Plasma Phosphatidylcholine and Sphingomyelin Concentrations Are Associated with Depression and Anxiety Symptoms in a Dutch Family-Based Lipidomics Study
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The central nervous system has the second highest concentration of lipids after adipose tissue. Alterations in neural membrane phospho- and sphingolipid composition can influence crucial intra- and intercellular signalling and alter the membrane's properties. Recently, the polyunsaturated fatty acids (PUFA) hypothesis for depression suggests that phospho- and sphingolipid metabolism includes potential pathways for the disease. In 742 people from a Dutch family-based study, we assessed the relationships between 148 different plasma phospho- and sphingolipid species and depression/anxiety symptoms as measured by the Hospital Anxiety and Depression Scales (HADS-A and HADS-D) and the Centre for Epidemiological Studies Depression Scale (CES-D). We observed significant differences in plasma sphingomyelins (SPM), particularly the SPM 23:1/SPM 16:0 ratio, which was inversely correlated with depressive symptom scores. We observed a similar trend for plasma phosphatidylcholines (PC), particularly the molar proportion of PC O 36:4 and its ratio to ceramide CER 20:0. Absolute levels of PC O 36:4 were also associated with depression symptoms in an independent replication. To our knowledge this is the first study on depressive symptoms that focuses on specific phospho- and sphingolipid molecules in plasma rather than total PUFA concentrations. The findings of this lipidomic study suggests that plasma sphingomyelins and ether phospholipids should be further studied for their potential as biomarkers and for a better understanding of the underlying mechanisms of this systemic disease.
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Several studies have indicated an association between the lipid concentrations of PE-O, SM, and PC-O and symptom severity according to specific scales.
“Several studies have indicated an association between the lipid concentrations of octadecyl-phosphatidylethanolamine (PE-O) [58], SM, and PC-O [63] and symptom severity according to the specific scales.”
From Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers (2024) · cites this paper as [63]
Cites
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267 · see citing works
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
The validity of the Hospital Anxiety and Depression Scale
Bjelland, I., Dahl, A. A., Haug, T. T., & Neckelmann, D. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(01)00296-3 · Cited by 9,779 · cited 1× · see citing works
“Several validation studies on various types of patients using different diagnostic tools have shown that HADS performs well in assessing symptom severity and case status for anxiety disorders and depression in both somatic, psychiatric and primary care patients and in the general population (Bjelland et al., 2002).”
MethodMultipoint Quantitative-Trait Linkage Analysis in General Pedigrees
Almasy, L. A., & Blangero, J. (1998) · The American Journal of Human Genetics · doi:10.1086/301844 · Cited by 3,007 · see citing works
Fisher, R. A. (1915) · Biometrika · doi:10.1093/biomet/10.4.507 · Cited by 2,159 · see citing works
Fisher, R. A. (1915) · Biometrika · doi:10.2307/2331838 · Cited by 1,334 · see citing works
Beekman, A. T. F., Deeg, D. J. H., van Limbeek, J., Braam, A. W., VRIES, M. Z. D., & van Tilburg, W. (1997) · Psychological Medicine · doi:10.1017/s0033291796003510 · Cited by 1,135 · see citing works
Brügger, B., Erben, G., Sandhoff, R., Wieland, F., & Lehmann, W. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2339 · Cited by 882 · see citing works
Farooqui, A. A., Horrocks, L. A., & Farooqui, T. (2000) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(00)00128-6 · Cited by 555 · see citing works
Handbook of clinical neurology
Munsat, T. L. (1993) · Neuromuscular Disorders · doi:10.1016/0960-8966(93)90014-b · Cited by 552 · see citing works
A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression
Lin, P.-Y., Huang, S.-Y., & Su, K.-P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.018 · Cited by 530 · see citing works
Ceramide: second messenger or modulator of membrane structure and dynamics?
BLITTERSWIJK, W. J. V., van der Luit, A. H., Veldman, R. J., Verheij, M., & Borst, J. G. (2003) · Biochemical Journal · doi:10.1042/bj20021528 · Cited by 436 · see citing works
Functions and biosynthesis of plasmalogens in health and disease
Brites, P., Waterham, H. R., & Wanders, R. J. A. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2003.12.010 · Cited by 415 · see citing works
Horrocks, L. A., & Farooqui, A. A. (2004) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.12.011 · Cited by 356 · see citing works
Liebisch, G., Lieser, B., Rathenberg, J., Drobnik, W., & Schmitz, G. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2004.09.003 · Cited by 336 · see citing works
Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study
Tiemeier, H. W., van Tuijl, H. R., Albert Hofman, D., Kiliaan, A. J., & Breteler, M. M. B. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.1.40 · Cited by 285 · see citing works
Berry, K. A. Z., & Murphy, R. C. (2004) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2004.07.009 · Cited by 279 · see citing works
Roles and regulation of secretory and lysosomal acid sphingomyelinase
Jenkins, R. W., Canals, D., & Hannun, Y. A. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.01.026 · Cited by 276 · see citing works
Ceramide-enriched membrane domains—Structure and function
Zhang, Y., Li, X., Becker, K. A., & Gulbins, E. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.07.030 · Cited by 263 · see citing works
Effects of ceramide and other simple sphingolipids on membrane lateral structure
Goñi, F. M., & Alonso, A. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.09.002 · Cited by 224 · see citing works
Horrobin, D. F., & Bennett, C. N. (1999) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.1999.0037 · Cited by 222 · see citing works
Ganglioside/glycosphingolipid turnover: New concepts
Tettamanti, G. (2003) · Glycoconjugate Journal · doi:10.1023/b:glyc.0000033627.02765.cc · Cited by 212 · see citing works
Lithium Treatment Reduces Suicide Risk in Recurrent Major Depressive Disorder
Guzzetta, F., Tondo, L., Centorrino, F., & Baldessarini, R. J. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0304 · Cited by 208 · see citing works
Demirkan, A., van Duijn, C. M., Ugocsai, P., Isaacs, A., Pramstaller, P. P., Liebisch, G., Wilson, J. F., Johansson, Å., Rudan, I., Aulchenko, Y. S., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002490 · Cited by 205 · see citing works
Kölzer, M., Werth, N., & Sandhoff, K. (2004) · FEBS Letters · doi:10.1016/s0014-5793(04)00033-x · Cited by 200 · see citing works
Liebisch, G., Drobnik, W., Lieser, B., & Schmitz, G. (2002) · Clinical Chemistry · doi:10.1093/clinchem/48.12.2217 · Cited by 199 · see citing works
Plasma Free Fatty Acid and Lipoproteins as Sources of Polyunsaturated Fatty Acid for the Brain
Spector, A. A. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:2-3:159 · Cited by 189 · see citing works
Sphingomyelin and ceramide as regulators of development and lifespan
Cutler, R. G. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00246-9 · Cited by 171 · see citing works
Fatty acid transport into the brain: Of fatty acid fables and lipid tails
Mitchell, R. W., & Hatch, G. M. (2011) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2011.04.007 · Cited by 167 · see citing works
Lithium decreases turnover of arachidonate in several brain phospholipids
Chang, M., Grange, E., Rabin, O., Bell, J. M., Allen, D. D., & Rapoport, S. I. (1996) · Neuroscience Letters · doi:10.1016/s0304-3940(96)13264-x · Cited by 150 · see citing works
High activity of acid sphingomyelinase in major depression
Kornhuber, J., Medlin, A., Bleich, S., Jendrossek, V., Henkel, A. W., Wiltfang, J., & Gulbins, E. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-005-0374-5 · Cited by 143 · see citing works
Altered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patients
Kim, H., Рапопорт, С. И., & Rao, J. S. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.137 · Cited by 121 · see citing works
Linkage disequilibrium in young genetically isolated Dutch population
Aulchenko, Y. S., Heutink, P., Mackay, I., Bertoli‐Avella, A. M., Pullen, J., Vaessen, N., Rademaker, T., Sandkuijl, L. A., Cardon, L. R., Oostra, B. A., et al. (2004) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201188 · Cited by 121 · see citing works
Brain phospholipases A2: a perspective on the history
Farooqui, A. A., & Horrocks, L. A. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2004.03.004 · Cited by 120 · see citing works
Popják, G. J. (1960) · Cited by 120 · see citing works
Trajectory classes of depressive symptoms in a community sample of older adults
Kuchibhatla, M. N., Fillenbaum, G. G., Hybels, C. F., & Blazer, D. G. (2011) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2011.01801.x · Cited by 119 · see citing works
Harlow, S. D., Goldberg, E. L., & Comstock, G. W. (1991) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116125 · Cited by 102 · cited 1× · see citing works
“, 1997) and has proven to be relatively stable over time: 82% of older adults had stable CES-D scores over four measurement rounds in ten years (Harlow et al., 1991; Kuchibhatla et al., 2012) A broad range of phospho- and sphingolipid species (n 1⁄4 148) were measured in 742 participants who also had measurements of d…”
BackgroundFarooqui, A. A. (2009) · The Neuroscientist · doi:10.1177/1073858409337035 · Cited by 97 · see citing works
Chronic Lithium Treatment Decreases Brain Phospholipase A2 Activity
Chang, M., & Jones, C. R. (1998) · Neurochemical Research · doi:10.1023/a:1022415113421 · Cited by 83 · see citing works
Studies on Plasmalogen-Selective Phospholipase A2 in Brain
Farooqui, A. A. (2010) · Molecular Neurobiology · doi:10.1007/s12035-009-8091-y · Cited by 72 · see citing works
Horrobin, D. F., & Bennett, C. N. (1999) · Cited by 60 · see citing works
The role of ceramide in major depressive disorder
Kornhuber, J., Reichel, M., Tripal, P., Groemer, T. W., Henkel, A. W., Mühle, C., & Gulbins, E. (2009) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-009-0061-x · Cited by 59 · see citing works
Koumanov, K. S., Momchilova, A., Quinn, P. J., & Wolf, C. (2002) · Biochemical Journal · doi:10.1042/0264-6021:3630045 · Cited by 59 · see citing works
An approach for cutting large and complex pedigrees for linkage analysis
Liu, F., Kirichenko, A. V., Axenovich, T. I., van Duijn, C. M., & Aulchenko, Y. S. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.24 · Cited by 56 · see citing works
Brain Uptake and Utilization of Fatty Acids: Applications to Peroxisomal Biogenesis Diseases
Watkins, P. A., Hamilton, J. A., Leaf, A., Spector, A. A., Moore, S. A., Anderson, R. E., Moser, H. W., Noetzel, M. J., & Katz, R. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:2-3:87 · Cited by 53 · see citing works
Chilton, F. H., Fonteh, A. N., Sung, C.-M., Hickey, D. M. B., Torphy, T. J., Mayer, R. J., Marshall, L. A., Heravi, J., & Winkler, J. D. (1995) · Biochemistry · doi:10.1021/bi00016a011 · Cited by 50 · see citing works
Horrobin, D. F. (2001) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.182 · Cited by 49 · see citing works
Igarashi, M., Kim, H., Chang, L., Ma, K., & Rapoport, S. I. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07597.x · Cited by 44 · see citing works
Cellular phospholipid uptake: Flexible paths to coregulate the functions of intracellular lipids
Engelmann, B., & Wiedmann, M. K. H. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.02.013 · Cited by 42 · see citing works
Effects of polyunsaturated fatty acids on psychiatric disorders
Su, K., Shen, W. W., & Huang, S. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.5.1241 · Cited by 23 · see citing works
Winkler, J. D., Bolognese, B. J., Roshak, A., Sung, C.-M., & Marshall, L. A. (1997) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/s0005-2760(97)00032-5 · Cited by 21 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Brain membrane lipids in major depression and anxiety disorders
Müller, C. P., Reichel, M., Mühle, C., Rhein, C., Gulbins, E., & Kornhuber, J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.12.014 · Cited by 308 · see citing works
Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide
Gulbins, A., Schumacher, F., Becker, K. A., Wilker, B., Soddemann, M., Boldrin, F., Müller, C. P., Edwards, M. J., Goodman, M. D., Caldwell, C. C., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0090-9 · Cited by 230 · see citing works
Analytical Methods in Lipidomics and Their Applications
Li, M., Li, Y., Bai, Y., & Liu, H. (2013) · Analytical Chemistry · doi:10.1021/ac403554h · Cited by 210 · see citing works
Gadad, B. S., Jha, M. K., Czysz, A., Furman, J. L., Mayes, T. L., Emslie, M. P., & Trivedi, M. H. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.07.001 · Cited by 205 · see citing works
Regulation of sphingomyelin metabolism
Bienias, K., Fiedorowicz, A., Sadowska, A. J., Prokopiuk, S., & Car, H. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2015.12.008 · Cited by 193 · see citing works
Peripheral Markers of Depression
Nobis, A., Zalewski, D., & Waszkiewicz, N. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9123793 · Cited by 197 · see citing works
Liu, X., Zheng, P., Zhao, X., Zhang, Y., Hu, C., Li, J., Zhao, J., Zhou, J., Xie, P., & Xu, G. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00144 · Cited by 193 · see citing works
Ceramides as Novel Disease Biomarkers
Kurz, J., Parnham, M. J., Geißlinger, G., & Schiffmann, S. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.10.009 · Cited by 189 · see citing works
Ishikawa, M., Maekawa, K., Saito, K., Senoo, Y., Urata, M., Murayama, M., Tajima, Y., Kumagai, Y., & Saito, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091806 · Cited by 187 · see citing works
Lipids in Psychiatric Disorders and Preventive Medicine
Schneider, M., Levant, B., Reichel, M., Gulbins, E., Kornhuber, J., & Müller, C. P. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.002 · Cited by 175 · see citing works
Dorninger, F., Forss‐Petter, S., & Berger, J. (2017) · FEBS Letters · doi:10.1002/1873-3468.12788 · Cited by 162 · see citing works
Plasma lipidomics reveals potential lipid markers of major depressive disorder
Liu, X., Li, J., Zheng, P., Zhao, X., Zhou, C., Hu, C., Hou, X., Wang, H., Xie, P., & Xu, G. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-9768-5 · Cited by 148 · see citing works
The ceramide system as a novel antidepressant target
Kornhuber, J., Müller, C. P., Becker, K. A., Reichel, M., & Gulbins, E. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.04.003 · Cited by 121 · see citing works
Lipids as biomarkers of brain disorders
Hussain, G., Anwar, H., Rasul, A., Imran, A., Qasim, M., Zafar, S., Imran, M., Kamran, S., Aziz, N., Razzaq, A., et al. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1529653 · Cited by 105 · see citing works
MahmoudianDehkordi, S., Ahmed, A. T., Bhattacharyya, S., Han, X., Baillie, R. A., Arnold, M., Skime, M. K., John-Williams, L. S., Moseley, M. A., Thompson, J. W., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01097-6 · Cited by 95 · see citing works
Ceramides and depression: A systematic review
Dinoff, A., Herrmann, N., & Lanctôt, K. L. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.02.008 · Cited by 95 · see citing works
Tkachev, A., Stekolshchikova, E., Vanyushkina, A., Zhang, H., Morozova, A. Y., Zozulya, S. A., Kurochkin, I., Anikanov, N. A., Egorova, A., Yushina, E., et al. (2023) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2022.4350 · Cited by 78 · see citing works
Lipidomics in Major Depressive Disorder
Walther, A., Cannistraci, C. V., Simons, K., Durán, C., Gerl, M. J., Wehrli, S., & Kirschbaum, C. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00459 · Cited by 77 · see citing works
Faria, R., Santana, M. M., Aveleira, C. A., Simões, C. S. O., Maciel, E. A., Melo, T., Santinha, D. R., Oliveira, M. M., Peixoto, F., Domingues, P. M., et al. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.042 · Cited by 76 · see citing works
Metabolomic Biomarkers in Anxiety Disorders
Humer, E. C., Pieh, C., & Probst, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134784 · Cited by 68 · see citing works
Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities
Javaid, S., Farooq, T., Rehman, Z., Afzal, A., Ashraf, W., Rasool, M. F., Alqahtani, F., Alsanea, S., Alasmari, F. F., Alanazi, M. M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111313 · Cited by 68 · see citing works
Xing, Y., Tang, Y., Zhao, L., Wang, Q., Qin, W., Ji, X., Zhang, J., & Jia, J. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.09.028 · Cited by 63 · see citing works
Sphingolipids in Psychiatric Disorders and Pain Syndromes
Mühle, C., Reichel, M., Gulbins, E., & Kornhuber, J. (2013) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-7091-1511-4_22 · Cited by 58 · see citing works
Contribution of ceramides metabolism in psychiatric disorders
Bernal‐Vega, S., García‐Juárez, M., & Camacho‐Morales, A. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15759 · Cited by 57 · see citing works
Huang, T., Balasubramanian, R., Yao, Y., Clish, C. B., Shadyab, A. H., Liu, B., Tworoger, S. S., Rexrode, K. M., Manson, J. E., Kubzansky, L. D., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00870-9 · Cited by 52 · see citing works
Adaptation of Lipid Profiling in Depression Disease and Treatment: A Critical Review
Pinto, B., Conde, T., Domingues, I., & Domingues, M. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042032 · Cited by 51 · see citing works
“PC-O(36:4); Cer(20:0); SM(16:0); SM(23:1) [69]”
Kim, E. Y., Lee, J. W., Lee, M. Y., Kim, S. H., Mok, H. J., Ha, K., Ahn, Y. M., & Kim, K. P. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.04.029 · Cited by 50 · see citing works
Schumacher, F., Edwards, M. J., Mühle, C., Carpinteiro, A., Wilson, G. C., Wilker, B., Soddemann, M., Keitsch, S., Scherbaum, N., Müller, B. W., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102185 · Cited by 50 · see citing works
Mazereeuw, G., Herrmann, N., Bennett, S. A. L., Swardfager, W., Xu, H., Valenzuela, N., Fai, S., & Lanctôt, K. L. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.06.010 · Cited by 47 · see citing works
Buchenauer, L., Haange, S., Bauer, M., Rolle-Kampczyk, U. E., Wagner, M., Stucke, J., Elter, E., Fink, B., Vass, M., von Bergen�, M., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.167034 · Cited by 44 · see citing works
Analytical approaches for lipidomics and its potential applications in neuropsychiatric disorders
Sethi, S., Hayashi, M. A. F., Sussulini, A., Tasić, L., & Brietzke, E. M. (2015) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2015.1117656 · Cited by 44 · see citing works
Knowles, E. E. M., Huynh, K., Meikle, P. J., Göring, H. H. H., Olvera, R. L., Mathias, S. R., Duggirala, R., Almasy, L. A., Blangero, J., Curran, J. E., et al. (2017) · European Psychiatry · doi:10.1016/j.eurpsy.2017.02.479 · Cited by 43 · see citing works
Walther, A., Mackens-Kiani, A., Eder, J., Herbig, M., Herold, C., Kirschbaum, C., Guck, J. R., Wittwer, L. D., Beesdo‐Baum, K., & Kräter, M. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01911-3 · Cited by 42 · see citing works
Wang, C., Lin, H., Yang, N., Wang, H., Zhao, Y. H., Li, P., Liu, J., & Wang, F. (2019) · Molecules · doi:10.3390/molecules24091712 · Cited by 41 · see citing works
Can targeted metabolomics predict depression recovery? Results from the CO-MED trial
Czysz, A. H., South, C. C., Gadad, B. S., Arning, E., Soyombo, A. A., Bottiglieri, T., & Trivedi, M. H. (2019) · Translational Psychiatry · doi:10.1038/s41398-018-0349-6 · Cited by 38 · see citing works
Filho, A. J. M. C., Braniff, O., Angelova, A., Deng, Y., & Tremblay, M. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110702 · Cited by 39 · see citing works
Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers
Zorkina, Y., Ushakova, V., Ochneva, A., Tsurina, A., Abramova, O., Savenkova, V., Goncharova, A., Alekseenko, I., Morozova, I., Riabinina, D., et al. (2024) · Metabolites · doi:10.3390/metabo14020080 · Cited by 36 · see citing works
Mühle, C., Wagner, C., Färber, K., Richter‐Schmidinger, T., Gulbins, E., Lenz, B., & Kornhuber, J. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8060846 · Cited by 36 · see citing works
Miao, G., Deen, J. F., Struzeski, J. B., Chen, M., Zhang, Y., Cole, S. A., Fretts, A. M., Lee, E. T., Howard, B. V., Fiehn, O., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01948-w · Cited by 36 · see citing works
Sphingolipids as Biomarkers of Disease
Matanes, F., Twal, W. O., & Hammad, S. M. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-21162-2_7 · Cited by 34 · see citing works
Mazi, T. A., Sarode, G. V., Członkowska, A., Litwin, T., Kim, K., Shibata, N. M., & Medici, V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20235937 · Cited by 34 · see citing works
Lipid and energy metabolism in Wilson disease
Mazi, T. A., Shibata, N. M., & Medici, V. (2020) · Liver Research · doi:10.1016/j.livres.2020.02.002 · Cited by 34 · see citing works
Wu, L. M., Han, Y., Zheng, Z., Zhu, S., Chen, J., Yao, Y., Yue, S., Teufel, A., Weng, H., Li, L., et al. (2021) · Nutrients · doi:10.3390/nu13030940 · Cited by 34 · see citing works
Lipidomic analyses in epidemiology
Mundra, P. A., Shaw, J. E., & Meikle, P. J. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw112 · Cited by 33 · see citing works
Ge, Z., Hu, Y., Kan, W., Li, L., Xu, J., Zhang, Y., Zheng, N., Wang, G., & Du, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1625087 · Cited by 33 · see citing works
Xue, S., Zhou, C., Xue, F., Liu, L., Cai, Y., Luo, J., Wang, Y., Tan, Q., Wang, H., & Peng, Z. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109946 · Cited by 32 · see citing works
Weng, R., Shen, S., Burton, C., Yang, L., Nie, H., Tian, Y., Bai, Y., & Liu, H. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-015-9256-3 · Cited by 31 · see citing works
Žáček, P., Bukowski, M. R., Rosenberger, T. A., & Picklo, M. J. (2016) · Journal of Lipid Research · doi:10.1194/jlr.d070656 · Cited by 30 · see citing works
Xu, M., Legradi, J., & Leonards, P. E. G. (2020) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-020-02661-1 · Cited by 30 · see citing works
Zoicas, I., Mühle, C., Schmidtner, A. K., Gulbins, E., Neumann, I. D., & Kornhuber, J. (2020) · Cells · doi:10.3390/cells9051239 · Cited by 29 · see citing works
Schoeny, H., Rampler, E., Abiead, Y. E., Hildebrand, F., Zach, O., Hermann, G., & Koellensperger, G. (2021) · The Analyst · doi:10.1039/d0an02443k · Cited by 29 · see citing works
Sphingolipids in Major Depression
Jernigan, P. L., Hoehn, R. S., Grassmé, H., Edwards, M. J., Müller, C. P., Kornhuber, J., & Gulbins, E. (2015) · Neurosignals · doi:10.1159/000442603 · Cited by 29 · see citing works
Reichel, M., Hönig, S., Liebisch, G., Lüth, A., Kleuser, B., Gulbins, E., Schmitz, G., & Kornhuber, J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.08.005 · Cited by 28 · see citing works
Nonsynonymous Variation in NKPD1 Increases Depressive Symptoms in European Populations
Amin, N., Belonogova, N. M., Jovanova, O., Brouwer, R. W. W., van Rooij, J., van den Hout, M. C. G. N., Svishcheva, G. R., Kraaij, R., Zorkoltseva, I. V., Kirichenko, A. V., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.08.008 · Cited by 28 · see citing works
Keksel, N., Bussmann, H., Unger, M., Drewe, J., Boonen, G., Häberlein, H., & Franken, S. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.06.013 · Cited by 28 · see citing works
Serum phosphatidylinositol as a biomarker for bipolar disorder liability
Knowles, E. E. M., Meikle, P. J., Huynh, K., Göring, H. H. H., Olvera, R. L., Mathias, S. R., Duggirala, R., Almasy, L. A., Blangero, J., Curran, J. E., et al. (2017) · Bipolar Disorders · doi:10.1111/bdi.12468 · Cited by 27 · see citing works
Plasma Ceramides and Neuropsychiatric Symptoms of Alzheimer’s Disease
Xing, Y., Tang, Y., Zhao, L., Wang, Q., Qin, W., Zhang, J., & Jia, J. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-151158 · Cited by 26 · see citing works
Plasma sphingolipids and depressive symptoms in coronary artery disease
Dinoff, A., Saleem, M., Herrmann, N., Mielke, M. M., OH, P. I., Venkata, S. L. V., Haughey, N. J., & Lanctôt, K. L. (2017) · Brain and Behavior · doi:10.1002/brb3.836 · Cited by 26 · see citing works
Pujol-Lereis, L. M., Liebisch, G., Schick, T., Lin, Y.-C., Graßmann, F., Uchida, K., Zipfel, P. F., Fauser, S., Skerka, C., & Weber, B. H. F. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200739 · Cited by 26 · see citing works
Zoicas, I., Schumacher, F., Kleuser, B., Reichel, M., Gulbins, E., Fejtová, A., Kornhuber, J., & Rhein, C. (2020) · Cells · doi:10.3390/cells9051244 · Cited by 25 · see citing works
Abildgaard, A. M., Kern, T., Pedersen, O. B., Hansen, T. F., Lund, S. A., & Wegener, G. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.09.001 · Cited by 24 · see citing works
Guo, L., Zhang, T., Li, R., Cui, Z.-Q., Du, J., Yang, J.-B., Xue, F., Chen, Y., Tan, Q.-R., & Peng, Z. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.802710 · Cited by 23 · see citing works
mRNA Expression of SMPD1 Encoding Acid Sphingomyelinase Decreases upon Antidepressant Treatment
Rhein, C., Zoicas, I., Marx, L. M., Zeitler, S., Hepp, T., von Zimmermann, C., Mühle, C., Richter‐Schmidinger, T., Lenz, B., Erim, Y., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115700 · Cited by 22 · see citing works
Alterations of Plasma Lipids in Adult Women With Major Depressive Disorder and Bipolar Depression
Zhang, T., Guo, L., Li, R., Wang, F., Yang, W., Yang, J.-B., Cui, Z.-Q., Zhou, C., Chen, Y., Yu, H., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.927817 · Cited by 22 · see citing works
Singh, R., Sharma, S., Singh, R. K., & Cornélissen, G. (2015) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-015-0519-8 · Cited by 22 · see citing works
Role of dietary and nutritional interventions in ceramide-associated diseases
Wang, S., Jin, Z., Wu, B., Morris, A. J., & Deng, P. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100726 · Cited by 22 · see citing works
Ziarrusta, H., Ribbenstedt, A., Mijangos, L., Picart‐Armada, S., Perera-Lluna, A., Prieto, A., Izagirre, U., Benskin, J. P., Olivares, M., Zuloaga, O., et al. (2019) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4381 · Cited by 21 · see citing works
A multi-omics study of circulating phospholipid markers of blood pressure
Liu, J., de Vries, P. S., Fabiola Del Greco, M., Johansson, Å., Schraut, K. E., Hayward, C., van Dijk, K. W., Franco, O. H., Hicks, A. A., Vitart, V., et al. (2022) · Scientific Reports · doi:10.1038/s41598-021-04446-7 · Cited by 20 · see citing works
Khan, A., Pan, J. H., Cho, S., Lee, S., Kim, Y. J., & Park, Y. H. (2017) · Journal of Medicinal Food · doi:10.1089/jmf.2016.3874 · Cited by 20 · see citing works
Wu, Z., Zhao, P., Long, Z., Li, J., Yang, G., Zhang, Q., Duan, G., & Li, H. (2019) · BMC Psychiatry · doi:10.1186/s12888-019-2241-1 · Cited by 20 · see citing works
Homorogan, C., Nitusca, D., Enatescu, V., Schubart, P., Moraru, C., Socaciu, C., & Marian, C. (2021) · Metabolites · doi:10.3390/metabo11070466 · Cited by 19 · see citing works
Ephraim, E., Brockman, J. A., & Jewell, D. E. (2022) · Biology · doi:10.3390/biology11070976 · Cited by 19 · see citing works
Lanctôt, K. L., Mazereeuw, G., Herrmann, N., Xu, H., Blanchard, A. P., Figeys, D., OH, P. I., & Bennett, S. A. L. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s87111 · Cited by 19 · see citing works
Wang, F., Guo, L., Zhang, T., Cui, Z., Wang, J., Zhang, C., Xue, F., Zhou, C., Li, B., Tan, Q., et al. (2022) · Medicina · doi:10.3390/medicina58111509 · Cited by 18 · see citing works
Hong, L., Wang, H., Leijie, X., Dandan, Z., Liu, P., Hu, Z., Ma, R., Yijun, S., Guanghui, Z., & Guojun, Z. (2021) · Clinica Chimica Acta · doi:10.1016/j.cca.2021.03.014 · Cited by 18 · see citing works
Lokhov, P. G., Maslov, D. L., Balashova, E. E., Trifonova, O. P., Medvedeva, N. V., Torkhovskaya, T. I., Ipatova, O. M., Archakov, A. I., Прокопьевич, М. П., Kukharchuk, V. V., et al. (2015) · Biomeditsinskaya Khimiya · doi:10.18097/pbmc20156101007 · Cited by 17 · see citing works
Song, Y., Lai, M., Liao, Z., Zhang, Z., Zhu, G., Yang, M., Ai, Z., Zheng, Q., & Su, D. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155829 · Cited by 16 · see citing works
Urinary Lipidomics: evidence for multiple sources and sexual dimorphism in healthy individuals
Graessler, J., Mehnert, C. S., Schulte, K., Bergmann, S., Strauss, S., Bornstein, T. D., Licinio, J., Wong, M., Birkenfeld, A. L., & Bornstein, S. R. (2017) · The Pharmacogenomics Journal · doi:10.1038/tpj.2017.24 · Cited by 16 · see citing works
Screening for depression in the general population through lipid biomarkers
Tkachev, A., Stekolshchikova, E., Golubova, A., Serkina, A., Morozova, A. Y., Zorkina, Y., Riabinina, D., Golubeva, E., Ochneva, A., Savenkova, V., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105455 · Cited by 15 · see citing works
Application of fatty acid and lipid measurements in neuropsychiatry
Grela, A., Rachel, W., Cole, M., Zyss, T., Zięba, A., & Piekoszewski, W. (2015) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2015-0394 · Cited by 14 · see citing works
Chen, G., Zhou, S., Chen, Q., Liu, M., Dong, M.-X., Hou, J., & Zhou, B. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.965697 · Cited by 14 · see citing works
Wang, Y., Chen, H., Wang, J., Chen, S., Liu, J., Chen, X., Li, S., Tang, H., Zhou, J., Ye, Y., et al. (2025) · Depression and Anxiety · doi:10.1155/da/5564796 · Cited by 13 · see citing works
Chang, C., Wu, H.-C., Hsieh, Y.-R., Lai, W.-D., Tung, T.-H., Huang, J.-J., Kao, W., & Huang, S. (2023) · Food & Function · doi:10.1039/d3fo01452e · Cited by 13 · see citing works
Hernández-Baixauli, J., Puigbò, P., Abasolo-Zabalo, N., Palacios, H. H., Foguet‐Romero, E., Suñol, D., Galofré, M., Caimari, A., Baselga‐Escudero, L., Bas-Prior, J. M. D., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312931 · Cited by 13 · see citing works
Shorter Chain Triglycerides Are Negatively Associated with Symptom Improvement in Schizophrenia
Tkachev, A., Stekolshchikova, E., Anikanov, N., Zozulya, S., Barkhatova, A., Klyushnik, T., & Petrova, D. (2021) · Biomolecules · doi:10.3390/biom11050720 · Cited by 11 · see citing works
He, L., Duan, N., Wang, C., Shan, R., Li, J., Wang, L., Liu, Q., Tao, J., Liu, L., Ma, X., et al. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07191-7 · Cited by 11 · see citing works
SGMS2 in primary osteoporosis with facial nerve palsy
Pihlström, S., Richardt, S., Määttä, K. M., Pekkinen, M., Olkkonen, V. M., Mäkitie, O., & Mäkitie, R. E. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1224318 · Cited by 11 · see citing works
Kelley, D. P., Chaichi, A., Duplooy, A., Singh, D. P., Gartia, M. R., & Francis, J. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100476 · Cited by 11 · see citing works
Metabolomic profiles in night shift workers: A cross-sectional study on hospital female nurses
Borroni, E., Frigerio, G., Polledri, E., Mercadante, R., Maggioni, C., Fedrizzi, L., Pesatori, A. C., Fustinoni, S., & Carugno, M. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1082074 · Cited by 11 · see citing works
Xie, J., Li, Y., Liang, Y., Kui, H., Wang, C., & Huang, J. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116571 · Cited by 11 · see citing works
Mazereeuw, G., Herrmann, N., David, W. L., Hillyer, L. M., OH, P. I., & Lanctôt, K. L. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.12.009 · Cited by 11 · see citing works
Danyang, L., Yang, J., Jin, W., Zhong, Q., & Zhou, T. (2021) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-021-03349-w · Cited by 11 · see citing works
Gary, A. A., Prislovsky, A., Tovar, A., Locatelli, E. V. T., Felix, E. R., Stephenson, D., Chalfant, C. E., Lai, J. M., Kim, C. K., Mandal, N. A., et al. (2023) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.14343 · Cited by 10 · see citing works
Altered lipidomics biosignatures in schizophrenia: A systematic review
Messinis, A., Panteli, E., Paraskevopoulou, A., Zymarikopoulou, A.-K., & Filiou, M. D. (2024) · Schizophrenia Research · doi:10.1016/j.schres.2024.06.043 · Cited by 10 · see citing works
Saito, K., Ishikawa, M., Murayama, M., Urata, M., Senoo, Y., Toyoshima, K., Kumagai, Y., Maekawa, K., & Saito, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112266 · Cited by 10 · see citing works
Zhou, C., Xue, F., Shi, Q., Xue, S., Zhang, T., Ma, X., Yu, L., Liu, C., Wang, H., & Peng, Z. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.812479 · Cited by 9 · see citing works
Maehashi, S., Arora, K., Fisher, A. L., Schweitzer, D. R., & Akefe, I. O. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105741 · Cited by 9 · see citing works
Kurkinen, K., Kärkkäinen, O. K., Lehto, S. M., Luoma, I., Kraav, S., Nieminen, A. I., Kivimäki, P., Therman, S., & Tolmunen, T. (2021) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2021.100261 · Cited by 9 · see citing works
Donato, P., Cacciola, F., Beccaria, M., Dugo, P., & Mondello, L. (2015) · Comprehensive analytical chemistry · doi:10.1016/b978-0-444-63340-8.00008-x · Cited by 9 · see citing works
Bisle, E., Haange, S., Rojas, R., Behnke, A., Karabatsiakis, A., Gumpp, A. M., Mack, M., Mavioğlu, R. N., Lutz‐Bonengel, S., Rolle-Kampczyk, U. E., et al. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116569 · Cited by 10 · see citing works
- Authors
- Demirkan, A., Isaacs, A., Ugocsai, P., Liebisch, G., Struchalin, M., Rudan, I., Wilson, J. F., Pramstaller, P. P., Gyllensten, U., Campbell, H., Schmitz, G., Oostra, B. A., & van Duijn, C. M.
- Affiliations
- Erasmus MC (NL)
- University Hospital Regensburg (DE)
- University of Split (HR)
- University of Edinburgh (GB)
- Eurac Research (IT)
- Uppsala University (SE)
- Corresponding author
- Isaacs, Aaron
- ORCID
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 47
- Issue
- 3
- Pages
- 357-362
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2164766370
- Cited by
- 163
- References
- 51
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 22 · 2023: 14 · 2022: 15 · 2021: 14 · 2020: 11 · 2019: 10 · 2018: 9 · 2017: 9 · 2016: 12 · 2015: 11 · 2014: 7 · 2013: 3
- FWCI
- 6.25
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Open Research (University of Surrey) (submittedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- H2020 European Research Council
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- depression, anxiety, phospholipids, sphingolipids, ether phospholipids, polyunsaturated fatty acids, lipid biomarkers, family studies, ceramide
- MeSH terms
- Adult, Aged, Anxiety, Depression, Family Health, Female, Humans, Male, Middle Aged, Netherlands, Phosphatidylcholines, Psychiatric Status Rating Scales, Sphingomyelins
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