Differential effects of paroxetine on fatigue and depression: a randomized, double-blind trial from the University of Rochester Cancer center Community Clinical Oncology Program
Abstract
Purpose: Fatigue and depression typically occur together in cancer patients, suggesting a common etiology, perhaps based on serotonin. This randomized clinical trial tested whether paroxetine, a selective serotonin reuptake inhibitor antidepressant known to modulate brain serotonin, would reduce fatigue in cancer patients and whether any reduction was related to depression. Patients and Methods: Cancer patients undergoing chemotherapy for the first time were assessed for fatigue. Of 704 patients who reported fatigue at their second chemotherapy cycle, 549 patients were randomly assigned to receive either 20 mg of oral paroxetine hydrochloride daily or placebo for 8 weeks. The assessments of fatigue and depression were performed at cycles 3 and 4 of chemotherapy. Results: A total of 244 patients treated with paroxetine and 235 patients treated with placebo provided assessable data. No difference was detected in fatigue between patient groups. At the end of the study, there was a difference between groups in the mean level of depression (Center for Epidemiologic Studies Depression scores, 12.0 v 14.8, respectively; P < .01). Conclusion: Paroxetine had no influence on fatigue in patients receiving chemotherapy. A possible explanation is that cancer-related fatigue does not involve a reduction in brain 5-HT levels.
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Among chemotherapy patients with cancer, paroxetine lowered depressed mood but did not reduce fatigue.
“Similar findings have been observed in cancer patients, where paroxetine led to reductions in depressed mood but not fatigue in patients undergoing chemotherapy (Morrow et al., 2003).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Morrow et al., 2003
Cites
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267 · see citing works
Measurement of depressive symptoms in cancer patients
Hann, D., Winter, K., & Jacobsen, P. (1999) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(99)00004-5 · Cited by 822 · see citing works
Cognitive behaviour therapy for chronic fatigue syndrome: a multicentre randomised controlled trial
Prins, J. B., Bleijenberg, G., Bazelmans, E., Elving, L. D., de Boo, T. M., Severens, J. L., van der Wilt, G. J., Spinhoven, P., & van der Meer, J. W. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04198-2 · Cited by 531 · see citing works
Stone, P., Richardson, A., Ream, E., Smith, A. G., Kerr, D. J., & Kearney, N. (2000) · Annals of Oncology · doi:10.1023/a:1008318932641 · Cited by 438 · see citing works
Correlates of Fatigue in Older Adults with Rheumatoid Arthritis
Belza, B. L., Henke, C. J., Yelin, E. H., Epstein, W. V., & Gilliss, C. L. (1993) · Nursing Research · doi:10.1097/00006199-199303000-00006 · Cited by 434 · see citing works
Chronic Fatigue and its Syndromes
Wessely, P. S., Hotopf, D. M., & Sharpe, D. M. (1998) · doi:10.1093/oso/9780192621818.001.0001 · Cited by 407 · see citing works
Psychosocial problems among survivors of Hodgkin's disease.
Fobair, P., Hoppe, R. T., Bloom, J. R., Cox, R. S., Varghese, A., & Spiegel, D. (1986) · Journal of Clinical Oncology · doi:10.1200/jco.1986.4.5.805 · Cited by 363 · see citing works
Comparison of self-reported fatigue in rheumatoid arthritis and controls.
Bl, B. (1995) · PubMed · Cited by 357 · see citing works
Fatigue in Women Receiving Adjuvant Chemotherapy for Breast Cancer
Jacobsen, P. B., Hann, D. M., Azzarello, L. M., Horton, J., Balducci, L., & Lyman, G. H. (1999) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(99)00082-2 · Cited by 355 · see citing works
Fatigue in patients with cancer
Stone, P. C., Richards, M., & Hardy, J. R. (1998) · European Journal of Cancer · doi:10.1016/s0959-8049(98)00167-1 · Cited by 268 · see citing works
Detecting depression in chronic pain patients: Adequacy of self-reports
Turk, D. C., & Okifuji, A. (1994) · Behaviour Research and Therapy · doi:10.1016/0005-7967(94)90078-7 · Cited by 256 · see citing works
Correlates of fatigue in people with breast or lung cancer.
Blesch, K. S., Paice, J. A., Wickham, R., Harte, N., Schnoor, D. K., Purl, S., Rehwalt, M., Kopp, P., Manson, S., & Coveny, S. B. (1991) · PubMed · Cited by 248 · see citing works
Fatigue associated with cancer and its treatment
Morrow, G. R., Andrews, P. L. R., Hickok, J. T., Roscoe, J. A., & Matteson, S. E. (2001) · Supportive Care in Cancer · doi:10.1007/s005200100293 · Cited by 241 · see citing works
Self-citationBREITBART, W. S., Rosenfeld, B. D., Kaim, M., & Funesti-Esch, J. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.3.411 · Cited by 200 · see citing works
Three Characteristic Patterns of Subjective Fatigue Symptoms
YOSHITAKE, H. (1978) · Ergonomics · doi:10.1080/00140137808931718 · Cited by 189 · see citing works
Miller, R. G., Giannini, D., Milner‐Brown, H. S., Layzer, R. B., Koretsky, A. P., Hooper, D., & Weiner, M. W. (1987) · Muscle & Nerve · doi:10.1002/mus.880100906 · Cited by 181 · see citing works
Quality of life after adjuvant chemotherapy for breast cancer
Broeckel, J. A., Jacobsen, P. B., Balducci, L., Horton, J., & Lyman, G. H. (2000) · Breast Cancer Research and Treatment · doi:10.1023/a:1006401914682 · Cited by 170 · see citing works
Psychological problems associated with diagnosis and treatment of lymphomas. I: Retrospective study.
Devlen, J., Maguire, P., Phillips, P. H., Crowther, D., & Chambers, H. (1987) · BMJ · doi:10.1136/bmj.295.6604.953 · Cited by 78 · see citing works
A comparison of paroxetine and placebo in depressed outpatients
Dunbar, G., Claghorn, J., Kiev, A., Rickels, K., & Smith, W. (1993) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1993.tb03376.x · Cited by 50 · see citing works
Neurobiological aspects of the chronic fatigue syndrome
Bearn, J., & Wessely, S. C. (1994) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1994.tb00971.x · Cited by 49 · see citing works
Paroxetine: A Selective Serotonin Reuptake Inhibiting Antidepressant
Caley, C. F., & Weber, S. S. (1993) · Annals of Pharmacotherapy · doi:10.1177/106002809302701012 · Cited by 46 · see citing works
Fatigue in Women Receiving Chemotherapy for Ovarian Cancer
Jamar, S. C. (1989) · doi:10.1007/978-1-349-13397-0_28 · Cited by 39 · see citing works
Steroid hormones and human breast cancer.An hypothesis
Adams, J. B. (1977) · Cancer · doi:10.1002/1097-0142(197707)40:1 · Cited by 34 · see citing works
Therapeutic self-care demands expressed by outpatients receiving external radiation therapy
KUBRICHT, D. W. (1984) · Cancer Nursing · doi:10.1097/00002820-198402000-00004 · Cited by 32 · see citing works
Selecting a tool for measuring fatigue.
Cg, V. (1985) · PubMed · Cited by 30 · see citing works
Flagged first, then by citations
1 of the 26 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009 · see citing works
Breast Cancer, Version 4.2017, NCCN Clinical Practice Guidelines in Oncology
Gradishar, W. J., Anderson, B. O., Balassanian, R., Blair, S. L., Burstein, H. J., Cyr, A. E., ELIAS, A. D., Farrar, W. B., Forero, A., Giordano, S. H., et al. (2018) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2018.0012 · Cited by 1,607 · see citing works
Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications
Felger, J. C., & Lotrich, F. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.060 · Cited by 1,180 · see citing works
Cancer-Related Fatigue, Version 2.2015
Berger, A. M., Mooney, K. H., Alvarez-Perez, A., BREITBART, W. S., Carpenter, K. M., Cella, D. F., Cleeland, C. S., Dotan, E., Eisenberger, M. A., Escalante, C. P., et al. (2015) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2015.0122 · Cited by 961 · see citing works
Stasi, R., Abriani, L., Beccaglia, P., Terzoli, E., & Amadori, S. (2003) · Cancer · doi:10.1002/cncr.11742 · Cited by 710 · see citing works
Anxiety disorders and comorbid medical illness
Roy-Byrne, P. P., Davidson, K. W., Kessler, R. C., Asmundson, G. J. G., Goodwin, R. D., Kubzansky, L., Lydiard, R. B., Massie, M. J., Katon, W., Laden, S. K., et al. (2008) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2007.12.006 · Cited by 668 · see citing works
Colloca, L., & BARSKY, A. J. (2020) · New England Journal of Medicine · doi:10.1056/nejmra1907805 · Cited by 695 · see citing works
Cytokines and their relationship to the symptoms and outcome of cancer
Seruga, B., Zhang, H., Bernstein, L. J., & Tannock, I. F. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2507 · Cited by 652 · see citing works
Neuroendocrine-Immune Mechanisms of Behavioral Comorbidities in Patients With Cancer
Miller, A. H., Ancoli‐Israel, S., Bower, J. E., Capuron, L., & Irwin, M. R. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.10.7805 · Cited by 609 · see citing works
Mechanisms of Cancer-Related Fatigue
Ryan, J. L., Carroll, J. K., Ryan, E. P., Mustian, K. M., Fiscella, K. A., & Morrow, G. R. (2007) · The Oncologist · doi:10.1634/theoncologist.12-s1-22 · Cited by 588 · see citing works
Self-citationMajor depression after breast cancer: a review of epidemiology and treatment
Fann, J. R., Thomas-Rich, A. M., Katon, W. J., Cowley, D., Pepping, M., McGregor, B. A., & Gralow, J. (2008) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2007.10.008 · Cited by 586 · see citing works
Cancer-related fatigue: ESMO Clinical Practice Guidelines for diagnosis and treatment
Fabi, A., Bhargava, R., Fatigoni, S., Guglielmo, M., Horneber, M., Roila, F., Weis, J., Jordan, K., & Ripamonti, C. I. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2020.02.016 · Cited by 583 · see citing works
Cytokines and psychopathology: Lessons from interferon-α
Capuron, L., & Miller, A. H. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.009 · Cited by 562 · see citing works
Palesh, O. G., Roscoe, J. A., Mustian, K. M., Roth, T., Savard, J., Ancoli-Israel, S., Heckler, C., Purnell, J. Q., Janelsins, M. C., & Morrow, G. R. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.5011 · Cited by 557 · see citing works
Self-citationBehavioral Symptoms in Patients With Breast Cancer and Survivors
Bower, J. E. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.14.3248 · Cited by 488 · see citing works
Bower, J., Ganz, P., Irwin, M. R., Kwan, L., Breen, E., & Cole, S. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.36.1154 · Cited by 497 · see citing works
Symptom Burden: Multiple Symptoms and Their Impact as Patient-Reported Outcomes
Cleeland, C. S. (2007) · JNCI Monographs · doi:10.1093/jncimonographs/lgm005 · Cited by 455 · see citing works
Inflammation Effects on Motivation and Motor Activity: Role of Dopamine
Felger, J. C., & Treadway, M. T. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.143 · Cited by 453 · see citing works
Imaging the Role of Inflammation in Mood and Anxiety-related Disorders
Felger, J. C. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666171123201142 · Cited by 432 · see citing works
Felger, J. C., & Miller, A. H. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.09.003 · Cited by 394 · see citing works
Psychiatric disorders in advanced cancer
Miovic, M., & Block, S. (2007) · Cancer · doi:10.1002/cncr.22980 · Cited by 376 · see citing works
Bower, J. E., & Lamkin, D. M. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.06.011 · Cited by 373 · see citing works
Fatigue and cancer: causes, prevalence and treatment approaches
Wagner, L. I., & Cella, D. F. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6602012 · Cited by 365 · see citing works
Cancer-related fatigue and associated disability in post-treatment cancer survivors
Jones, J. M., Olson, K. L., Catton, P. A., Catton, C., Fleshner, N. E., Krzyzanowska, M. K., McCready, D. R., Wong, R. K. S., Jiang, H., & Howell, D. (2015) · Journal of Cancer Survivorship · doi:10.1007/s11764-015-0450-2 · Cited by 339 · see citing works
A systematic review of the scales used for the measurement of cancer-related fatigue (CRF)
Minton, O., & Stone, P. C. (2008) · Annals of Oncology · doi:10.1093/annonc/mdn537 · Cited by 323 · see citing works
Barton, D. L., Liu, H., Dakhil, S. R., Linquist, B. M., Sloan, J. A., Nichols, C. R., McGinn, T. W., Stella, P. J., Seeger, G. R., Sood, A., et al. (2013) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt181 · Cited by 299 · see citing works
Berger, A. M., Abernethy, A. P., Atkinson, A., Barsevick, A. M., BREITBART, W. S., Cella, D. F., Cimprich, B., Cleeland, C. S., Eisenberger, M. A., Escalante, C. P., et al. (2010) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2010.0067 · Cited by 295 · see citing works
Kim, S. H., Son, B. H., Hwang, S. Y., Han, W., Yang, J.-H., Lee, S., & Yun, Y. H. (2008) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2007.08.012 · Cited by 292 · see citing works
Bower, J. E., Lacchetti, C., Alici, Y., Barton, D. L., Bruner, D. W., Canin, B. E., Escalante, C. P., Ganz, P. A., Garland, S. N., Gupta, S., et al. (2024) · Journal of Clinical Oncology · doi:10.1200/jco.24.00541 · Cited by 314 · see citing works
Drug therapy for the management of cancer-related fatigue
Minton, O., Richardson, A., Sharpe, M., Hotopf, M. H., & Stone, P. C. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006704.pub3 · Cited by 288 · see citing works
A Systematic Review and Meta-Analysis of the Pharmacological Treatment of Cancer-Related Fatigue
Minton, O., Richardson, A., Sharpe, M., Hotopf, M. H., & Stone, P. C. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn250 · Cited by 283 · see citing works
Troublesome Symptoms in Cancer Survivors: Fatigue, Insomnia, Neuropathy, and Pain
Pachman, D. R., Barton, D. L., Swetz, K. M., & Loprinzi, C. L. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2012.41.7238 · Cited by 282 · see citing works
The Concept of Depression as a Dysfunction of the Immune System
Leonard, B. E. (2010) · Current Immunology Reviews · doi:10.2174/157339510791823835 · Cited by 296 · see citing works
Integrative Nonpharmacologic Behavioral Interventions for the Management of Cancer-Related Fatigue
Mustian, K. M., Morrow, G. R., Carroll, J. K., Figueroa-Moseley, C., Jean‐Pierre, P., & Williams, G. C. (2007) · The Oncologist · doi:10.1634/theoncologist.12-s1-52 · Cited by 255 · see citing works
Self-citationCancer-related fatigue: Links with inflammation in cancer patients and survivors
Bower, J. E. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.03.013 · Cited by 256 · see citing works
Williams, S., & Dale, J. R. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6602949 · Cited by 243 · see citing works
Evidence‐based treatment of depression in patients with cancer
Li, M., Fitzgerald, P., & Rodin, G. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.39.7372 · Cited by 236 · see citing works
Pharmacological treatments for fatigue associated with palliative care
Mücke, M., Mochamat, M., Cuhls, H., Peuckmann-Post, V., Minton, O., Stone, P., & Radbruch, L. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006788.pub3 · Cited by 227 · see citing works
Stone, P. C., & Minton, O. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2008.02.037 · Cited by 225 · see citing works
Cancer-related fatigue: a practical review
Campos, M. P., Hassan, B. J., Riechelmann, R. P., & del Giglio, A. (2011) · Annals of Oncology · doi:10.1093/annonc/mdq458 · Cited by 222 · see citing works
Bower, J. (2019) · Cancer · doi:10.1002/cncr.31790 · Cited by 190 · see citing works
Ramasubbu, R., Taylor, V. H., Samaan, Z., Sockalingham, S., Li, M., Patten, S., Rodin, G., Schaffer, A., Beaulieu, S., & McIntyre, R. S. (2012) · Annals of Clinical Psychiatry · doi:10.1177/104012371202400110 · Cited by 206 · see citing works
Management of Cancer-Related Fatigue
Morrow, G. R., Shelke, A. R., Roscoe, J. A., Hickok, J. T., & Mustian, K. M. (2005) · Cancer Investigation · doi:10.1081/cnv-200055960 · Cited by 205 · see citing works
Self-citationI’m so tired: biological and genetic mechanisms of cancer-related fatigue
Barsevick, A. M., Frost, M. H., Zwinderman, A. H., Hall, P. N., & Halyard, M. Y. (2010) · Quality of Life Research · doi:10.1007/s11136-010-9757-7 · Cited by 201 · see citing works
Roscoe, J. A., Morrow, G. R., Hickok, J. T., Mustian, K. M., Griggs, J. J., Matteson, S. E., Bushunow, P. W., Qazi, R., & Smith, B. (2005) · Breast Cancer Research and Treatment · doi:10.1007/s10549-004-2175-1 · Cited by 197 · see citing works
Self-citationAntidepressants for depression in physically ill people
Rayner, L., Price, A. C., Evans, A., Valsraj, K. M., Higginson, I. J., & Hotopf, M. H. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007503.pub2 · Cited by 194 · see citing works
Jean‐Pierre, P., Morrow, G. R., Roscoe, J. A., Heckler, C. E., Mohile, S. G., Janelsins, M. C., Peppone, L. J., Hemstad, A., Esparaz, B. T., & Hopkins, J. O. (2010) · Cancer · doi:10.1002/cncr.25083 · Cited by 192 · see citing works
Self-citationCancer‐Related Fatigue: State of the Science
Mitchell, S. A. (2010) · PM&R · doi:10.1016/j.pmrj.2010.03.024 · Cited by 189 · see citing works
Depression in cancer patients: a critical review.
Pasquini, M., & Biondi, M. (2007) · Clinical Practice and Epidemiology in Mental Health · doi:10.1186/1745-0179-3-2 · Cited by 188 · see citing works
Antidepressants for the treatment of depression in people with cancer.
Ostuzzi, G., Matcham, F., Dauchy, S., Barbui, C., & Hotopf, M. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011006.pub2 · Cited by 54 · see citing works
Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses
Morris, G., Berk, M., Walder, K. R., & Maes, M. H. J. (2015) · BMC Medicine · doi:10.1186/s12916-014-0259-2 · Cited by 179 · see citing works
Dooley, L. N., Kuhlman, K. R., Robles, T. F., Eisenberger, N. I., Craske, M. G., & Bower, J. E. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.006 · Cited by 176 · see citing works
VanderWeele, T. J., Hawkley, L. C., Thisted, R. A., & Cacioppo, J. T. (2011) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0022610 · Cited by 177 · see citing works
Felger, J. C., Li, L., Marvar, P. J., Woolwine, B. J., Harrison, D. G., Raison, C. L., & Miller, A. H. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.010 · Cited by 176 · see citing works
The pathophysiology of cancer-related fatigue: current controversies
O'Higgins, C. M., Brady, B., O’Connor, B., Walsh, D., & Reilly, R. B. (2018) · Supportive Care in Cancer · doi:10.1007/s00520-018-4318-7 · Cited by 175 · see citing works
Cancer-related and treatment-related fatigue
Wang, X. S., & Woodruff, J. F. (2014) · Gynecologic Oncology · doi:10.1016/j.ygyno.2014.10.013 · Cited by 173 · see citing works
Mustian, K. M., Katula, J. A., Gill, D. L., Roscoe, J. A., Lang, D., & Murphy, K. (2004) · Supportive Care in Cancer · doi:10.1007/s00520-004-0682-6 · Cited by 170 · see citing works
Self-citationManaging the adverse effects of radiation therapy.
Berkey, F. J. (2010) · PubMed · Cited by 166 · see citing works
Prevalence and Correlates of Fatigue in Long-Term Survivors of Childhood Leukemia
Meeske, K., Siegel, S. E., GLOBE, D. R., Mack, W. J., & Bernstein, L. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.210 · Cited by 164 · see citing works
Morris, G., Berk, M., Gałecki, P., Walder, K. R., & Maes, M. H. J. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9090-9 · Cited by 160 · see citing works
Mitchell, S. A., Beck, S. L., Hood, L. E., Moore, K., & Tanner, E. R. (2007) · Clinical journal of oncology nursing · doi:10.1188/07.cjon.99-113 · Cited by 162 · see citing works
Cancer-Related Fatigue in Cancer Survivorship
Ebede, C. C., Jang, Y., & Escalante, C. P. (2017) · Medical Clinics of North America · doi:10.1016/j.mcna.2017.06.007 · Cited by 160 · see citing works
Antidepressants for the treatment of depression in people with cancer
Ostuzzi, G., Matcham, F., Dauchy, S., Barbui, C., & Hotopf, M. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011006.pub3 · Cited by 158 · see citing works
Pathophysiology of Cancer-Related Fatigue
Wang, X. S. (2008) · Clinical journal of oncology nursing · doi:10.1188/08.cjon.s2.11-20 · Cited by 151 · see citing works
Stockler, M., O'Connell, R., Nowak, A., Goldstein, D., Turner, J., Wilcken, N., Wyld, D., Abdi, E., Glasgow, A., Beale, P., et al. (2007) · The Lancet Oncology · doi:10.1016/s1470-2045(07)70148-1 · Cited by 146 · see citing works
Nardo, P. D., Lisanti, C., Garutti, M., Buriolla, S., Alberti, M., Mazzeo, R., & Puglisi, F. (2022) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2022.2151584 · Cited by 157 · see citing works
Harbeck, N., Scharl, A. J., Thomssen, C., & Müller, V. (2013) · Breast Care · doi:10.1159/000353590 · Cited by 146 · see citing works
Cancer Symptom Clusters: Clinical and Research Methodology
Kirkova, J., Aktaş, A., Walsh, D., & Davis, M. P. (2011) · Journal of Palliative Medicine · doi:10.1089/jpm.2010.0507 · Cited by 140 · see citing works
Mitchell, S. A., Hoffman, A. J., Clark, J. C., DeGennaro, R., Poirier, P., Robinson, C. B., & Weisbrod, B. L. (2014) · Clinical journal of oncology nursing · doi:10.1188/14.cjon.s3.38-58 · Cited by 131 · see citing works
Biobehavioral Influences on Cancer Progression
Costanzo, E. S., Sood, A. K., & Lutgendorf, S. K. (2010) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2010.09.001 · Cited by 130 · see citing works
Depression as a Risk Factor for Cancer: From Pathophysiological Advances to Treatment Implications
Currier, M. B., & Nemeroff, C. B. (2014) · Annual Review of Medicine · doi:10.1146/annurev-med-061212-171507 · Cited by 126 · see citing works
Fadiga relacionada ao câncer: uma revisão
Campos, M. P. D. O., Hassan, B. J., Riechelmann, R. P., & del Giglio, A. (2011) · Revista da Associação Médica Brasileira · doi:10.1590/s0104-42302011000200021 · Cited by 125 · see citing works
Laoutidis, Z. G., & Mathiak, K. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-140 · Cited by 121 · see citing works
Advances in Supportive Care for Late Effects of Head and Neck Cancer
Murphy, B. A., & Deng, J. F. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.61.3836 · Cited by 120 · see citing works
Dimeo, F., Schwartz, S., Wesel, N., Voigt, A., & Thiel, E. (2008) · Annals of Oncology · doi:10.1093/annonc/mdn068 · Cited by 117 · see citing works
Bardwell, W. A., & Ancoli‐Israel, S. (2008) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.10.011 · Cited by 116 · see citing works
The role of dopamine in inflammation-associated depression: mechanisms and therapeutic implications
Felger, J. C. (2016) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2016_13 · Cited by 115 · see citing works
Donepezil for Cancer Fatigue: A Double-Blind, Randomized, Placebo-Controlled Trial
Bruera, E. D., Osta, B. E. E., Valero, V., Driver, L., Pei, B.-L., Shen, L. F., Poulter, V. A., & Palmer, J. L. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.10.9231 · Cited by 114 · see citing works
Dimeo, F., Schmittel, A. H., Fietz, T. J., Schwartz, S., Köhler, P., Boning, D. G., & Thiel, E. (2004) · Annals of Oncology · doi:10.1093/annonc/mdh314 · Cited by 112 · see citing works
Treatment of Depression in Cancer
Fisch, M. J. (2004) · JNCI Monographs · doi:10.1093/jncimonographs/lgh011 · Cited by 109 · see citing works
Psychiatric considerations in the oncology setting
Mehta, R. D., & Roth, A. J. L. (2015) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21285 · Cited by 103 · see citing works
Heutte, N., Flechtner, H., Mounier, N., Mellink, W. A. M., Meerwaldt, J. H., Eghbali, H., Veer, M. B. V., Noordijk, E. M., Kluin‐Nelemans, H. C., Lampka, E., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70258-x · Cited by 102 · see citing works
Fatigue and Functional Dependence in Older Cancer Patients
Luciani, A., Jacobsen, P. B., Extermann, M., Foa, P., Marussi, D., Overcash, J. A., & Balducci, L. (2008) · American Journal of Clinical Oncology · doi:10.1097/coc.0b013e31816d915f · Cited by 101 · see citing works
Sloan, J. A., Berk, L. B., Roscoe, J. A., Fisch, M. J., Shaw, E. G., Wyatt, G. K., Morrow, G. R., & Dueck, A. C. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.12.7670 · Cited by 101 · see citing works
Self-citationPharmacologic Treatment of Cancer-Related Fatigue
Carroll, J. K., Kohli, S., Mustian, K. M., Roscoe, J. A., & Morrow, G. R. (2007) · The Oncologist · doi:10.1634/theoncologist.12-s1-43 · Cited by 98 · see citing works
Self-citationJager, A., Sleijfer, S., & van der Rijt, C. C. D. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2007.11.023 · Cited by 95 · see citing works
Lotrich, F. E., Albusaysi, S., & Ferrell, R. E. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.263 · Cited by 92 · see citing works
Kim, S., Miller, B. J., Stefanek, M. E., & Miller, A. H. (2015) · Cancer · doi:10.1002/cncr.29302 · Cited by 90 · see citing works
Role of Inflammation in Depression and Treatment Implications
Felger, J. C. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_166 · Cited by 92 · see citing works
Cancer-Related Fatigue: The Approach and Treatment
Escalante, C. P., & Manzullo, E. F. (2009) · Journal of General Internal Medicine · doi:10.1007/s11606-009-1056-z · Cited by 87 · see citing works
Brain metastasis: clinical manifestations, symptom management, and palliative care
Noh, T., & Walbert, T. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-12-811161-1.00006-2 · Cited by 85 · see citing works
Depression and cancer: An unexplored and unresolved emergent issue in elderly patients
Spoletini, I., Gianni, W., Repetto, L., Bria, P., Caltagirone, C., Bossù, P., & Spalletta, G. (2008) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2007.10.005 · Cited by 83 · see citing works
Are inflammatory cytokines the common link between cancer-associated cachexia and depression?
Illman, J., Corringham, R. E., Robinson, D., Davis, H. M., Rossi, J., Cella, D. F., & Trikha, M. (2005) · PubMed · Cited by 84 · see citing works
Aiming for a Better Understanding and Management of Cancer-Related Fatigue
Neefjes, E. C. W., van der Vorst, M. J. D. L., Blauwhoff-Buskermolen, S., & Verheul, H. M. W. (2013) · The Oncologist · doi:10.1634/theoncologist.2013-0076 · Cited by 83 · see citing works
Taylor, D. M., Meader, N., Bird, V. J., Pilling, S., Creed, F. H., & Goldberg, D. P. (2011) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.110.077610 · Cited by 82 · see citing works
Comprehensive Symptom Management in Patients with Advanced-Stage Non–Small-Cell Lung Cancer
Temel, J. S., Pirl, W. F., & Lynch, T. J. (2006) · Clinical Lung Cancer · doi:10.3816/clc.2006.n.001 · Cited by 82 · see citing works
Lagged relationships among sleep disturbance, fatigue, and depressed mood during chemotherapy.
Jim, H., Jacobsen, P. B., Phillips, K. M., Wenham, R. M., Roberts, W. S., & Small, B. J. (2013) · Health Psychology · doi:10.1037/a0031322 · Cited by 77 · see citing works
Roth, M. E., O’Mara, A. M., Seibel, N. L., Dickens, D. S., Langevin, A., Pollock, B. H., & Freyer, D. R. (2016) · Journal of Oncology Practice · doi:10.1200/jop.2015.009084 · Cited by 77 · see citing works
Pharmacological treatment of depression in patients with a primary brain tumour
Rooney, A. G., & Grant, R. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006932.pub3 · Cited by 76 · see citing works
Reuter, K., Classen, C. C., Roscoe, J. A., Morrow, G. R., Kirshner, J. J., Rosenbluth, R. J., Flynn, P. J., Shedlock, K., & Spiegel, D. (2005) · Psycho-Oncology · doi:10.1002/pon.1012 · Cited by 76 · see citing works
Self-citation
- Authors
- Morrow, G. R., Hickok, J. T., Roscoe, J. A., Raubertas, R. F., Andrews, P. L. R., Flynn, P. J., Hynes, H. E., Banerjee, T. K., Kirshner, J. J., & King, D. K.
- Affiliations
- St George's, University of London (GB)
- Venue
- Journal of Clinical Oncology
- Published
- 2003-12-15
- Volume
- 21
- Issue
- 24
- Pages
- 4635-4641
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2118527171
- Cited by
- 324
- References
- 26
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 8 · 2018: 16 · 2017: 8 · 2016: 10 · 2015: 17 · 2014: 17 · 2013: 24 · 2012: 24
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (U10CA037420, U10-CA37420)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- paroxetine, cancer-related fatigue, depression, chemotherapy-induced fatigue, selective serotonin reuptake inhibitors, serotonin, first-line chemotherapy, cancer patients
- MeSH terms
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Depression, Double-Blind Method, Fatigue, Female, Humans, Male, Middle Aged, Neoplasms, Psychiatric Status Rating Scales, Chi-Square Distribution, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Paroxetine
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