Cited by 63Parkinson's Disease Mechanisms and TreatmentsSphingolipid Metabolism and SignalingDementia and Cognitive Impairment Research

Associations between Plasma Ceramides and Cognitive and Neuropsychiatric Manifestations in Parkinson’s Disease Dementia

Xing, Yi, Tang, Yi, Zhao, Lina, Wang, Qi, Qin, Wei, Ji, Xiaojuan, Zhang, Jinlan, Jia, Jianping·2016·Journal of the Neurological Sciences

Abstract

Background The abnormal metabolism of ceramides may account for the pathogenesis of Parkinson's disease dementia (PDD). However, the effect of ceramides on cognitive domain impairments and neuropsychiatric symptoms of PDD remains unknown.Methods A total of 38 PDD, 40 PD with no cognitive impairment (PD-NC) and 40 normal controls were included. A series of cognitive tests and the Neuropsychiatric Inventory (NPI) were used to assess cognitive domains and neuropsychiatric symptoms. A non-fasting blood sample was obtained from each subject. Plasma ceramide levels were tested by HPLC-MS/MS analysis.Results C14:0 and C24:1 levels were significantly higher in PDD than in PD-NC and normal controls. Verbal memory was negatively correlated with C14:0 and C24:1. After controlling for confounding factors, C22:0, C20:0 and C18:0 were significantly associated with hallucinations, anxiety and sleep behavior disturbances, respectively.Conclusion In PDD, the increase in ceramide levels was correlated with decreased memory function and associated with higher odds of multiple neuropsychiatric symptoms.

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Crossref · 10.1016/j.jns.2016.09.028

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Authors
Xing, Y., Tang, Y., Zhao, L., Wang, Q., Qin, W., Ji, X., Zhang, J., & Jia, J.
Affiliations
  • Capital Medical University (CN)
  • Beijing Jishuitan Hospital (CN)
  • Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Corresponding author
  • Zhang, Jinlan
  • Jia, Jianping
Venue
Journal of the Neurological Sciences
Publisher
Elsevier BV
Published
2016-11
Volume
370
Pages
82-87
ISSN
0022-510X (ISSN-L)
OpenAlex
W2522236364
Cited by
63
References
36
Citations by year
2026: 1 · 2025: 9 · 2024: 10 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 12 · 2019: 9 · 2018: 5 · 2017: 3
FWCI
4.26
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of the Neurological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National 973 Project Grant of China (2011CB504104)
  • Beijing Municipal Administration of Hospitals (ZYLX201301)
  • Beijing Municipal Science & Technology Commission (Z151100004015078)
  • Specialized Research Fund for the Doctoral Program of Higher Education (20131107120002)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Parkinson's disease dementia, plasma ceramides, ceramide metabolism, cognitive impairment, verbal memory, neuropsychiatric symptoms, hallucinations, anxiety
MeSH terms
Aged, Anxiety, Blood Chemical Analysis, Ceramides, Chromatography, High Pressure Liquid, Dementia, Female, Hallucinations, Humans, Male, Memory, Mental Status Schedule, Neuropsychological Tests, Parkinson Disease, Regression Analysis, Sleep, Sleep Wake Disorders, Biomarkers, Tandem Mass Spectrometry

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