Protective effects of grape stem extract against UVB-induced damage in C57BL mice skin
Abstract
Humans have become exposed to another form of a trait which is ultraviolet B (UVB) radiation reaching the earth's surface. This has become a major source of oxidative stress that ultimately leads to inflammation, DNA damage, photoaging and pigmentation disorders etc. Although several studies have shown the photo-protective role of different grape parts like the fruits and seeds, little or no data demonstrating the in vivo photo-protective role of grape stem, which is the most discarded part of the grape are available. We evaluated the protective influence of grape stem extract against UVB-induced oxidative damage in C57BL mice characterized by epidermal hyperplasia, pigmentation, collagen degradation and inflammation. Grape stem extract was administered topically 1week before UVB irradiation (120mJ/cm 2) and continued until the termination of the experiment. A group of non-irradiated mice and a group of irradiated mice topically administered with propylene were used as a negative and positive control. Epidermal thickness, pigmentation, erythema, mast cell and neutrophil infiltration, collagen degradation and COX-2, Nrf2, and HO-1 expressions were evaluated. Grape stem extract markedly recovered skin damage induced by the UVB radiation through the prevention of epidermal hyperplasia, pigmentation, erythema, mast cell and neutrophil infiltrations, collagen degradation and COX-2, Nrf2, and HO-1 expressions. Our study demonstrated for the first time in C57BL mice that grape stem extract reduces UVB-induced oxidative damage and hence can play a protective role in skin photo-damage.
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Grape extracts from stems reduce UVB-induced oxidative damage.
“Recently, it has been found that also grape extracts from the stems, a part of the grape tree rich in phenolic compounds, are able to reduce UVB-induced oxidative damage [93].”
From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [93]
Topical application of stem's grape extracts on mice skin before UVB treatment prevented epidermal thickness, erythema, pigmentation, mast cell and inflammatory neutrophil infiltrations, collagen degradation, and expression of COX-2, Nrf-2, and HO-1 genes.
“Indeed, the topical application of stem's grape extracts on mice skin before UVB treatment was able to prevent epidermal thickness, erythema, pigmentation, mast cell and inflammatory neutrophil infiltrations, collagen degradation, and the expression of COX-2, Nrf-2, and HO-1 genes [93].”
From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [93]
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Antioxidants from Plants Protect against Skin Photoaging
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- Authors
- Che, D. N., Xie, G. H., Cho, B. O., Shin, J. Y., Kang, H. J., & Jang, S. I.
- Affiliations
- Jeonju University (KR)
- Yanbian University Hospital (CN)
- Corresponding author
- Jang, Seon Il
- Venue
- Journal of Photochemistry and Photobiology B: Biology
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 173
- Pages
- 551-559
- ISSN
- 1011-1344 (ISSN-L)
- OpenAlex
- W2729103069
- Cited by
- 44
- References
- 39
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 11 · 2020: 6 · 2019: 11 · 2018: 4
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Photochemistry and Photobiology B Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Small and Medium Business Administration (C0394984)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- UV-B radiation, oxidative stress, epidermal hyperplasia, skin pigmentation, collagen degradation, mast cell infiltration, neutrophil infiltration, cyclooxygenase-2, Nrf2, heme oxygenase-1, topical administration, C57BL mice
- MeSH terms
- Animals, Chromatography, High Pressure Liquid, Collagen, Erythema, Glutathione, Male, Malondialdehyde, Membrane Proteins, Mice, Inbred C57BL, Plant Extracts, Skin, Skin Pigmentation, Ultraviolet Rays, Gene Expression, Protective Agents, Mice, Cyclooxygenase 2, Heme Oxygenase-1, Grape Seed Extract
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