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Cited by 30Connective tissue disorders researchGenetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesAortic Disease and Treatment Approaches

Aortic dimensions in Turnerʼs syndrome: two-dimensional echocardiography versus magnetic resonance imaging

Lanzarini, Luca, Larizza, Daniela, Prete, Giovanna, Calcaterra, Valeria, Meloni, Giulia, Sammarchi, Luigi, Klersy, Catherine·2007·Journal of Cardiovascular Medicine
DOI 10.2459/01.jcm.0000269716.33435.d3
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Abstract

BACKGROUND: Patients with Turner's syndrome have an increased risk of cardiac death caused by aortic disease. Consensus has not been reached about the best method to image the aorta in this syndrome. AIM: This present study aimed: (i) to evaluate thoracic and abdominal aortic dimensions by two-dimensional echo (2-DE) and magnetic resonance imaging (MRI) and (ii) to assess agreement between 2-DE and MRI measurements. MATERIAL AND METHODS: Among 75 kariotypically proven Turner's syndrome patients, 59 (79%) (mean age: 22 +/- 7 years) underwent a 2-DE and an MRI study of the thoracic and proximal abdominal aorta. The aortic root (AR), the sino-tubular aortic junction (STJ), the first part of the ascending thoracic aorta (AscTA), the aortic arch (AArch), the descending thoracic aorta (DTAp) a few centimetres below the isthmus and the abdominal aorta (AbA) were analysed. The Bland and Altman method and Lin's concordance correlation coefficient were utilized to compare 2-DE and MRI aortic dimensions. RESULTS: Compared to MRI, feasibility of aortic imaging by 2-DE was identical at AR level, but lower when measuring distal aorta (88% at DTAp and 91.5% at AbA level versus 100%). The 2-DE and MRI showed a very slight difference between measurements and a high concordance correlation coefficient at the level of AR and AscTA; correlations were weaker at the other aortic levels. Absolute differences calculated at each measurement level showed that concordance (defined as differences within 1 mm between 2-DE and MRI absolute measures) was highest at AR (45.6%) and AscTA (28%) level and lowest at STJ (12.2%) level. The 2-DE overestimated aortic arch diameters in approximately 70% of cases, whereas at the remaining aortic levels MRI measurements were usually 1 mm higher compared to the corresponding 2-DE values. CONCLUSIONS: Concordance between 2-DE and MRI was found to be very good at the AR and AscTA levels. Because the risk of aortic complication is higher when AR and proximal thoracic aorta are dilated, 2-DE may be considered a useful method to screen for aortic disease and a good choice to follow proximal aortic dimensions over time in Turner's syndrome patients.

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  • TTE is valuable for the diagnosis and surveillance of CHD and aortic dilation, but may be limited by poor acoustic windows, especially in older children and adults.

    “TTE is valuable for the diagnosis and surveillance of CHD and aortic dilation,426-428 but may be limited by poor acoustic windows, especially in older children and adults.”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [427]

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Authors
Lanzarini, L., Larizza, D., Prete, G., Calcaterra, V., Meloni, G., Sammarchi, L., & Klersy, C.
Affiliations
  • University of Pavia (IT)
  • Policlinico San Matteo Fondazione (IT)
Corresponding author
Lanzarini, Luca
ORCID
Venue
Journal of Cardiovascular Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-06
Volume
8
Issue
6
Pages
428-437
ISSN
1558-2027 (ISSN-L)
DOI
10.2459/01.jcm.0000269716.33435.d3
OpenAlex
W2007019245
Cited by
30
References
37
Citations by year
2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 2
FWCI
0.36
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cardiovascular Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Disease and Treatment Approaches
Keywords
aortic dimensions, aortic root, aortic arch, thoracic aorta, abdominal aorta, two-dimensional echocardiography, magnetic resonance imaging, aortic dilatation, aortic isthmus, aortic arch dilation, aortic root dilatation, aortic arch stenosis
MeSH terms
Adolescent, Adult, Aorta, Abdominal, Aorta, Thoracic, Child, Child, Preschool, Echocardiography, Female, Humans, Magnetic Resonance Imaging, Turner Syndrome

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