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Cited by 13Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesCongenital Heart Disease StudiesCardiac Imaging and Diagnostics

Cardiac magnetic resonance imaging in pediatric Turner syndrome

Somerville, Scott, Rosolowsky, Elizabeth, Suntratonpipat, Somjate, Girgis, Rose, Goot, Benjamin H., Tham, Edythe B.·2016·The Journal of Pediatrics
DOI 10.1016/j.jpeds.2016.04.080
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Abstract

Objective To compare the detection of cardiac lesions with the use of cardiac magnetic resonance imaging (CMR) and conventional echocardiography in children with Turner syndrome.Study design Twenty-four girls with Turner syndrome, 8-18 years of age, were recruited through the Pediatric Endocrinology Program. Participants underwent CMR and echocardiography within a 2-year period, and discrepancies between the results of each modality were identified.Results Fifteen of 24 (63%) girls had a cardiac lesion identified on CMR or echocardiography. Both modalities identified the same lesion in 10 of 15 (67%); however, 6 of 15 (40%) participants had a lesion identified on CMR but not echocardiography. Participants with a missed lesion had a trend towards greater body mass index. Aortic dilation and bicuspid aortic valve were the most commonly missed lesions by echocardiography.Conclusions CMR identifies significant cardiac lesions missed by echocardiography in pediatric patients with Turner syndrome, particularly along the aorta. These findings support the current guidelines that recommend screening CMR in addition to echocardiogram. Early identification of cardiac abnormalities in patients with Turner syndrome will allow for a greater understanding of the natural history in these patients and potentially identify candidates for earlier intervention.

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  • CMR is superior to TTE for the diagnosis of BAV, aortic dilation and aortic arch anomalies while also providing important data on shunt fractions and ventricular volumes.

    “CMR is also superior to TTE for the diagnosis of BAV, aortic dilation and aortic arch anomalies395,429-433 while also providing important data on shunt fractions and ventricular volumes that may inform clinical management.388”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [430]

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Authors
Somerville, S., Rosolowsky, E., Suntratonpipat, S., Girgis, R., Goot, B. H., & Tham, E. B.
Affiliations
University of Alberta (CA)
Corresponding author
Tham, Edythe B.
ORCID
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
2016-08
Volume
175
Pages
111-115.e1
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/j.jpeds.2016.04.080
OpenAlex
W2403482054
Cited by
13
References
28
Citations by year
2025: 3 · 2024: 2 · 2022: 3 · 2020: 1 · 2019: 2 · 2018: 2
FWCI
1.08
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Keywords
Turner syndrome, cardiac magnetic resonance imaging, echocardiography, cardiac lesions, aortic dilatation, bicuspid aortic valve, diagnostic accuracy, body mass index, cardiac screening, children
MeSH terms
Adolescent, Child, Cross-Sectional Studies, Echocardiography, Female, Heart, Humans, Magnetic Resonance Imaging, Turner Syndrome

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