Cited by 87Endodontics and Root Canal TreatmentsOral microbiology and periodontitis researchInflammatory mediators and NSAID effects

Eugenol suppressed the expression of lipopolysaccharide-induced proinflammatory mediators in human macrophages

Lee, Ya-Yun, Hung, Shan-Ling, Pai, Sheng-Fang, Lee, Yuan-Ho, Yang, Shue-Fen·2007·Journal of Endodontics

Abstract

Eugenol is commonly used as an analgesic agent during acute pulpitis and is a major component of root canal sealers. Despite the frequent applications of eugenol in the practice of dentistry, little is known about the role of eugenol under the status of inflammation. This study was aimed to investigate the influence of eugenol on human macrophages (U937) under the stimulation of lipopolysaccharide (LPS). Eugenol was shown to block the release of the bone resorbing mediators, including interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and prostaglandin E2 from LPS-stimulated macrophages. In contrast, eugenol alone did not alter the expression levels of these proinflammatory mediators in macrophages. Consistent with downregulation of bone-resorbing mediators, eugenol suppressed the messenger RNA expression of LPS-induced IL-1beta, TNF-alpha, and cyclooxygenase-2 in macrophages. The results suggest a potential anti-inflammatory effect of eugenol in the acute inflamed pulps and apical periodontitis.

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Crossref · 10.1016/j.joen.2007.02.010

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Authors
Lee, Y.-Y., Hung, S.-L., Pai, S.-F., Lee, Y.-H., & Yang, S.-F.
Affiliations
  • National Yang Ming University (TW)
  • Taipei Veterans General Hospital (TW)
Corresponding author
Yang, Shue-Fen
Venue
Journal of Endodontics
Publisher
Elsevier BV
Published
2007-06
Volume
33
Issue
6
Pages
698-702
ISSN
0099-2399 (ISSN-L)
OpenAlex
W2089438372
Cited by
87
References
39
Citations by year
2026: 1 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 2 · 2014: 9 · 2013: 7 · 2012: 6
FWCI
6.24
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Endodontics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Dentistry › Oral Surgery › Endodontics and Root Canal Treatments
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
Keywords
eugenol, lipopolysaccharide, macrophages, U937 cells, pro-inflammatory mediators, anti-inflammatory activity, IL-1β, TNF-α, prostaglandin E2, cyclooxygenase-2, bone resorption, apical periodontitis, pulpitis, endodontic sealers
MeSH terms
Anti-Inflammatory Agents, Eugenol, Humans, Lipopolysaccharides, Macrophages, Tumor Necrosis Factor-alpha, Dinoprostone, Down-Regulation, Inflammation Mediators, U937 Cells, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Interleukin-1beta

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