The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration
Open accessAbstract
Catechins are dietary polyphenolic compounds associated with a wide variety of beneficial health effects in vitro, in vivo and clinically. These therapeutic properties have long been attributed to the catechins' antioxidant and free radical scavenging effects. Emerging evidence has shown that catechins and their metabolites have many additional mechanisms of action by affecting numerous sites, potentiating endogenous antioxidants and eliciting dual actions during oxidative stress, ischemia and inflammation. Catechins have proven to modulate apoptosis at various points in the sequence, including altering expression of anti- and proapoptotic genes. Their anti-inflammatory effects are activated through a variety of different mechanisms, including modulation of nitric oxide synthase isoforms. Catechins' actions of attenuating oxidative stress and the inflammatory response may, in part, account for their confirmed neuroprotective capabilities following cerebral ischemia. The versatility of the mechanisms of action of catechins increases their therapeutic potential as interventions for numerous clinical disorders. However, more epidemiological and clinical studies need to be undertaken for their efficacy to be fully elucidated.
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Cites
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“This is significant because many fruits and vegetables also have catechin and flavonol components (see Table 1) [62].”
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Cited by
A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding
Perron, N. R., & Brumaghim, J. L. (2009) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-009-9043-x · Cited by 1,370
Flavonoids as Anticancer Agents
Kopustinskiene, D. M., Jakstas, V., Savickas, A., & Bernatoniene, J. (2020) · Nutrients · doi:10.3390/nu12020457 · Cited by 1,295
Kalogeris, T., Baines, C. P., Krenz, M., & Korthuis, R. J. (2016) · Comprehensive Physiology · doi:10.1002/cphy.c160006 · Cited by 718
The Role of Catechins in Cellular Responses to Oxidative Stress
Bernatoniene, J., & Kopustinskiene, D. M. (2018) · Molecules · doi:10.3390/molecules23040965 · Cited by 698
Neuroprotective potential of phytochemicals
Kumar, G., & Khanum, F. (2012) · Pharmacognosy Reviews · doi:10.4103/0973-7847.99898 · Cited by 511
Metadata
- Authors
- Sutherland, B. A., Rahman, R. M. A., & Appleton, I.
- Venue
- The Journal of Nutritional Biochemistry
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 17
- Issue
- 5
- Pages
- 291-306
- ISSN
- 0955-2863 (ISSN-L)
- OpenAlex
- W2132337002
- Cited by
- 325
- References
- 7
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- green
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- Sutherland, B. A., Rahman, R. M. A., & Appleton, I. (2006). Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration. The Journal of Nutritional Biochemistry. https://doi.org/10.1016/j.jnutbio.2005.10.005
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
