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Altered lymphocyte distribution in Alzheimer’s disease
Abstract
The contribution of immunological factors in the etiopathogenesis of Alzheimer's disease (AD) is increasingly noted. Apart from cerebral immunological findings, peripheral changes of the immune systems have been reported including lymphocyte function and subset distribution. As data still remain inconsistent, we investigated a sample of 43 patients with AD and of 34 healthy age-matched controls. Distribution of the T-, B- and NK cell subsets was determined by flow cytometry (FACS). We found a significant decrease of CD3(+) lymphocytes as well as of CD19(+) lymphocytes. A slight increase of the CD4(+) and a decrease of the CD8(+) subpopulation could be observed, without significant change of the CD4(+)/CD8(+) ratio. CD16(+)56(+) cells were not altered. Our findings of decreased T- and B-Cell numbers in AD sustain the hypothesis of a general decline of immune activity in AD. A putative association with premature immunosenescence in AD and possible pathogenetic implications are discussed.
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“while other reports showed either no correlation [86] or a positive association [90].”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [86]
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“Investigations performed on the proportions and phenotypes of circulating B cells in AD patients compared to age-matched healthy controls have concluded in a significant reduction of both the absolute numbers and percentages of blood B cells in AD patients [84 -87].”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [86]
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Metadata
- Authors
- RICHARTZSALZBURGER, E., BATRA, A., STRANSKY, E., LASKE, C., KOHLER, N., BARTELS, M., BUCHKREMER, G., & SCHOTT, K.
- Affiliations
- University of Tübingen (DE)
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 41
- Issue
- 1-2
- Pages
- 174-178
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W1986300349
- Cited by
- 167
- References
- 49
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 8 · 2023: 8 · 2022: 21 · 2021: 10 · 2020: 11 · 2019: 11 · 2018: 10 · 2017: 12 · 2016: 5 · 2015: 10 · 2014: 6 · 2013: 11 · 2012: 5
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, lymphocyte subsets, T cells, B cells, natural killer cells, immunosenescence, CD4/CD8 ratio, neuroinflammation
- MeSH terms
- Aged, Alzheimer Disease, Female, Humans, Male, Severity of Illness Index, Antigens, CD, Lymphocyte Subsets
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