Cited by 204Medicinal Plant ResearchCurcumin's Biomedical ApplicationsBioactive natural compounds

Cancer cell signaling pathways targeted by spice-derived nutraceuticals

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Sung, Bokyung, Prasad, Sahdeo, Yadav, Vivek R., Aggarwal, Bharat B.·2012·Nutrition and Cancer

Abstract

Extensive research within the last half a century has revealed that cancer is caused by dysregulation of as many as 500 different gene products. Most natural products target multiple gene products and thus are ideally suited for prevention and treatment of various chronic diseases, including cancer. Dietary agents such as spices have been used extensively in the Eastern world for a variety of ailments for millennia, and five centuries ago they took a golden journey to the Western world. Various spice-derived nutraceuticals, including 1'-acetoxychavicol acetate, anethole, capsaicin, cardamonin, curcumin, dibenzoylmethane, diosgenin, eugenol, gambogic acid, gingerol, thymoquinone, ursolic acid, xanthohumol, and zerumbone derived from galangal, anise, red chili, black cardamom, turmeric, licorice, fenugreek, clove, kokum, ginger, black cumin, rosemary, hop, and pinecone ginger, respectively, are the focus of this review. The modulation of various transcription factors, growth factors, protein kinases, and inflammatory mediators by these spice-derived nutraceuticals are described. The anticancer potential through the modulation of various targets is also the subject of this review. Although they have always been used to improve taste and color and as a preservative, they are now also used for prevention and treatment of a wide variety of chronic inflammatory diseases, including cancer.

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Crossref · 10.1080/01635581.2012.630551

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  • Eugenol inhibits tumor proliferation and formation, increases reactive oxygen species (ROS), generates apoptosis, and has a genotoxic effect in different cancer cells.

    “Eugenol inhibits tumor proliferation and formation, increases reactive oxygen species (ROS), generates apoptosis, and has a genotoxic effect in different cancer cells [23,29,30,31].”

    From Clove essential oil (Syzygium aromaticum L. Myrtaceae): Extraction, chemical composition, food applications, and essential bioactivity for human health (2021) · cites this paper as [29]

    The Proinflammatory Mediators section (page unavailable) reports that eugenol inhibited proliferation of HT-29 cancer cells. A cited study listed in the References (page unavailable) describes prevention of mouse skin carcinogenesis and induction of apoptosis, but the copy does not establish these effects across different cancer cells. It also does not support the claimed increase in ROS or genotoxic effect. (LLM, conf=0.87)

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  1. [198]Sun ZJ Chen G Zhang W Hu X Liu Y Curcumin dually inhibits both mTOR and NF-{kappa}B pathways through a crossed PI3K/Akt/IKK signaling axis in adenoid cystic carcinoma Mol Pharmacol 79 106 118 2011 20959361

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Authors
Sung, B., Prasad, S., Yadav, V. R., & Aggarwal, B. B.
Affiliations
The University of Texas MD Anderson Cancer Center (US)
Venue
Nutrition and Cancer
Published
2012-02
Volume
64
Issue
2
Pages
173-197
ISSN
  • 0163-5581 (ISSN-L)
  • 1532-7914
OpenAlex
W2035997417
Cited by
204
References
324
Citations by year
2026: 7 · 2025: 6 · 2024: 11 · 2023: 10 · 2022: 18 · 2021: 28 · 2020: 11 · 2019: 17 · 2018: 9 · 2017: 15 · 2016: 18 · 2015: 14 · 2014: 13 · 2013: 20 · 2012: 7
FWCI
1.31
Type
journal article
Language
en
Open access
Locations
  • Nutrition and Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (CA-16672, P01CA124787, CA-124787-01A2, P30CA016672)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
Keywords
anticancer agents, curcumin, gingerol, xanthohumol, eugenol, thymoquinone, capsaicin, anethole, cardamonin, gambogic acid, ursolic acid, dibenzoylmethane, diosgenin, Nigella sativa, licorice, turmeric, Syzygium aromaticum, black cardamom, galangal, red chili, Rosmarinus officinalis, Humulus lupulus, fenugreek, kokum, transcription factors, protein kinases, growth factors, inflammatory mediators, cancer prevention
MeSH terms
Animals, Antineoplastic Agents, Phytogenic, Humans, Phytotherapy, Neoplasms, Protein Kinases, Transcription Factors, Signal Transduction, NF-kappa B, Spices, Receptors, Growth Factor, Inflammation Mediators, Dietary Supplements, Intercellular Signaling Peptides and Proteins, Cell Line, Tumor, Protein Kinase Inhibitors

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