The DOI matches its Crossref record; 101 of the 106 references it cites were found in a registry or an index.
Mind-Body Treatments for the Pain-Fatigue-Sleep Disturbance Symptom Cluster in Persons with Cancer
Open accessAbstract
Context Co-occurring pain, fatigue, and sleep disturbance comprise a common symptom cluster in patients with cancer. Treatment approaches that target the cluster of symptoms rather than just a single symptom need to be identified and tested.Objectives To synthesize evidence regarding mind-body interventions that have shown efficacy in treating two or more symptoms in the pain-fatigue-sleep disturbance cancer symptom cluster.Methods A literature search was conducted using CINAHL, Medline, and PsychInfo databases through March 2009. Studies were categorized based on the type of mind-body intervention (relaxation, imagery/hypnosis, cognitive-behavioral therapy/coping skills training [CBT/CST], meditation, music, and virtual reality), and a preliminary review was conducted with respect to efficacy for pain, fatigue, and sleep disturbance. Mind-body interventions were selected for review if there was evidence of efficacy for at least two of the three symptoms. Forty-three studies addressing five types of mind-body interventions met criteria and are summarized in this review.Results Imagery/hypnosis and CBT/CST interventions have produced improvement in all the three cancer-related symptoms individually: pain, fatigue, and sleep disturbance. Relaxation has resulted in improvements in pain and sleep disturbance. Meditation interventions have demonstrated beneficial effects on fatigue and sleep disturbance. Music interventions have demonstrated efficacy for pain and fatigue. No trials were found that tested the mind-body interventions specifically for the pain-fatigue-sleep disturbance symptom cluster.Conclusion Efficacy studies are needed to test the impact of relaxation, imagery/hypnosis, CBT/CST, meditation, and music interventions in persons with cancer experiencing concurrent pain, fatigue, and sleep disturbance. These mind-body interventions could help patients manage all the symptoms in the cluster with a single treatment strategy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Meta-analysis confirms that psychological interventions such as cognitive behavioral therapy (CBT) are effective in reducing physical symptoms across the cancer continuum into survivorship [15].”
From Acceptance and commitment therapy in adult cancer survivors: a systematic review and conceptual model (2021) · cites this paper as [15]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90047-4 · Cited by 35,234
Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., Filiberti, A., Flechtner, H., Fleishman, S. B., Haes, J. C. J. M. D., et al. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.5.365 · Cited by 16,005
Smets, E. M. A., Garssen, B., Bonke, B., & de Haes, J. C. J. M. (1995) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(94)00125-o · Cited by 3,622 · cited 2×
“Instruments that most frequently detected changes in fatigue included the visual analog scale, the fatigue, and vigor subscales from the Profile of Mood States,(94) and the Multidimensional Fatigue Inventory.(95) Measures most frequently sensitive to the effects of mind-body interventions on sleep disturbance included…”
MethodMcNair, D. M. (1992) · Medical Entomology and Zoology · Cited by 2,527
(1993) · Medical Entomology and Zoology · Cited by 2,324
Prevalence of pain in patients with cancer: a systematic review of the past 40 years
van den Beuken-van Everdingen, M. H. J., de Rijke, J. M., Kessels, A. G., Schouten, H. C., van Kleef, M., & Patijn, J. (2007) · Annals of Oncology · doi:10.1093/annonc/mdm056 · Cited by 1,923 · cited 1×
“Pain is reported by 59% of persons receiving anticancer treatment and 64% of those with advanced, metastatic, or terminal disease.(8) Fatigue, the most common symptom experienced by all the persons with cancer, impacts more than 75% of patients.”
BackgroundCarmody, J., & Baer, R. A. (2008) · Journal of Behavioral Medicine · doi:10.1007/s10865-007-9130-7 · Cited by 1,823 · cited 1×
“Some MBSR techniques include training in meditative exercises such as gentle yoga poses to help bring about the meditative state.(76) Symptoms such as pain, fatigue, and sleep disturbance may be modified through meditation by focusing attention away from the symptom experience, by focusing on strengths and positive th…”
BackgroundSerlin, R. C., Mendoza, T. R., Nakamura, Y., Edwards, K. R., & Cleeland, C. S. (1995) · Pain · doi:10.1016/0304-3959(94)00178-h · Cited by 1,493
Impact of Cancer-Related Fatigue on the Lives of Patients: New Findings From the Fatigue Coalition
Curt, G. A., Breitbart, W., Cella, D., Groopman, J. E., Horning, S. J., Itri, L. M., Johnson, D. H., Miaskowski, C., Scherr, S. L., Portenoy, R. K., et al. (2000) · The Oncologist · doi:10.1634/theoncologist.5-5-353 · Cited by 1,248
Advancing the science of symptom management
Dodd, M. J., Janson, S. L., Facione, N. C., Faucett, J. A., Froelicher, E. S., Humphreys, J. C., Lee, K. A., Miaskowski, C. A., Puntillo, K., Rankin, S. H., et al. (2001) · Journal of Advanced Nursing · doi:10.1046/j.1365-2648.2001.01697.x · Cited by 1,104 · cited 1×
“Symptom clusters are defined as combinations of two or more cooccurring symptoms that are related to each other and that are independent of other symptoms or symptom clusters.(3,4) Symptoms within the cluster may share the same etiology, but are not required to do so.”
Background
Research works printed but not linked: 3
- Breitbart, 2007, Psychiatric aspects of cancer pain management, Prim Psychiatry, 14, 81
- Cholburi, 2004, Effects of music therapy on anxiety and pain in cancer patients, Thai J Nurs Res, 8, 173
- Aaronson, 1993, The EORTC-QLQ-30: a quality of life instrument for use in international clinical trials in oncology, Qual Life Res, 2, 51
Cited by
Sorted by citations
Adult Cancer Pain, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology
Swarm, R. A., Paice, J. A., Anghelescu, D. L., Are, M., Bruce, J. Y., Buga, S., Chwistek, M., Cleeland, C. S., Craig, D. S., Gafford, E. F., et al. (2019) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2019.0038 · Cited by 641
Paice, J. A., Portenoy, R. K., Lacchetti, C., Campbell, T. C., Cheville, A. L., Citron, M. L., Constine, L. S., Cooper, A., Glare, P. A., Keefe, F., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.68.5206 · Cited by 604
“Furthermore, psychological-based interventions showed promise, with moderate and significant effects on pain reported in six systematic reviews that considered acceptance-based interventions, patient education, relaxation, guided imagery, meditation, hypnosis, and music interventions.(45,52-55) Finally, interventional…”
BackgroundInfluentialMiaskowski, C. A., Barsevick, A. M., Berger, A. M., Casagrande, R. J., Grady, P. A., Jacobsen, P. B., Kutner, J. S., Patrick, D. L., Zimmerman, L. M., Xiao, C., et al. (2016) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djw253 · Cited by 507
Portenoy, R. K. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60236-5 · Cited by 491
Psychological and behavioral approaches to cancer pain management
Syrjala, K. L., Jensen, M. P., Mendoza, M. E., Yi, J. C., Fisher, H. M., & Keefe, F. J. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.54.4825 · Cited by 344
Swarm, R. A., Abernethy, A. P., Anghelescu, D. L., Benedetti, C., Blinderman, C. D., Boston, B., Cleeland, C. S., Coyle, N., deLeon-Casasola, O. A., Eilers, J., et al. (2010) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2010.0076 · Cited by 333
Glare, P. A., Davies, P. S., Finlay, E., Gulati, A., Lemanne, D., Moryl, N., Oeffinger, K. C., Paice, J. A., Stubblefield, M. D., & Syrjala, K. L. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.52.4629 · Cited by 329
Emotional foundations of music as a non-pharmacological pain management tool in modern medicine
Bernatzky, G., Presch, M., Anderson, M., & Panksepp, J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.06.005 · Cited by 284
Troublesome Symptoms in Cancer Survivors: Fatigue, Insomnia, Neuropathy, and Pain
Pachman, D. R., Barton, D. L., Swetz, K. M., & Loprinzi, C. L. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2012.41.7238 · Cited by 282
Wayne, P. M., Lee, M. S., Novakowski, J., Osypiuk, K., Ligibel, J., Carlson, L. E., & Song, R. (2018) · Journal of Cancer Survivorship · doi:10.1007/s11764-017-0665-5 · Cited by 251
“, exercise, meditation), impact individual as well as constellations of symptoms [11] represents a rich area for further research.”
BackgroundBerger, A. M., Mitchell, S. A., Jacobsen, P. B., & Pirl, W. F. (2015) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21268 · Cited by 207
“components presents an additional constraint when interpreting the findings.(225,299,300)”
BackgroundCancer‐related fatigue and its impact on functioning
Minton, O., Berger, A. M., Barsevick, A. M., Cramp, F. L., Goedendorp, M. M., Mitchell, S. A., & Stone, P. C. (2013) · Cancer · doi:10.1002/cncr.28058 · Cited by 200
“tigue, including yoga, relaxation, mindfulness-based stress reduction, acupuncture, medical Qigong, massage, healing touch, Reiki, and combined modality interventions that include aromatherapy, lavender foot soaks, and reflexology.(34,40) However, the studies examining these interventions have tended to have small and…”
BackgroundCancer‐Related Fatigue: State of the Science
Mitchell, S. A. (2010) · PM&R · doi:10.1016/j.pmrj.2010.03.024 · Cited by 194
So, W. K. W., Law, B. M. H., Ng, M. S. N., He, X., Chan, D. N. S., Chan, C. W. H., & McCarthy, A. L. (2021) · Cancer Medicine · doi:10.1002/cam4.3794 · Cited by 181
Cancer-related and treatment-related fatigue
Wang, X. S., & Woodruff, J. F. (2014) · Gynecologic Oncology · doi:10.1016/j.ygyno.2014.10.013 · Cited by 191
Wang, C., Sun, Y.-L., & Zang, H.-X. (2013) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2013.03.008 · Cited by 172
Complementary Therapies and Integrative Medicine in Lung Cancer
Deng, G. E., Rausch, S. M., Jones, L. W., Gulati, A., Kumar, N. B., Greenlee, H., Pietanza, M. C., & Cassileth, B. R. (2013) · CHEST Journal · doi:10.1378/chest.12-2364 · Cited by 165
Kwekkeboom, K. L., Abbott‐Anderson, K., Cherwin, C. H., Roiland, R. A., Serlin, R. C., & Ward, S. E. (2012) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2011.12.281 · Cited by 148
“Cancer diagnosis Lung 10 (23) 15 (35) 25 (29) Prostate 6 (14) 9 (21) 15 (17) Colorectal 6 (14) 4 (9) 10 (12) Gynecologic 21 (49) 15 (35) 36 (42)”
Self-citationMitchell, S. A., Hoffman, A. J., Clark, J. C., DeGennaro, R., Poirier, P., Robinson, C. B., & Weisbrod, B. L. (2014) · Clinical journal of oncology nursing · doi:10.1188/14.cjon.s3.38-58 · Cited by 135
“…have predominantly been studied using open-label and/or uncontrolled study designs and small sample sizes with no random assignment, making it difficult to draw conclusions about efficacy (Finnegan-John et al., 2013; Kwekkeboom et al., 2010; Shneerson, Taskila, Gale, Greenfield, & Chen, 2013).”
Luckett, T., Davidson, P., Green, A., Boyle, F., Stubbs, J., & Lovell, M. (2013) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2012.07.021 · Cited by 99
Tibetan sound meditation for cognitive dysfunction: results of a randomized controlled pilot trial
Milbury, K., Chaoul, A., Biegler, K. A., Wangyal, T., Spelman, A. R., Meyers, C. A., Arun, B., Palmer, J. L., Taylor, J. A., & Cohen, L. G. (2013) · Psycho-Oncology · doi:10.1002/pon.3296 · Cited by 118
Yeh, C. H., Chien, L.-C., Lin, W.-C., Bovbjerg, D. H., & Londen, G. J. V. (2015) · Cancer Nursing · doi:10.1097/ncc.0000000000000303 · Cited by 112
Stable Symptom Clusters and Evolving Symptom Networks in Relation to Chemotherapy Cycles
Rha, S. Y., & Lee, J. (2020) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2020.08.008 · Cited by 108
Self-citationMind–Body Therapies in Integrative Oncology
Elkins, G. R., Fisher, W. I., & Johnson, A. K. (2010) · Current Treatment Options in Oncology · doi:10.1007/s11864-010-0129-x · Cited by 108
“• The technique of meditation has been operationalized as providing training in a self-directed mental exercise to intentionally and continually focus the mind on a single target perception [ 9 ].”
BackgroundMethodResultInfluentialPsychosocial Issues in Cancer Pain
Porter, L. S., & Keefe, F. J. (2011) · Current Pain and Headache Reports · doi:10.1007/s11916-011-0190-6 · Cited by 97
“Preliminary evidence suggests that yoga and meditation may produce improvements in pain and related symptoms such as fatigue and distress [45, 46].”
BackgroundMathew, A., Doorenbos, A. Z., Jang, M. K., & Hershberger, P. E. (2021) · Journal of Cancer Survivorship · doi:10.1007/s11764-020-00938-z · Cited by 91
Dikmen, H. A., & Terzioğlu, F. (2018) · Pain Management Nursing · doi:10.1016/j.pmn.2018.03.001 · Cited by 98
Anderson, J. G., & Taylor, A. G. (2012) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2011.0022 · Cited by 91
“Research suggests that guided imagery may aid the reduction of cancer pain.(16,17) Various types of meditation have been shown to improve quality of Table 5.”
BackgroundDe Paolis, G., Naccarato, A., Cibelli, F., D'Alete, A., Mastroianni, C., Surdo, L., Casale, G., & Magnani, C. (2019) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2018.12.014 · Cited by 89
Kwekkeboom, K. L., Zhang, Y., Campbell, T. C., Coe, C. L., Costanzo, E. S., Serlin, R. C., & Ward, S. E. (2018) · Psycho-Oncology · doi:10.1002/pon.4883 · Cited by 91
“In addition, rationale provided during training may counter commonly held beliefs that cancer symptoms cannot be managed, raise expectations for symptom improvement, and facilitate patients' ability to actively control their symptom experience.(22,23) We hypothesized that such strategies could be effective in simultan…”
BackgroundSelf-citationOpportunities for cannabis in supportive care in cancer
Kleckner, A. S., Kleckner, I. R., Kamen, C. S., Tejani, M. A., Janelsins, M. C., Morrow, G. R., & Peppone, L. J. (2019) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835919866362 · Cited by 92
Maindet, C., Burnod, A., Minello, C., George, B., Allano, G., & Lemaire, A. (2019) · Supportive Care in Cancer · doi:10.1007/s00520-019-04829-7 · Cited by 97
Kwekkeboom, K. L., Abbott‐Anderson, K., & Wanta, B. (2010) · Oncology nursing forum · doi:10.1188/10.onf.e151-e159 · Cited by 80
Self-citationThe mechanisms of pain tolerance and pain-related anxiety in acute pain
Cîmpean, A., & David, D. (2019) · Health Psychology Open · doi:10.1177/2055102919865161 · Cited by 88
“As Kwekkeboom et al. (2010) noted, the generation of “crossover” treatments has the possible benefit of using a single intervention to simplify treatment, which may reduce costs.”
BackgroundInfluentialComplementary therapies for symptom management in cancer patients
Bhatnagar, S., & Satija, A. (2017) · Indian Journal of Palliative Care · doi:10.4103/ijpc.ijpc_100_17 · Cited by 78
“This is done using counseling approach or programmed education.[17] It involves techniques such as autogenic training, biofeedback, hypnosis, imagery, meditation, problem-solving, and systematic desensitization.”
BackgroundMethodResultInfluentialGori, A., Topino, E., Sette, A., & Cramer, H. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.10.044 · Cited by 84
Jahn, P., Kuß, O., Schmidt, H., Bauer, A., Kitzmantel, M., Jordan, K., Krasemann, S., & Landenberger, M. (2014) · Pain · doi:10.1016/j.pain.2014.01.006 · Cited by 72
“The SCION-PAIN program group patients did respond to the PMR offering and included this in their pain management strategies as an option for self-management [35].”
MethodKwekkeboom, K. L., & Bratzke, L. C. (2015) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000000274 · Cited by 70
Self-citationRambod, M., Sharif, F., Pourali-Mohammadi, N., Pasyar, N., & Rafii, F. (2013) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2013.11.004 · Cited by 68
Interventions for cancer-related fatigue: a scoping review
Pearson, E. J. M., Morris, M. E., Stefano, M. D., & McKinstry, C. (2016) · European Journal of Cancer Care · doi:10.1111/ecc.12516 · Cited by 73
Adult Cancer Pain, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology
Swarm, R. A., Youngwerth, J. M., Agne, J. L., Anițescu, M., Are, M., Buga, S., Butler, T., Chwistek, M., Cleary, J. F., Copenhaver, D. J., et al. (2025) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2025.0032 · Cited by 77
The effect of meditative movement on sleep quality: A systematic review
Wang, F., Lee, O. E., Feng, F., Vitiello, M. V., Wang, W.-D., Benson, H., Fricchione, G. L., & Denninger, J. W. (2015) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.12.001 · Cited by 67
Rambod, M., Pasyar, N., & Shamsadini, M. (2019) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2019.101678 · Cited by 65
Opioids for cancer pain: the challenge of optimizing treatment
Plante, G. E., & VanItallie, T. B. (2010) · Metabolism · doi:10.1016/j.metabol.2010.07.010 · Cited by 63
Shahriari, M., Dehghan, M., Pahlavanzadeh, S., & Hazini, A. (2017) · Journal of Education and Health Promotion · doi:10.4103/jehp.jehp_147_14 · Cited by 62
“Progressive muscle relaxation is a physical stimulation and mental peace with emphasis on muscle systematic stretching and release (contraction‐release).[15] Progressive muscle relaxation can be applied in all stages of cancer patients and can notably reduce cancer complications.”
BackgroundKaragözoğlu, Ş., & Kahve, E. (2013) · Applied Nursing Research · doi:10.1016/j.apnr.2013.07.002 · Cited by 60
“In cancer patients, there is a strong association between depression and fatigue (Dimeo et al., 2004; Kwekkeboom et al., 2010; Winell & Roth, 2004) and between anxiety and fatigue (Brown & Kroenke, 2009; Li & Yuan, 2011; Mansky & Wallerstedt, 2006; Oh & Seo, 2011; Reddick, Nanda, Campbell, Ryman, & Gaston-Johansson, 2…”
BackgroundInfluentialExplaining fatigue in ANCA-associated vasculitis
Basu, N., McClean, A., Harper, L., Amft, E. N., Dhaun, N., Luqmani, R. A., Little, M. A., Jayne, D. R. W., Floßmann, O., McLaren, J., et al. (2013) · Lara D. Veeken · doi:10.1093/rheumatology/ket191 · Cited by 57
Usual and Worst Symptom Severity and Interference With Function in Breast Cancer Survivors
Berger, A. M., Visovsky, C. M., Hertzog, M. A., Holtz, S., & Loberiza, F. R. (2012) · The Journal of Supportive Oncology · doi:10.1016/j.suponc.2011.11.001 · Cited by 57
Lipschitz, D. L., Kuhn, R., Kinney, A. Y., Donaldson, G. W., & Nakamura, Y. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.12.021 · Cited by 55
“As an alternative to conventional treatments for sleep disturbance in cancer patients and survivors (besides in many other clinical populations), non-pharmacological or behavioral interventions such as mind-body therapies have increasingly shown promise (Carlson and Bultz, 2008; Kwekkeboom et al., 2010).”
BackgroundMusic's Use for Anesthesia and Analgesia
Matsota, P. K., Christodoulopoulou, T. C., Smyrnioti, M., Pandazi, A., Kanellopoulos, I., Koursoumi, E., Karamanis, P., & Kostopanagiotou, G. G. (2012) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2010.0235 · Cited by 59
Benson Relaxation Technique in Reducing Pain Intensity in Women After Cesarean Section
Solehati, T., & Rustina, Y. (2015) · Anesthesiology and Pain Medicine · doi:10.5812/aapm.22236v2 · Cited by 51
“Several studies showed that relaxation is effective in reducing pain (12, 14-22).”
BackgroundInfluentialSymptom Clusters and Quality of Life in Subjects With COPD
Lim, K. E., Kim, S. R., Kim, H. K., & Kim, S. R. (2017) · Respiratory Care · doi:10.4187/respcare.05374 · Cited by 49
Yennurajalingam, S., Kang, D.-H., Hwu, W., Padhye, N. S., Masino, C., Dibaj, S. S., Liu, D. D., Williams, J. L., Lu, Z., & Bruera, E. D. (2017) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2017.08.027 · Cited by 51
Emotional distress among adult survivors of childhood cancer
Oancea, S. C., Brinkman, T. M., Ness, K. K., Krull, K. R., Smith, W. A., Srivastava, D. K., Robison, L. L., Hudson, M. M., & Gurney, J. G. (2014) · Journal of Cancer Survivorship · doi:10.1007/s11764-013-0336-0 · Cited by 48
“Cognitive remediation approaches have shown promise in treating cognitive late effects of childhood cancer treatment [33–35], while pharmacologic, cognitive-behavioral, and complementary medicine approaches have been used for the management of cancer-related pain [36, 37].”
BackgroundImpact of Clinical Pharmacy Services on KAP and QOL in Cancer Patients: A Single-Center Experience
Wang, Y., Wu, H., & Xu, F. (2015) · BioMed Research International · doi:10.1155/2015/502431 · Cited by 48
“Sleep disturbance not only caused depression patients, interfered with their daily activities, and reduced quality of life but also impaired cancer-treatment adherence, affected the treatment outcomes, and even possibly increased patients’mortality [24, 25].”
BackgroundSymptom clusters in patients with nasopharyngeal carcinoma during radiotherapy
Xiao, W., Chan, C. W. H., Fan, Y., Leung, D. Y. P., Xia, W., He, Y., & Tang, L. (2017) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2017.02.004 · Cited by 48
Cebolla, A., Luciano, J. V., Demarzo, M., Navarro‐Gil, M., & García‐Campayo, J. (2013) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-11-6 · Cited by 47
“Research studies on such mitigating effects suggest that mindfulness alters the contextual evaluation of pain [5], reduces pain catastrophising and pain sensitivity [6], reduces psychopathological symptoms [11,12], and alters pain-related anxiety [13].”
BackgroundAssessment and Management of Cancer-Related Fatigue
Borneman, T. R. (2013) · Journal of Hospice and Palliative Nursing · doi:10.1097/njh.0b013e318286dc19 · Cited by 51
Cancer Pain Management and Bone Metastases: An Update for the Clinician
Schneider, G., Voltz, R., & Gaertner, J. (2012) · Breast Care · doi:10.1159/000338579 · Cited by 43
Bailey, D. E., Hendrix, C. C., Steinhauser, K. E., Stechuchak, K. M., Porter, L. S., Hudson, J., Olsen, M. K., Muir, A. J., Lowman, S. G., DiMartini, A. F., et al. (2016) · Patient Education and Counseling · doi:10.1016/j.pec.2016.10.017 · Cited by 43
Tarrasch, R., Neiderman, N. N. C., Ben-Ami, S., Kaufman, B., Pfeffer, R., Ben-David, M. A., & Gamus, D. (2017) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2017.0023 · Cited by 44
“Findings of this study are in line with conclusions of the review of mind–body treatments for the pain-fatigue-sleep disturbance cluster in cancer patients.(22) This review demonstrated that fatigue and sleep disturbances were the most common symptoms improved by mind–body interventions, while relaxation, which is oft…”
Common and Co-Occurring Symptoms Experienced by Patients With Gastric Cancer
Lin, Y., Docherty, S. L., Porter, L. S., & Bailey, D. E. (2020) · Oncology nursing forum · doi:10.1188/20.onf.187-202 · Cited by 43
Xiao, W., Chow, K. M., So, W. K. W., Leung, D. Y. P., & Chan, C. W. H. (2016) · Cancer Nursing · doi:10.1097/ncc.0000000000000313 · Cited by 39
“Managing a symptom cluster as a whole instead of single symptoms could be more efficient and effective.(7,8) A recent review on managing symptom clusters identified several interventions, pharmacological and nonpharmacological, being tested on patients with cancer.”
BackgroundGuan, H., Xu, Y., & Zhao, D. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/1373170 · Cited by 42
“Mind-body interventions such as relaxation, hypnosis, meditation, and music interventions for cancer patients who experience pain, fatigue, and sleep disturbances helped patients manage all symptoms in a group with a single treatment strategy [109].”
BackgroundUpdate on interventions focused on symptom clusters
Berger, A. M., Yennurajalingam, S., & Million, R. (2013) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e32835c7d88 · Cited by 40
“A variety of mind–body treatments have demonstrated beneficial effects on a single symptom, but few studies have focused on the response of concurrent symptoms to a single treatment strategy [16].”
BackgroundHarorani, M., Davodabady, F., Farahani, Z., Hezave, A. K., & Rafiei, F. (2020) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2020.102344 · Cited by 38
Mikolasek, M., Witt, C. M., & Barth, J. (2021) · JMIR Cancer · doi:10.2196/16785 · Cited by 36
“Such MBM treatments can have beneficial effects on cancer-related symptoms, such as pain, fatigue, and sleep disturbance [9-11].”
BackgroundBragard, I., Étienne, A.-M., Faymonville, M.-É., Coucke, P., Lifrange, É., Schroeder, H., Wagener, A., Dupuis, G., & Jérusalem, G. (2017) · PubMed · doi:10.1080/00207144.2017.1276363 · Cited by 41
“Similarly, hypnosis also seems to be effective for BC patients for pain (Kwekkeboom, Cherwin, Lee, & Wanta, 2010), anxiety and depression symptoms (Cramer et al., 2015), fatigue (Montgomery et al., 2007), and sleep disturbances (Kwekkeboom et al., 2010).”
BackgroundResultSheikh-Wu, S. F., Downs, C. A., & Anglade, D. (2020) · Oncology nursing forum · doi:10.1188/20.onf.e107-e119 · Cited by 36
“A symptom cluster of pain, fatigue, and sleep disturbances is the most common, occurring in more than 40% of cancer survivors (Kwekkeboom et al., 2009; Kwekkeboom, Tostrud, et al., 2018; Miaskowski et al., 2017; Mosher & DuHamel, 2012).”
BackgroundCancer-Related Fatigue—Is There a Role for Complementary and Integrative Medicine?
David, A., Hausner, D., & Frenkel, M. A. (2021) · Current Oncology Reports · doi:10.1007/s11912-021-01135-6 · Cited by 35
The effect of massage therapy on the quality of sleep in breast cancer patients.
Kashani, F., & Kashani, P. (2014) · Europe PMC (PubMed Central) · Cited by 35
Complementary and Alternative Medicine and Breast Cancer
Subramani, R., & Lakshmanaswamy, R. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.07.008 · Cited by 35
Eaton, L. H., Brant, J. M., McLeod, K., & Yeh, C. H. (2017) · Clinical journal of oncology nursing · doi:10.1188/17.cjon.s3.54-70 · Cited by 33
“ONS.ORG APPENDIX B. PUTTING EVIDENCE INTO PRACTICE: EFFECTIVENESS NOT ESTABLISHED FOR BODY-BASED INTERVENTIONS STUDY INTERVENTION SAMPLE AND DESIGN FINDINGS LIMITATIONS Acupuncture Bao et al., 2013 Acupuncture 47 patients with breast cancer on aromatase inhibitors; RCT No difference in pain outcomes between groups Sam…”
InfluentialMind-Body Therapies: Evidence and Implications in Advanced Oncology Practice
Mayden, K. D. (2012) · Journal of the Advanced Practitioner in Oncology · doi:10.6004/jadpro.2012.3.6.2 · Cited by 32
“The studies demonstrated improvements in all three symptoms, but the majority of support favored fatigue and sleep disturbance (Kwekkeboom et al., 2010).”
Effect of acupressure on pain in Iranian leukemia patients: A randomized controlled trial study
Nia, H. S., Sharif, S. P., Yaghoobzadeh, A., Yeoh, K. K., Goudarzian, A. H., Soleimani, M. A., & Jamali, S. (2017) · International Journal of Nursing Practice · doi:10.1111/ijn.12513 · Cited by 31
Survivorship: Pain Version 1.2014
Denlinger, C. S., Ligibel, J. A., Are, M., Baker, K. S., Demark‐Wahnefried, W., Friedman, D. L., Goldman, M. E., Jones, L. W., King, A. A., Ku, G., et al. (2014) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2014.0054 · Cited by 30
Challenges and concerns of persistent opioid use in cancer patients
Manchikanti, L., Manchikanti, K. N., Kaye, A. D., Kaye, A. M., & Hirsch, J. A. (2018) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2018.1474103 · Cited by 30
Chen, E., Nguyen, J., Khan, L., Zhang, L., Cramarossa, G., Tsao, M. N., Danjoux, C. E., Barnes, E. A., Sahgal, A., Holden, L., et al. (2012) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2011.07.011 · Cited by 29
“Concurrent symptoms are burdensome for these patients and often impact their functional status, quality of life, and mood.(3) When multiple symptoms occur simultaneously, their interrelationship is likely complex and warrants multivariate analyses to describe it comprehensively.”
BackgroundSchaffer, L., Jallo, N., Howland, L. C., James, K. S., Glaser, D. N., & Arnell, K. (2013) · The Journal of Perinatal & Neonatal Nursing · doi:10.1097/jpn.0b013e3182870426 · Cited by 29
“about positive physical or emotional effects.(28,29) This technique captures the power of the mind by including mental imaging of the senses to form connection”
Pain-related diseases and sleep disorders
Roizenblatt, M., Neto, N. S. R., Tufik, S., & Roizenblatt, S. (2012) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2012007500110 · Cited by 29
Shahrokhi, M., Ghaeli, P., Arya, P., Shakiba, A., Noormandi, A., Soleimani, M., & Esfandbod, M. (2021) · Basic and Clinical Neuroscience Journal · doi:10.32598/bcn.12.1.1650.2 · Cited by 28
Gupta, M., Sahi, M. S., Bhargava, A., & Talwar, V. (2015) · Indian Journal of Palliative Care · doi:10.4103/0973-1075.164894 · Cited by 27
“[19,20] It is therefore imperative to shift the focus of management strategy from a single symptom to the symptom cluster as a whole.”
Guided imagery effects on chemotherapy induced nausea and vomiting in Iranian breast cancer patients
Hosseini, M.-S., Tirgari, B., Forouzi, M. A., & Jahani, Y. (2016) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2016.07.002 · Cited by 28
“These kinds of therapies are particularly appealing options for the treatment of cancer symptoms in addition to pharmacological strategies, as these methods have beneficial outcomes including few negative side effects, ability to be used by patients independently with sufficient training and being inexpensive [12].”
BackgroundMiladinia, M., Jahangiri, M., Kennedy, A. B., Fagerström, C., Tuvesson, H., Safavi, S. S., Maniati, M., Javaherforooshzadeh, F., & Karimpourian, H. (2022) · Palliative Medicine · doi:10.1177/02692163221129158 · Cited by 27
Henneghan, A. M., & Harrison, T. C. (2014) · Journal of Holistic Nursing · doi:10.1177/0898010114539191 · Cited by 27
Wiggenraad, F., Bolam, K. A., Mijwel, S., van der Wall, E., Wengström, Y., & Altena, R. (2020) · Integrative Cancer Therapies · doi:10.1177/1534735420905003 · Cited by 30
Grégoire, C., Faymonville, M.-É., Vanhaudenhuyse, A., Jérusalem, G., Willems, S. J., & Bragard, I. (2020) · Quality of Life Research · doi:10.1007/s11136-020-02655-7 · Cited by 32
“Indeed, complementary and alternative medicine, such as hypnosis, is estimated to be used by 43% of patients with cancer [30, 31], and is becoming popular because of its ease of integration into cancer care [32].”
BackgroundCastellar, J. I., Fernandes, C. A., & Tosta, C. E. (2014) · Integrative Cancer Therapies · doi:10.1177/1534735414534730 · Cited by 25
Systematic Review for the Medical Applications of Meditation in Randomized Controlled Trials
Kim, D.-Y., Hong, S.-H., Jang, S.-H., Park, S., Noh, J.-H., Seok, J.-M., Jo, H.-J., Son, C., & Lee, E. J. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19031244 · Cited by 24
Li, R., Shen, X., Zhang, L., Chan, Y., Yao, W., Zhang, G., & Li, H. (2023) · Asia-Pacific Journal of Oncology Nursing · doi:10.1016/j.apjon.2023.100243 · Cited by 24
PainDroid: an android-based virtual reality application for pain assessment
Spyridonis, F., Hansen, J., Grønli, T., & Ghinea, G. (2013) · Multimedia Tools and Applications · doi:10.1007/s11042-013-1358-3 · Cited by 24
“Finally, VR technology has also been well-reported in a series of studies [34–36] to be an effective aid in reducing pain through hypnosis, as well as shown to decrease pain in persons with cancer [18, 39, 45].”
BackgroundAcar, K., & Aygın, D. (2019) · Journal of PeriAnesthesia Nursing · doi:10.1016/j.jopan.2019.05.006 · Cited by 23
“Techniques such as hypnosis, biofeedback, meditation, and imagery are effective with the interaction between mind and body.(2) The general purpose in these applications is to benefit from the self-healing capacity of body by influencing the mind.”
BackgroundThe Comprehensive Cancer Center
Aljurf, M., Majhail, N. S., Koh, M., Kharfan-Dabaja, M. A., & Chao, N. J. A. (2021) · Springer eBooks · doi:10.1007/978-3-030-82052-7 · Cited by 24
Khan, L., Cramarossa, G., Lemke, M., Nguyen, J., Zhang, L., Chen, E., & Chow, E. (2012) · Supportive Care in Cancer · doi:10.1007/s00520-012-1540-6 · Cited by 23
Music as Non-Pharmacological Pain Management in Clinics*
Bernatzky, G., Strickner, S., Presch, M., Wendtner, F., & Kullich, W. (2012) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199586974.003.0019 · Cited by 25
“…of a nurse using music therapy to reduce the acute pain Wound care after orthopaedic s. Individualtailored music therapy X Pain, negative feelings ↓ ; own spiritual strength ↑ Kwekkeboom et al. (2009 ) Investigation of different interventions on fatigue, pain, sleep disturbances in cancer…”
BackgroundMethodTuran, G. B., Özer, Z., & Sariköse, A. (2024) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2024.102580 · Cited by 25
The Effect of Benson Relaxation on Quality of Sleep of Cancer Patients
Efendi, S., Agus, A. I., Syatriani, S., Amir, H., Alam, R. I., Nurdin, S., Batara, A. S., & Ikhtiar, M. (2022) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2022.8295 · Cited by 21
“Some methods of complementary clinical treatment can be useful interventions for treating pain, fatigue, and sleep disorders in cancer patients such as hypnosis, training, cognitive behavioral care, relaxation, pain music therapy, and fatigue [12].”
MethodHan, J., Cheng, H., Bi, L., & Molassiotis, A. (2023) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2023.102954 · Cited by 21
Bean, H. R., Stafford, L., Little, R., Diggens, J., Ftanou, M., Alexander, M., Francis, P. A., Bei, B., & Wiley, J. F. (2020) · Trials · doi:10.1186/s13063-020-4196-4 · Cited by 22
Guided Imagery for Pain Control
Burhenn, P., Olausson, J. M., Villegas, G., & Kravits, K. G. (2014) · Clinical journal of oncology nursing · doi:10.1188/14.cjon.501-503 · Cited by 23
“The primary aim of the pilot study was not to test the efficacy of guided imagery because that has been previously documented in the literature (Astin et al., 2003; Deng & Cassileth, 2013; Kwekkeboom et al., 2010; Portenoy, 2011).”
Metadata
- Authors
- Kwekkeboom, K. L., Cherwin, C. H., Lee, J. W., & Wanta, B.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Kwekkeboom, Kristine L.
- Venue
- Journal of Pain and Symptom Management
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 39
- Issue
- 1
- Pages
- 126-138
- ISSN
- 0885-3924 (ISSN-L)
- PMC
- PMC3084527
- OpenAlex
- W1971153042
- Cited by
- 228
- References
- 106
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 9 · 2023: 11 · 2022: 14 · 2021: 21 · 2020: 16 · 2019: 13 · 2018: 18 · 2017: 14 · 2016: 12 · 2015: 13 · 2014: 17 · 2013: 16 · 2012: 19
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Pain and Symptom Management (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Nursing Research (P20NR008987)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Keywords
- mind-body interventions, cancer pain, cancer-related fatigue, sleep disorders, symptom clusters, cognitive behavioral therapy, coping skills training, relaxation, meditation, music therapy, virtual reality, symptom management
- MeSH terms
- Fatigue, Humans, Neoplasms, Pain, Sleep Wake Disorders, Mind-Body Therapies, Pain Management
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
