Symptom Prevalence and Clustering of Symptoms in People Living with Chronic Hepatitis C Infection
Open accessAbstract
Quality of life has been shown to be poor among people living with chronic hepatitis C. However, it is not clear how this relates to the presence of symptoms and their severity. The aim of this study was to describe the typology of a broad array of symptoms that were attributed to hepatitis C virus (HCV) infection. Phase 1 used qualitative methods to identify symptoms. In Phase 2, 188 treatment-naïve people living with HCV participated in a quantitative survey. The most prevalent symptom was physical tiredness (86%) followed by irritability (75%), depression (70%), mental tiredness (70%), and abdominal pain (68%). Temporal clustering of symptoms was reported in 62% of participants. Principal components analysis identified four symptom clusters: neuropsychiatric (mental tiredness, poor concentration, forgetfulness, depression, irritability, physical tiredness, and sleep problems); gastrointestinal (day sweats, nausea, food intolerance, night sweats, abdominal pain, poor appetite, and diarrhea); algesic (joint pain, muscle pain, and general body pain); and dysesthetic (noise sensitivity, light sensitivity, skin problems, and headaches). These data demonstrate that symptoms are prevalent in treatment-naïve people with HCV and support the hypothesis that symptom clustering occurs.
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Patients with chronic hepatitis C virus (HCV) experience diffuse symptoms that may be associated with HCV and report poor health-related quality of life.
“Patients complain of several diffuse symptoms that may be associated with HCV and report poor health-related quality of life (HRQOL) [3, 4].”
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- Authors
- Lang, C. A., Conrad, S., Garrett, L., Battistutta, D., Cooksley, W. G. E., Dunne, M. P., & Macdonald, G. A.
- Affiliations
- The University of Queensland (AU)
- Queensland University of Technology (AU)
- Corresponding author
- Lang, Carolyn A.
- Venue
- Journal of Pain and Symptom Management
- Publisher
- Elsevier BV
- Published
- 2006-04
- Volume
- 31
- Issue
- 4
- Pages
- 335-344
- ISSN
- 0885-3924 (ISSN-L)
- OpenAlex
- W1484346757
- Cited by
- 99
- References
- 37
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 2 · 2015: 7 · 2014: 5 · 2013: 1 · 2012: 7
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Pain and Symptom Management (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Queensland Health
- Queensland University of Technology
- Townsville Hospital and Health Service
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Keywords
- chronic hepatitis C, hepatitis C virus, symptom prevalence, symptom clustering, irritability, depression, abdominal pain, gastrointestinal symptoms, quality of life, treatment-naive patients
- MeSH terms
- Adult, Mental Disorders, Female, Gastrointestinal Diseases, Health Surveys, Humans, Male, Middle Aged, Pain, Paresthesia, Quality of Life, Severity of Illness Index, Prevalence, Cluster Analysis, Hepatitis C, Chronic
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