α-Glucosidase inhibitory effect of resveratrol and piceatannol

Zhang, Albert J.; Rimando, Agnes M.; Mizuno, Cassia S.; Mathews, Suresh T.

doi:10.1016/j.jnutbio.2017.05.008

Cited by 99Natural Antidiabetic Agents StudiesSirtuins and Resveratrol in MedicinePhytochemicals and Antioxidant Activities

α-Glucosidase inhibitory effect of resveratrol and piceatannol

Zhang, Albert J., Rimando, Agnes M., Mizuno, Cassia S., Mathews, Suresh T.·2017·The Journal of Nutritional Biochemistry

DOI 10.1016/j.jnutbio.2017.05.008

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Abstract

Dietary polyphenols have been shown to inhibit α-glucosidase, an enzyme target of some antidiabetic drugs. Resveratrol, a polyphenol found in grapes and wine, has been reported to inhibit the activity of yeast α-glucosidase. This triggered our interest to synthesize analogs and determine their effect on mammalian α-glucosidase activity. Using either sucrose or maltose as substrate resveratrol, piceatannol and 3'-hydroxypterostilbene showed strong inhibition of mammalian α-glucosidase activity; pinostilbene, cis-desoxyrhapontigenin and trans-desoxyrhapontigenin had moderate inhibition. Compared to acarbose (IC 50 3-13 μg/ml), piceatannol and resveratrol inhibited mammalian α-glucosidase to a lesser extent (IC 50 14-84 and 111-120 μg/ml, respectively). 3'-Hydroxypterostilbene (IC 50 105-302 μg/ml) was 23-35-fold less potent than acarbose. We investigated the effect of piceatannol and resveratrol on postprandial blood glucose response in high-fat-fed C57Bl/6 mice. Animals administered resveratrol (30 mg/kg body weight [BW]) or piceatannol (14 mg/kg BW) 60 min prior to sucrose or starch loading had a delayed absorption of carbohydrates, resulting in significant lowering of postprandial blood glucose concentrations, similar to the antidiabetic drug acarbose, while no significant effect was observed with the glucose-loaded animals. Our studies demonstrate that the dietary polyphenols resveratrol and piceatannol lower postprandial hyperglycemia and indicate that inhibition of intestinal α-glucosidase activity may be a potential mechanism contributing to their antidiabetic property.

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Flavonoids may possess strong inhibitory activities on the intestinal alpha-glucosidase enzyme, delaying the absorption of glucose and flattening postprandial hyperinsulinemic/hyperglycemic excursions.
“In addition to this, several in vitro studies have confirmed that flavonoids may possess strong inhibitory activities on the intestinal α-glucosidase enzyme that catalyzes the cleavage of glucose from disaccharides, thereby delaying the absorption of glucose and flattening postprandial hyperinsulinemic/hyperglycemic excursions [61,62].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [61]

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057 · see citing works
A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice
Barger, J. L., Kayo, T., Vann, J. M., Arias, E. B., Wang, J., Hacker, T. A., Wang, Y., Raederstorff, D., Morrow, J. D., Leeuwenburgh, C., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002264 · Cited by 580 · see citing works
Comparative study of radical scavenger and antioxidant properties of phenolic compounds from Vitis vinifera cell cultures using in vitro tests
Fauconneau, B., Waffo‐Téguo, P., Huguet, F., Barrier, L., Décendit, A., & Mérillon, J. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00883-7 · Cited by 437 · see citing works
Alpha-glucosidase inhibitors for type 2 diabetes mellitus
Van de Laar, F. A., Lucassen, P. L., Akkermans, R. P., Van de Lisdonk, E. H., Rutten, G. E., & Van Weel, C. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003639.pub2 · Cited by 335 · see citing works
Cancer Chemopreventive and Antioxidant Activities of Pterostilbene, a Naturally Occurring Analogue of Resveratrol
Rimando, A. M., Cuendet, M., Desmarchelier, C., Mehta, R. G., Pezzuto, J. M., & Duke, S. O. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0116855 · Cited by 295 · see citing works
Self-citation
Antihyperglycemic Activity of Phenolics from Pterocarpus marsupium
Manickam, M., Ramanathan, M., Jahromi, M. A. F., et al. (1997) · Journal of Natural Products · doi:10.1021/np9607013 · Cited by 258 · see citing works
Is There a Role for ??-Glucosidase Inhibitors in the Prevention of Type 2 Diabetes Mellitus?
Scheen, A. J. (2003) · Drugs · doi:10.2165/00003495-200363100-00002 · Cited by 242 · see citing works
Isolation and Identification ofα-Glucosidase Inhibitors from Tochu-cha (Eucommia ulmoides)
Watanabe, J., Kawabata, J., Kurihara, H., & Niki, R. (1997) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.61.177 · Cited by 220 · see citing works
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Rivière, C., Richard, T., Quentin, L., Krisa, S., Mérillon, J., & Monti, J. (2006) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2006.09.069 · Cited by 216 · see citing works
Inhibitory Effect of α-Glucosidase Inhibitors Varies According to Its Origin
Oki, T., Matsui, T., & Osajima, Y. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980788t · Cited by 209 · see citing works
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Shinde, J. U., Taldone, T., Barletta, M. A., et al. (2008) · Carbohydrate Research · doi:10.1016/j.carres.2008.03.003 · Cited by 193 · see citing works
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Lee, D.-S., & Lee, S. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02631-x · Cited by 187 · see citing works
Antioxidant Effect of trans-Resveratrol, Pterostilbene, Quercetin and Their Combinations in Human Erythrocytes In Vitro
Mikstacka, R., Rimando, A. M., & Ignatowicz, E. (2010) · Plant Foods for Human Nutrition · doi:10.1007/s11130-010-0154-8 · Cited by 185 · see citing works
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Albani, D., Polito, L., Signorini, A., & Forloni, G. (2010) · BioFactors · doi:10.1002/biof.118 · Cited by 184 · see citing works
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Rimando, A. M., Nagmani, R., Feller, D. R., & YOKOYAMA, W. H. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0580364 · Cited by 184 · see citing works
Self-citation
Resveratrol protects myocardial ischemia–reperfusion injury through both NO-dependent and NO-independent mechanisms
Hung, L., Su, M., & Chen, J. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.12.016 · Cited by 178 · see citing works
Pterostilbene and 3′-hydroxypterostilbene are effective apoptosis-inducing agents in MDR and BCR-ABL-expressing leukemia cells
Tolomeo, M., Grimaudo, S., Cristina, A. D., Roberti, M., Pizzirani, D., Meli, M., Dusonchet, L., Gebbia, N., Abbadessa, V., Crosta, L., et al. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.03.004 · Cited by 162 · see citing works
Phosphatidylinositol-3-kinase is involved in the antihyperglycemic effect induced by resveratrol in streptozotocin-induced diabetic rats
Chi, T.-C., Chen, W.-P., Chi, T.-L., Kuo, T., Lee, S., Cheng, J., & Su, M. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.02.002 · Cited by 156 · see citing works
Antioxidant effects of resveratrol and other stilbene derivatives on oxidative stress and NO bioavailability: Potential benefits to cardiovascular diseases
Frombaum, M., Clanche, S. L., Bonnefont‐Rousselot, D., & Borderie, D. (2011) · Biochimie · doi:10.1016/j.biochi.2011.11.001 · Cited by 156 · see citing works
Dealcoholized red wine containing known amounts of resveratrol suppresses atherosclerosis in hypercholesterolemic rabbits without affecting plasma lipid levels.
Wang, Z., Zou, J., Cao, K., Hsieh, T., Huang, Y., & WU, J. M. (2005) · PubMed · Cited by 152 · see citing works
Resveratrol attenuates hyperglycemia-mediated oxidative stress, proinflammatory cytokines and protects hepatocytes ultrastructure in streptozotocin–nicotinamide-induced experimental diabetic rats
Periyasamy, P., Sivakumar, S., & Subramanian, S. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.03.028 · Cited by 145 · see citing works
Yeast and mammalian alpha-glucosidase inhibitory constituents from Himalayan rhubarb Rheum emodi Wall.ex Meisson.
Babu, K. S., Tiwari, A., Srinivas, P., Ali, A. Z., Raju, B., & Rao, J. (2004) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2004.04.062 · Cited by 137 · see citing works
Anti-inflammatory mechanisms of resveratrol in activated HMC-1 cells: Pivotal roles of NF-κB and MAPK
Kang, O., Jang, H.-J., Chae, H., et al. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.01.009 · Cited by 137 · see citing works
Piceatannol, Natural Polyphenolic Stilbene, Inhibits Adipogenesis via Modulation of Mitotic Clonal Expansion and Insulin Receptor-dependent Insulin Signaling in Early Phase of Differentiation
Kwon, J. Y., Seo, S. G., Heo, Y., Yue, S., Cheng, J., Lee, K. W., & Kim, K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.259721 · Cited by 134 · see citing works
Inhibitory effects of five medicinal plants on rat alpha-glucosidase: Comparison with their effects on yeast alpha-glucosidase
Shai, Magano, Lebelo, et al. (2011) · Journal of Medicinal Plants Research · doi:10.5897/jmpr.9000811 · Cited by 128 · see citing works
Grape Polyphenol Resveratrol and the Related Molecule 4-Hydroxystilbene Induce Growth Inhibition, Apoptosis, S-Phase Arrest, and Upregulation of Cyclins A, E, and B1 in Human SK-Mel-28 Melanoma Cells
Larrosa, M., Tomás-Barberán, F. A., & Espı́n, J. C. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030073c · Cited by 120 · see citing works
Fighting Cancer with Red Wine? Molecular Mechanisms of Resveratrol
Kraft, T. E., Parisotto, D. A., Schempp, C. M., & Efferth, T. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390802248627 · Cited by 116 · see citing works
α-Glucosidase inhibitors from the seeds of Syagrus romanzoffiana
Lam, S.-H., Chen, J., Kang, C.-J., Chen, C.-H., & Lee, S. (2008) · Phytochemistry · doi:10.1016/j.phytochem.2007.12.004 · Cited by 112 · see citing works
Pterostilbene is equally potent as resveratrol in inhibiting 12-O-tetradecanoylphorbol-13-acetate activated NFκB, AP-1, COX-2, and iNOS in mouse epidermis
Cichocki, M., Paluszczak, J., Szaefer, H., Piechowiak, A., Rimando, A. M., & Baer‐Dubowska, W. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700466 · Cited by 108 · see citing works
Self-citation
Antioxidant Activity and Inhibition of α-Glucosidase by trans-Resveratrol, Piceid, and a Novel trans-Stilbene from the Roots of Israeli Rumex bucephalophorus L.
Kerem, Z., Bilkis, I. I., Flaishman, M. A., & Sivan, L. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf052436+ · Cited by 93 · see citing works
Piceatannol, a catechol-type polyphenol, inhibits phorbol ester-induced NF-κB activation and cyclooxygenase-2 expression in human breast epithelial cells: cysteine 179 of IKKβ as a potential target
Son, P.-S., Park, S., Na, H., et al. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq099 · Cited by 93 · see citing works
Morphological Changes and Increased Sucrase and Isomaltase Activity in Small Intestines of Insulin-Deficient and Type 2 Diabetic Rats
Adachi, T., Mori, C., Sakurai, K., et al. (2003) · Endocrine Journal · doi:10.1507/endocrj.50.271 · Cited by 88 · see citing works
Antidiabetic stilbene and anthraquinone derivatives fromRheum undulatum
Choi, S. Z., Lee, S. O., Jang, K. U., Chung, S. H., Park, S. H., Kang, H. C., Yang, E. Y., Cho, H. J., & Lee, K. R. (2005) · Archives of Pharmacal Research · doi:10.1007/bf02977396 · Cited by 84 · see citing works
Type 2 diabetes mellitus: what is the optimal treatment regimen?
Bell, D. S. H. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.10.017 · Cited by 82 · see citing works
Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1‐independent sensitization to TRAIL‐induced apoptosis
Mader, I., Wabitsch, M., Debatin, K., Fischer‐Posovszky, P., & Fulda, S. (2010) · The FASEB Journal · doi:10.1096/fj.09-142943 · Cited by 78 · see citing works
Protective Effects of Piceatannol against Beta‐Amyloid–Induced Neuronal Cell Death
Kim, H. J., Lee, K. W., & Lee, H. J. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1397.051 · Cited by 75 · see citing works
The grape and wine constituent piceatannol inhibits proliferation of human bladder cancer cells via blocking cell cycle progression and inducing Fas/membrane bound Fas ligand‐mediated apoptotic pathway
Kuo, P., & Hsu, Y. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700252 · Cited by 73 · see citing works
Piceatannol induces heme oxygenase-1 expression in human mammary epithelial cells through activation of ARE-driven Nrf2 signaling
Lee, H.-H., Park, S., Almazari, I., Kim, E. H., Na, H., & Surh, Y. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.06.011 · Cited by 70 · see citing works
The 4′-hydroxy group is responsible for the in vitro cytogenetic activity of resveratrol
Matsuoka, A., Takeshita, K., Furuta, A., Ozaki, M., Fukuhara, K., & Miyata, N. (2002) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(02)00211-5 · Cited by 70 · see citing works
Activation of the erythrocyte plasma membrane redox system by resveratrol: a possible mechanism for antioxidant properties
Rizvi, S. I., & Pandey, K. B. (2010) · Pharmacological Reports · doi:10.1016/s1734-1140(10)70330-3 · Cited by 59 · see citing works
Correction: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice
Barger, J. L., Kayo, T., Vann, J. M., Arias, E. B., Wang, J., Hacker, T. A., Wang, Y., Raederstorff, D., Morrow, J. D., Leeuwenburgh, C., et al. (2008) · PLoS ONE · doi:10.1371/annotation/c54ef754-1962-4125-bf19-76d3ec6f19e5 · Cited by 51 · see citing works
The insulin-suppressive effect of resveratrol — An in vitro and in vivo phenomenon
Szkudelski, T. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.12.008 · Cited by 49 · see citing works
Design, synthesis, biological evaluation and docking studies of pterostilbene analogs inside PPARα
Mizuno, C. S., Ma, G., Khan, S. I., Patny, A., Avery, M. A., & Rimando, A. M. (2008) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2008.01.051 · Cited by 43 · see citing works
Self-citation
Constituents of Stem Bark of Callistemon rigidus Showing Inhibitory Effects on Mouse .ALPHA.-Amylase Activity
Kobayashi, K., Ishihara, T., Khono, E., et al. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.1275 · Cited by 42 · see citing works
Dimerization of piceatannol by Momordica charantia peroxidase and α-glucosidase inhibitory activity of the biotransformation products
Wan, X., Wang, X., Yang, M.-H., Wang, J., & Kong, L. (2011) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2011.07.032 · Cited by 33 · see citing works
Algicidal Activity of Stilbene Analogues
Mizuno, C. S., Schrader, K. K., & Rimando, A. M. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf801988p · Cited by 33 · see citing works
Self-citation
Oral administration of resveratrol in suppression of pulmonary metastasis of BALB/c mice challenged with CT26 colorectal adenocarcinoma cells
Weng, Y., Liao, H., Li, A. F., et al. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900049 · Cited by 31 · see citing works
Small Molecule Inhibiting Nuclear Factor‐ kB Ameliorates Oxidative Stress and Suppresses Renal Inflammation in Early Stage of Alloxan‐Induced Diabetic Nephropathy in Rat
Borgohain, M. P., Lahkar, M., Ahmed, S., Chowdhury, L., Kumar, S., Pant, R., & Choubey, A. (2016) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12718 · Cited by 31 · see citing works
Efficient Isolation of Glycosidase Inhibitory Stilbene Glycosides from Rheum palmatum
Kubo, I., Murai, Y., Soediro, I., et al. (1991) · Journal of Natural Products · doi:10.1021/np50076a034 · Cited by 22 · see citing works
Desoxyrhaponticin (3,5-Dihydroxy-4′-methoxystilbene 3-O-β-d-glucoside) Inhibits Glucose Uptake in the Intestine and Kidney: In Vitro and in Vivo Studies
Li, J. M., Che, C. T., Lau, C. B., Leung, P. S., & Cheng, C. H. K. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.111526 · Cited by 17 · see citing works
Isolation of an Active Compound with Alpha‐glucosidase Inhibitory Activity from Amomum xanthioides Wallich
Kim, Y., Kim, M., Zhang, J. A., et al. (2007) · The FASEB Journal · doi:10.1096/fasebj.21.6.a1085-b · Cited by 1 · see citing works

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“In addition to this, several in vitro studies have confirmed that flavonoids may possess strong inhibitory activities on the intestinal α-glucosidase enzyme that catalyzes the cleavage of glucose from disaccharides, thereby delaying the absorption of glucose and flattening postprandial hyperinsulinemic/hyperglycemic e…”
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Authors: Zhang, A. J., Rimando, A. M., Mizuno, C. S., & Mathews, S. T.
Affiliations: Auburn University (US)
Agricultural Research Service (US)
Corresponding author: Mathews, Suresh T.
ORCID: Rimando, Agnes M.
Mizuno, Cassia S.
Mathews, Suresh T.
Venue: The Journal of Nutritional Biochemistry
Publisher: Elsevier BV
Published: 2017-09
Volume: 47
Pages: 86-93
ISSN: 0955-2863 (ISSN-L)
DOI: 10.1016/j.jnutbio.2017.05.008
OpenAlex: W2618610934
Cited by: 99
References: 51
Citations by year: 2026: 9 · 2025: 10 · 2024: 15 · 2023: 3 · 2022: 13 · 2021: 12 · 2020: 15 · 2019: 13 · 2018: 7 · 2017: 2
FWCI: 7.99
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Journal of Nutritional Biochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords: resveratrol, piceatannol, α-glucosidase inhibition, dietary polyphenols, postprandial hyperglycemia, antidiabetic activity, acarbose, sucrose loading
MeSH terms: Resveratrol, alpha-Glucosidases, Animals, Blood Glucose, Dietary Carbohydrates, Gastrointestinal Agents, Hyperglycemia, Hypoglycemic Agents, Intestinal Absorption, Kinetics, Mice, Inbred C57BL, Obesity, Random Allocation, Starch, Stilbenes, Dietary Sucrose, Postprandial Period, Acarbose, Rats, Diet, High-Fat, Glycoside Hydrolase Inhibitors

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α-Glucosidase inhibitory effect of resveratrol and piceatannol

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