Comparative evaluation of natural antioxidants spirulina and aloe vera for the treatment of oral submucous fibrosis
Open accessAbstract
Aim Oral submucous fibrosis (OSMF) is a high risk premalignant condition predominantly seen in the Indian subcontinent. The aim of the present study was to compare the efficacy of spirulina and aloe vera in the management of OSMF.Material and methods 42 subjects with clinico-pathologically diagnosed OSMF were included in the study and divided equally in 2 groups, Group A (spirulina group) and Group B (aloe vera group). Group A was administered 500 mg spirulina in 2 divided doses for 3 months and Group B was given 5 mg aloe vera gel to be applied topically thrice daily for 3 months. Evaluation for different clinical parameters was done at regular intervals and data was analyzed using the Chi-square test. P-value <0.05 was considered to be statistically significant.Results The patients in Group A showed significant clinical improvement in mouth opening and ulcers/erosions/vesicles (p < 0.05). However, there was no significant improvement in burning sensation (p = 0.06) and pain associated with the lesion (p = 0.04) among the 2 groups.Conclusion Both the drugs showed improvement in the condition; however spirulina can bring about significant clinical improvements in the symptoms like mouth opening and ulcers/erosion/vesicles. Thus, spirulina appears to be more promising when compared to aloe vera for the treatment of OSMF.
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By reducing oxidative stress and increasing the amount of substances with antioxidant properties in the body, Arthrospira platensis exerts a neuroprotective effect on the body.
“By reducing oxidative stress and increasing the amount of substances with antioxidant properties in the body, Arthrospira platensis exerts a neuroprotective effect on the body [94,95].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [94]
The Discussion (page not provided) says spirulina contains phenolic acid, tocopherols, and beta-carotene, which have antioxidant properties. It does not report that spirulina increases antioxidant substances in the body, reduces oxidative stress, or exerts a neuroprotective effect; the study assessed clinical outcomes in oral submucous fibrosis. (LLM, conf=0.84)
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- Authors
- Patil, S., Al-Zarea, B. K., Maheshwari, S., & Sahu, R.
- Affiliations
- Jouf University (SA)
- Chhattisgarh Dental College & Research Institute (IN)
- Corresponding author
- Patil, Santosh
- ORCID
- Patil, Santosh
- Venue
- Journal of Oral Biology and Craniofacial Research
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 5
- Issue
- 1
- Pages
- 11-15
- ISSN
- 2212-4268 (ISSN-L)
- PMC
- PMC4382509
- OpenAlex
- W2003494655
- Cited by
- 60
- References
- 24
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 10 · 2022: 11 · 2021: 8 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 6 · 2014: 3
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Oral Biology and Craniofacial Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral Health Pathology and Treatment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Oral health in cancer treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › HIV/AIDS oral health manifestations
- Keywords
- oral submucous fibrosis, Spirulina, Aloe vera, natural antioxidants, mouth opening, oral ulcers, oral erosions, oral burning sensation, oral pain, oral potentially malignant disorders, herbal medicine
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