Dermatological Complications of Continuous Subcutaneous Insulin Infusion in Children and Adolescents
Abstract
Objectives To describe the dermatological changes associated with continuous subcutaneous insulin infusion (CSII) therapy in youth with type 1 diabetes mellitus (T1D). To assess their association with duration of CSII, age, adiposity, HbA1(c), insulin dose, insulin brand, infusion set or site. Study design We conducted a cross-sectional study of 50 consecutive patients with T1D who were using CSII for >6 months (26 female; age, 13.3 +/- 3.5 years [mean +/- SD]; CSII duration, 2.8 +/- 1.7 years; HbA1(c), 7.7% +/- 1.1%). A grading scale was devised. Ultrasound scanning was performed in 8 subjects. Results The mean (+/-SD) severity score was 6.3 +/- 3.5 (range, 0-14; maximum possible, 69). Most common were scars Conclusions Dermatological changes were frequent, with increased severity associated with lower adiposity. These complications were not associated with glycemic control, nor did they prompt most to consider stopping CSII.
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The acute inflammatory response and the infusion of insulin may directly increase local blood flow, which may contribute to increased insulin uptake on day 5 of catheter wear-time.
“Furthermore, the acute inflammatory response and the infusion of insulin may directly increase local blood flow,33–38 which may contribute to increased insulin uptake on day 5 of catheter wear-time.”
From Detailed Analysis of Insulin Absorption Variability and the Tissue Response to Continuous Subcutaneous Insulin Infusion Catheter Implantation in Swine (2017) · cites this paper as [33]
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- Authors
- Conwell, L. S., Pope, E., Artiles, A. M., Mohanta, A., Daneman, A., & Daneman, D.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Daneman, Denis
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 152
- Issue
- 5
- Pages
- 622-628
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2001685706
- Cited by
- 111
- References
- 1
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 11 · 2022: 17 · 2021: 9 · 2020: 7 · 2019: 6 · 2018: 8 · 2017: 7 · 2016: 5 · 2015: 6 · 2014: 8 · 2013: 2 · 2012: 3
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Keywords
- insulin pump therapy, type 1 diabetes, pediatric diabetes, adolescents, skin complications, lipohypertrophy, subcutaneous nodules, erythema, body mass index, glycemic control
- MeSH terms
- Adolescent, Age Factors, Child, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Female, Humans, Hypoglycemic Agents, Insulin, Insulin Infusion Systems, Male, Severity of Illness Index, Skin Diseases, Ultrasonography, Cohort Studies, Adiposity
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