Oral Probiotics Prevent Necrotizing Enterocolitis in Very Low Birth Weight Preterm Infants: A Multicenter, Randomized, Controlled Trial

Lin, Hung-Chih; Hsu, Chyong-Hsin; Chen, Hsiu-Lin; Chung, Mei-Yung; Hsu, Jen-Fu; Lien, Rey-in; Tsao, Lon-Yen; Chen, Chao-Huei; Su, Bai-Horng

doi:10.1542/peds.2007-3007

Cited by 506Infant Nutrition and HealthProbiotics and Fermented FoodsNeonatal and Maternal Infections

Oral Probiotics Prevent Necrotizing Enterocolitis in Very Low Birth Weight Preterm Infants: A Multicenter, Randomized, Controlled Trial

Lin, Hung-Chih, Hsu, Chyong-Hsin, Chen, Hsiu-Lin, Chung, Mei-Yung, Hsu, Jen-Fu, Lien, Rey-in, Tsao, Lon-Yen, Chen, Chao-Huei +1 more·2008·Pediatrics

DOI 10.1542/peds.2007-3007

Open this paper in CoChat — free account

Abstract

OBJECTIVE. The goal was to investigate the efficacy of orally administered probiotics in preventing necrotizing enterocolitis for very low birth weight preterm infants. METHODS. A prospective, blinded, randomized, multicenter controlled trial was conducted at 7 NICUs in Taiwan, to evaluate the beneficial effects of probiotics in necrotizing enterocolitis among very low birth weight infants (birth weight: <1500 g). Very low birth weight infants who survived to start enteral feeding were eligible and were assigned randomly to 2 groups after parental informed consent was obtained. Infants in the study group were given Bifidobacterium bifidum and Lactobacillus acidophilus, added to breast milk or mixed feeding (breast milk and formula), twice daily for 6 weeks. Infants in the control group were fed with breast milk or mixed feeding. The clinicians caring for the infants were blinded to the group assignment. The primary outcome measurement was death or necrotizing enterocolitis (Bell's stage ≥2). RESULTS. Four hundred thirty-four infants were enrolled, 217 in the study group and 217 in the control group. The incidence of death or necrotizing enterocolitis (stage ≥2) was significantly lower in the study group (4 of 217 infants vs 20 of 217 infants). The incidence of necrotizing enterocolitis (stage ≥2) was lower in the study group, compared with the control group (4 of 217 infants vs 14 of 217 infants). No adverse effect, such as sepsis, flatulence, or diarrhea, was noted. CONCLUSION. Probiotics, in the form of Bifidobacterium and Lactobacillus, fed enterally to very low birth weight preterm infants for 6 weeks reduced the incidence of death or necrotizing enterocolitis.

Integrity signals

Registry

Crossref · 10.1542/peds.2007-3007

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Different bifidobacteria species, mostly combined with St. thermophilus and/or Lb. acidophilus, have been shown to be effective in the prevention of necrotizing enterocolitis in children.
“as well as in the prevention of necrotizing enterocolitis in children [138,145,146]”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [138]
A commercial product containing B. infantis reduces the incidence and severity of necrotizing enterocolitis in very-low-birth-weight infants and preterm infants.
“A commercial product containing a strain of B. infantis was able to reduce the incidence and severity of NEC in very-low-birth-weight infants (146) and in very-low-birth-weight preterm infants (147).”
From Bifidobacteria and Their Health-Promoting Effects (2017) · cites this paper as [147]
Randomised controlled trials support a protective role of probiotics against necrotising enterocolitis.
“randomised controlled trials support a protective role of probiotics.162,163”
From The microbiome and critical illness (2016) · cites this paper as [163]

Neonatal Necrotizing Enterocolitis
BELL, M. J., Ternberg, J. L., Feigin, R. D., Keating, J., MARSHALL, R., Barton, L. L., & Brotherton, T. J. (1978) · Annals of Surgery · doi:10.1097/00000658-197801000-00001 · Cited by 3,582 · see citing works
Analysis of Intestinal Flora Development in Breast-Fed and Formula-Fed Infants by Using Molecular Identification and Detection Methods
Harmsen, H. J. M., Wildeboer-Veloo, A. C. M., Raangs, G. C., Wagendorp, A. A., Klijn, N., BINDELS, J. G., & Welling, G. W. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200001000-00019 · Cited by 1,326 · see citing works
The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract
Schell, M. A., Karmirantzou, M., Snel, ‎., Vilanova, D., Berger, B. W., Pessi, G., Zwahlen, M.-C., Desiere, F., Peer Bork, B., Delley, M., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212527599 · Cited by 942 · see citing works
Necrotising enterocolitis
Lin, P. W., & Stoll, B. J. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69525-1 · Cited by 869 · see citing works
Molecular Monitoring of Succession of Bacterial Communities in Human Neonates
Favier, C. F., Vaughan, E. E., de Vos, W. M., & Akkermans, A. D. L. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.1.219-226.2002 · Cited by 859 · see citing works
Prokaryotic Regulation of Epithelial Responses by Inhibition of IκB-α Ubiquitination
Neish, A. S., Gewirtz, A. T., Zeng, H., Young, A. N., Hobert, M. E., Karmali, V., Rao, A. S., & Madara, J. (2000) · Science · doi:10.1126/science.289.5484.1560 · Cited by 843 · see citing works
Neurodevelopmental and Growth Outcomes of Extremely Low Birth Weight Infants After Necrotizing Enterocolitis
Hintz, S. R., Kendrick, D. E., Stoll, B. J., et al. (2005) · PEDIATRICS · doi:10.1542/peds.2004-0569 · Cited by 774 · see citing works
Oral Probiotics Reduce the Incidence and Severity of Necrotizing Enterocolitis in Very Low Birth Weight Infants
Lin, H.-C., Su, B.-H., Chen, A.-C., Lin, T.-W., Tsai, C.-H., Yeh, T.-F., & Oh, W. (2005) · Pediatrics · doi:10.1542/peds.2004-1463 · Cited by 660 · see citing works
Self-citation
Oral Probiotics Prevent Necrotizing Enterocolitis in Very Low Birth Weight Neonates
Bin-Nun, A., Bromiker, R., Wilschanski, M., Kaplan, M., Rudensky, B., Caplan, M., & Hammerman, C. (2005) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2005.03.054 · Cited by 590 · see citing works
Supply of Pre- and Probiotics Reduces Bacterial Infection Rates After Liver Transplantation—A Randomized, Double-Blind Trial
Rayes, N., Seehofer, D., Theruvath, T. P., Schiller, R. A., Langrehr, J. M., Jonas, S., Bengmark, S., & Neuhaus, P. (2005) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2004.00649.x · Cited by 477 · see citing works
<i>Lactobacillus</i> Bacteremia, Clinical Significance, and Patient Outcome, with Special Focus on Probiotic <i>L. Rhamnosus</i> GG
Salminen, M. K., Rautelin, H., Tynkkynen, S., Poussa, T., Saxelin, M., Valtonen, V., & Jarvinen, A. (2004) · Clinical Infectious Diseases · doi:10.1086/380455 · Cited by 426 · see citing works
Hypothesis: inappropriate colonization of the premature intestine can cause neonatal necrotizing enterocolitis
Claud, E. C., & Walker, W. A. (2001) · The FASEB Journal · doi:10.1096/fj.00-0833hyp · Cited by 415 · see citing works
The NICHD neonatal research network: changes in practice and outcomes during the first 15 years.
Fanaroff, A., Hack, M., & Walsh, M. (2003) · Seminars in Perinatology · doi:10.1016/s0146-0005(03)00055-7 · Cited by 388 · see citing works
Stool microflora in extremely low birthweight infants
Gewolb, I. H., Schwalbe, R. S., Taciak, V. L., Harrison, T. S., & Panigrahi, P. (1999) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.80.3.f167 · Cited by 355 · see citing works
The intestine and its microflora are partners for the protection of the host: report on the Danone Symposium “The Intelligent Intestine,” held in Paris, June 14, 2002
Bourlioux, P., Koletzko, B. V., Guarner, F., & Braesco, V. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.4.675 · Cited by 348 · see citing works
Necrotising enterocolitis hospitalisations among neonates in the United States
Holman, R. C., Stoll, B. J., Curns, A. T., Christensen, K. L. Y., Steiner, C., & Schonberger, L. B. (2006) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2006.00756.x · Cited by 345 · see citing works
Probiotics for prevention of necrotising enterocolitis in preterm neonates with very low birthweight: a systematic review of randomised controlled trials
Deshpande, G. C., Rao, S. C., & Patole, S. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60748-x · Cited by 337 · see citing works
Infections in VLBW infants: studies from the NICHD Neonatal Research Network.
Stoll, B., & Hansen, N. (2003) · Seminars in Perinatology · doi:10.1016/s0146-0005(03)00046-6 · Cited by 329 · see citing works
Two cases of Lactobacillus bacteremia during probiotic treatment of short gut syndrome
Kunz, A. N., Noel, J. M., & Fairchok, M. P. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200404000-00017 · Cited by 319 · see citing works
Bifidobacterial supplementation reduces the incidence of necrotizing enterocolitis in a neonatal rat model
Caplan, M. S., Miller–Catchpole, R., Kaup, S. M., Russell, T., Lickerman, M. J., Amer, M. D., Xiao, Y., & Thomson, R. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70450-6 · Cited by 269 · see citing works
Neonatal gut barrier and multiple organ failure: role of endotoxin and proinflammatory cytokines in sepsis and necrotizing enterocolitis
Sharma, R. R., Tepas, J. J., Hudak, M. L., et al. (2007) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2006.10.038 · Cited by 212 · see citing works
Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-κB activation
Riedel, C. U. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i23.3729 · Cited by 210 · see citing works
Clostridial pathogenicity in experimental necrotising enterocolitis in gnotobiotic quails and protective role of bifidobacteria
Butel, M. J., Roland, N., Hibert, A., Popot, F., Favre, A., Tessèdre, A., Bensaada, M., Rimbault, A., & Szylit, O. (1998) · Journal of Medical Microbiology · doi:10.1099/00222615-47-5-391 · Cited by 181 · see citing works
The intestinal LABs.
Vaughan, E. E., de Vries, M. C., Zoetendal, E. G., Amor, K. B., Akkermans, A. D. L., & de Vos, W. M. (2002) · PubMed · Cited by 175 · see citing works
Conditions of Bifidobacterial Colonization in Preterm Infants: A Prospective Analysis
Butel, M., Suau, A., Campeotto, F., Magne, F., Aires, J., Ferraris, L., Kalach, N., Leroux, B., & Dupont, C. M. (2007) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3180406b20 · Cited by 170 · see citing works
CYTOKINES IN NECROTIZING ENTEROCOLITIS
Markel, T. A., Crisostomo, P. R., Wairiuko, G. M., Pitcher, J. M., Tsai, B. M., & Meldrum, D. R. (2006) · Shock · doi:10.1097/01.shk.0000192126.33823.87 · Cited by 144 · see citing works
The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis
Caplan, M. S., Simon, D., & Jilling, T. (2005) · Seminars in Pediatric Surgery · doi:10.1053/j.sempedsurg.2005.05.002 · Cited by 140 · see citing works
The Developing Intestinal Ecosystem: Implications for the Neonate
Caicedo, R. A., Schanler, R. J., Li, N., & Neu, J. (2005) · Pediatric Research · doi:10.1203/01.pdr.0000180533.09295.84 · Cited by 136 · see citing works
Colonization of congenitally immunodeficient mice with probiotic bacteria
Wagner, R. D., WARNER, T. F. C. S., Roberts, L., Farmer, J., & Balish, E. (1997) · Infection and Immunity · doi:10.1128/iai.65.8.3345-3351.1997 · Cited by 129 · see citing works
Up-Regulation of IL-18 and IL-12 in the Ileum of Neonatal Rats with Necrotizing Enterocolitis
Halpern, M. D., Holubec, H., Dominguez, J. A., et al. (2002) · Pediatric Research · doi:10.1203/00006450-200206000-00012 · Cited by 123 · see citing works
Cutting Edge: Bacterial Modulation of Epithelial Signaling via Changes in Neddylation of Cullin-1
Collier-Hyams, L. S., Sloane, V. M., Batten, B. C., & Neish, A. S. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4194 · Cited by 119 · see citing works
Design of a multispecies probiotic mixture to prevent infectious complications in critically ill patients
Timmerman, H. M., Niers, L. E. M., Ridwan, B. U., Koning, C. J., Mulder, L. H. C., Akkermans, L. M. A., Rombouts, F. M., & Rijkers, G. T. (2007) · Clinical Nutrition · doi:10.1016/j.clnu.2007.04.008 · Cited by 113 · see citing works
INFLAMMATORY CYTOKINE mRNAs IN SURGICAL SPECIMENS OF NECROTIZING ENTEROCOLITIS AND NORMAL NEWBORN INTESTINE
Viscardi, R. M., Lyon, N. H., Sun, C. J., Hebel, J. R., & Hasday, J. D. (1997) · Pediatric Pathology & Laboratory Medicine · doi:10.1080/15513819709168731 · Cited by 109 · see citing works
Effects of Lactobacillus GG Yogurt on Human Intestinal Microecology in Japanese Subjects
Benno, Y., He, F., Hosoda, M., Hashimoto, H., KOJIMA, T. U., Yamazaki, K., UNO, H., Mykkänen, H. M., & Salminen, S. (1996) · Nutrition Today · doi:10.1097/00017285-199611001-00004 · Cited by 84 · see citing works
Endocarditis by Lactobacillus rhamnosus due to Yogurt Ingestion?
Presterl, E. (2001) · Scandinavian Journal of Infectious Diseases · doi:10.1080/00365540110026953 · Cited by 84 · see citing works
Development of the Intestinal Mucosal Barrier
Walker, W. A. (2002) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200205001-00009 · Cited by 82 · see citing works
Microbes and the Developing Gastrointestinal Tract
Neu, J., Douglas‐Escobar, M., & Lopez, M. (2007) · Nutrition in Clinical Practice · doi:10.1177/0115426507022002174 · Cited by 81 · see citing works
Concentrations of IL-10 in preterm human milk and in milk from mothers of infants with necrotizing enterocolitis
Fituch, C. C., Palkowetz, K. H., Goldman, A. S., & Schanler, R. J. (2004) · Acta Paediatrica · doi:10.1080/08035250410022314 · Cited by 68 · see citing works
Probiotic lactobacilli and bacteraemia in Stockholm
Sullivan, Å., & Nord, C. E. (2006) · Scandinavian Journal of Infectious Diseases · doi:10.1080/00365540500449826 · Cited by 66 · see citing works
Oral administration of Bifidobacterium longum prevents gut-derived Pseudomonas aeruginosa sepsis in mice
Matsumoto, T., Ishikawa, H., Tateda, K., Yaeshima, T., Ishibashi, N., & Yamaguchi, K. (2007) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2007.03593.x · Cited by 64 · see citing works
Identification and screening for antimicrobial activity against Clostridium difficile of Bifidobacterium and Lactobacillus species isolated from healthy infant faeces
Lee, Y.-J., Yu, W.-K., & Heo, T. (2003) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(02)00389-8 · Cited by 62 · see citing works
Concentrations of IL‐10 in preterm human milk and in milk from mothers of infants with necrotizing enterocolitis
Fituch, C. C., Palkowetz, K. H., Goldman, A., et al. (2004) · Acta Paediatrica · doi:10.1111/j.1651-2227.2004.tb02636.x · Cited by 55 · see citing works
Germ warfare: probiotics in defense of the premature gut
Hammerman, C., Bin‐Nun, A., & Kaplan, M. (2004) · Clinics in Perinatology · doi:10.1016/j.clp.2004.04.015 · Cited by 44 · see citing works
Bacterial Colonization of the Neonatal Gut
Pietzak, M. M. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200404000-00005 · Cited by 37 · see citing works
Colonization of the Human Gastrointestinal Tract by Probiotic Bacteria
Saxelin, M. (1996) · Nutrition Today · doi:10.1097/00017285-199611001-00003 · Cited by 37 · see citing works
Probiotics and necrotising enterocolitis in premature infants
Schanler, R. J. (2006) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/adc.2005.092742 · Cited by 35 · see citing works
Short Communication. Age at Onset of Necrotizing Enterocolitis
Wilson, R., Kanto, W. P., McCarthy, B. J., et al. (1982) · Pediatric Research · doi:10.1203/00006450-198201001-00017 · Cited by 34 · see citing works
The effect of protective nutrients on mucosal defense in the immature intestine
Forchielli, M. L., & Walker, W. A. (2005) · Acta Paediatrica · doi:10.1111/j.1651-2227.2005.tb02159.x · Cited by 30 · see citing works
Role of bacterial colonization in neonatal necrotizing enterocolitis and its prevention.
Dai, D., & Walker, W. A. (1999) · PubMed · Cited by 29 · see citing works
Adverse Host Responses to Bacterial Toxins in Human Infants
Shah, U. S., & Walker, W. A. (2000) · Journal of Nutrition · doi:10.1093/jn/130.2.420s · Cited by 17 · see citing works
Advances in fetal and neonatal surgery for gastrointestinal anomalies and disease
Cass, D. L., & Wesson, D. E. (2002) · Clinics in Perinatology · doi:10.1016/s0095-5108(03)00062-9 · Cited by 14 · see citing works
Inflammatory Cytokine mRNAs in Surgical Specimens of Necrotizing Enterocolitis and Normal Newborn Intestine
Viscardi, R. M., Lyon, N., Sun, C. J., et al. (1997) · Fetal and Pediatric Pathology · doi:10.3109/15513819709168731 · Cited by 9 · see citing works
The Intestinal LABs
Vaughan, E. E., de Vries, M. C., Zoetendal, E. G., et al. (2002) · Springer eBooks · doi:10.1007/978-94-017-2029-8_23 · Cited by 5 · see citing works

Flagged first, then by citations

Sorted by citations

Necrotizing Enterocolitis
Neu, J., & Walker, W. A. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1005408 · Cited by 2,141 · see citing works
Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function
Abreu, M. T. (2010) · Nature Reviews Immunology · doi:10.1038/nri2707 · Cited by 1,288 · see citing works
Probiotics and the gut microbiota in intestinal health and disease
Gareau, M. G., Sherman, P. M., & Walker, W. A. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.117 · Cited by 907 · see citing works
Safety assessment of probiotics for human use
Sanders, M. E., Akkermans, L. M. A., Haller, D., Hammerman, C., Heimbach, J. T., Hörmannsperger, G., & Huys, G. (2010) · Gut Microbes · doi:10.4161/gmic.1.3.12127 · Cited by 816 · see citing works
Bifidobacteria and Their Health-Promoting Effects
Hidalgo-Cantabrana, C., Delgado, S., Ruiz, L., Ruas-Madiedo, P., Sánchez, B., & Margolles, A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0010-2016 · Cited by 490 · see citing works
The microbiome and critical illness
Dickson, R. P. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00427-0 · Cited by 460 · see citing works
Breast milk oligosaccharides: structure-function relationships in the neonate
Smilowitz, J. T., Lebrilla, C. B., Mills, D. A., German, J. B., & Freeman, S. L. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071813-105721 · Cited by 410 · see citing works
Bifidobacterium breve BBG-001 in very preterm infants: a randomised controlled phase 3 trial
Costeloe, K., Hardy, P., Juszczak, E., Wilks, M., & Millar, M. R. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01027-2 · Cited by 387 · see citing works
A systematic review of the safety of probiotics
Didari, T., Solki, S., Mozaffari, S., Nikfar, S., & Abdollahi, M. (2014) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2014.872627 · Cited by 367 · see citing works
Intestinal nitrogen recycling and utilization in health and disease
Bergen, W. G., & Wu, G. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.104497 · Cited by 183 · see citing works
Probiotics for Preterm Infants: A Strain‐Specific Systematic Review and Network Meta‐analysis
van den Akker, C. H. P., van Goudoever, J. B., Szajewska, H., Embleton, N. D., Hojsak, I., Reid, D., Shamir, R., & ESPGHAN Working Group for Probiotics, P. &. C. O. N. (2018) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001897 · Cited by 167 · see citing works
Safety of probiotics in patients receiving nutritional support: A systematic review of case reports, randomized controlled trials, and nonrandomized trials
Whelan, K., & Myers, C. E. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28759 · Cited by 161 · see citing works
Initial Intestinal Colonization in the Human Infant and Immune Homeostasis
Walker, W. A. (2013) · Annals of Nutrition and Metabolism · doi:10.1159/000354907 · Cited by 161 · see citing works
Recommendations for Probiotic Use—2015 Update: Proceedings and Consensus Opinion
Floch, M. H., Walker, W. A., Sanders, M. E., Nieuwdorp, M., Kim, A. S., Brenner, D. A., Qamar, A. A., Miloh, T. A., Guarino, A., Guslandi, M., et al. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000420 · Cited by 119 · see citing works
Probiotic sepsis in preterm neonates-a systematic review
Kulkarni, T., Majarikar, S., Deshmukh, M., Ananthan, A., Balasubramanian, H., Keil, A., & Patole, S. (2022) · European Journal of Pediatrics · doi:10.1007/s00431-022-04452-5 · Cited by 71 · see citing works
Facultative to strict anaerobes ratio in the preterm infant microbiota: A target for intervention?
Arboleya, S., Solís, G., Fernández, N., de los Reyes-Gavilán, C. G., & Gueimonde, M. (2012) · Gut Microbes · doi:10.4161/gmic.21942 · Cited by 74 · see citing works
Using probiotics in the paediatric population
Marchand, V. (2012) · Paediatrics & Child Health · doi:10.1093/pch/17.10.575 · Cited by 42 · see citing works
Maternal Fish Consumption in Pregnancy Is Associated with a Bifidobacterium-Dominant Microbiome Profile in Infants
Simione, M., Harshman, S. G., Castro, I., Linnemann, R., Roche, B., Ajami, N. J., Petrosino, J. F., Raspini, B., Portale, S., Camargo, Jr., et al. (2020) · Current Developments in Nutrition · doi:10.1093/cdn/nzz133 · Cited by 13 · see citing works

NECROTIZING ENTEROCOLITIS IN THE ERA OF INCREASING DONOR BREAST MILK USE IN PREMATURE INFANTS.
Bishop, C., Blanco, C. L., Burney, K., et al. (2007) · Journal of Investigative Medicine · doi:10.1097/00042871-200701010-00763
The role of human milk nutrients in preventing necrotizing enterocolitis
Sami, A. S., Frazer, L. C., Miller, C. M., Singh, D. K., Clodfelter, L. G., Orgel, K., & Good, M. L. (2023) · Frontiers in Pediatrics · doi:10.3389/fped.2023.1188050 · Cited by 28 · see citing works
Detection of bifidobacterium and lactobacillus in Hirschsprung's disease associated enterocolitis by realtime quantitative PCR
Sun, L.-P. (2007) · Zhonghua xiaoerwaike zazhi
Human breast milk exosomes may protect against necrotizing enterocolitis in preterm infants
Madden, J. W. (2021) · Pediatric Research · doi:10.1038/s41390-021-01580-w · Cited by 11 · see citing works
Nutritional Modulation of Neonatal Outcomes
Diehl‐Jones, W. L., & Askin, D. F. (2004) · AACN Clinical Issues Advanced Practice in Acute & Critical Care · doi:10.1097/00044067-200401000-00007 · Cited by 38 · see citing works

Authors: Lin, H.-C., Hsu, C.-H., Chen, H.-L., Chung, M.-Y., Hsu, J.-F., Lien, R.-I., Tsao, L.-Y., Chen, C.-H., & Su, B.-H.
Affiliations: China Medical University (TW)
Mackay Memorial Hospital (TW)
Kaohsiung Medical University (TW)
Kaohsiung Chang Gung Memorial Hospital (TW)
Chang Gung Children's Hospital (TW)
Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, Taiwan
Changhua Christian Hospital (TW)
Taichung Veterans General Hospital (TW)
ORCID: Lin, Hung-Chih
Chen, Hsiu-Lin
Chung, Mei-Yung
Hsu, Jen-Fu
Chen, Chao-Huei
Venue: Pediatrics
Publisher: American Academy of Pediatrics (AAP)
Published: 2008-10-01
Volume: 122
Issue: 4
Pages: 693-700
ISSN: 0031-4005 (ISSN-L)
1098-4275
DOI: 10.1542/peds.2007-3007
OpenAlex: W2120528311
Cited by: 506
References: 53
Citations by year: 2026: 4 · 2025: 4 · 2024: 13 · 2023: 24 · 2022: 22 · 2021: 20 · 2020: 18 · 2019: 26 · 2018: 17 · 2017: 34 · 2016: 34 · 2015: 38 · 2014: 45 · 2013: 59 · 2012: 47
FWCI: 32.12
Type: journal article
Language: en
Open access: closed
Locations: PEDIATRICS (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Board
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
Keywords: probiotics, necrotizing enterocolitis, very low birth weight infants, preterm infants, Bifidobacterium bifidum, Lactobacillus acidophilus, enteral nutrition, breast milk, mixed feeding, neonatal mortality, neonatal intensive care
MeSH terms: Administration, Oral, Bifidobacterium, Female, Follow-Up Studies, Humans, Infant, Newborn, Infant, Premature, Lactobacillus acidophilus, Male, Pilot Projects, Prospective Studies, Taiwan, Incidence, Survival Rate, Single-Blind Method, Treatment Outcome, Infant, Very Low Birth Weight, Probiotics, Enterocolitis, Necrotizing

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oral Probiotics Prevent Necrotizing Enterocolitis in Very Low Birth Weight Preterm Infants: A Multicenter, Randomized, Controlled Trial

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks