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Cited by 124Multiple Sclerosis Research StudiesCancer-related cognitive impairment studiesDementia and Cognitive Impairment Research

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

The association between cognitive impairment and quality of life in patients with early multiple sclerosis

Glanz, Bonnie I., Healy, Brian C., Rintell, David J., Jaffin, Sharon K., Bakshi, Rohit, Weiner, Howard L.·2010·Journal of the Neurological Sciences
DOI 10.1016/j.jns.2009.11.004
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Abstract

Cognitive deficits are common in patients with multiple sclerosis (MS) and may be observed early in the course of the disease. Current knowledge about the association between cognitive impairment and health-related quality of life (HQOL) in patients with early MS is limited. We used a well-established battery of cognitive tests and standardized HQOL measures to examine the associations between overall and domain-specific cognitive performance and quality of life in patients with early MS. Ninety-two patients with CIS or MS diagnosed in the previous three years participating in the CLIMB Natural History Study underwent a neurologic examination, neuropsychological evaluation and quality of life assessment. Associations between cognitive scores and HQOL measures were examined. There were no differences between cognitively impaired versus unimpaired subjects on any of the HQOL measures. After controlling for depression, scores on tests of information processing speed were significantly associated with several measures of HQOL including physical well-being, fatigue, and social support. In all cases, correlations between HQOL and cognitive measures were mild. These findings were observed in patients with limited cognitive impairment and minimal physical disability. Our results suggest that cognitive remediation programs aimed at improving cognitive skills may also improve quality of life for patients with early MS.

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Crossref · 10.1016/j.jns.2009.11.004

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Citations

Cites

Research works printed but not linked: 2

  1. 1998, Burden of illness of multiple sclerosis. II. Quality of life, Can J Neurol Sci, 25, 31
  2. Smith, 1968, The Symbol–Digit Modalities Test: a neuropsychologic test for economic screening of learning and other cerebral disorders, Learn Disord, 3, 83

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Metadata

Authors
Glanz, B. I., Healy, B. C., Rintell, D. J., Jaffin, S. K., Bakshi, R., & Weiner, H. L.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Glanz, Bonnie I.
ORCID
Venue
Journal of the Neurological Sciences
Publisher
Elsevier BV
Published
2010-03
Volume
290
Issue
1-2
Pages
75-79
ISSN
0022-510X (ISSN-L)
DOI
10.1016/j.jns.2009.11.004
OpenAlex
W2055969760
Cited by
124
References
41
Citations by year
2026: 3 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 9 · 2020: 5 · 2019: 3 · 2018: 13 · 2017: 7 · 2016: 11 · 2015: 10 · 2014: 5 · 2013: 6 · 2012: 13
FWCI
7.07
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of the Neurological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
multiple sclerosis, cognitive impairment, health-related quality of life, early multiple sclerosis, processing speed, cognitive remediation, fatigue, social support, physical well-being, depression, clinical trial participants
MeSH terms
Adaptation, Psychological, Adult, Cognition, Cognition Disorders, Depressive Disorder, Disability Evaluation, Fatigue, Female, Health Status, Health Surveys, Humans, Male, Middle Aged, Multiple Sclerosis, Neuropsychological Tests, Quality of Life, Severity of Illness Index, Social Support, Cognitive Behavioral Therapy, Disease Progression

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