CoChat
Sign Up
Cited by 590Infant Nutrition and HealthProbiotics and Fermented FoodsNeonatal and Maternal Infections

The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.

Oral Probiotics Prevent Necrotizing Enterocolitis in Very Low Birth Weight Neonates

Bin-Nun, Alona, Bromiker, Ruben, Wilschanski, Michael, Kaplan, Michael, Rudensky, Bernard, Caplan, Michael, Hammerman, Cathy·2005·The Journal of Pediatrics
DOI 10.1016/j.jpeds.2005.03.054
Open this paper in CoChat — free account

Abstract

Objective To test the hypothesis that normalizing the intestinal flora by administration of prophylactic probiotics would provide a natural defense, thereby reducing both the incidence and severity of necrotizing enterocolitis (NEC) in preterm neonates. Study design Neonates < or =1500 g birth weight were randomized to either receive a daily feeding supplementation with a probiotic mixture (Bifidobacteria infantis, Streptococcus thermophilus, and Bifidobacteria bifidus; Solgar, Israel) of 10(9) colony forming units (CFU)/day or to not receive feed supplements. NEC was graded according to Bell's criteria. Results For 72 study and 73 control infants, respectively, birth weight (1152 +/- 262 g vs 1111 +/- 278 g), gestational age (30 +/- 3 weeks vs 29 +/- 4 weeks), and time to reach full feeds (14.6 +/- 8.7 days vs 17.5 +/- 13.6 days) were not different. The incidence of NEC was reduced in the study group (4% vs 16.4%; P=.03). NEC was less severe in the probiotic-supplemented infants (Bell's criteria 2.3 +/- 0.5 vs 1.3 +/- 0.5; P=.005). Three of 15 babies who developed NEC died, and all NEC-related deaths occurred in control infants. Conclusion Probiotic supplementation reduced both the incidence and severity of NEC in our premature neonatal population.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.jpeds.2005.03.054

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 28 references

Cited by

Sorted by citations

Items 401–500 of 586

Related

See all

Metadata

Authors
Bin-Nun, A., Bromiker, R., Wilschanski, M., Kaplan, M., Rudensky, B., Caplan, M., & Hammerman, C.
Affiliations
Ben-Gurion University of the Negev (IL)
Corresponding author
Hammerman, Cathy
ORCID
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
2005-08
Volume
147
Issue
2
Pages
192-196
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/j.jpeds.2005.03.054
OpenAlex
W2100119754
Cited by
590
References
28
Citations by year
2026: 7 · 2025: 6 · 2024: 14 · 2023: 20 · 2022: 8 · 2021: 16 · 2020: 11 · 2019: 18 · 2018: 12 · 2017: 24 · 2016: 60 · 2015: 36 · 2014: 34 · 2013: 41 · 2012: 45
FWCI
33.33
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
Keywords
necrotizing enterocolitis, probiotics, very low birth weight infants, preterm infants, Bifidobacterium infantis, Streptococcus thermophilus, Bifidobacterium bifidum, probiotic supplementation, gut microbiota, NEC incidence, NEC severity, NEC mortality
MeSH terms
Administration, Oral, Apgar Score, Bifidobacterium, Female, Gestational Age, Humans, Infant, Newborn, Male, Severity of Illness Index, Infant, Very Low Birth Weight, Probiotics, Enterocolitis, Necrotizing, Streptococcus thermophilus

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review