Fatigue and depression in disease-free breast cancer survivors: prevalence, correlates, and association with quality of life
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We performed this study to examine the prevalence and correlates of fatigue and depression, and their relevance to health-related quality of life in disease-free breast cancer survivors. A total of 1,933 breast cancer survivors recruited from five large hospitals in Korea completed a mailed survey, which included the Brief Fatigue Inventory, Beck Depression Inventory, European Organization for Research and Treatment of Cancer QLQ-C30, and QLQ-BR23. With a framework that included sociodemographic, clinical, and symptom characteristics, multivariate logistic regression models were used to identify factors associated with fatigue and depression. Among breast cancer survivors, 66.1% reported moderate to severe fatigue and 24.9% reported moderate to severe depression. Risk factors common to both fatigue and depression were lower income, dyspnea, insomnia, appetite loss, constipation, and arm symptoms. Risk factors for fatigue only included younger age, employment, presence of gastrointestinal disease, and pain. Having a musculoskeletal disease was identified as a risk factor for depression only. Both fatigue and depression were influenced by sociodemographic factors, comorbidity and symptom characteristics rather than cancer or treatment-related factors. Both fatigue and depression were negatively associated with survivors' health-related quality of life. However, the patterns of differences in health-related quality of life according to severity of fatigue or depression were similar. This concurrent examination of risk factors for fatigue and depression may be helpful in the development of clinical management strategies in disease-free breast cancer survivors.
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Fatigue in breast cancer survivors is associated with pre-treatment fatigue, pain, dyspnea, depression, physical inactivity, high body mass index, significant disability, health care utilization, and poor HRQoL.
“Other studies have found an association between fatigue and pre-treatment fatigue (Bower, 2014), pain (Kim et al., 2008), dyspnea, depression, physical inactivity and high body mass index (Bower, 2014), significant disability and health care utilization (Goldstein et al., 2012) and poor HRQoL (Kim et al., 2008).”
From A guided internet-delivered individually-tailored ACT-influenced cognitive behavioural intervention to improve psychosocial outcomes in breast cancer survivors (iNNOVBC): Study protocol (2019) · cites this paper as Kim et al., 2008
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“Subjects were split into 3 groups (low [9–17], intermediate [18–30], and high [31–63]) according to FSS score distribution (9–63 points).”
Method
- Authors
- Kim, S. H., Son, B. H., Hwang, S. Y., Han, W., Yang, J.-H., Lee, S., & Yun, Y. H.
- Affiliations
- National Cancer Center (KR)
- Asan Medical Center (KR)
- Duksung Women's University (KR)
- Seoul National University Hospital (KR)
- Samsung Medical Center (KR)
- Corresponding author
- Yun, Young Ho
- Venue
- Journal of Pain and Symptom Management
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 35
- Issue
- 6
- Pages
- 644-655
- ISSN
- 0885-3924 (ISSN-L)
- OpenAlex
- W2023815654
- Cited by
- 292
- References
- 59
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 17 · 2023: 12 · 2022: 15 · 2021: 13 · 2020: 10 · 2019: 16 · 2018: 16 · 2017: 27 · 2016: 26 · 2015: 17 · 2014: 20 · 2013: 13 · 2012: 23
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Pain and Symptom Management (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- breast cancer survivors, cancer-related fatigue, depression, health-related quality of life, risk factors, comorbidities, musculoskeletal disorders, dyspnea, insomnia, socioeconomic factors, Korean women
- MeSH terms
- Adult, Breast Neoplasms, Data Collection, Depression, Fatigue, Female, Humans, Middle Aged, Psychiatric Status Rating Scales, Quality of Life, Survivors
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