The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Flavonoids as Anticancer Agents
Open accessAbstract
Flavonoids are polyphenolic compounds subdivided into 6 groups: isoflavonoids, flavanones, flavanols, flavonols, flavones and anthocyanidins found in a variety of plants. Fruits, vegetables, plant-derived beverages such as green tea, wine and cocoa-based products are the main dietary sources of flavonoids. Flavonoids have been shown to possess a wide variety of anticancer effects: they modulate reactive oxygen species (ROS)-scavenging enzyme activities, participate in arresting the cell cycle, induce apoptosis, autophagy, and suppress cancer cell proliferation and invasiveness. Flavonoids have dual action regarding ROS homeostasis—they act as antioxidants under normal conditions and are potent pro-oxidants in cancer cells triggering the apoptotic pathways and downregulating pro-inflammatory signaling pathways. This article reviews the biochemical properties and bioavailability of flavonoids, their anticancer activity and its mechanisms of action.
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Citations
Cites
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
How mitochondria produce reactive oxygen species
Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207
Gut microbiota functions: metabolism of nutrients and other food components
Rowland, I., Gibson, G., Heinken, A., Scott, K., Swann, J., Thiele, I., & Tuohy, K. (2018) · European Journal of Nutrition · doi:10.1007/s00394-017-1445-8 · Cited by 2,878 · cited 1×
“Intestinal epithelium, besides nutrient absorption, provides a barrier controlling the entrance of microorganisms, their metabolic products and toxins as well as toxins present in ingested foods [194].”
BackgroundThe gut microbiota and host health: a new clinical frontier
Marchesi, J. R., Adams, D. H., Fava, F., Hermes, G. D. A., Hirschfield, G. M., Hold, G., Quraishi, M. N., Kinross, J., Smidt, H., Tuohy, K. M., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309990 · Cited by 2,302
The Immunomodulatory and Anti-Inflammatory Role of Polyphenols
Yahfoufi, N., Alsadi, N., Jambi, M., & Matar, C. (2018) · Nutrients · doi:10.3390/nu10111618 · Cited by 1,737
Reciprocal interactions of the intestinal microbiota and immune system
Maynard, C. L., Elson, C. O., Hatton, R. D., & Weaver, C. T. (2012) · Nature · doi:10.1038/nature11551 · Cited by 1,598 · cited 1×
“These studies show that flavonoids can affect microbial populations by changing endotoxin production, converting primary into secondary bile acids [220], sustaining immune homeostasis [221] and participating in bioactive and nutrient absorption and metabolism, thereby regulating short-chain fatty acid formation [222].”
BackgroundKaempferol and inflammation: from chemistry to medicine
Devi, K. P., Malar, D. S., Nabavi, S. F., Sureda, A., Xiao, J., Nabavi, S. M., & Daglia, M. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.05.002 · Cited by 619
Absorption, metabolism and health effects of dietary flavonoids in man
Hollman, P., & Katan, M. (1997) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(97)88045-6 · Cited by 609 · cited 3×
“After consumption, prior to absorption intestinal or colon microflora are able to hydrolyze glycosylated flavonoids such as flavones, isoflavones, flavonols and anthocyanins into their respective aglycones [33,34].”
BackgroundShortt, C., Hasselwander, O., Meynier, A., Nauta, A., Fernández, E. N., Putz, P., Rowland, I., Swann, J., Türk, J., Vermeiren, J., et al. (2018) · European Journal of Nutrition · doi:10.1007/s00394-017-1546-4 · Cited by 194
Xu, L., Zhang, Y., Tian, K., Chen, X., Zhang, R., Mu, X., Wu, Y., Wang, D., Wang, S., Liu, F., et al. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0929-6 · Cited by 177 · cited 1×
“The studies on flavonoids as possible suppressors of PD-L1/PD-1 immune checkpoint have not been very intense yet, nevertheless the first encouraging results were obtained demonstrating the inhibition of PD-L1 expression by flavone apigenin in A375 melanoma cells [142] and PD-1/PD-L1 inhibition in vitro by flavonols qu…”
Result
Cited by
The role of plant‐derived natural antioxidants in reduction of oxidative stress
Akbari, B., Baghaei‐Yazdi, N., Bahmaie, M., & Mahdavi Abhari, F. (2022) · BioFactors · doi:10.1002/biof.1831 · Cited by 523
Yusoff, I. M., Mat Taher, Z., Rahmat, Z., & Chua, L. S. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111268 · Cited by 510
RETRACTED: Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms
Slika, H., Mansour, H., Wehbe, N., Nasser, S. A., Iratni, R., Nasrallah, G., Shaito, A., Ghaddar, T., Kobeissy, F., & Eid, A. H. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112442 · Cited by 441
RetractedHanssen, K. M., Haber, M., & Fletcher, J. I. (2021) · Drug Resistance Updates · doi:10.1016/j.drup.2021.100795 · Cited by 102
Zhao, P., Li, X., Yang, Q., Lu, Y., Wang, G., Yang, H., Dong, J., & Zhang, H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1038802 · Cited by 43
Metadata
- Authors
- Kopustinskiene, D. M., Jakstas, V., Savickas, A., & Bernatoniene, J.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2020-02-12
- Volume
- 12
- Issue
- 2
- Pages
- 457
- ISSN
- 2072-6643 (ISSN-L)
- OpenAlex
- W3005533031
- Cited by
- 1,295
- References
- 12
- FWCI
- 68.18
- Type
- journal article
- Language
- en
- Open access
- gold
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