Sphingolipids in Psychiatric Disorders and Pain Syndromes

No health without mental health

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Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.

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Major depressive disorder

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Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders

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The Relationship of Depression to Cardiovascular Disease: Epidemiology, Biology, and Treatment

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Biologically active sphingolipids in cancer pathogenesis and treatment

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Glial activation: a driving force for pathological pain

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Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

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Inflammatory Cytokine Alterations in Schizophrenia: A Systematic Quantitative Review

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Convergent evidence for impaired AKT1-GSK3β signaling in schizophrenia

Emamian, E. S., Hall, D., Birnbaum, M. J., Karayiorgou, M., & Gogos, J. A. (2004) · Nature Genetics · doi:10.1038/ng1296 · Cited by 914 · see citing works

JNK-Induced MCP-1 Production in Spinal Cord Astrocytes Contributes to Central Sensitization and Neuropathic Pain

Gao, Y., Zhang, L., Samad, O. A., Suter, M. R., Kawasaki, Y., Xu, Z., Park, J. Y., Lind, A., Ma, Q., & Ji, R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3623-08.2009 · Cited by 569 · see citing works

Acid sphingomyelinase activity triggers microparticle release from glial cells

Bianco, F., Perrotta, C., Novellino, L., Francolini, M., Riganti, L., Menna, E., Saglietti, L., Schuchman, E. H., Furlan, R., Clementi, E., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.45 · Cited by 550 · see citing works

Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts

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Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases

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Oxidative stress in schizophrenia: An integrated approach

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The membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental concept of schizophrenia

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Role of the Serotonergic System in the Pathogenesis of Major Depression and Suicidal Behavior

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Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I

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Cytokines and Alcohol

Crews, F. T., Bechara, R. I., Brown, L. A. S., Guidot, D. M., Mandrekar, P., Oak, S. A., Qin, L., Szabó, G., Wheeler, M. D., & Zou, J. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00084.x · Cited by 414 · see citing works

Lipopolysaccharide Induces Disseminated Endothelial Apoptosis Requiring Ceramide Generation

Haimovitz‐Friedman, A., Cordon‐Cardo, C., Bayoumy, S. S., Garzotto, M. G., McLoughlin, M., Gallily, R., Edwards, C. K., Schuchman, E. H., FUKS, Z. Y., & Kolesnick, R. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.11.1831 · Cited by 409 · see citing works

Effects of ethanol on lipid metabolism.

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Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain

Contreras, F. ‐., Ernst, A. M., Haberkant, P., Björkholm, P., Lindahl, E. R., Gonen, B., Tischer, C., Elofsson, A., von HEIJNE, G., Thiele, C., et al. (2012) · Nature · doi:10.1038/nature10742 · Cited by 373 · see citing works

A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior

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Oxidative Stress and Alcoholic Liver Disease

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Cloning and characterization of the mammalian brain-specific, Mg 2+ -dependent neutral sphingomyelinase

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Psychoneuroimmunology and the cytokine action in the CNS: Implications for psychiatric disorders

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Vectorial Budding of Vesicles by Asymmetrical Enzymatic Formation of Ceramide in Giant Liposomes

Holopainen, J. M., Angelova, M. I., & Kinnunen, P. K. J. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76640-9 · Cited by 295 · see citing works

Membrane phospholipid abnormalities in postmortem brains from schizophrenic patients

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Genome-wide association scan for five major dimensions of personality

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CDT, GGT, and AST As Markers of Alcohol Use: The WHO/ISBRA Collaborative Project

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Changes in cerebrospinal fluid levels of pro-inflammatory cytokines in CRPS

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Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction.

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Sphingolipids and gangliosides of the nervous system in membrane function and dysfunction

Chaves, E., & Sipione, S. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.12.010 · Cited by 273 · see citing works

Cloned mammalian neutral sphingomyelinase: Functions in sphingolipid signaling?

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Ceramide-enriched membrane domains—Structure and function

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The Cellular Trafficking and Zinc Dependence of Secretory and Lysosomal Sphingomyelinase, Two Products of the Acid Sphingomyelinase Gene

Schissel, S. L., Keesler, G. A., Schuchman, E. H., Williams, K. J., & Tabas, I. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18250 · Cited by 247 · see citing works

A role for AMPA receptors in mood disorders

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N,N-Dimethylsphingosine Is a Potent Competitive Inhibitor of Sphingosine Kinase but Not of Protein Kinase C: Modulation of Cellular Levels of Sphingosine 1-Phosphate and Ceramide

Edsall, L. C., Brocklyn, J. R. V., Cuvillier, O., Kleuser, B., & Spiegel, S. (1998) · Biochemistry · doi:10.1021/bi980744d · Cited by 227 · see citing works

Rhinoviruses Infect Human Epithelial Cells via Ceramide-enriched Membrane Platforms

Grassmé, H., Riehle, A., Wilker, B., & Gulbins, E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500835200 · Cited by 226 · see citing works

Identification of New Functional Inhibitors of Acid Sphingomyelinase Using a Structure−Property−Activity Relation Model

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High Throughput Lipidomic Profiling of Schizophrenia and Bipolar Disorder Brain Tissue Reveals Alterations of Free Fatty Acids, Phosphatidylcholines, and Ceramides

Schwarz, E., Prabakaran, S., Whitfield, P. D., Major, H. J., Leweke, F. M., Koethe, D., McKenna, P. J., & Bahn, S. (2008) · Journal of Proteome Research · doi:10.1021/pr800188y · Cited by 222 · see citing works

Oral l-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1

Garofalo, K., Penno, A., Schmidt, B. P., Lee, H.-J., Frosch, M. P., von Eckardstein, A., Brown, R. H., Hornemann, T., & Eichler, F. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57549 · Cited by 215 · see citing works

Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations

Hicks, A. A., Pramstaller, P. P., Johansson, Å., Vitart, V., Rudan, I., Ugocsai, P., Aulchenko, Y. S., Franklin, C. S., Liebisch, G., Erdmann, J., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000672 · Cited by 214 · see citing works

Reactive oxygen species limit neutrophil life span by activating death receptor signaling

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Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations

Demirkan, A., van Duijn, C. M., Ugocsai, P., Isaacs, A., Pramstaller, P. P., Liebisch, G., Wilson, J. F., Johansson, Å., Rudan, I., Aulchenko, Y. S., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002490 · Cited by 205 · see citing works

Sphingosine‐1‐Phosphate in Cell Growth and Cell Deatha

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Sphingomyelinase Treatment Induces ATP-independent Endocytosis

Zha, X., Pierini, L. M., Leopold, P. L., Skiba, P. J., Tabas, I. A., & Maxfield, F. R. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.1.39 · Cited by 201 · see citing works

Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin

Patti, G. J., Yanes, Ó., Shriver, L. P., Courade, J., Tautenhahn, R., Manchester, M., & Siuzdak, G. E. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.767 · Cited by 196 · see citing works

Enzymic Hydrolysis and Synthesis of Ceramides

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Tumor necrosis factor‐α‐induced neutral sphingomyelinase‐2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors

Wheeler, D., Knapp, E., Bandaru, V. V. R., Wang, Y., Knorr, D., Poirier, C., Mattson, M. P., Geiger, J. D., & Haughey, N. J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06038.x · Cited by 194 · see citing works

Ceramidase and ceramide synthesis in human kidney and cerebellum

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Identification of Novel Functional Inhibitors of Acid Sphingomyelinase

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Genetic impairment of interleukin-1 signaling attenuates neuropathic pain, autotomy, and spontaneous ectopic neuronal activity, following nerve injury in mice

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Sphingomyelinase activity at pH 7.4 in human brain and a comparison to activity at pH 5.0

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Plasma Phosphatidylcholine and Sphingomyelin Concentrations Are Associated with Depression and Anxiety Symptoms in a Dutch Family-Based Lipidomics Study

Demirkan, A., Isaacs, A., Ugocsai, P., Liebisch, G., Struchalin, M., Rudan, I., Wilson, J. F., Pramstaller, P. P., Gyllensten, U., Campbell, H., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.11.001 · Cited by 163 · see citing works

Evidence for white matter abnormalities in schizophrenia

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Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo : A possible link between inflammatory cytokines and atherogenesis

Wong, M., Xie, B., Beatini, N., Phu, P., Marathe, S. V., Johns, A., Gold, P. W., Hirsch, E., Williams, K. J., Licinio, J., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.150098097 · Cited by 157 · see citing works

NMDA receptor subunit NRI and postsynaptic protein PSD-95 in hippocampus and orbitofrontal cortex in schizophrenia and mood disorder

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Early weaning induces anxiety and precocious myelination in the anterior part of the basolateral amygdala of male Balb/c mice

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The Reverse Activity of Human Acid Ceramidase

Okino, N., He, X., Gátt, S., Sandhoff, K., Ito, M., & Schuchman, E. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303310200 · Cited by 147 · see citing works

Sequence variants at CYP1A1–CYP1A2 and AHR associate with coffee consumption

Sulem, P., Gudbjartsson, D. F., Geller, F., Prokopenko, I., Feenstra, B., Aben, K. K. H., Franke, B., den Heijer, M., Kovacs, P. L., Stümvoll, M., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr086 · Cited by 145 · see citing works

High activity of acid sphingomyelinase in major depression

Kornhuber, J., Medlin, A., Bleich, S., Jendrossek, V., Henkel, A. W., Wiltfang, J., & Gulbins, E. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-005-0374-5 · Cited by 143 · see citing works

Novel Tumor Necrosis Factor-responsive Mammalian Neutral Sphingomyelinase-3 Is a C-tail-anchored Protein

Krut, O., Wiegmann, K., Kashkar, H., Yazdanpanah, B., & Krönke, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511306200 · Cited by 140 · see citing works

Altered thalamic membrane phospholipids in schizophrenia: a postmortem study

Schmitt, A., Wilczek, K., Blennow, K., Maras, A., Jatzko, A., Petroianu, G. A., Braus, D. F., & Gattaz, W. F. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.03.019 · Cited by 134 · see citing works

Biology and therapy of fibromyalgia. Evidence-based biomarkers for fibromyalgia syndrome

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The lysosomal localization of sphingolipid hydrolases

Weinreb, N. J., Brady, R. O., & Tappel, A. L. (1968) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(68)90251-9 · Cited by 120 · see citing works

Depression in adults with Fabry disease: A common and under‐diagnosed problem

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Evidence for disruption of sphingolipid metabolism in schizophrenia

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Acid Sphingomyelinase Amplifies Redox Signaling in Pseudomonas aeruginosa -Induced Macrophage Apoptosis

Zhang, Y., Li, X., Carpinteiro, A., & Gulbins, E. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.4247 · Cited by 109 · see citing works

Ceramidase Regulates Synaptic Vesicle Exocytosis and Trafficking

Rohrbough, J. C., Rushton, E., Musselman, L. P., Woodruff, E. A., Matthies, H. J. G., Acharya, U. R., Acharya, J., & Broadie, K. S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1146-04.2004 · Cited by 104 · see citing works

Inhibition of neutral sphingomyelinase‐2 perturbs brain sphingolipid balance and spatial memory in mice

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Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A

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The CB1 Cannabinoid Receptor of Astrocytes Is Coupled to Sphingomyelin Hydrolysis through the Adaptor Protein Fan

Sánchez, C., Rueda, D., Ségui, B., Galve‐Roperh, I., Levade, T., & Guzmán, M. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.5.955 · Cited by 101 · see citing works

Distribution of alkaline sphingomyelinase activity in human beings and animals

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Elevated Plasma Ceramides in Depression

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Neuropsychiatric Aspects of the Adult Variant of Tay-Sachs Disease

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Erythrocyte membrane phospholipids in psychotic patients

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Phosphatidylserine-dependent phagocytosis of apoptotic glioma cells by normal human microglia, astrocytes, and glioma cells

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Changes in Levels of Phosphorus Metabolites in Temporal Lobes of Drug-Naive Schizophrenic Patients

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Counter-Regulation of Opioid Analgesia by Glial-Derived Bioactive Sphingolipids

Muscoli, C., Doyle, T. M., Dagostino, C., Bryant, L., Chen, Z., Watkins, L. R., Ryerse, J. S., Bieberich, E., Neumman, W., & Salvemini, D. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2391-10.2010 · Cited by 92 · see citing works

Ceramide and sphingomyelinases in the regulation of stress responses

Sawai, H., & Hannun, Y. A. (1999) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(99)00082-1 · Cited by 88 · see citing works

Ceramide pathways modulate ethanol‐induced cell death in astrocytes

Pascual, M., Vallés, S. L., Renau‐Piqueras, J., & Guerri, C. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02130.x · Cited by 87 · see citing works

Purification and Characterization of a Membrane-bound Nonlysosomal Ceramidase from Rat Brain

Bawab, S. E., Bielawska, A. E., & Hannun, Y. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.39.27948 · Cited by 86 · see citing works

Impaired Glial Glutamate Uptake Induces Extrasynaptic Glutamate Spillover in the Spinal Sensory Synapses of Neuropathic Rats

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Imipramine blocks ethanol-induced ASMase activation, ceramide generation, and PP2A activation, and ameliorates hepatic steatosis in ethanol-fed mice

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Modulation of sphingosine 1-phosphate (S1P) attenuates spatial learning and memory impairments in the valproic acid rat model of autism

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Sphingolipids as Biomarkers of Disease

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Looking into the genetic bases of OCD dimensions: a pilot genome-wide association study

Alemany-Navarro, M., Cruz, R., Real, E., Segalàs, C., Bertolín, S., Rabionet, R., Carracedo, Á., Menchón, J. M., & Alonso, P. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0804-z · Cited by 31 · see citing works

Sphingomyelin Synthases in Neuropsychiatric Health and Disease

Mühle, C., Canalejas, R. D. B., & Kornhuber, J. (2019) · Neurosignals · doi:10.33594/000000200 · Cited by 29 · see citing works

Anxiety and Depression Are Related to Higher Activity of Sphingolipid Metabolizing Enzymes in the Rat Brain

Zoicas, I., Mühle, C., Schmidtner, A. K., Gulbins, E., Neumann, I. D., & Kornhuber, J. (2020) · Cells · doi:10.3390/cells9051239 · Cited by 29 · see citing works

Sphingolipid and Endocannabinoid Profiles in Adult Attention Deficit Hyperactivity Disorder

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System-based proteomic and metabonomic analysis of the Df(16)A+/− mouse identifies potential miR-185 targets and molecular pathway alterations

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Beneficial Effects of Fingolimod on Social Interaction, CNS and Peripheral Immune Response in the BTBR Mouse Model of Autism

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Supplementation with milk fat globule membrane from early life reduces maternal separation-induced visceral pain independent of enteric nervous system or intestinal permeability changes in the rat

Collins, J. M., Caputi, V., Manurung, S., Gross, G., Fitzgerald, P., Golubeva, A. V., Popov, J., Deady, C., Dinan, T. G., Cryan, J. F., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109026 · Cited by 22 · see citing works

The ceramide-S1P pathway as a druggable target to alleviate peripheral neuropathic pain

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Dysregulation of sphingolipid metabolism in pain

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Astrocyte-derived extracellular vesicles in stress-associated mood disorders. Does the immune system get astrocytic?

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Lipidomic and proteomic insights from extracellular vesicles in the postmortem dorsolateral prefrontal cortex reveal substance use disorder-induced brain changes

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Development of Comorbid Depression after Social Fear Conditioning in Mice and Its Effects on Brain Sphingolipid Metabolism

Zoicas, I., Mühle, C., Schumacher, F., Kleuser, B., & Kornhuber, J. (2023) · Cells · doi:10.3390/cells12101355 · Cited by 11 · see citing works

Sphingomyelin is involved in multisite musculoskeletal pain: evidence from metabolomic analysis in 2 independent cohorts

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Lipid and metabolic alteration involvement in physiotherapy for chronic nonspecific low back pain

Zhang, Z., Zhang, C., Li, Y., Wang, C., & Yu, Q. (2022) · Lipids in Health and Disease · doi:10.1186/s12944-022-01737-4 · Cited by 10 · see citing works

The Current Landscape in the Development of Small-molecule Modulators Targeting Sphingosine-1-phosphate Receptors to Treat Neurodegenerative Diseases

Kar, S. S., Gharai, S. R., Sahu, S. K., Ravichandiran, V., & Swain, S. P. (2024) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266288509240422112839 · Cited by 10 · see citing works

Brain region specific regulation of anandamide (down) and sphingosine-1-phosphate (up) in association with anxiety (AEA) and resilience (S1P) in a mouse model of chronic unpredictable mild stress

Fischer, C., Thomas, D., Gurke, R., & Tegeder, I. (2024) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-024-03012-0 · Cited by 9 · see citing works

Repetitive and compulsive behavior after Early-Life-Pain associated with reduced long-chain sphingolipid species

Vogel, A., Ueberbach, T., Wilken‐Schmitz, A., Hahnefeld, L., Franck, L., Weyer, M.-P., Jungenitz, T., Schmid, T., Buchmann, G., Freudenberg, F., et al. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01106-3 · Cited by 7 · see citing works

Serum metabolic profile evidence for relationship between schizophrenia and depression: An untargeted metabolomics

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An unraveled mystery: What's the role of brain sphingolipids in neurodegenerative and psychiatric disorders

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Dysregulation in Sphingolipid Signaling Pathways is Associated With Symptoms and Functional Connectivity of Pain Processing Brain Regions in Provoked Vestibulodynia

Labus, J. S., Mayer, E. A., Tillisch, K., Aagaard, K. M., Stains, J., Broniowska, K., Remortel, C. V., Tun, G., & Rapkin, A. J. (2021) · Journal of Pain · doi:10.1016/j.jpain.2021.04.017 · Cited by 6 · see citing works

Characterization of a Neutral Sphingomyelinase Activity in Human Serum and Plasma

Mühle, C., & Kornhuber, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032467 · Cited by 6 · see citing works

Chronic exposure to nanocellulose altered depression-related behaviors in mice on a western diet: The role of immune modulation and the gut microbiome

Xu, H. S., Chen, Y., Patel, A. R., Wang, Z., McDonough, C. M., & Guo, T. L. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122259 · Cited by 5 · see citing works

Healthy plasma lipidomic signatures depend on sex, age, body mass index, and contraceptives but not perceived stress

Hahnefeld, L., Hackel, J., Trautmann, S., Angioni, C., Schreiber, Y., Gurke, R., Thomas, D., Wicker, S., Geißlinger, G., & Tegeder, I. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00630.2024 · Cited by 4 · see citing works

Acid sphingomyelinase modulates anxiety-like behavior likely through toll-like receptor signaling pathway

Yuan, H., Xu, Y., Jiang, H., Jiang, M., Zhang, L., Wei, S., Cao, L., & Zhigang, Z. (2025) · Molecular Brain · doi:10.1186/s13041-025-01178-x · Cited by 4 · see citing works

Mechanistic insights on metabolic dysfunction in PTSD: Role of glucocorticoid receptor sensitivity and energy deficitPreprint

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Brain Region-Specific Expression Levels of Synuclein Genes in an Acid Sphingomyelinase Knockout Mouse Model: Correlation with Depression-/Anxiety-Like Behavior and Locomotor Activity in the Absence of Genotypic Variation

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Molecular mechanisms of synergistic analgesic and neuroprotective action of B group vitamins according to the results of proteomic analysis

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Role of PAR-4 in Ceramide-Inducible Effects in Neurodegeneration

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Genome Wide Analysis Identifies Sphingolipid Metabolism As A New Target Of Valproic Acid

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Contribution of Neural Membrane Phospholipids, Sphingolipids, and Cholesterol in the Pathogenesis of Alzheimer’s Disease

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Repetitive and compulsive behavior after Early-Life-Pain in micePreprint

Vogel, A., Ueberbach, T., Wilken‐Schmitz, A., Hahnefeld, L., Franck, L., Weyer, M.-P., Jungenitz, T., Schmid, T., Buchmann, G., Freudenberg, F., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2560826/v1

Sex, age, body mass index, and contraceptive use but not perceived stress influence healthy plasma lipidomic profilesPreprint

Hahnefeld, L., Hackel, J., Trautmann, S., Angioni, C., Schreiber, Y., Gurke, R., Thomas, D., Wicker, S., Geißlinger, G., & Tegeder, I. (2024) · Research Square · doi:10.21203/rs.3.rs-4408378/v1

Investigating the Eye as a Biomarker of Gulf War Illness: Sphingolipid and Eicosanoid Composition in Tears and Plasma

Jimenez, L. B. P., Prislovsky, A., Parchejo, L. A., Cabrera, K., Nafziger, A. J., Stephenson, D., Chalfant, C. E., Aenlle, K. K., Klimas, N. G., Tang, F., et al. (2025) · Biomolecules · doi:10.3390/biom15121716

Untargeted plasma metabolomics identifies metabolite signatures associated with suicidality status in chronic schizophrenia

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Identification of fluid endocannabinoid and sphingolipid biomarkers in schizophrenia. A machine learning approach toward clinical value

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Ceramide and Its Related Neurochemical Networks as Targets for Some Brain Disorder Therapies

Brodowicz, J., Przegaliński, E., Müller, C. P., & Filip, M. (2017) · Neurotoxicity Research · doi:10.1007/s12640-017-9798-6 · Cited by 70 · see citing works

The critical role of ceramide in mental health and psychiatric diseases

Xu, X., Li, H., Zhu, Y., Fu, X., Hu, Q., & Dong, X. (2026) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2026.109093

Anxiety and Depression Are Related to Higher Activity of Sphingolipid Metabolizing Enzymes in the Rat Brain

Zoicas, I., Mühle, C., Schmidtner, A. K., Gulbins, E., Neumann, I. D., & Kornhuber, J. (2020) · Cells · doi:10.3390/cells9051239 · Cited by 29 · see citing works

Contribution of ceramides metabolism in psychiatric disorders

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Ceramides and depression: A systematic review

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