Neurobehavioral Effects of Interferon-α in Patients with Hepatitis-C: Symptom Dimensions and Responsiveness to Paroxetine
Open accessAbstract
In patients at high risk for recurrence of malignant melanoma, interferon-α (IFN-α), a stimulator of innate immunity, appears to induce distinct neurobehavioral symptom dimensions: a mood and anxiety syndrome, and a neurovegetative syndrome, of which the former is responsive to prophylactic administration of paroxetine. We sought to determine whether symptom dimensions (and treatment responsiveness) arise in patients with hepatitis C administered IFN-α and ribavirin. In a randomized, double-blind, 6-month study, 61 patients with hepatitis C eligible for therapy with IFN-α and ribavirin received the antidepressant paroxetine (n=28) or a placebo (n=33). Study medication began 2 weeks before IFN-α/ribavirin therapy. Neuropsychiatric assessments included the 10-item Montgomery-Asberg Depression Rating Scale (MADRS). The items of the MADRS were grouped into depression, anxiety, cognitive dysfunction, and neurovegetative symptom dimensions, and analyzed using a mixed model. By 2 weeks of IFN-α/ribavirin therapy, all four dimensions increased, with the symptom dimensions of anxiety and cognitive dysfunction fluctuating and worsening, respectively, in both groups over time. The depression symptom dimension was significantly lower in the paroxetine treatment group (p=0.04); severity of the neurovegetative symptom dimension was similar in both groups. Similar to patients with malignant melanoma receiving high-dose IFN-α, the depression symptom dimension is more responsive to paroxetine treatment in individuals undergoing concomitant IFN-α/ribavirin therapy. However, the anxiety, cognitive dysfunction, and neurovegetative symptom dimensions appear less responsive to prophylactic paroxetine administration. Different neurobiologic pathways may contribute to the responsiveness of IFN-α-induced symptom dimensions to antidepressant treatment, requiring relevant psychopharmacologic strategies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SSRIs are very effective in treating anxiety, depressed mood, and cognitive aspects of cytokine-induced depression, but not as effective for fatigue and neurovegetative symptoms.
“In terms of the role of 5-HT in the treatment of cytokine-induced depression, SSRIs have been very effective in treating anxiety, depressed mood, and cognitive aspects of cytokine-induce depression, but not as effective for fatigue and neurovegetative symptoms (Capuron et al., 2002, Raison et al., 2005b, McNutt et al., 2012).”
From Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications (2013) · cites this paper as McNutt et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962 · see citing works
RUBIN, D. B. (1976) · Biometrika · doi:10.1093/biomet/63.3.581 · Cited by 9,925 · see citing works
DiMatteo, M. R., Lepper, H. S., & Croghan, T. W. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.14.2101 · Cited by 4,177 · see citing works
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
Ge, D., Fellay, J., Thompson, A. J. V., Simon, J. S., Shianna, K. V., Urban, T. J., Heinzen, E. L., Qiu, P., Bertelsen, A. H., Muir, A. J., et al. (2009) · Nature · doi:10.1038/nature08309 · Cited by 3,510 · see citing works
McHutchison, J. G., Gordon, S. C., Schiff, E. R., Shiffman, M. L., Lee, W. M., Rustgi, V. K., Goodman, Z. D., Ling, M.-H., Cort, S., & Albrecht, J. K. (1998) · New England Journal of Medicine · doi:10.1056/nejm199811193392101 · Cited by 3,457 · see citing works
Poynard, T., Marcellin, P., Lee, S. S., Niederau, C., Minuk, G., Ideo, G., Bain, V. G., Heathcote, J., Zeuzem, S., TREPO, C. G., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)07124-4 · Cited by 2,310 · see citing works
O'Connor, J. C., Lawson, M. A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002148 · Cited by 1,278 · see citing works
Handbook of Psychiatric Measures
Salzman, C. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.8.1343 · Cited by 1,172 · see citing works
Symptom clusters and their effect on the functional status of patients with cancer.
Dodd, M. J., Miaskowski, C., & Paul, S. M. (2001) · PubMed · Cited by 775 · see citing works
Cytokine-induced sickness behavior
Kelley, K. W., Bluthé, R.-M., Dantzer, R., Zhou, J.-H., Shen, W.-H., Johnson, R. W., & Broussard, S. R. (2003) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(02)00077-6 · Cited by 716 · see citing works
Raison, C. L., Dantzer, R., Kelley, K. W., Lawson, M. A., Woolwine, B. J., Vogt, G., Spivey, J. R., Saito, K., & Miller, A. H. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.116 · Cited by 630 · see citing works
Self-citationAntidepressants and Body Weight: A Comprehensive Review and Meta-Analysis
Serretti, A., & Mandelli, L. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09r05346blu · Cited by 621 · see citing works
Walsh, D., Donnelly, S. M., & Rybicki, L. A. (2000) · Supportive Care in Cancer · doi:10.1007/s005200050281 · Cited by 620 · see citing works
Kim, H., McGuire, D. B., Tulman, L. J., & Barsevick, A. M. (2005) · Cancer Nursing · doi:10.1097/00002820-200507000-00005 · Cited by 600 · see citing works
Cytokines and psychopathology: Lessons from interferon-α
Capuron, L., & Miller, A. H. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.009 · Cited by 562 · see citing works
Self-citationHepatitis C and cognitive impairment in a cohort of patients with mild liver disease
Forton, D. M., Thomas, H. C., Murphy, C. A., Allsop, J. M., Foster, G. R., Main, J., Wesnes, K. A., & Taylor-Robinson, S. D. (2002) · Hepatology · doi:10.1053/jhep.2002.30688 · Cited by 450 · see citing works
Bonaccorso, S., Marino, V., Puzella, A., Pasquini, M., Biondi, M., Artini, M., Almerighi, C., Verkerk, R., Meltzer, H., & Maes, M. (2002) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200202000-00014 · Cited by 437 · see citing works
Symptom Clusters: The New Frontier in Symptom Management Research
Miaskowski, C. A. (2004) · JNCI Monographs · doi:10.1093/jncimonographs/lgh023 · Cited by 405 · see citing works
Interferon-Alpha Produces Sustained Cytogenetic Responses in Chronic Myelogenous Leukemia
Talpaz, M., Kantarjian, H. M., Kurzrock, R., Trujillo, J. M., & Gutterman, J. U. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-7-532 · Cited by 380 · see citing works
Wheatley, K., Ives, N. J., Hancock, B. W., Gore, M. E., Eggermont, A. M. M., & Suciu, S. (2003) · Cancer Treatment Reviews · doi:10.1016/s0305-7372(03)00074-4 · Cited by 341 · see citing works
Mood and cognitive side effects of interferon-alpha therapy.
Valentine, A. D., Meyers, C. A., Kling, M. A., Richelson, E., & Hauser, P. (1998) · PubMed · Cited by 312 · see citing works
Hauser, P., Khosla, J., Aurora, H., Laurin, J. M., Kling, M. A., Hill, J., Gulati, M. S., Thornton, A. J., Schultz, R. L., Valentine, A. D., et al. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001119 · Cited by 309 · see citing works
Depression During Pegylated Interferon-Alpha Plus Ribavirin Therapy
Raison, C. L., Borisov, A. S., Broadwell, S. D., Capuron, L., Woolwine, B. J., Jacobson, I. M., Nemeroff, C. B., & Miller, A. H. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0106 · Cited by 298 · see citing works
Self-citationCapuron, L., Ravaud, A., & Dantzer, R. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.10.2143 · Cited by 293 · see citing works
A Comparison of Depression Rating Scales
Kearns, N. P., Cruickshank, C. A., McGuigan, K. J., Riley, S., Shaw, S. P., & Snaith, R. P. (1982) · The British Journal of Psychiatry · doi:10.1192/bjp.141.1.45 · Cited by 273 · see citing works
Symptom clustering in advanced cancer
Walsh, D., & Rybicki, L. A. (2006) · Supportive Care in Cancer · doi:10.1007/s00520-005-0899-z · Cited by 265 · see citing works
Miller, A. H. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.08.006 · Cited by 261 · see citing works
Self-citationBull, S. J., Huezo-Diaz, P., Binder, E. B., Cubells, J. F., Ranjith, G., Maddock, C., Miyazaki, C., Alexander, N., Hotopf, M., Cleare, A. J., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.48 · Cited by 228 · see citing works
Self-citationInterferon α Treatment and Retreatment of Hepatitis B e Antigen-Negative Chronic Hepatitis B
Manesis, E. K., & Hadziyannis, S. J. (2001) · Gastroenterology · doi:10.1053/gast.2001.25524 · Cited by 217 · see citing works
Therapy of hepatitis C: Overview
Lindsay, K. L. (1997) · Hepatology · doi:10.1002/hep.510260713 · Cited by 214 · see citing works
Hepatitis C, interferon alfa, and depression
Zdilar, D., Franco-Bronson, K., Buchler, N. M., Locala, J. A., & Younossi, Z. M. (2000) · Hepatology · doi:10.1053/jhep.2000.7880 · Cited by 213 · see citing works
Symptom Clusters in Breast Cancer Across 3 Phases of the Disease
Bender, C. M., Erg??n, F. S., Rosenzweig, M. Q., Cohen, S. M., & Sereika, S. M. (2005) · Cancer Nursing · doi:10.1097/00002820-200505000-00011 · Cited by 194 · see citing works
Successful Treatment of Infantile Hemangiomas with Interferon-α-2b
Chang, E., Boyd, A. S., Nelson, C. C., Crowley, D. C., Law, T., Keough, K. M. W., Folkman, J., Ezekowitz, R. A. B., & Castle, V. P. (1997) · Journal of Pediatric Hematology/Oncology · doi:10.1097/00043426-199705000-00011 · Cited by 191 · see citing works
Su, K., Huang, S., Peng, C., Lai, H., Huang, C., Chen, Y.-C., Aitchison, K. J., & Pariante, C. M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.005 · Cited by 165 · see citing works
Khan, A., Khan, S., Shankles, E. B., & Polissar, N. L. (2002) · International Clinical Psychopharmacology · doi:10.1097/00004850-200211000-00003 · Cited by 162 · see citing works
Symptom clusters in cancer patients
Chen, M.-L., & Tseng, H.-C. (2006) · Supportive Care in Cancer · doi:10.1007/s00520-006-0019-8 · Cited by 159 · see citing works
A Cluster of Symptoms Over Time in Patients With Lung Cancer
Gift, A. G., Stommel, M., Jablonski, A., & Given, C. W. (2003) · Nursing Research · doi:10.1097/00006199-200311000-00007 · Cited by 154 · see citing works
Detection and Analysis of Hepatitis C Virus Sequences in Cerebrospinal Fluid
Laskus, T., Radkowski, M., Bednarska, A., Wilkinson, J., Adair, D. M., Nowicki, M. J., Nikolopoulou, G. B., Vargas, H. E., & Rakela, J. L. (2002) · Journal of Virology · doi:10.1128/jvi.76.19.10064-10068.2002 · Cited by 153 · see citing works
Repeated interferon-α administration inhibits dopaminergic neural activity in the mouse brain
Shuto, H., Kataoka, Y., Horikawa, T., Fujihara, N., & Oishi, R. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01371-6 · Cited by 151 · see citing works
Mood Alterations During Interferon-Alfa Therapy in Patients With Chronic Hepatitis C
Constant, A., Castéra, L., Dantzer, R., Couzigou, P., de Lédinghen, V., Demotes‐Mainard, J., & Henry, C. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0814 · Cited by 151 · see citing works
Quinolinic Acid Production by Macrophages Stimulated with IFN-γ, TNF-α, and IFN-α
PEMBERTON, L. A., KERR, S. J., SMYTHE, G., & BREW, B. J. (1997) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1997.17.589 · Cited by 149 · see citing works
Weißenborn, K., Ennen, J. C., Bokemeyer, M., Ahl, B., Wurster, U., Hl, T., Trebst, C., Hecker, H., & Berding, G. (2006) · Gut · doi:10.1136/gut.2005.080267 · Cited by 144 · see citing works
RAISON, C. L., WOOLWINE, B. J., DEMETRASHVILI, M. F., BORISOV, A. S., WEINREIB, R., STAAB, J. P., ZAJECKA, J. M., BRUNO, C. J., HENDERSON, M. A., REINUS, J. F., et al. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03316.x · Cited by 142 · see citing works
Self-citationGuillemin, G. J., Wang, L. H.-C., & Brew, B. J. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-16 · Cited by 135 · see citing works
Raison, C. L., Broadwell, S. D., Borisov, A. S., Manatunga, A. K., Capuron, L., Woolwine, B. J., Jacobson, I. M., Nemeroff, C. B., & Miller, A. H. (2004) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2004.05.001 · Cited by 130 · see citing works
Self-citationWang, X. S., Fairclough, D. L., Liao, Z. X., Komaki, R. R., Chang, J. Y., Mobley, G. M., & Cleeland, C. S. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.07.1126 · Cited by 123 · see citing works
Wilkie, M. J. V., Smith, G. C., Day, R. K., Matthews, K., Smıth, D. J., Blackwood, D., Reid, I., & Wolf, C. R. (2008) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500491 · Cited by 117 · see citing works
Loftis, J. M., Huckans, M. S., Ruimy, S., Hinrichs, D. J., & Hauser, P. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.11.001 · Cited by 117 · see citing works
Kamata, M. (2000) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(99)00067-x · Cited by 105 · see citing works
Ho, S. B., Nguyen, H. A., Tetrick, L. L., Opitz, G., Basara, M. L., & Dieperink, E. W. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03468.x · Cited by 103 · see citing works
Symptom Prevalence and Clustering of Symptoms in People Living with Chronic Hepatitis C Infection
Lang, C. A., Conrad, S., Garrett, L., Battistutta, D., Cooksley, W. G. E., Dunne, M. P., & Macdonald, G. A. (2006) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2005.08.016 · Cited by 99 · see citing works
Ambermoon, P., Carter, A., Hall, W., Dissanayaka, N. N., & O’Sullivan, J. D. (2010) · Addiction · doi:10.1111/j.1360-0443.2010.03218.x · Cited by 99 · see citing works
Cancer Symptom Clusters: Old Concept But New Data
Kirkova, J., Walsh, D., Aktaş, A., & Davis, M. P. (2010) · American Journal of Hospice and Palliative Medicine® · doi:10.1177/1049909110364048 · Cited by 98 · see citing works
Morasco, B. J., Rifai, M. A., Loftis, J. M., Indest, D. W., Moles, J. K., & Hauser, P. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.01.007 · Cited by 96 · see citing works
Cancer symptom clusters—a dynamic construct
Kirkova, J., & Walsh, D. (2007) · Supportive Care in Cancer · doi:10.1007/s00520-007-0259-2 · Cited by 90 · see citing works
Hosoda, S., Takimura, H., Shibayama, M., Kanamura, H., Ikeda, K., & Kumada, H. (2000) · Psychiatry and Clinical Neurosciences · doi:10.1046/j.1440-1819.2000.00754.x · Cited by 85 · see citing works
Early increase in vegetative symptoms predicts IFN-α-induced cognitive-depressive changes
Wichers, M., Koek, G. H., Robaeys, G., Praamstra, A. J., & Maes, M. H. J. (2004) · Psychological Medicine · doi:10.1017/s0033291704003526 · Cited by 84 · see citing works
Yates, W. R., & Gleason, O. C. (1998) · Depression and Anxiety · doi:10.1002/(sici)1520-6394(1998)7:4 · Cited by 81 · see citing works
Aerosolized interferon-alpha treatment in patients with multi-drug-resistant pulmonary tuberculosis.
Giosuè, S., Casarini, M., Ameglio, F., ZANGRILLI, P., Palla, M., Altieri, A. M., & Bisetti, A. (2000) · PubMed · Cited by 74 · see citing works
Kraus, M. R., Schäfer, A., Csef, H., Faller, H., Mörk, H., & Scheurlen, M. (2001) · Digestive Diseases and Sciences · doi:10.1023/a:1011973823032 · Cited by 73 · see citing works
Vargas, H. E., Laskus, T., Radkowski, M., Wilkinson, J., Balan, V., Douglas, D. D., Harrison, M. E., Mulligan, D. C., Olden, K. W., Adair, D. M., et al. (2002) · Liver Transplantation · doi:10.1053/jlts.2002.36393 · Cited by 66 · see citing works
Neurotransmitter Changes by Interferon-Alpha and Therapeutic Implications
Schaefer, M., Schwaiger, M., Pich, M. G. L., Lieb, K., & Heinz, A. (2003) · Pharmacopsychiatry · doi:10.1055/s-2003-45131 · Cited by 61 · see citing works
Maggi, F., Giorgi, M., Fornai, C., Morrica, A., Vatteroni, M. L., Pistello, M., Siciliano, G., Nuccorini, A., & Bendinelli, M. (1999) · Journal of NeuroVirology · doi:10.3109/13550289909015819 · Cited by 61 · see citing works
Khan, A., Brodhead, A. E., & Kolts, R. L. (2004) · International Clinical Psychopharmacology · doi:10.1097/00004850-200405000-00006 · Cited by 58 · see citing works
Morasco, B. J., Loftis, J. M., Indest, D. W., Ruimy, S., Davison, J. W., Felker, B. L., & Hauser, P. (2010) · Psychosomatics · doi:10.1176/appi.psy.51.5.401 · Cited by 53 · see citing works
Emotional indicators on human figure drawings of shy and aggressive children
Koppitz, E. M. (1966) · Journal of Clinical Psychology · doi:10.1002/1097-4679(196610)22:4 · Cited by 48 · see citing works
Weight loss during pegylated interferon and ribavirin treatment of chronic hepatitis C*
Seyam, M., Freshwater, D. A., O'Donnell, K., & Mutimer, D. (2005) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2005.00637.x · Cited by 48 · see citing works
Interferon-gamma (+874) T/A genotypes and risk of IFN-alpha-induced depression
Oxenkrug, G. F., Perianayagam, M. C., Mikolich, D., REQUINTINA, P. J., Shick, L., Ruthazer, R., Zucker, D. R., & D, P. S. M. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0525-1 · Cited by 47 · see citing works
Clinicopathologic correlates of hepatitis C virus in brain: A pilot study
Murray, J., Fishman, S. L., Ryan, E., Eng, F. J., Walewski, J. L., Branch, A. D., & Morgello, S. (2008) · Journal of NeuroVirology · doi:10.1080/13550280701708427 · Cited by 46 · see citing works
Horikawa, N., Yamazaki, T., Sagawa, M., & Nagata, T. (1999) · General Hospital Psychiatry · doi:10.1016/s0163-8343(99)00026-2 · Cited by 43 · see citing works
Effect of interferon-α on tyrosine hydroxylase and catecholamine levels in the brain of rats
Kumai, T., Tateishi, T., Tanaka, M., WATANABÉ, M., Shimizu, H., & Kobayashi, S. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00660-3 · Cited by 40 · see citing works
Vécsei, L., & Beal, M. F. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90043-h · Cited by 38 · see citing works
Yoshida, K., Alagbe, O., Wang, X., Woolwine, B. J., Thornbury, M., Raison, C. L., & Miller, A. H. (2005) · Neuropsychobiology · doi:10.1159/000086605 · Cited by 37 · see citing works
Self-citationLotrich, F. E., Loftis, J. M., Ferrell, R. E., Rabinovitz, M., & Hauser, P. (2010) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2010.0074 · Cited by 35 · see citing works
Bagaglio, S., Cinque, P. M., Racca, S., Pedale, R., Grasso, M. A., Lazzarin, A., & Morsica, G. (2005) · AIDS · doi:10.1097/01.aids.0000192085.87302.39 · Cited by 30 · see citing works
Sunami, M., Nishikawa, T., Yorogi, A., & Shimoda, M. (2000) · Clinical Neuropharmacology · doi:10.1097/00002826-200001000-00012 · Cited by 29 · see citing works
Auyeung, S. F., Long, Q., Royster, E. B., Murthy, S., McNutt, M. D., Lawson, D. H., Miller, A. H., Manatunga, A. K., & Musselman, D. L. (2009) · Clinical Trials · doi:10.1177/1740774509344633 · Cited by 27 · see citing works
Self-citationYoon, J. C., Crane, P. K., Ciechanowski, P. S., Harrington, R. D., Kitahata, M. M., & Crane, H. M. (2011) · AIDS Care · doi:10.1080/09540121.2011.555739 · Cited by 20 · see citing works
Williams, G. W., Barton, G. M., White, A. A., & Won, H. (1976) · The British Journal of Psychiatry · doi:10.1192/bjp.129.2.178 · Cited by 15 · see citing works
Phillips, A. N., McLean, A. R., Johnson, M. A., Tyrer, M., Emery, V. C., Griffiths, P. D., Bofill, M., Janossy, G., & Loveday, C. (1997) · Journal of Medical Virology · doi:10.1002/(sici)1096-9071(199711)53:3 · Cited by 14 · see citing works
Horikawa, N., Yamazaki, T., Sagawa, M., & Nagata, T. (1999) · General Hospital Psychiatry · doi:10.1016/s0163-8343(98)00082-6 · Cited by 14 · see citing works
Multivariate symptom analysis related to response to lorazepam treatment
Haward, L. R. C. (1979) · Current Medical Research and Opinion · doi:10.1185/03007997909109393 · Cited by 1 · see citing works
Wills, W., Trieman, N., & Leff, J. (1998) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(199804)13:4
Flagged first, then by citations
Research works printed but not linked: 1
- American Psychiatric Association 1994Diagnostic and Statistical Manual of Mental Disorders: DSM-IV4th ednAmerican Psychiatric Association: Washington, DC [Google Scholar]
Cited by
Sorted by citations
Psychobiotics: A novel class of psychotropic
Dinan, T. G., Stanton, C., & Cryan, J. F. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.001 · Cited by 1,287 · see citing works
Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications
Felger, J. C., & Lotrich, F. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.060 · Cited by 1,180 · see citing works
Psychobiotics and the manipulation of bacteria–gut–brain signals
Sarkar, A., Lehto, S. M., Harty, S., Dinan, T. G., Cryan, J. F., & Burnet, P. W. J. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.09.002 · Cited by 1,068 · see citing works
The gut-brain axis: the missing link in depression
Evrensel, A., & Ceylan, M. E. (2015) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2015.13.3.239 · Cited by 338 · see citing works
Biomarkers and clinical staging in psychiatry
McGorry, P. D., Keshavan, M. S., Goldstone, S. D., Amminger, G. P., Allott, K., Berk, M., Lavoie, S., Pantelis, C., Yung, A. R., Wood, S. J., et al. (2014) · World Psychiatry · doi:10.1002/wps.20144 · Cited by 305 · see citing works
Gut microbial metabolites in depression: understanding the biochemical mechanisms
Caspani, G., Kennedy, S. H., Foster, J. A., & Swann, J. R. (2019) · Microbial Cell · doi:10.15698/mic2019.10.693 · Cited by 285 · see citing works
Ohgi, Y., Futamura, T., Kikuchi, T., & Hashimoto, K. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.12.003 · Cited by 208 · see citing works
Su, K.-P., Lai, H.-C., Yang, H.-T., Su, W.-P., Peng, C.-Y., Chang, J. P.-C., Chang, H.-C., & Pariante, C. M. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.01.008 · Cited by 205 · see citing works
Role of neuro-immunological factors in the pathophysiology of mood disorders
Bhattacharya, A., Derecki, N. C., Lovenberg, T. W., & Drevets, W. C. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4214-0 · Cited by 149 · see citing works
Jaremka, L. M., Lindgren, M. E., & Kiecolt‐Glaser, J. K. (2013) · Depression and Anxiety · doi:10.1002/da.22078 · Cited by 137 · see citing works
Zheng, L., Kaneko, N., & Sawamoto, K. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00005 · Cited by 126 · see citing works
Hoyo-Becerra, C., Schlaak, J., & Hermann, D. M. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.200 · Cited by 117 · see citing works
Finding the needle in the haystack: systematic identification of psychobiotics
Bambury, A., Sandhu, K., Cryan, J. F., & Dinan, T. G. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14127 · Cited by 107 · see citing works
Clark, S. M., Pocivavsek, A., Nicholson, J. D., Notarangelo, F. M., LANGENBERG, P. W., McMahon, R. P., Kleinman, J. E., Hyde, T. M., Stiller, J. W., Postolache, T. T., et al. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.150226 · Cited by 92 · see citing works
Jha, M. K., & Trivedi, M. H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010233 · Cited by 86 · see citing works
Lombardi, V. C., Meirleir, K. L. D., Subramanian, K., Nourani, S. M., Dagda, R. K., Delaney, S. L., & Palotás, A. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.04.004 · Cited by 85 · see citing works
Role of Brain-Gut-Microbiota Axis in Depression: Emerging Therapeutic Avenues
Bhatt, S., Kanoujia, J., Lakshmi, S. M., Patil, C., Gupta, G., Chellappan, D. K., & Dua, K. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220329140804 · Cited by 81 · see citing works
Hepatitis C virus and neurological damage
Mathew, S., Faheem, M., Ibrahim, S. M., Iqbal, W., Rauff, B., Fatima, K., & Qadri, I. (2016) · World Journal of Hepatology · doi:10.4254/wjh.v8.i12.545 · Cited by 77 · see citing works
Bhattacharya, A., & Drevets, W. C. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_43 · Cited by 76 · see citing works
Tripathi, A., Whitehead, C., Surrao, K., Pillai, A., Madeshiya, A. K., Li, Y., Khodadadi, H., Ahmed, A. O., Turecki, G., Baban, B., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01065-6 · Cited by 58 · see citing works
Modabbernia, A., Poustchi, H., & Malekzadeh, R. (2013) · Hepatitis Monthly · doi:10.5812/hepatmon.8340 · Cited by 57 · see citing works
Murri, M. B., Folesani, F., Zerbinati, L., Nanni, M. G., Ounalli, H., Caruso, R., & Grassi, L. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17155545 · Cited by 47 · see citing works
Hayley, S., Scharf, J., & Anisman, H. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.07.023 · Cited by 48 · see citing works
van Heesch, F., Prins, J., Konsman, J. P., Westphal, K. G. C., Olivier, B., Kraneveld, A. D., & Korte, S. M. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.12.013 · Cited by 46 · see citing works
Dahiya, D., & Nigam, P. S. (2022) · Microorganisms · doi:10.3390/microorganisms10091687 · Cited by 40 · see citing works
Adiponectin Role in Neurodegenerative Diseases: Focus on Nutrition Review
Polito, R., Meo, I. D., Barbieri, M., Daniele, A., Paolisso, G., & Rizzo, M. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239255 · Cited by 38 · see citing works
Cattie, J. E., Letendre, S. L., Woods, S. P., Barakat, F., Perry, W., Cherner, M., Umlauf, A., Franklin, D., Heaton, R. K., Hassanein, T., et al. (2014) · Journal of NeuroVirology · doi:10.1007/s13365-014-0265-3 · Cited by 36 · see citing works
Kruse, J. L., Boyle, C. C., Olmstead, R., Breen, E. C., Tye, S. J., Eisenberger, N. I., & Irwin, M. R. (2022) · Scientific Reports · doi:10.1038/s41598-022-16364-3 · Cited by 22 · see citing works
Mohiuddin, M., Asghar, T., Hameed, H., Din, A. M., Siddique, A., Younas, S., Din, M. M. U., & Ara, R. (2025) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-025-04632-z · Cited by 13 · see citing works
Whale, R., Fialho, R., Rolt, M., Eccles, J., Pereira, M., Keller, M., File, A., Haq, I., & Tibble, J. A. (2015) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2015.06.003 · Cited by 12 · see citing works
Zhang, L., Chen, K., Li, S., Liu, S. K., & Wang, Z. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47121061 · Cited by 11 · see citing works
Self-citationDrug-symptom networking: Linking drug-likeness screening to drug discovery
Xu, X. J., Zhang, C., Li, P., Zhang, F., Gao, K., Chen, M., & Shang, H. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.11.015 · Cited by 11 · see citing works
Sakamaki, A., Kamimura, K., Fukui, N., Watanabe, H., Sakai, N., Tominaga, K., Mizuno, K., Takamura, M., Kawai, H., Sugai, T., et al. (2019) · BMC Gastroenterology · doi:10.1186/s12876-019-1013-1 · Cited by 11 · see citing works
Gut-Microbiota-Brain Axis and Depression
Evrensel, A., & Ceylan, M. E. (2017) · Springer eBooks · doi:10.1007/978-981-10-6580-4_17 · Cited by 10 · see citing works
Musselman, D. L., Shenvi, N. V., Manatunga, A. K., Miller, A. H., Lin, E., & Gletsu-Miller, N. A. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.02.013 · Cited by 10 · see citing works
Self-citationLee, E., Kim, J. S., Chang, D.-I., Park, J. H., Ahn, S. H., Cha, J.-K., Heo, J. H., Sohn, S.-I., Lee, B.-C., Kim, H. Y., et al. (2020) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988720957108 · Cited by 7 · see citing works
Coch, C., Viviani, R., Breitfeld, J., Münzer, K., Daßler‐Plenker, J., Holdenrieder, S., Coenen, M., Steffens, M., Müller, M., Hartmann, G., et al. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.102020 · Cited by 7 · see citing works
The Role of Immune System in Depression Disorder
Hoseinzadeh, F., Abadi, P. H., Agheltar, M., Aghayinejad, A., Torabian, F., Rezayat, A. A., Akbarzadeh, F., & Rahimi, H. R. (2016) · Health · doi:10.4236/health.2016.815167 · Cited by 6 · see citing works
Inflammatory cytokines and depression in children with cancer: A review of the literature
Narendran, G., Tomfohr‐Madsen, L. M., & Schulte, F. (2018) · Pediatric Hematology and Oncology · doi:10.1080/08880018.2018.1440335 · Cited by 4 · see citing works
Chang, S., Hung, C., Li, S.-F., Lee, H.-M., Chung, Y., Pai, L., & Yang, S. (2013) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2013.08.011 · Cited by 3 · see citing works
Drugs that Act on the Immune System
Baldo, B. A. (2014) · Side effects of drugs annual · doi:10.1016/b978-0-444-63407-8.00037-x · Cited by 3 · see citing works
Fecal Microbiota Transplantation in the Treatment-Resistant Psychiatric Disorders
Evrensel, A., & Ceylan, M. E. (2018) · Springer eBooks · doi:10.1007/978-981-10-4358-1_24 · Cited by 3 · see citing works
Evrensel, A., & Ceylan, M. E. (2015) · Cited by 2 · see citing works
Psychobiotics as an Emerging Category of Probiotic Products
Choudhary, S., Shanu, K., & Devi, S. (2023) · Springer eBooks · doi:10.1007/978-981-99-1463-0_19 · Cited by 2 · see citing works
Innate Immune Signaling and Alcoholism
Vetreno, R. P., & Crews, F. T. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4729-0_8 · Cited by 2 · see citing works
Tungland, B. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814649-1.00012-0 · Cited by 1 · see citing works
Psychobiotics: A Newer Approach Toward the Treatment of Neurodevelopmental Disorders
Chakraborty, T., Begum, J., Mandal, D., & Sengupta, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822909-5.00013-7 · Cited by 1 · see citing works
Inflammation-induced depression : Studying the role of proinflammatory cytokines in anhedonia
van Heesch, F. (2014) · Utrecht University Repository (Utrecht University) · Cited by 2 · see citing works
BOLAND, R. J., Gaud, K. G., & Keller, M. B. (2015) · Wiley eBooks · doi:10.1002/9781118753378.ch103 · Cited by 1 · see citing works
Mynbaev, O. A., Eliseeva, M. Y., Chernov, A. L., Kosmas, I. P., Tinelli, A., Radzinsky, V., & Tsarev, V. (2013) · Open Journal of Obstetrics and Gynecology · doi:10.4236/ojog.2013.32048
大木, 雄., オオギ, ユ., & Yuta, O. (2013) · Institutional Repositories DataBase (IRDB)
Giesbrecht, C. J. (2017) · Summit (Simon Fraser University)
Zito, S., Mercurio, S., Mercurio, G., Pigoni, A., Mandolini, G. M., & Caletti, E. (2019) · Minerva Psichiatrica · doi:10.23736/s0391-1772.19.02012-0
Khan, M. A., Wani, M. A., Agarwal, N. B., & Yasmeen (2022) · Current Drug Therapy · doi:10.2174/1574885517666220617124629
Depression and Anxiety in Stroke
Kim, J. S. (2024) · Springer eBooks · doi:10.1007/978-981-97-1821-4_1
Saillart, E., Jacobs, K., Claes, S. J., & Vergaelen, E. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101334
- Authors
- McNutt, M. D., Liu, S., Manatunga, A., Royster, E. B., Raison, C. L., Woolwine, B. J., Demetrashvili, M. F., Miller, A. H., & Musselman, D. L.
- Affiliations
- University of Miami (US)
- Emory University (US)
- Moffitt Cancer Center (US)
- Corresponding author
- Musselman, Dominique L
- Venue
- Neuropsychopharmacology
- Published
- 2012-02-22
- Volume
- 37
- Issue
- 6
- Pages
- 1444-1454
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3327849
- OpenAlex
- W2024101775
- Cited by
- 56
- References
- 84
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 6 · 2013: 7 · 2012: 4
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- GlaxoSmithKline
- National Institutes of Health (UL1TR000454, RR 00039)
- National Institute of Mental Health (R01MH071580, MH-00680, M01 RR00039, K23MH064619, MH 60723, MH 64619, R01MH060723, MH071580, MH060723)
- National Center for Research Resources (M01-RR00039, UL1RR025008, M01RR000039)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- interferon-alpha, hepatitis C, paroxetine, ribavirin, depression, anxiety, cognitive impairment, neurovegetative symptoms, antidepressant prophylaxis, treatment response, neuropsychiatric adverse effects
- MeSH terms
- Adult, Aged, Antiviral Agents, Double-Blind Method, Female, Follow-Up Studies, Hepatitis C, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Retrospective Studies, Ribavirin, Time Factors, Treatment Outcome, Interferon-alpha, Paroxetine, Antidepressive Agents, Second-Generation, Mood Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
