Nonmetabolic Complications of Continuous Subcutaneous Insulin Infusion: A Patient Survey

Pickup, John C.; Yemane, Nardos; Brackenridge, Anna; Pender, Siobhan

doi:10.1089/dia.2013.0192

Cited by 123Diabetes Management and ResearchDiabetes Management and EducationIntravenous Infusion Technology and Safety

Nonmetabolic Complications of Continuous Subcutaneous Insulin Infusion: A Patient Survey

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Pickup, John C., Yemane, Nardos, Brackenridge, Anna, Pender, Siobhan·2014·Diabetes Technology & Therapeutics

DOI 10.1089/dia.2013.0192PMC PMC3934434

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Abstract

Background Little is known about the frequencies and types of nonmetabolic complications occurring in type 1 diabetes patients being treated by modern insulin pump therapy (continuous subcutaneous insulin infusion [CSII]), when recorded by standardized questionnaire rather than clinical experience. Subjects and methods A self-report questionnaire was completed by successive subjects with type 1 diabetes attending an insulin pump clinic, and those with a duration of CSII of ≥6 months were selected for analysis (n=92). Questions included pump manufacturer, insulin, infusion set type and duration of use, frequency of infusion set and site problems, pump malfunctions, and patient-related problems such as weight change since starting CSII. Results Median (range) duration of CSII was 3.3 (0.5-32.0) years, and mean ± SD duration of infusion set use was 3.2 ± 0.7 (range 2-6) days. The commonest infusion set problems were kinking (64.1% of subjects) and blockage (54.3%). Blockage was associated with >3 days of use of infusion sets plus lispro insulin in the pump (relative risk [95% confidence interval], 1.71 [1.03-2.85]; P=0.07). The commonest infusion site problem was lipohypertrophy (26.1%), which occurred more often in those with long duration of CSII (4.8 [2.38-9.45] vs. 3.0 [1.50-4.25] years; P=0.01). Pump malfunction had occurred in 48% of subjects (43% in the first year of CSII), with "no delivery," keypad, and battery problems commonly occurring. Although some patients reporte…

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The success of insulin pump therapy may be dependent on the robustness of insertion methods to avoid catheter kinking and failed delivery of insulin into the tissue.
“The success of insulin pump therapy may further be dependent on the robustness of insertion methods to avoid issues such as catheter kinking and therefore failed delivery of insulin into the tissue.”
From Detailed Analysis of Insulin Absorption Variability and the Tissue Response to Continuous Subcutaneous Insulin Infusion Catheter Implantation in Swine (2017) · cites this paper as [18]
The infusion site skin infection rate in this study was lower than the self-reported rates of 17.4% and 28% by individuals who completed survey reporting on a prior year of standard IIS use.
“This rate was lower than the self-reported rates of 17.4%16 and 28%17 by individuals who completed survey reporting on a prior year of standard IIS use.”
From Evaluation of Extended Infusion Set Performance in Adults with Type 1 Diabetes: Infusion Set Survival Rate and Glycemic Outcomes from a Pivotal Trial (2022) · cites this paper as [16]

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus
(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667 · see citing works
Severe hypoglycaemia and glycaemic control in Type 1 diabetes: meta‐analysis of multiple daily insulin injections compared with continuous subcutaneous insulin infusion
Pickup, J. C., & Sutton, A. J. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2008.02486.x · Cited by 618 · see citing works
Self-citation
Use of Insulin Pump Therapy in the Pediatric Age-Group
Phillip, M., Battelino, T., Rodriguez, H., Danne, T., KAUFMAN, F. R., & participants, F. T. C. F. (2007) · Diabetes Care · doi:10.2337/dc07-9922 · Cited by 311 · see citing works
Insulin-pump therapy for type 1 diabetes mellitus
Pickup, J. C. (2012) · New England Journal of Medicine · doi:10.1056/nejmct1113948 · Cited by 270 · see citing works
Self-citation
Continuous Subcutaneous Insulin Infusion Versus Multiple Daily Injections
Retnakaran, R. R., Hochman, J., DeVries, J. H., Hanaire, H. P., Heine, R. J., Melki, V., & Zinman, B. (2004) · Diabetes Care · doi:10.2337/diacare.27.11.2590 · Cited by 214 · see citing works
Diabetic Lipohypertrophy Delays Insulin Absorption
Young, R. J., Hannan, W. J., Frier, B. M., Steel, J. M., & Duncan, L. J. P. (1984) · Diabetes Care · doi:10.2337/diacare.7.5.479 · Cited by 145 · see citing works
Dermatological Complications of Continuous Subcutaneous Insulin Infusion in Children and Adolescents
Conwell, L. S., Pope, E., Artiles, A. M., Mohanta, A., Daneman, A., & Daneman, D. (2008) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2007.10.006 · Cited by 111 · see citing works
Continuous subcutaneous insulin infusion (CSII) 30 years later: still the best option for insulin therapy
Bruttomesso, D., Costa, S., & Baritussio, A. (2009) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.931 · Cited by 98 · see citing works
Pilot Study for Assessment of Optimal Frequency for Changing Catheters in Insulin Pump Therapy—Trouble Starts on Day 3
Schmid, V., Hohberg, C., Borchert, M., Forst, T., & Pfützner, A. (2010) · Journal of Diabetes Science and Technology · doi:10.1177/193229681000400429 · Cited by 97 · see citing works
Continuous subcutaneous insulin infusion (CSII) in the Veneto region: efficacy, acceptability and quality of life
Bruttomesso, D., Pianta, A., Crazzolara, D., Scaldaferri, E., Lora, L., Guarneri, G., Mongillo, A., Gennaro, R., Miola, M., Moretti, M., et al. (2002) · Diabetic Medicine · doi:10.1046/j.1464-5491.2002.00750.x · Cited by 83 · see citing works
Technical risks with subcutaneous insulin infusion
Guilhem, I., Leguerrier, A., Lecordier, F., Jy, P., & Maugendre, D. (2006) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70281-1 · Cited by 67 · see citing works
Insulin Pump Therapy Guidelines for Successful Outcomes
Scheiner, G., Sobel, R., Smith, D., Pick, A. J., Kruger, D. F., King, J., & Green, K. (2009) · The Science of Diabetes Self-Management and Care · doi:10.1177/0145721709333493 · Cited by 65 · see citing works
Comparison of pharmacokinetic properties, physicochemical stability, and pump compatibility of 3 rapid-acting insulin analogues— aspart, lispro, and glulisine
Bode, B. W. (2011) · Endocrine Practice · doi:10.4158/ep10260.ra · Cited by 56 · see citing works
Laboratory-Based Non-Clinical Comparison of Occlusion Rates Using Three Rapid-Acting Insulin Analogs in Continuous Subcutaneous Insulin Infusion Catheters Using Low Flow Rates
Kerr, D., Morton, J., Whately-Smith, C., Everett, J., & Begley, J. P. (2008) · Journal of Diabetes Science and Technology · doi:10.1177/193229680800200314 · Cited by 55 · see citing works
Adolescent Use of Insulin and Patient-Controlled Analgesia Pump Technology: A 10-Year Food and Drug Administration Retrospective Study of Adverse Events
Cope, J. U., Morrison, A. E., & Samuels‐Reid, J. H. (2008) · PEDIATRICS · doi:10.1542/peds.2007-1707 · Cited by 53 · see citing works
Consequences of delayed pump infusion line change in patients with type 1 diabetes mellitus treated with continuous subcutaneous insulin infusion
Thethi, T. K., Rao, A., Kawji, H., Mallik, T., Yau, C. L., Christians, U., & Fonseca, V. (2010) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2009.03.002 · Cited by 53 · see citing works
Malfunction of Continuous Subcutaneous Insulin Infusion Systems: A One-Year Prospective Study of 127 Patients
Mecklenburg, R. S., Guinn, T. S., Sannar, C., & Blumenstein, B. A. (1986) · Diabetes Care · doi:10.2337/diacare.9.4.351 · Cited by 50 · see citing works
Insulin pump failures are still frequent: a prospective study over 6 years from 2001 to 2007
Guilhem, I., Balkau, B., Lecordier, F., Malécot, J.-M., Elbadii, S., Leguerrier, A.-M., Poirier, J.-Y., Derrien, C., & Bonnet, F. (2009) · Diabetologia · doi:10.1007/s00125-009-1549-7 · Cited by 46 · see citing works
The Role of Basal Insulin and Glucagon-Like Peptide-1 Agonists in the Therapeutic Management of Type 2 Diabetes—A Comprehensive Review
Garg, S. K. (2010) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2009.0127 · Cited by 38 · see citing works
Psychological Aspects in Continuous Subcutaneous Insulin Infusion: A Retrospective Study
Aberle, I., Scholz, U., Bach-Kliegel, B., Fischer, C., Gorny, M., Langer, K., & Kliegel, M. (2009) · The Journal of Psychology · doi:10.3200/jrlp.143.2.147-160 · Cited by 27 · see citing works
Insulin Pump Use in Adults with Type 1 Diabetes—Practical Issues
Shetty, G. K., & Wolpert, H. A. (2010) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2010.0002 · Cited by 21 · see citing works
Insulin Pump Therapy and Continuous Glucose Monitoring
Schütz-Fuhrmann, I., Rami-Merhar, B. M., Fröhlich-Reiterer, E. E., Hofer, S. E., Tauschmann, M., Mader, J. K., Resl, M., Kautzky‐Willer, A., Winhofer-Stöckl, Y., Laimer, M., et al. (2009) · Oxford University Press eBooks · doi:10.1093/med/9780199568604.001.0001 · Cited by 18 · see citing works

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American Association of Clinical Endocrinology clinical practice guideline: the use of advanced technology in the management of persons with diabetes mellitus
Grunberger, G., Sherr, J., Allende, M., Blevins, T., Bode, B., Handelsman, Y., Hellman, R., Lajara, R., Roberts, V. L., Rodbard, D., et al. (2021) · Endocrine Practice · doi:10.1016/j.eprac.2021.04.008 · Cited by 288 · see citing works
Advances in technology for management of type 1 diabetes
Beck, R. W., Bergenstal, R. M., Laffel, L. M., & Pickup, J. C. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31142-0 · Cited by 242 · see citing works
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Latres, E., Finan, D. A., Greenstein, J. L., Kowalski, A. J., & Kieffer, T. J. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.02.007 · Cited by 118 · see citing works
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Clinical review: insulin pump-associated adverse events in adults and children
Ross, P., Milburn, J., Reith, D. M., Wiltshire, E. J., & Wheeler, B. J. (2015) · Acta Diabetologica · doi:10.1007/s00592-015-0784-2 · Cited by 95 · see citing works
Lipohypertrophy in China: Prevalence, Risk Factors, Insulin Consumption, and Clinical Impact
Ji, L., Sun, Z., Li, Q., Qin, G., Wei, Z., Liu, J., Chandran, A., & Hirsch, L. J. (2017) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2016.0334 · Cited by 91 · see citing works
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Nimri, R., Nir, J., & Phillip, M. (2019) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000001097 · Cited by 73 · see citing works
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Deiss, D., Adolfsson, P., Alkemade-van Zomeren, M., Bolli, G. B., Charpentier, G., Cobelli, C., Danne, T., Girelli, A., Mueller, H., Verderese, C. A., et al. (2016) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2016.07281.sf · Cited by 62 · see citing works
Impact of Insulin Injection and Infusion Routines on Lipohypertrophy and Glycemic Control in Children and Adults with Diabetes
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Continuous subcutaneous insulin infusion therapy and multiple daily insulin injections in type 1 diabetes mellitus: a comparative overview and future horizons
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Pfützner, A., Sachsenheimer, D., Grenningloh, M., Heschel, M., Walther-Johannesen, L., Gharabli, R., & Klonoff, D. (2015) · Journal of Diabetes Science and Technology · doi:10.1177/1932296815604438 · Cited by 53 · see citing works
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Phenolic excipients of insulin formulations induce cell death, pro-inflammatory signaling and MCP-1 release
Weber, C., Kammerer, D., Streit, B., & Licht, A. H. (2014) · Toxicology Reports · doi:10.1016/j.toxrep.2014.11.019 · Cited by 48 · see citing works
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“The success of insulin pump therapy may further be dependent on the robustness of insertion methods to avoid issues such as catheter kinking and therefore failed delivery of insulin into the tissue.(18,19) We hypothesize that the flow of insulin from a CSII catheter into adjacent vascular tissue is affected by the cha…”
Background
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Ibrahim, M., Beneyto, A., Contreras, I., & Vehı́, J. (2023) · IFAC-PapersOnLine · doi:10.1016/j.ifacol.2023.10.441 · Cited by 1 · see citing works
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Risi, R., Pauletto, D., Buffi, V. Z., Berna, V., Carafa, A., Barbaro, F., Vita, F. D., D’Onofrio, L., Amendolara, R., Pantano, A. L., et al. (2026) · Diabetes Obesity and Metabolism · doi:10.1111/dom.70629 · Cited by 1 · see citing works
Analysis of “Randomized Cross-Over Study Comparing Two Infusion Sets for CSII in Daily Life”
Renard, É. (2016) · Journal of Diabetes Science and Technology · doi:10.1177/1932296816675177 · Cited by 1 · see citing works
Avaliação dos Efeitos da Transição de Múltiplas Injeções Diárias de Insulina para Infusão Subcutânea Contínua de Insulina no Tratamento Intensivo da Diabetes Mellitus Tipo 1
Oliveira, S. C., Neves, C., Esteves, C., Neves, J. S., Oliveira, A., Pereira, M., Arteiro, C., Costa, A. D., Redondo, M., Baltazar, R., et al. (2019) · Revista Portuguesa de Endocrinologia Diabetes e Metabolismo · doi:10.26497/ao190004 · Cited by 1 · see citing works
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Orbell, S. L., Codario, R. A., Zupa, M. F., & Estock, J. L. (2024) · Journal of Diabetes Science and Technology · doi:10.1177/19322968241254521 · Cited by 1 · see citing works

Perceptions and experiences of adult patients with type 1 diabetes using continuous subcutaneous insulin infusion therapy: Results of an online survey
Taleb, N., Messier, V., Ott-Braschi, S., Ardilouze, J.-L., & Rabasa-Lhoret, R. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.07.035 · Cited by 20 · see citing works
Continuous subcutaneous insulin infusion: A long-term study
Lombardo, A., Scavino, S., Scornavacca, G., Oliva, G., Sipione, C., Cacciola, R. R., & Motta, L. (1986) · Acta Diabetologica · doi:10.1007/bf02581348 · Cited by 2 · see citing works
The Pump Life: Patient Responses and Clinical and Technological Problems
Pickup, J. C., Sherwin, R. S., Tamborlane, W. V., Rizza, R. A., Service, F. J., & The Kroc Collaborative Study Group (1985) · Diabetes · doi:10.2337/diab.34.3.s37 · Cited by 15 · see citing works
Self-citation
Technical risks with subcutaneous insulin infusion
Guilhem, I., Leguerrier, A., Lecordier, F., Jy, P., & Maugendre, D. (2006) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70281-1 · Cited by 67 · see citing works
RESEARCH LETTER
(2001)

Authors: Pickup, J. C., Yemane, N., Brackenridge, A., & Pender, S.
Affiliations: Guy's Hospital (GB)
Guy's and St Thomas' NHS Foundation Trust (GB)
Corresponding author: Pickup, John C.
ORCID: Pickup, John C.
Brackenridge, Anna
Venue: Diabetes Technology & Therapeutics
Publisher: SAGE Publications
Published: 2014-03
Volume: 16
Issue: 3
Pages: 145-149
ISSN: 1520-9156 (ISSN-L)
1557-8593
DOI: 10.1089/dia.2013.0192
PMC: PMC3934434
OpenAlex: W2094458427
Cited by: 123
References: 22
Citations by year: 2026: 4 · 2025: 5 · 2024: 9 · 2023: 11 · 2022: 11 · 2021: 10 · 2020: 3 · 2019: 20 · 2018: 18 · 2017: 10 · 2016: 15 · 2015: 6 · 2014: 1
FWCI: 5.78
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Diabetes Technology & Therapeutics (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: Eli Lilly and Company
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
Physical Sciences › Engineering › Biomedical Engineering › Intravenous Infusion Technology and Safety
Keywords: insulin pump therapy, type 1 diabetes, lipohypertrophy, pump failure, insulin lispro, weight change, patient survey
MeSH terms: Adipose Tissue, Adult, Diabetes Mellitus, Type 1, Female, Humans, Hypertrophy, Hypoglycemic Agents, Injections, Subcutaneous, Insulin, Insulin Infusion Systems, Male, Surveys and Questionnaires, Risk Factors, Weight Gain, Prevalence, Odds Ratio, Treatment Outcome, Health Care Surveys, Self Report

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Nonmetabolic Complications of Continuous Subcutaneous Insulin Infusion: A Patient Survey

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