Hippocampal volume reduction is associated with intellectual functions in adolescents with congenital heart disease
Open accessAbstract
Background Adolescents undergoing early cardiopulmonary bypass surgery for congenital heart disease (CHD) may demonstrate a variety of neurocognitive impairments. These impairments can affect overall intellectual functions, but also specific memory deficits, language, and executive functions. As the hippocampus is a critical structure involved in these functions, we sought to determine whether hippocampal volume was reduced in adolescents with CHD and whether altered volumes were related to functional outcome.Methods At a mean age of 13.8 y, 48 adolescent survivors of childhood cardiopulmonary bypass surgery for CHD and 32 healthy controls underwent neurocognitive testing and cerebral magnetic resonance imaging. Images were quantitatively analyzed using an automated regional segmentation tool (FSL-FIRST).Results Adolescents with CHD had 10% lower total hippocampal volumes compared with controls. After controlling for total brain volume, total hippocampal volume correlated with total IQ, with working memory, and verbal comprehension in CHD patients, but not in controls.Conclusions In adolescent survivors of cardiopulmonary bypass surgery for CHD, specific brain regions such as the hippocampus may show long-term persistent alteration and correlate with intellectual deficits, particularly with verbal and memory functions.
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MRI studies in adolescents with CHD have shown an association between decreased brain volumes and lower Full-scale IQ and executive functioning.
“MRI studies in adolescents with CHD have shown an association between decreased brain volumes and lower Full-scale IQ and executive functioning.22,23”
From Perioperative neonatal brain injury is associated with worse school-age neurodevelopment in children with critical congenital heart disease (2018) · cites this paper as [22]
The Results section, “Correlation Between Hippocampal Volume and Functional Outcome” (page unavailable), reports that smaller hippocampal volume was associated with lower total IQ and working memory in adolescents with CHD. Working memory is relevant to executive functioning, but the paper does not establish an association between brain volume and executive functioning broadly. (LLM, conf=0.83)
Experimental — accuracy not yet measuredDelays in these cognitive functions are also associated with lower hippocampal volume in adolescents with congenital heart disease.
“Delays in these cognitive functions are also associated with lower hippocampal volume in adolescents with CHD. 45”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [45]
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Claessens, N. H. P., Algra, S. O., Ouwehand, T. L., Jansen, N. J. G., Schappin, R., Haas, F., Eijsermans, M. J. C., de Vries, L. S., Benders, M. J. N. L., & CHD Lifespan Study Group Utrecht (2018) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.13747 · Cited by 123 · see citing works
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- Authors
- ; on behalf of the Research Group Heart and Brain., Latal, B., Patel, P., Liamlahi, R., Knirsch, W., O’Gorman Tuura, R., & von Rhein, M.
- Affiliations
- University of Zurich (CH)
- University Children's Hospital Zurich (CH)
- Corresponding author
- Latal, Beatrice
- Venue
- Pediatric Research
- Published
- 2016-06-06
- Volume
- 80
- Issue
- 4
- Pages
- 531-537
- ISSN
- 0031-3998 (ISSN-L)
- 1530-0447
- PMC
- PMC8920533
- OpenAlex
- W2474935243
- Cited by
- 62
- References
- 44
- Citations by year
- 2026: 8 · 2025: 2 · 2024: 8 · 2023: 6 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 1
- FWCI
- 5.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pediatric Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T35HD007446)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- hippocampal volume, congenital heart disease, cardiopulmonary bypass, adolescents, intellectual functioning, IQ, working memory, verbal comprehension, neurocognitive impairment, brain structural changes
- MeSH terms
- Adolescent, Cardiopulmonary Bypass, Child, Preschool, Female, Heart Defects, Congenital, Hippocampus, Humans, Infant, Infant, Newborn, Magnetic Resonance Imaging, Male, Intellectual Disability, Case-Control Studies, Neurocognitive Disorders
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