Cited by 590Infant Nutrition and HealthProbiotics and Fermented FoodsNeonatal and Maternal Infections

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Oral Probiotics Prevent Necrotizing Enterocolitis in Very Low Birth Weight Neonates

Bin-Nun, Alona, Bromiker, Ruben, Wilschanski, Michael, Kaplan, Michael, Rudensky, Bernard, Caplan, Michael, Hammerman, Cathy·2005·The Journal of Pediatrics

DOI 10.1016/j.jpeds.2005.03.054

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Abstract

Objective To test the hypothesis that normalizing the intestinal flora by administration of prophylactic probiotics would provide a natural defense, thereby reducing both the incidence and severity of necrotizing enterocolitis (NEC) in preterm neonates. Study design Neonates < or =1500 g birth weight were randomized to either receive a daily feeding supplementation with a probiotic mixture (Bifidobacteria infantis, Streptococcus thermophilus, and Bifidobacteria bifidus; Solgar, Israel) of 10(9) colony forming units (CFU)/day or to not receive feed supplements. NEC was graded according to Bell's criteria. Results For 72 study and 73 control infants, respectively, birth weight (1152 +/- 262 g vs 1111 +/- 278 g), gestational age (30 +/- 3 weeks vs 29 +/- 4 weeks), and time to reach full feeds (14.6 +/- 8.7 days vs 17.5 +/- 13.6 days) were not different. The incidence of NEC was reduced in the study group (4% vs 16.4%; P=.03). NEC was less severe in the probiotic-supplemented infants (Bell's criteria 2.3 +/- 0.5 vs 1.3 +/- 0.5; P=.005). Three of 15 babies who developed NEC died, and all NEC-related deaths occurred in control infants. Conclusion Probiotic supplementation reduced both the incidence and severity of NEC in our premature neonatal population.

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Authors: Bin-Nun, A., Bromiker, R., Wilschanski, M., Kaplan, M., Rudensky, B., Caplan, M., & Hammerman, C.
Affiliations: Ben-Gurion University of the Negev (IL)
Corresponding author: Hammerman, Cathy
ORCID: Bromiker, Ruben
Wilschanski, Michael
Kaplan, Michael
Caplan, Michael
Hammerman, Cathy
Venue: The Journal of Pediatrics
Publisher: Elsevier BV
Published: 2005-08
Volume: 147
Issue: 2
Pages: 192-196
ISSN: 0022-3476 (ISSN-L)
DOI: 10.1016/j.jpeds.2005.03.054
OpenAlex: W2100119754
Cited by: 590
References: 28
Citations by year: 2026: 7 · 2025: 6 · 2024: 14 · 2023: 20 · 2022: 8 · 2021: 16 · 2020: 11 · 2019: 18 · 2018: 12 · 2017: 24 · 2016: 60 · 2015: 36 · 2014: 34 · 2013: 41 · 2012: 45
FWCI: 33.33
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Journal of Pediatrics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
Keywords: necrotizing enterocolitis, probiotics, very low birth weight infants, preterm infants, Bifidobacterium infantis, Streptococcus thermophilus, Bifidobacterium bifidum, probiotic supplementation, gut microbiota, NEC incidence, NEC severity, NEC mortality
MeSH terms: Administration, Oral, Apgar Score, Bifidobacterium, Female, Gestational Age, Humans, Infant, Newborn, Male, Severity of Illness Index, Infant, Very Low Birth Weight, Probiotics, Enterocolitis, Necrotizing, Streptococcus thermophilus

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Oral Probiotics Prevent Necrotizing Enterocolitis in Very Low Birth Weight Neonates

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