sakaguchi, M., Adachi, K., Kojima, T., Hirota, Y., Kawase, T., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0149-06.2006 · Cited by 720 · see citing works

Molecular targets in cerebral ischemia for developing novel therapeutics

Mehta, S. L., Manhas, N., & Raghubir, R. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.11.003 · Cited by 707 · see citing works

Emerging Multipotent Aspects of Hepatocyte Growth Factor

Matsumoto, K., & Nakamura, T. (1996) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021283 · Cited by 666 · see citing works

Short‐term and long‐term survival of new neurons in the rat dentate gyrus

Dayer, A. G., Ford, A. A., Cleaver, K. M., Yassaee, M., & Cameron, H. A. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10675 · Cited by 628 · see citing works

Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia

Candelario‐Jalil, E., Yang, Y., & Rosenberg, G. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.025 · Cited by 524 · see citing works

Functional Recovery of Stroke Rats Induced by Granulocyte Colony-Stimulating Factor–Stimulated Stem Cells

Shyu, W., Lin, S., Yang, H.-I., Tzeng, Y.-S., Pang, C., Yen, P.-S., & Li, H. (2004) · Circulation · doi:10.1161/01.cir.0000142616.07367.66 · Cited by 343 · see citing works

Adult neural stem cells in the mammalian central nervous system

Ma, D. K., Bonaguidi, M. A., Ming, G., & Song, H. (2009) · Cell Research · doi:10.1038/cr.2009.56 · Cited by 330 · see citing works

Localization and functional coupling of HGF and c-Met/HGF receptor in rat brain: implication as neurotrophic factor

Honda, S., Kagoshima, M., Wanaka, A., Tohyama, M., Matsumoto, K., & Nakamura, T. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(95)00075-4 · Cited by 184 · see citing works

Induction of neurogenesis in the adult rat subventricular zone and neostriatum following dopamine D3 receptor stimulation

Kampen, J. M. V., Hagg, T., & Robertson, H. A. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03342.x · Cited by 168 · see citing works

Mesenchymal stem cells promote proliferation of endogenous neural stem cells and survival of newborn cells in a rat stroke model

Yoo, S., Kim, S., Lee, S., Lee, H.-S., Kim, H.-S., Lee, Y., & Suh‐Kim, H. (2008) · Experimental & Molecular Medicine · doi:10.3858/emm.2008.40.4.387 · Cited by 167 · see citing works

Implications of vascular endothelial growth factor for postischemic neurovascular remodeling

Hermann, D. M., & Zechariah, A. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.100 · Cited by 162 · see citing works

Protection of Hippocampal Neurons from Ischemia-Induced Delayed Neuronal Death by Hepatocyte Growth Factor: A Novel Neurotrophic Factor

Miyazawa, T., Matsumoto, K., Ohmichi, H., Katoh, H., Yamashima, T., & Nakamura, T. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199804000-00001 · Cited by 136 · see citing works

Novel Therapeutic Strategy to Treat Brain Ischemia

Shimamura, M., Sato, N., Oshima, K., Aoki, M., Kurinami, H., Waguri, S., Uchiyama, Y., Ogihara, T., Kaneda, Y., & Morishita, R. (2004) · Circulation · doi:10.1161/01.cir.0000109496.82683.49 · Cited by 116 · see citing works

Hypoxic Preconditioning-Induced Cerebral Ischemic Tolerance

Wacker, B. K., Park, T. S., & Gidday, J. M. (2009) · Stroke · doi:10.1161/strokeaha.109.560714 · Cited by 115 · see citing works

Neural stem/precursor cells for the treatment of ischemic stroke

Bacigaluppi, M., Pluchino, S., Martino, G., Kilic, E., & Hermann, D. M. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.06.012 · Cited by 111 · see citing works

Early Beneficial Effect of Matrix Metalloproteinase Inhibition on Blood—Brain Barrier Permeability as Measured by Magnetic Resonance Imaging Countered by Impaired Long-Term Recovery after Stroke in Rat Brain

Sood, R., Taheri, S., Candelario‐Jalil, E., Estrada, E. Y., & Rosenberg, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600534 · Cited by 108 · see citing works

Expression of HGF and cMet in the developing and adult brain

Achim, C. L., Katyal, S. L., Wiley, C. A., Shiratori, M., Wang, G., Oshika, E., Petersen, B. E., Li, J., & Michalopoulos, G. K. (1997) · Developmental Brain Research · doi:10.1016/s0165-3806(97)00108-9 · Cited by 92 · see citing works

Effect of Basic Fibroblast Growth Factor Treatment on Brain Progenitor Cells After Permanent Focal Ischemia in Rats

Wada, K., Sugimori, H., Bhide, P. G., Moskowitz, M. A., & Finklestein, S. P. (2003) · Stroke · doi:10.1161/01.str.0000094421.61917.71 · Cited by 78 · see citing works

Endogenous Hepatocyte Growth Factor Is a Niche Signal for Subventricular Zone Neural Stem Cell Amplification and Self-Renewal

Nicoleau, C., Benzakour, O., Agasse, F., Thiriet, N., Petit, J., Prestoz, L., Roger, M., Jaber, M., & Coronas, V. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0226 · Cited by 75 · see citing works

Prevention of Apoptosis-Inducing Factor Translocation is a Possible Mechanism for Protective Effects of Hepatocyte Growth Factor against Neuronal Cell Death in the Hippocampus after Transient Forebrain Ischemia

Niimura, M., Takagi, N., Takagi, K., Mizutani, R., Ishihara, N., Matsumoto, K., Funakoshi, H., Nakamura, T., & Takeo, S. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600287 · Cited by 69 · see citing works

Hepatocyte growth factor attenuates cerebral ischemia-induced learning dysfunction

Date, I., Takagi, N., Takagi, K., Kago, T., Matsumoto, K., Nakamura, T., & Takeo, S. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.100 · Cited by 68 · see citing works

Vascular endothelial growth factor improves recovery of sensorimotor and cognitive deficits after focal cerebral ischemia in the rat

Wang, Y., Galván, V., Gorostiza, O. F., Ataie, M., Jin, K., & Greenberg, D. A. (2006) · Brain Research · doi:10.1016/j.brainres.2006.07.060 · Cited by 65 · see citing works

Antiapoptotic and antiautophagic effects of glial cell line‐derived neurotrophic factor and hepatocyte growth factor after transient middle cerebral artery occlusion in rats

Shang, J., Deguchi, K., Yamashita, T., Ohta, Y., Zhang, H., Morimoto, N., Liu, N., Zhang, X., Tian, F., Matsuura, T., et al. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22373 · Cited by 61 · see citing works

Hepatocyte growth factor attenuates cerebral ischemia-induced increase in permeability of the blood–brain barrier and decreases in expression of tight junctional proteins in cerebral vessels

Date, I., Takagi, N., Takagi, K., Tanonaka, K., Funakoshi, H., Matsumoto, K., Nakamura, T., & Takeo, S. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.08.050 · Cited by 58 · see citing works

Transient focal cerebral ischemia induces sensorimotor deficits in mice

Gerlai, R. T. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00130-8 · Cited by 56 · see citing works

Hepatocyte growth factor promotes proliferation and neuronal differentiation of neural stem cells from mouse embryos

Kokuzawa, J., Yoshimura, S., Kitajima, H., Shinoda, J., Kaku, Y., Iwama, T., Morishita, R., Shimazaki, T., Okano, H., Kunisada, T., et al. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00160-x · Cited by 50 · see citing works

D3 dopamine receptors do not regulate neurogenesis in the subventricular zone of adult mice

Baker, S. A., Baker, K. A., & Hagg, T. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.01.004 · Cited by 50 · see citing works

Transplantation of TAT-Bcl-xL-transduced neural precursor cells: Long-term neuroprotection after stroke

Doeppner, T. R., Aanbouri, M. E., Dietz, G. P. H., Weise, J., Schwarting, S., & Bähr, M. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.05.033 · Cited by 39 · see citing works

TAT-Bcl-xL improves survival of neuronal precursor cells in the lesioned striatum after focal cerebral ischemia

Doeppner, T. R., Dietz, G. P. H., Aanbouri, M. E., Gerber, J., Witte, O. W., Bähr, M., & Weise, J. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.12.013 · Cited by 36 · see citing works

Anti-VEGF receptor antagonist (VGA1155) reduces infarction in rat permanent focal brain ischemia.

Chiba, Y., Sasayama, T., Miyake, S., Koyama, J., Kondoh, T., Hosoda, K., & Kohmura, E. (2008) · PubMed · doi:10.24546/81000770 · Cited by 33 · see citing works

Growth factors and stroke

Greenberg, D. A., & Jin, K. (2006) · NeuroRx · doi:10.1016/j.nurx.2006.08.003 · Cited by 33 · see citing works

Hepatocyte growth factor promotes neuronal differentiation of neural stem cells derived from embryonic stem cells

Kato, M., Yoshimura, S., Kokuzawa, J., Kitajima, H., Kaku, Y., Iwama, T., Shinoda, J., Kunisada, T., & Sakai, N. (2003) · Neuroreport · doi:10.1097/00001756-200401190-00002 · Cited by 24 · see citing works

Effects of hepatocyte growth factor on phosphorylation of extracellular signal-regulated kinase and hippocampal cell death in rats with transient forebrain ischemia

Niimura, M., Takagi, N., Takagi, K., Funakoshi, H., Nakamura, T., & Takeo, S. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.01.037 · Cited by 24 · see citing works

The protective effect of hepatocyte growth factor against cell death in the hippocampus after transient forebrain ischemia is related to the improvement of apurinic/apyrimidinic endonuclease/redox factor-1 level and inhibition of NADPH oxidase activity

Niimura, M., Takagi, N., Takagi, K., Mizutani, R., Tanonaka, K., Funakoshi, H., Matsumoto, K., Nakamura, T., & Takeo, S. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.08.060 · Cited by 18 · see citing works

HVJ-based non-viral gene transfer method: successful gene therapy using HGF and VEGF genes in experimental ischemia

Shimamura, M. (2006) · Frontiers in bioscience · doi:10.2741/1833 · Cited by 15 · see citing works

Antiapoptotic and antiautophagic effects of glial cell line-derived neurotrophic factor and hepatocyte growth factor after transient middle cerebral artery occlusion in rats

商, 敬. (2011) · Institutional Repositories DataBase (IRDB) · Cited by 10 · see citing works

[Relationship between cytokine concentration and activities of daily living in rehabilitation patients with stroke].

Ozaki, S., Beppu, H., Sonoda, S., Okazaki, H., Mizutani, K., Itani, Y., Hayashi, N., Okamotos, S., & Matsui, T. (2007) · PubMed · Cited by 3 · see citing works

Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets

Zhang, M., Liu, Q., Meng, H., Duan, H., Liu, X., Wu, J., Gao, F., Wang, S., Tan, R., & Yuan, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01688-x · Cited by 773 · see citing works

Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation

Hermann, D. M., & Chopp, M. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70039-x · Cited by 333 · see citing works

Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway

Zhang, L., Wei, W., Ai, X., Kılıç, E., Hermann, D. M., Venkataramani, V., Bähr, M., & Doeppner, T. R. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04363-7 · Cited by 192 · see citing works

MicroRNA-124 protects against focal cerebral ischemia via mechanisms involving Usp14-dependent REST degradation

Doeppner, T. R., Doehring, M., Bretschneider, E., Zechariah, A., Kaltwasser, B., Müller, B., Koch, J. C., Bähr, M., Hermann, D. M., & Michel, U. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1142-5 · Cited by 155 · see citing works

HGF and MET: From Brain Development to Neurological Disorders

Desole, C., Gallo, S., Vitacolonna, A., Montarolo, F., Bertolotto, A., Vivien, D., Comoglio, P., & Crepaldi, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.683609 · Cited by 114 · see citing works

Tetramethylpyrazine nitrone activates the BDNF/Akt/CREB pathway to promote post‐ischaemic neuroregeneration and recovery of neurological functions in rats

Zhang, G., Zhang, T., Li, N., Wu, L., Gu, J., Li, C., Zhao, C., Liu, W., Shan, L., Yu, P., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14102 · Cited by 90 · see citing works

Neuroprotective Effect of Human Placenta-Derived Cell Treatment of Stroke in Rats

Chen, J., Shehadah, A., Pal, A., Zacharek, A., Cui, X., Cui, Y., Roberts, C., Lu, M., Zeitlin, A., Hariri, R., et al. (2013) · Cell Transplantation · doi:10.3727/096368911x637380 · Cited by 70 · see citing works

The novel proteasome inhibitor BSc2118 protects against cerebral ischaemia through HIF1A accumulation and enhanced angioneurogenesis

Doeppner, T. R., Młynarczuk-Biały, I., Kuckelkorn, U., Kaltwasser, B., Herz, J., Hasan, M. R., Hermann, D. M., & Bähr, M. (2012) · Brain · doi:10.1093/brain/aws269 · Cited by 64 · see citing works

The pericyte secretome: Potential impact on regeneration

Gaceb, A., Barbariga, M., Özen, Í., & Paul, G. (2018) · Biochimie · doi:10.1016/j.biochi.2018.04.015 · Cited by 63 · see citing works

Growth Factors Released from Gelatin Hydrogel Microspheres Increase New Neurons in the Adult Mouse Brain

Nakaguchi, K., Jinnou, H., Kaneko, N., Sawada, M., Hikita, T., Saitoh, S., Tabata, Y., & Sawamoto, K. (2012) · Stem Cells International · doi:10.1155/2012/915160 · Cited by 58 · see citing works

Neural Progenitor Cell-Derived Extracellular Vesicles Enhance Blood-Brain Barrier Integrity by NF-κB (Nuclear Factor-κB)-Dependent Regulation of ABCB1 (ATP-Binding Cassette Transporter B1) in Stroke Mice

Zhang, L., Graf, I., Kuang, Y., Zheng, X., Haupt, M., Majid, A., Kılıç, E., Hermann, D. M., Psychogios, M., Weber, M. S., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315031 · Cited by 56 · see citing works

Neuroprotective Effects of Quercetin on Ischemic Stroke: A Literature Review

Zhang, L., Ma, J., Yang, F., Li, S., Ma, W., Chang, X., & Yang, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.854249 · Cited by 55 · see citing works

Neural stem cell survival factors

Ramasamy, S., Narayanan, G., Sankaran, S., Yu, Y. H., & Ahmed, S. (2013) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2013.02.004 · Cited by 54 · see citing works

Notoginsenoside R1 Improves Cerebral Ischemia/Reperfusion Injury by Promoting Neurogenesis via the BDNF/Akt/CREB Pathway

Zhu, T., Wang, L., Xie, W., Meng, X., Feng, Y., Sun, G., & Sun, X. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.615998 · Cited by 55 · see citing works

The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases

Wright, J. W., Kawas, L. H., & Harding, J. W. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.11.004 · Cited by 51 · see citing works

Biotherapies in stroke

Detante, O., Jaillard, A. S., Moisan, A., Barbieux, M., Favre, I., Garambois, K., Hommel, M., & Rémy, C. (2014) · Revue Neurologique · doi:10.1016/j.neurol.2014.10.005 · Cited by 49 · see citing works

Lithium enhances post-stroke blood-brain barrier integrity, activates the MAPK/ERK1/2 pathway and alters immune cell migration in mice

Haupt, M., Zechmeister, B., Bosche, B., Lieschke, S., Zheng, X., Zhang, L., Venkataramani, V., Jin, F., Hein, K., Weber, M. S., et al. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108357 · Cited by 48 · see citing works

Agonistic analog of growth hormone–releasing hormone promotes neurofunctional recovery and neural regeneration in ischemic stroke

Liu, Y., Yang, J., Che, X., Huang, J., Zhang, X., Fu, X., Cai, J., Yao, Y., Zhang, H., Cai, R., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2109600118 · Cited by 44 · see citing works

Transforming growth factor-β1 selectively inhibits hepatocyte growth factor expression via a micro-RNA-199–dependent posttranscriptional mechanism

Mungunsukh, O., & Day, R. M. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-01-0017 · Cited by 41 · see citing works

Ischemic Post-Conditioning Induces Post-Stroke Neuroprotection via Hsp70-Mediated Proteasome Inhibition and Facilitates Neural Progenitor Cell Transplantation

Doeppner, T. R., Doehring, M., Kaltwasser, B., Majid, A., Lin, F., Bähr, M., Kılıç, E., & Hermann, D. M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0137-3 · Cited by 40 · see citing works

Increase in Blood Levels of Growth Factors Involved in the Neuroplasticity Process by Using an Extremely Low Frequency Electromagnetic Field in Post-stroke Patients

Cichoń, N., Bijak, M., Czarny, P. L., Miller, E. D., Synowiec, E., Śliwiński, T., & Saluk, J. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00294 · Cited by 39 · see citing works

TAT-Hsp70 Induces Neuroprotection Against Stroke Via Anti-Inflammatory Actions Providing Appropriate Cellular Microenvironment for Transplantation of Neural Precursor Cells

Doeppner, T. R., Kaltwasser, B., Fengyan, J., Hermann, D. M., & Bähr, M. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.126 · Cited by 37 · see citing works

Plasmid-based gene therapy with hepatocyte growth factor stimulates peripheral nerve regeneration after traumatic injury

Boldyreva, M. A., Bondar, I. V., Stafeev, I., Макаревич, П. И., Beloglazova, I. B., Zubkova, E., Шевченко, Е. К., Molokotina, Y. D., Karagyaur, M. N., Ratner, E. I., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.02.138 · Cited by 35 · see citing works

Systemic Proteasome Inhibition Induces Sustained Post-stroke Neurological Recovery and Neuroprotection via Mechanisms Involving Reversal of Peripheral Immunosuppression and Preservation of Blood–Brain–Barrier Integrity

Doeppner, T. R., Kaltwasser, B., Kuckelkorn, U., Henkelein, P., Bretschneider, E., Kılıç, E., & Hermann, D. M. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9533-3 · Cited by 28 · see citing works

Treadmill exercise ameliorates ischemia-induced brain edema while suppressing Na+/H+ exchanger 1 expression

Nishioka, R., Sugimoto, K., Aono, H., Mise, A., Choudhury, M. E., Miyanishi, K., Islam, A., Fujita, T., Takeda, H., Takahashi, H., et al. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.12.016 · Cited by 27 · see citing works

Sustained Functional Improvement by Hepatocyte Growth Factor-Like Small Molecule BB3 after Focal Cerebral Ischemia in Rats and Mice

Chaparro, R. E., Izutsu, M., Sasaki, T., Sheng, H., Zheng, Y. Z., Sadeghian, H., Qin, T., von Bornstaedt, D., Hérisson, F., Duan, B., et al. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.23 · Cited by 26 · see citing works

Periplaneta Americana (L.) extract activates the ERK/CREB/BDNF pathway to promote post-stroke neuroregeneration and recovery of neurological functions in rats

Rao, J., Li, H., Zhang, H., Xiang, X., Ding, X., Li, L., Geng, F., & Qi, H. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117400 · Cited by 26 · see citing works

Method parameters’ impact on mortality and variability in mouse stroke experiments: a meta-analysis

Ingberg, E., Dock, H., Theodorsson, E., Theodorsson, A., & Ström, J. O. (2016) · Scientific Reports · doi:10.1038/srep21086 · Cited by 25 · see citing works

Immunological Profile of Silent Brain Infarction and Lacunar Stroke

Sarchielli, P., Nardi, K., Chiasserini, D., Eusebi, P., Tantucci, M., Piero, V. D., Altieri, M., Marini, C., Russo, T., Silvestrini, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068428 · Cited by 25 · see citing works

Enriched Environment Elicits Proangiogenic Mechanisms After Focal Cerebral Ischemia

Xie, H., Yu, K., Zhou, N., Shen, X., Tian, S., Zhang, B., Wang, Y., Wu, J., Liu, G., Jiang, C., et al. (2018) · Translational Stroke Research · doi:10.1007/s12975-018-0629-8 · Cited by 24 · see citing works

High Concentration but Low Activity of Hepatocyte Growth Factor in Periodontitis

Lönn, J., Johansson, C. S., Nakka, S. S., Palm, E. C., Bengtsson, T., Nayeri, F., & Ravald, N. (2013) · Journal of Periodontology · doi:10.1902/jop.2013.130003 · Cited by 23 · see citing works

Role of STAT3‐FOXO3 Signaling in the Modulation of Neuroplasticity by PD‐L1‐HGF‐Decorated Mesenchymal Stem Cell‐Derived Exosomes in a Murine Stroke Model

Lin, S., Chang, Y., Lee, W., Chiang, C., Liu, S., Lee, H., Jeng, L., & Shyu, W. (2024) · Advanced Science · doi:10.1002/advs.202404882 · Cited by 22 · see citing works

Effects of an evidence-based nursing intervention on neurological function and serum inflammatory cytokines in patients with acute cerebral infarction: A randomized controlled trial

Liu, Y., Qu, M., Wang, N., & Wang, L. (2021) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-201080 · Cited by 20 · see citing works

Identification of neuronal and angiogenic growth factors in an in vitro blood-brain barrier model system: Relevance in barrier integrity and tight junction formation and complexity

Freese, C., Hanada, S., Fallier‐Becker, P., Kirkpatrick, C. J., & Unger, R. E. (2016) · Microvascular Research · doi:10.1016/j.mvr.2016.12.001 · Cited by 18 · see citing works

Fosgonimeton, a Novel Positive Modulator of the HGF/MET System, Promotes Neurotrophic and Procognitive Effects in Models of Dementia

Johnston, J. L., Reda, S. M., Setti, S. E., Taylor, R. W., Berthiaume, A.-A., Walker, W. E., Wu, W., Moebius, H. J., & Church, K. J. (2023) · Neurotherapeutics · doi:10.1007/s13311-022-01325-5 · Cited by 18 · see citing works

Naoxinqing tablet protects against cerebral ischemic/reperfusion injury by regulating ampkα/NAMPT/SIRT1/PGC-1α pathway

Sun, X. H., Pan, Y., Luo, Y., Guo, H., Zhang, Z., Wang, D., Li, C., & Sun, X. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117672 · Cited by 18 · see citing works

Alterations of inflammatory cytokines in super-acute stroke patients and the potential pathogenesis

Li, F., Ma, Q., Li, L., Zhang, L., Yang, Z., Huang, Y., Han, Z., Wang, R., Tao, Z., Zheng, Y., et al. (2022) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2022.02.034 · Cited by 17 · see citing works

Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases

Issa, S. S., Fayoud, H. J., Shaimardanova, A. A., Sufianov, A. A., Суфианова, Г. З., Solovyeva, V. V., & Rizvanov, A. A. (2024) · Biomedicines · doi:10.3390/biomedicines12081906 · Cited by 16 · see citing works

Reduced HGF/MET Signaling May Contribute to the Synaptic Pathology in an Alzheimer's Disease Mouse Model

Wei, J., Ma, X., Nehme, A., Cui, Y., Zhang, L., & Qiu, S. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.954266 · Cited by 13 · see citing works

Protective effects of HGF gene-expressing human mesenchymal stem cells in acetaminophen-treated hepatocytes

Jang, Y. H., You, D. H., & Nam, M. J. (2015) · Growth Factors · doi:10.3109/08977194.2015.1080695 · Cited by 12 · see citing works

Novel neuroprotective tetramethylpyrazine analog T-006 promotes neurogenesis and neurological restoration in a rat model of stroke

Wu, L., Cao, J., Li, N., Chen, H., Liu, W. D., Zhang, G., Liu, Y., Wang, Y., Sun, Y., & Zhang, Z. (2019) · Neuroreport · doi:10.1097/wnr.0000000000001256 · Cited by 11 · see citing works

The Case for a Novel Therapeutic Approach to Dementia: Small Molecule Hepatocyte Growth Factor (HGF/MET) Positive Modulators

Moebius, H. J., & Church, K. J. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-220871 · Cited by 9 · see citing works

Angiogenic cytokines in renovascular disease: do they have potential for therapeutic use?

Chade, A., & Stewart, N. J. (2013) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2013.01.004 · Cited by 9 · see citing works

Inhibition of Fatty Acid Synthesis Aggravates Brain Injury, Reduces Blood-Brain Barrier Integrity and Impairs Neurological Recovery in a Murine Stroke Model

Janssen, L., Ai, X., Zheng, X., Wei, W., Çağlayan, A. B., Kılıç, E., Wang, Y., Hermann, D. M., Venkataramani, V., Bähr, M., et al. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.733973 · Cited by 9 · see citing works

Typical and Atypical Stem Cell Niches of the Adult Nervous System in Health and Inflammatory Brain and Spinal Cord Diseases

Bernstock, J. D., Verheyen, J., Huang, B. Y., Hallenbeck, J. M., & Pluchino, S. (2014) · InTech eBooks · doi:10.5772/58599 · Cited by 8 · see citing works

Matriptase is required for the active form of hepatocyte growth factor induced Met, focal adhesion kinase and protein kinase B activation on neural stem/progenitor cell motility

Fang, J., & Lee, S.-L. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.03.020 · Cited by 8 · see citing works

Bone marrow mesenchymal stem cells overexpressing hepatocyte growth factor ameliorate hypoxic–ischemic brain damage in neonatal rats

Zeng, W., Wang, Y., Xi, Y., Wei, G., & Ju, R. (2021) · Translational Neuroscience · doi:10.1515/tnsci-2020-0204 · Cited by 7 · see citing works

Peripheral inflammatory response in people after acute ischaemic stroke and isolated spontaneous cervical artery dissection

Bauer, A., Boehme, C., Mayer‐Suess, L., Rudzki, D., Knoflach, M., Kiechl, S., & Reindl, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-62557-3 · Cited by 7 · see citing works

Therapeutic Factors in Ischemic Stroke Control

Soluki, M., Mahmoudi, F., & Abdolmaleki, A. (2022) · The Neuroscience Journal of Shefaye Khatam · doi:10.52547/shefa.10.4.77 · Cited by 7 · see citing works

Regenerative medicine for central nervous system disorders: Role of therapeutic molecules in stem cell therapy

Borlongan, C., Suárez-Meade, P., Carvajal, H. G., Yasuhara, T., Tajiri, N., & Date, I. (2015) · Brain Circulation · doi:10.4103/2394-8108.172884 · Cited by 7 · see citing works

Vertebrate Neural Stem Cells: Development, Plasticity, and Regeneration

Shimazaki, T. (2016) · The Keio Journal of Medicine · doi:10.2302/kjm.2015-0005-ir · Cited by 7 · see citing works

Stimulation of Plasticity and Functional Recovery After Stroke - Cell-based and Pharmacological Therapy

Chopp, M., & Li, Y. (2011) · European Neurological Review · doi:10.17925/enr.2011.06.02.97 · Cited by 6 · see citing works

The hepatocyte growth factor isoform NK2 activates motogenesis and survival but not proliferation due to lack of Akt activation

Mungunsukh, O., Lee, Y. H., Bottaro, D. P., & Day, R. M. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.05.012 · Cited by 6 · see citing works

Hepatocyte growth factor protects PC12 cells against OGD/R-induced injury by reducing iron

Li, S., Qian, Z., Xu, G.-J., Zheng, J., & Wu, Y. (2020) · Bioscience Reports · doi:10.1042/bsr20200287 · Cited by 6 · see citing works

Restorative Therapy in Stroke

Bhasin, A. (2014) · Journal of Transplantation Technologies & Research · doi:10.4172/2161-0991.1000136 · Cited by 4 · see citing works

Prototyping Minimal Extracellular Vesicle Mimetics Using Cell-Free Synthesis

Henson, T., Arizzi, A., Meyer, C. C., Wang, D., Lowe, N. M., Wang, Y., Ananda, K., Carney, R. P., Wang, A., & Tan, C. (2026) · ACS Nano · doi:10.1021/acsnano.5c05047 · Cited by 3 · see citing works

A methachromatic-based experimental model for identification of bowel as the focus of an acute inflammation

Nakka, S. S., Johansson, J., Shahzad, F., Hanning, A., & Nayeri, F. (2013) · Open Journal of Gastroenterology · doi:10.4236/ojgas.2013.31007 · Cited by 3 · see citing works

Patent Highlights

Mucke, H. A. (2013) · Pharmaceutical Patent Analyst · doi:10.4155/ppa.13.46 · Cited by 3 · see citing works

Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington’s Disease-Like Symptoms in Rats

Wells, R. G., Azzam, A. F., Hiller, A., & Sardinia, M. F. (2024) · Journal of Huntington s Disease · doi:10.3233/jhd-231507 · Cited by 2 · see citing works

Differences in the expression of hepatocyte growth factor in acute and chronic bowel inflammation—Implications for diagnosis?

Lönn, J., Nakka, S. S., Olsson, H., Bengtsson, T., Almer, S. H., & Nayeri, F. (2013) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2013.48a2006 · Cited by 2 · see citing works

Pharmacological Agents in Post Stroke Recovery

Moonis, M. (2014) · Journal of Neurology & Stroke · doi:10.15406/jnsk.2014.01.00040 · Cited by 1 · see citing works

Paradoxical role of hepatocyte growth factor in ischemic stroke: stroke risk/stroke recovery

Al-Ahmar, I., Mohamed, N., & Elshony, H. (2021) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-021-00364-7 · Cited by 1 · see citing works

MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

Cui, Y., Ma, X., Wei, J., Chen, C., Shakir, N., Guirram, H., Dai, Z., Anderson, T. R., Ferguson, D., & Qiu, S. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01471 · Cited by 1 · see citing works

Unraveling the impact of human cerebrospinal fluid on human neural stem cell fate

Radoszkiewicz, K., Bzinkowska, A., Sypecka, M., Sulejczak, D., Ferrari, D., Gelati, M., Vescovi, A. L., & Sarnowska, A. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1527557 · Cited by 1 · see citing works

Post‐ischemic protection of hepatocyte growth factor requires the type II transmembrane serine protease matriptase—A reciprocal regulation of the two for neuroprotection in stroke brain

Lee, S., Lee, M. H., Wu, K., Chiang, C., Chang, Y.-X., Fang, J., Tung, H., Kuo, L., & Wang, Y. (2022) · The FASEB Journal · doi:10.1096/fj.202200414r · Cited by 1 · see citing works

Growth factor polygenic disposition shapes associations of childhood adversity with gray matter and clinical profiles in depression: A two‐cohort imaging‐genetics study

Cazzella, T., Fortaner‐Uyà, L., Paolini, M., Percaccioli, C., Colombo, F., Venturelli, E., Colombo, C., Zanardi, R., Spadini, S., Lorenzi, C., et al. (2026) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.70144

VEGF-induced angiogenesis in the ischemic brain: effect of hyperlipidemia

Zechariah, A. (2012) · DuEPublico (University of Duisburg-Essen)

Neuroprotective Agents: An Overview on the General Modes of Action

Volsko, C. M., & Dutta, R. (2017) · doi:10.1002/9783527803781.ch2

Neuronal Regeneration by Using Endogenous Stem Cells and DDS Technology

Tsuboi, Y., Sawada, M., Otsuka, T., & Sawamoto, K. (2017) · Drug Delivery System · doi:10.2745/dds.32.46

Targeting Adult Neurogenesis for Brain Recovery After Stroke: The Next Frontier in Stroke Medicine

Ong, L. K., Ilicic, M., Hood, R. J., Warren, K. E., & Coupland, K. (2022) · Springer eBooks · doi:10.1007/978-981-16-8562-0_1

Neural progenitor cell-derived extracellular vesicles enhance blood-brain barrier integrity in stroke mice

Zhang, L. (2022) · doi:10.53846/goediss-9211

Naoxinqing Protects Against Cerebral Ischemic/Reperfusion Injury by Regulating Ampkα/Nampt/Sirt1/Pgc-1α PathwayPreprint

Sun, X. H., Pan, Y., Luo, Y., Guo, H., Zhang, Z.-X., Wang, D., Li, C., & Sun, X. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4618293

Cerebrospinal fluid inflammome analysis identifies host- and pathogen-specific inflammatory profiles and signaling pathways in meningitis and predicts clinical outcomePreprint

Lenhard, T., Herkel, M.-T., Falk, C. S., Balzer, V., Fricker, G., Schranz, C., & Meyding‐Lamadé, U. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.27.645675

Hepatocyte Growth Factor/MET Activator Rescues Working Memory Deficits after Repeated Mild Traumatic Brain Injury

Martino, K. A., Nakhre, A., Demarest, R. M., & Devilbiss, D. M. (2025) · Neurotrauma Reports · doi:10.1177/2689288x251392851

Hepatokines and stellakines in liver and neurological diseases: The liver-brain axis

Park, J., Guo, F., Lee, J. E., & Cheon, S. Y. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115899

Neuroprotective Effect of Hepatocyte Growth Factor

Miyazawa, T., Matsumoto, K., Tsuzuki, N., Nakau, H., Yamashima, T., Shima, K., & Nakamura, T. (1999) · Springer eBooks · doi:10.1007/978-3-642-58602-6_15

Protection of Hippocampal Neurons from Ischemia-Induced Delayed Neuronal Death by Hepatocyte Growth Factor: A Novel Neurotrophic Factor

Miyazawa, T., Matsumoto, K., Ohmichi, H., Katoh, H., Yamashima, T., & Nakamura, T. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199804000-00001 · Cited by 136 · see citing works

The hematopoietic growth factors - a new perspective in the neuroprotective therapy of the ischemic stroke

Fodor, D. M., & Perju‐Dumbravă, L. (2009) · Romanian Journal of Neurology · doi:10.37897/rjn.2009.4.4 · Cited by 1 · see citing works

Hepatocyte growth factor reduces the infarct volume after transient focal cerebral ischemia in rats

Tsuzuki, N., Miyazawa, T., Matsumoto, K., Nakamura, T., & Shima, K. (2001) · Neurological Research · doi:10.1179/016164101101198659 · Cited by 56 · see citing works

Gene Transfer of Hepatocyte Growth Factor Gene Improves Learning and Memory in the Chronic Stage of Cerebral Infarction

Shimamura, M., Sato, N., Waguri, S., Uchiyama, Y., Hayashi, T., Iida, H., Nakamura, T., Ogihara, T., Kaneda, Y., & Morishita, R. (2006) · Hypertension · doi:10.1161/01.hyp.0000208598.57687.3e · Cited by 68 · see citing works