Role of pattern recognition receptors of the neurovascular unit in inflamm-aging
Open accessAbstract
Aging is associated with chronic inflammation partly mediated by increased levels of damage-associated molecular patterns, which activate pattern recognition receptors (PRRs) of the innate immune system. Furthermore, many aging-related disorders are associated with inflammation. PRRs, such as Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain-like receptors (NLRs), are expressed not only in cells of the innate immune system but also in other cells, including cells of the neurovascular unit and cerebral vasculature forming the blood-brain barrier. In this review, we summarize our present knowledge about the relationship between activation of PRRs expressed by cells of the neurovascular unit-blood-brain barrier, chronic inflammation, and aging-related pathologies of the brain. The most important damage-associated molecular pattern-sensing PRRs in the brain are TLR2, TLR4, and NLR family pyrin domain-containing protein-1 and pyrin domain-containing protein-3, which are activated during physiological and pathological aging in microglia, neurons, astrocytes, and possibly endothelial cells and pericytes.
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Endothelial cells are particularly sensitive to reactive oxygen species (ROS) and other DNA-damaging stressors.
“recent evidence suggests that endothelial cells are particularly sensitive to reactive oxygen species (ROS) (Nagyoszi et al. 2015; Wilhelm et al. 2017) and other DNA-damaging stressors (Shi et al. 2007; Silva et al. 2017; V oghel et al. 2007)”
From Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain (2020) · cites this paper as Wilhelm et al. 2017
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Self-citationCerebral Pericytes and Endothelial Cells Communicate through Inflammasome-Dependent Signals
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Self-citation
- Authors
- Wilhelm, I., Nyúl-Tóth, Á., Kozma, M., Farkas, A. E., & Krizbai, I. A.
- Affiliations
- HUN-REN Szegedi Biológiai Kutatóközpont (HU)
- Institute of Biophysics, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary; and
- Corresponding author
- Wilhelm, Imola
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2017-11-01
- Volume
- 313
- Issue
- 5
- Pages
- H1000-H1012
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2743249858
- Cited by
- 56
- References
- 30
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 10 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 7
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed (publishedVersion)
- Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
- Funders
- Hungarian Scientific Research Fund
- Magyar Tudományos Akadémia (BO/00334/16/8, BO/00023/17/8)
- Emberi Eroforrások Minisztériuma (ÚNKP-16, ÚNKP-16-3)
- Nemzeti Kutatási Fejlesztési és Innovációs Hivatal (OTKA K-116158, GINOP-2.3.2-15-2016-0034, FK-124114, GINOP-2.3.2-15-2016-0030, K116158, GINOP-2, GINOP-2.3.2-15-2016-0020, GINOP-2.3.2, GINOP-2.3.2-15)
- Szegedi Tudományegyetem
- National Research, Development and Innovation Office (K-116158, OTKA K-116158, GINOP-2.3.2-15-2016-0030, FK-124114, GINOP-2.3.2-15-2016-0034, GINOP-2.3.2-15-2016-0020)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- inflammaging, neurovascular unit, pattern recognition receptors, damage-associated molecular patterns, Toll-like receptors, NLRP1, NLRP3, blood-brain barrier, chronic inflammation, microglia, astrocytes, neurons, pericytes, endothelial cells, brain aging, innate immunity
- MeSH terms
- Neurovascular Coupling, NLR Proteins, Age Factors, Aging, Animals, Blood-Brain Barrier, Humans, Immunity, Innate, Inflammation, Signal Transduction, Receptors, Pattern Recognition, Toll-Like Receptor 2, Toll-Like Receptor 4, Microvessels, Inflammasomes
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