Associations between Plasma Ceramides and Cognitive and Neuropsychiatric Manifestations in Parkinson’s Disease Dementia
Abstract
Background The abnormal metabolism of ceramides may account for the pathogenesis of Parkinson's disease dementia (PDD). However, the effect of ceramides on cognitive domain impairments and neuropsychiatric symptoms of PDD remains unknown.Methods A total of 38 PDD, 40 PD with no cognitive impairment (PD-NC) and 40 normal controls were included. A series of cognitive tests and the Neuropsychiatric Inventory (NPI) were used to assess cognitive domains and neuropsychiatric symptoms. A non-fasting blood sample was obtained from each subject. Plasma ceramide levels were tested by HPLC-MS/MS analysis.Results C14:0 and C24:1 levels were significantly higher in PDD than in PD-NC and normal controls. Verbal memory was negatively correlated with C14:0 and C24:1. After controlling for confounding factors, C22:0, C20:0 and C18:0 were significantly associated with hallucinations, anxiety and sleep behavior disturbances, respectively.Conclusion In PDD, the increase in ceramide levels was correlated with decreased memory function and associated with higher odds of multiple neuropsychiatric symptoms.
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Cer C 20:0 levels were positively associated with anxiety symptoms in Parkinson's disease.
“In particular, Xing et al. demonstrated a positive association of Cer C 20:0 levels with anxiety symptoms in Parkinson’s disease [75].”
From Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers (2024) · cites this paper as [75]
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Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers
Zorkina, Y., Ushakova, V., Ochneva, A., Tsurina, A., Abramova, O., Savenkova, V., Goncharova, A., Alekseenko, I., Morozova, I., Riabinina, D., et al. (2024) · Metabolites · doi:10.3390/metabo14020080 · Cited by 36 · see citing works
- Authors
- Xing, Y., Tang, Y., Zhao, L., Wang, Q., Qin, W., Ji, X., Zhang, J., & Jia, J.
- Affiliations
- Capital Medical University (CN)
- Beijing Jishuitan Hospital (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Zhang, Jinlan
- Jia, Jianping
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 370
- Pages
- 82-87
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W2522236364
- Cited by
- 63
- References
- 36
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 10 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 12 · 2019: 9 · 2018: 5 · 2017: 3
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National 973 Project Grant of China (2011CB504104)
- Beijing Municipal Administration of Hospitals (ZYLX201301)
- Beijing Municipal Science & Technology Commission (Z151100004015078)
- Specialized Research Fund for the Doctoral Program of Higher Education (20131107120002)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Parkinson's disease dementia, plasma ceramides, ceramide metabolism, cognitive impairment, verbal memory, neuropsychiatric symptoms, hallucinations, anxiety
- MeSH terms
- Aged, Anxiety, Blood Chemical Analysis, Ceramides, Chromatography, High Pressure Liquid, Dementia, Female, Hallucinations, Humans, Male, Memory, Mental Status Schedule, Neuropsychological Tests, Parkinson Disease, Regression Analysis, Sleep, Sleep Wake Disorders, Biomarkers, Tandem Mass Spectrometry
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