Phycocyanin: Anti-inflammatory effect and mechanism
Open accessAbstract
As the host defense response to various injuries and pathogens in the body, inflammation can remove damaged cells and pathogens in the host organism and protect the body. However, excessive inflammation may cause damage to normal tissue cells while removing pathogens, which in turn cause numerous inflammatory diseases and adversely affect the human health. Phycocyanin is an active substance extracted from algae; it has outstanding antioxidant and anti-inflammatory activities, and can effectively inhibit various diseases caused by inflammation. This review systematically summarizes recent applications of phycocyanin against various inflammatory diseases in lung, liver, cardiovascular, and cerebrovascular systems. In addition, possible anti-inflammatory action pathways of phycocyanin are reviewed to canvass the anti-inflammatory mechanism. At last, based on the existing research, phycocyanobilin in phycocyanin is proposed as a bilirubin analog by inducing heme oxygenase 1 in vivo to suppress inflammation.
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Experimental animals taking phycocyanin show resistance to various infectious diseases.
“Experimental animals taking phycocyanin show resistance to various infectious diseases [77].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [77]
Section 2.4.1 (Acute lung injury; page not supplied) reports that phycocyanin reduced inflammation and lung injury in an animal model of sepsis. It does not establish that animals taking phycocyanin resist infection, let alone various infectious diseases. (LLM, conf=0.81)
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- Authors
- Liu, R., Qin, S., & Li, W.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Li, Wenjun
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2022-09
- Volume
- 153
- Pages
- 113362
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W4285384602
- Cited by
- 157
- References
- 83
- Citations by year
- 2026: 52 · 2025: 50 · 2024: 40 · 2023: 14 · 2022: 1
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Knowledge Repository of Yantai Institute of Coastal Zone Research, CAS (Yantai Institute of Coastal Zone Research) (submittedVersion)
- Funders
- National Key Research and Development Program of China (2021YFC2103900)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
- Keywords
- phycocyanin, anti-inflammatory activity, inflammatory diseases, antioxidant activity, phycocyanobilin, heme oxygenase-1, inflammatory mechanisms, lung inflammation, liver inflammation, cardiovascular inflammation, cerebrovascular inflammation
- MeSH terms
- Anti-Inflammatory Agents, Antioxidants, Bilirubin, Humans, Inflammation, Phycocyanin
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