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Altered lymphocyte distribution in Alzheimer’s disease
Abstract
The contribution of immunological factors in the etiopathogenesis of Alzheimer's disease (AD) is increasingly noted. Apart from cerebral immunological findings, peripheral changes of the immune systems have been reported including lymphocyte function and subset distribution. As data still remain inconsistent, we investigated a sample of 43 patients with AD and of 34 healthy age-matched controls. Distribution of the T-, B- and NK cell subsets was determined by flow cytometry (FACS). We found a significant decrease of CD3(+) lymphocytes as well as of CD19(+) lymphocytes. A slight increase of the CD4(+) and a decrease of the CD8(+) subpopulation could be observed, without significant change of the CD4(+)/CD8(+) ratio. CD16(+)56(+) cells were not altered. Our findings of decreased T- and B-Cell numbers in AD sustain the hypothesis of a general decline of immune activity in AD. A putative association with premature immunosenescence in AD and possible pathogenetic implications are discussed.
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“while other reports showed either no correlation [86] or a positive association [90].”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [86]
In the citing paper
“Investigations performed on the proportions and phenotypes of circulating B cells in AD patients compared to age-matched healthy controls have concluded in a significant reduction of both the absolute numbers and percentages of blood B cells in AD patients [84 -87].”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [86]
Citations
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160
Inflammation in Neurodegenerative Disease—A Double-Edged Sword
Wyss-Coray, T., & Mucke, L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00794-8 · Cited by 1,235
Microglia as neuroprotective, immunocompetent cells of the CNS
Streit, W. J. (2002) · Glia · doi:10.1002/glia.10154 · Cited by 919
Rogers, J., Luber-Narod, J., Styren, S. D., & Civin, W. H. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80079-4 · Cited by 743
Inflammation, autotoxicity and Alzheimer disease
McGeer, P. L. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00289-5 · Cited by 485
Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases
Togo, T., Akiyama, H., Iseki, E., Kondo, H., Ikeda, K., Kato, M., Oda, T., Tsuchiya, K., & Kosaka, K. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00496-9 · Cited by 481
Telomere shortening in T cells correlates with Alzheimer's disease status
Panossian, L. A. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00043-x · Cited by 411
Cytokine-induced survival of activated T cells in vitro and in vivo
Vella, A. T., DOW, S. W., Potter, T. A., Kappler, J. W., & Marrack, P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3810 · Cited by 393
Microglia and inflammatory mechanisms in the clearance of amyloid β peptide
Rogers, J., Strohmeyer, R., Kovelowski, C. J., & Li, R. (2002) · Glia · doi:10.1002/glia.10153 · Cited by 381
Alzheimer's disease : basic mechanisms, diagnosis and therapeutic strategies
Iqbal, K. (1991) · Wiley eBooks · Cited by 322
Itagaki, S., McGeer, P. L., & Akiyama, H. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90690-8 · Cited by 271
Astrocytes Regulate Microglial Phagocytosis of Senile Plaque Cores of Alzheimer's Disease
DeWitt, D. A., Perry, G., Cohen, M., Doller, C., & Silver, J. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6738 · Cited by 261
Reduced levels of amyloid β-peptide antibody in Alzheimer disease
Du, Y., Dodel, R. C., Hampel, H. J., Büerger, K., Lin, S., Eastwood, B. J., Bales, K. R., Gao, F., Moeller, H. –., Oertel, W. H., et al. (2001) · Neurology · doi:10.1212/wnl.57.5.801 · Cited by 236
Intrahippocampal LPS injections reduce Aβ load in APP+PS1 transgenic mice
DiCarlo, G. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00292-5 · Cited by 223
Immunotherapeutic Approaches to Alzheimer's Disease
Monsonego, A., & Weiner, H. L. (2003) · Science · doi:10.1126/science.1088469 · Cited by 217
Psychoneuroimmunology: Interactions between central nervous system and immune system
Solomon, G. F. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490180103 · Cited by 216
Dual effect of CD4 + CD25 + regulatory T cells in neurodegeneration: A dialogue with microglia
Kipnis, J., Avidan, H., Caspi, R. R., & Schwartz, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404842101 · Cited by 163
Reale, M., Iarlori, C., Gambi, F., Feliciani, C., Salone, A., Toma, L., Luca, G. D., Salvatore, M., Conti, P., & Gambi, D. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2003.11.003 · Cited by 123
Trieb, K., Ransmayr, G. N., Sgonc, R., Lassmann, H., & Grubeck-Loebenstein, B. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00068-1 · Cited by 101
T lymphocyte subpopulations and activation markers correlate with severity of Alzheimer's disease.
Shalit, F., Sredni, B., Brodie, C., Kott, E., & Huberman, M. (1995) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1995.1078 · Cited by 97
Decline of immune responsiveness: A pathogenetic factor in Alzheimer’s disease?
Richartz, E., Stransky, E., Batra, A., Simon, P. D., Lewczuk, P., Buchkremer, G., BARTELS, M., & Schott, K. J. (2005) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2004.12.005 · Cited by 96
Self-citationFranceschi, C., Monti, D., Scarfı̀, M. R., Zeni, O., Temperani, P., Emilia, G., Sansoni, P., Lioi, M. B., Troiano, L., AGNESINI, C., et al. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb38643.x · Cited by 73
The decrease of CD8-positive lymphocytes in Alzheimer's disease
Pirttilä, T., Mattinen, S., & Frey, H. (1992) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(92)90284-r · Cited by 72
Immunology and Aging:Philip Levine Award
Walford, R. L. (1980) · American Journal of Clinical Pathology · doi:10.1093/ajcp/74.3.247 · Cited by 71
The Immunopathology of Alzheimer's Disease and Some Related Disorders
Kalaria, R. N. (1993) · Brain Pathology · doi:10.1111/j.1750-3639.1993.tb00761.x · Cited by 69
Immunologic dysfunction: simultaneous study of alzheimer's and older down's patients
Singh, V. K., Fudenberg, H. H., & Brown, F. R. (1986) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(86)90043-6 · Cited by 66
Studies of neuroimmune markers in Alzheimer's disease
Singh, V. K. (1994) · Molecular Neurobiology · doi:10.1007/bf02816106 · Cited by 60
Senile dementia of Alzheimer's type (SDAT)
Skias, D. D., Bania, M. B., Reder, A. T., Luchins, D. J., & Antel, J. P. (1985) · Neurology · doi:10.1212/wnl.35.11.1635 · Cited by 60
Park, E., Alberti, J., Mehta, P. D., Dalton, A. J., Sersen, E. A., & Schuller‐Levis, G. (2000) · Clinical Immunology · doi:10.1006/clim.2000.4834 · Cited by 57
Neuroautoimmunity: Pathogenic Implications for Alzheimer’s Disease
Singh, V. K. (2009) · Gerontology · doi:10.1159/000213837 · Cited by 57
Telomere Dysfunction of Lymphocytes in Patients With Alzheimer Disease
Zhang, J., Kong, Q., Zhang, Z., Ge, P., Ba, D., & He, W. (2003) · Cognitive and Behavioral Neurology · doi:10.1097/00146965-200309000-00004 · Cited by 56
The possible role of the immune system in Alzheimer’s disease
Marx, F., Blasko, I., Pavelka, M., & Grubeck-Loebenstein, B. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00028-x · Cited by 51
Immunological indices in presenile Alzheimer's disease
Tavolato, B. F., & Argentiero, V. (1980) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(80)90057-x · Cited by 48
Autoimmunity as a special case of immunity: removing threats from within
Nevo, U., Kipnis, J., Golding, I., Shaked, I., Neumann, A. U., AKSELROD, S., & Schwartz, M. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00024-8 · Cited by 41
An Analysis of T Lymphocyte Subpopulations in Patients with Alzheimer's Disease
Leffell, M. S., Lumsden, L., & Steiger, W. A. (1985) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1985.tb02851.x · Cited by 36
Ikeda, T., Yamamoto, K., Takahashi, K., & Yamada, M. (1991) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1991.tb05573.x · Cited by 28
T Cell Response to Amyloid-β and to Mitochondrial Antigens in Alzheimer’s Disease
Giubilei, F., Antonini, G., Montesperelli, C., Sepe‐Monti, M., Cannoni, S., Pichi, A., Tisei, P., Casini, A. R., Buttinelli, C., Prencipe, M., et al. (2003) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000069991 · Cited by 25
Lymphopenia in primary degenerative dementia
Tollefson, G. D., Michael Godes, J., Warren, B., Haus, E. L., Luxenberg, M. G., & Garvey, M. (1989) · Journal of Psychiatric Research · doi:10.1016/0022-3956(89)90024-1 · Cited by 20
Senile dementia, alzheimer type: A distinct entity in the immunosenescence?
Antonaci, S., Garofalo, A. R., Chicco, C., Polignano, A., Pugliese, P., Misefari, A., & Jirillo, E. (1990) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.1860040106 · Cited by 19
Licastro, F., Savorani, G., Sarti, G., Salsi, A., Cavazzuti, F., Zanichello, L., Tucci, G., Mocchegiani, E., & Fabris, N. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90070-4 · Cited by 19
Neuroimmune axis as a basis of therapy in Alzheimer’s disease
Singh, V. K. (1990) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7128-0_12 · Cited by 17
Hu, G., Walls, R. S., Creasey, H. M., McCusker, E. A., & Broe, G. A. (1995) · Australian and New Zealand Journal of Medicine · doi:10.1111/j.1445-5994.1995.tb01525.x · Cited by 17
Immunologic and inflammatory mediators and cognitive decline in Alzheimer's disease
Ahluwalia, N., & Vellas, B. J. (2003) · Immunology and Allergy Clinics of North America · doi:10.1016/s0889-8561(02)00048-6 · Cited by 17
Distribution of peripheral lymphocytes in Alzheimer patients and controls
Dysken, M. W., Minichiello, M. D., Hill, J., Skare, S. S., Little, J. T., Molchan, S. E., & Sunderland, T. (1992) · Journal of Psychiatric Research · doi:10.1016/0022-3956(92)90024-i · Cited by 16
Functional study of T lymphocyte responsiveness in patients with dementia of the Alzheimer type
Leonardi, A., Arata, L., Bino, G., Caira, M., Farinelli, M., Parodi, C., SCUDELETTI, M., & Canonica, G. W. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90004-0 · Cited by 14
Gender differences and the interpretation of genetic instability in Alzheimer's disease
Cherry, L. M., Funk, J., Lesser, J., & Lesam, M. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90009-e · Cited by 7
Zujovic (2000) · doi:10.1002/(sici)1098-1136(20000215)29:4
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Inflammaging as a prodrome to Alzheimer's disease
Giunta, B., Fernandez, F., Nikolic, W. V., Obregon, D., Rrapo, E., Town, T., & Tan, J. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-51 · Cited by 327
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Schwartz, M., & Shechter, R. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.71 · Cited by 240
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Larbi, A., Pawelec, G., Witkowski, J. M., Schipper, H. M., Derhovanessian, E., Goldeck, D., & Fülöp, T. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1015 · Cited by 207
Metadata
- Authors
- RICHARTZSALZBURGER, E., BATRA, A., STRANSKY, E., LASKE, C., KOHLER, N., BARTELS, M., BUCHKREMER, G., & SCHOTT, K.
- Affiliations
- University of Tübingen (DE)
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 41
- Issue
- 1-2
- Pages
- 174-178
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W1986300349
- Cited by
- 167
- References
- 49
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 8 · 2023: 8 · 2022: 21 · 2021: 10 · 2020: 11 · 2019: 11 · 2018: 10 · 2017: 12 · 2016: 5 · 2015: 10 · 2014: 6 · 2013: 11 · 2012: 5
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, lymphocyte subsets, T cells, B cells, natural killer cells, immunosenescence, CD4/CD8 ratio, neuroinflammation
- MeSH terms
- Aged, Alzheimer Disease, Female, Humans, Male, Severity of Illness Index, Antigens, CD, Lymphocyte Subsets
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