Microglia as neuroprotective, immunocompetent cells of the CNS

Inflammation and Alzheimer’s disease

Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works

Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo

Hickey, W. F., & Kimura, H. (1988) · Science · doi:10.1126/science.3276004 · Cited by 1,466 · see citing works

Role for Neuronally Derived Fractalkine in Mediating Interactions between Neurons and CX3CR1-Expressing Microglia

Harrison, J. K., Jiang, Y., Chen, S., Xia, Y., Maciejewski, D., McNamara, R. K., Streit, W. J., Salafranca, M. N., Adhikari, S., Thompson, D. A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10896 · Cited by 1,176 · see citing works

Reactive microgliosis

Streit, W. J., Walter, S. A., & Pennell, N. A. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00069-0 · Cited by 1,096 · see citing works

Down-Regulation of the Macrophage Lineage Through Interaction with OX2 (CD200)

Hoek, R. M., Ruuls, S. R., Murphy, C. A., Wright, G. J., Goddard, R., Zurawski, S. M., Blom, B., Homola, M. E., Streit, W. J., Brown, M. H., et al. (2000) · Science · doi:10.1126/science.290.5497.1768 · Cited by 1,022 · see citing works

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease

Itagaki, S., McGeer, P. L., Akiyama, H., Zhu, S., & Selkoe, D. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90115-x · Cited by 940 · see citing works

CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia

He, J., Chen, Y., Farzan, M., Choe, H., Öhagen, Å., Gartner, S., Busciglio, J. A., Yang, X., Hofmann, W., Newman, W., et al. (1997) · Nature · doi:10.1038/385645a0 · Cited by 915 · see citing works

Displacement of synaptic terminals from regenerating motoneurons by microglial cells

Blinzinger, K., & Kreutzberg, G. W. (1968) · Cell and Tissue Research · doi:10.1007/bf00325030 · Cited by 855 · see citing works

Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor

Paresce, D. M., Ghosh, R. N., & Maxfield, F. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80187-7 · Cited by 663 · see citing works

Identification of normal and pathological aging in prospectively studied nondemented elderly humans

Dickson, D. W., Crystal, H. A., Mattiace, L. A., Masur, D. M., Blau, A. D., Davies, P., Yen, S.-H., & Aronson, M. K. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90027-u · Cited by 643 · see citing works

Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells

Frei, K., Siepl, C., Groscurth, P., Bodmer, S., Schwerdel, C., & Fontana, A. (1987) · European Journal of Immunology · doi:10.1002/eji.1830170909 · Cited by 633 · see citing works

Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared

Ford, A. L., Goodsall, A. L., Hickey, W. F., & Sedgwick, J. D. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.9.4309 · Cited by 631 · see citing works

Inflammation, autotoxicity and Alzheimer disease

McGeer, P. L. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00289-5 · Cited by 474 · see citing works

Brain microglia constitutively express β-2 integrins

Akiyama, H., & McGeer, P. L. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90055-r · Cited by 430 · see citing works

Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro.

Platt, N., Suzuki, H., Kurihara, Y., Kodama, T., & Gordon, S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12456 · Cited by 428 · see citing works

Response of endogenous glial cells to motor neuron degeneration induced by toxic ricin

Streit, W. J., & Kreutzberg, G. W. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902680209 · Cited by 387 · see citing works

Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques.

Dickson, D. W., Farlo, J., Davies, P., Crystal, H., Fuld, P. A., & Yen, S. H. (1988) · PubMed Central · Cited by 383 · see citing works

Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells

Graeber, M. B., Streit, W. J., & Kreutzberg, G. W. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490210104 · Cited by 367 · see citing works

Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia?

Nishiyori, A., Minami, M., Ohtani, Y., Takami, S., Yamamoto, J., Kawaguchi, N., Kume, T., Akaike, A., & Satoh, M. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00583-3 · Cited by 367 · see citing works

Characterization of Fractalkine in Rat Brain Cells: Migratory and Activation Signals for CX3CR-1-Expressing Microglia

Maciejewski-Lenoir, D., Chen, S., Feng, L., Maki, R. A., & Bacon, K. B. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.3.1628 · Cited by 357 · see citing works

The Microglial Reaction in the Rat Dorsal Hippocampus following Transient Forebrain Ischemia

Morioka, T., Kalehua, A. N., & Streit, W. J. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.162 · Cited by 297 · see citing works

Microglia Express CCR5, CXCR4, and CCR3, but of These, CCR5 Is the Principal Coreceptor for Human Immunodeficiency Virus Type 1 Dementia Isolates

Albright, A. V., Shieh, J. T. C., Itoh, T., Lee, B., Pleasure, D., O’Connor, M. J., Doms, R. W., & González‐Scarano, F. (1999) · Journal of Virology · doi:10.1128/jvi.73.1.205-213.1999 · Cited by 296 · see citing works

Brain macrophages synthesize interleukin‐1 and interleukin‐1 mRNAs in vitro

Hetier, E., Ayala‐Sanmartín, J., Denèfle, P., Bousseau, A., Rouget, P., Mallat, M., & Prochiantz, A. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490210230 · Cited by 287 · see citing works

Neurotrophins inhibit major histocompatibility class II inducibility of microglia: Involvement of the p75 neurotrophin receptor

Neumann, H., Misgeld, T., Matsumuro, K., & Wekerle, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.10.5779 · Cited by 282 · see citing works

Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease

Perlmutter, L. S., Barron, E., & Chui, H. C. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90748-x · Cited by 240 · see citing works

Enlarged and phagocytic, but not primed, interleukin-1α-immunoreactive microglia increase with age in normal human brain

Sheng, J. G., Mrak, R. E., & Griffin, W. S. T. (1998) · Acta Neuropathologica · doi:10.1007/s004010050792 · Cited by 229 · see citing works

Modulation of CD4 antigen on macrophages and microglia in rat brain.

Perry, V. H., & Gordon, S. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.166.4.1138 · Cited by 229 · see citing works

Microglia in human immunodeficiency virus‐associated neurodegeneration

Garden, G. A. (2002) · Glia · doi:10.1002/glia.10155 · Cited by 206 · see citing works

Thrombin‐Induced Activation of Cultured Rodent Microglia

Möller, T., Hanisch, U., & Ransom, B. R. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751539.x · Cited by 175 · see citing works

Activation of microglia in the brains of humans with heart disease and hypercholesterolemic rabbits

Streit, W. J., & Sparks, D. L. (1997) · Journal of Molecular Medicine · doi:10.1007/s001090050097 · Cited by 167 · see citing works

Murine Microglial Cells Produce and Respond to Interleukin‐18

Prinz, M., & Hanisch, U. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0722215.x · Cited by 162 · see citing works

Brain macrophages stimulate neurite growth and regeneration by secreting thrombospondin

Chamak, B., Morandi, V., & Mallat, M. (1994) · Journal of Neuroscience Research · doi:10.1002/jnr.490380213 · Cited by 155 · see citing works

Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease.

Christie, R. H., Freeman, M. W., & Hyman, B. T. (1996) · PubMed · Cited by 152 · see citing works

Oligodendrocytes utilize a matrix metalloproteinase, MMP-9, to extend processes along an astrocyte extracellular matrix

Uhm, J. H., Dooley, N. P., Oh, L. Y. S., & Yong, V. W. (1998) · Glia · doi:10.1002/(sici)1098-1136(199801)22:1 · Cited by 144 · see citing works

Mechanisms of C5a and C3a Complement Fragment-Induced [Ca2+]iSignaling in Mouse Microglia

Möller, T., Nolte, C., Burger, R., Verkhratsky, A., & Kettenmann, H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-02-00615.1997 · Cited by 143 · see citing works

Microglia and Macrophages in the Developing CNS

Streit, W. J. (2001) · NeuroToxicology · doi:10.1016/s0161-813x(01)00033-x · Cited by 134 · see citing works

Characterisation of microglia isolated from adult human and rat brain

Hayes, G. M., Woodroofe, M. N., & Cuzner, M. L. (1988) · Journal of Neuroimmunology · doi:10.1016/0165-5728(88)90001-x · Cited by 117 · see citing works

Upregulation of the macrophage scavenger receptor in response to different forms of injury in the CNS

Bell, M. D., Lopez-Gonzalez, R., Lawson, L. J., Hughes, D. A., Fraser, I. P., Gordon, S., & Perry, V. H. (1994) · Journal of Neurocytology · doi:10.1007/bf01191555 · Cited by 117 · see citing works

Identification of FcγRI, II and III on normal human brain ramified microglia and on microglia in senile plaques in Alzheimer's disease

Peress, N. S., Fleit, H. B., Perillo, E., Kuljiš, R. O., & Pezzullo, C. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90060-c · Cited by 111 · see citing works

Wnt-1 dependent activation of the survival factor NF-?B in PC12 cells

Bournat, J. C., Brown, A. M. C., & Soler, A. P. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20000701)61:1 · Cited by 100 · see citing works

Balancing function vs. self defense: The CNS as an active regulator of immune responses

Carson, M. J., & Sutcliffe, J. G. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990101)55:1 · Cited by 99 · see citing works

Chemokines and Alzheimer's disease

Streit, W. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00290-1 · Cited by 94 · see citing works

Perineuronal glial responses after axotomy of central and peripheral axons. A comparison

Barron, K. D., Marciano, F. F., Amunson, R., & Mankes, R. F. (1990) · Brain Research · doi:10.1016/0006-8993(90)91490-8 · Cited by 92 · see citing works

Microglia and the Development of Spongiform Change in Creutzfeldt-Jakob Disease

Eitzen, U., Egensperger, R., Kösel, S., Grasbon-Frodl, E., Imai, Y., Bise, K., Kohsaka, S., Mehraein, P., & Graeber, M. (1998) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199803000-00006 · Cited by 92 · see citing works

Perivascular microglia defined

Graeber, M. B., & Streit, W. J. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90020-b · Cited by 91 · see citing works

Microglia only weakly present glioma antigen to cytotoxic T cells

Flügel, A., Labeur, M. S., Grasbon‐Frodl, E., Kreutzberg, G. W., & Graeber, M. B. (1999) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(99)00020-9 · Cited by 73 · see citing works

Immunophenotypic analysis of infiltrating leukocytes and microglia in an experimental rat glioma

Morioka, T., Baba, T., Black, K. L., et al. (1992) · Acta Neuropathologica · doi:10.1007/bf00299407 · Cited by 55 · see citing works

Perineuronal microglial reactivity following proximal and distal axotomy of rat rubrospinal neurons

Tseng, G., Wang, Y., & Lai, Q.-C. (1996) · Brain Research · doi:10.1016/0006-8993(95)01418-7 · Cited by 40 · see citing works

CD8+ phagocytes in focal ischemia of the rat brain: predominant origin from hematogenous macrophages and targeting to areas of pannecrosis

Schroeter, M., Jander, S., Huitinga, I., et al. (2001) · Acta Neuropathologica · doi:10.1007/s004010000304 · Cited by 39 · see citing works

Expression of complement C1gB and C4 mRNAs during rat brain development

Johnson, S. A., Pasinetti, G. M., & Finch, C. E. (1994) · Developmental Brain Research · doi:10.1016/0165-3806(94)90101-5 · Cited by 38 · see citing works

MK-801 prevents microglial reaction in rat hippocampus after forebrain ischemia

Streit, W. J., Morioka, T., & Kalehua, A. N. (1992) · Neuroreport · doi:10.1097/00001756-199202000-00006 · Cited by 36 · see citing works

Neuroprotective Roles of Microglia in the Central Nervous System

Nakajima, K., & Kohsaka, S. (2002) · Springer eBooks · doi:10.1007/978-1-4757-4139-1_9 · Cited by 15 · see citing works

Detection of delta opioid receptor and N-methyl-D-aspartate receptor-like immunoreactivity in retinoic acid-differentiated neuroblastoma x glioma (NG108-15) cells

Beczkowska, I. W., Gracy, K. N., Pickel, V. M., & Inturrisi, C. E. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970101)47:1 · Cited by 11 · see citing works

Microglial Response in the Axotomized Facial Motor Nucleus

Raivich, G. (2002) · Springer eBooks · doi:10.1007/978-1-4757-4139-1_8 · Cited by 6 · see citing works

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827 · see citing works

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110 · see citing works

Mechanisms underlying inflammation in neurodegeneration

Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580 · see citing works

Mammalian nicotinic acetylcholine receptors: from structure to function

Albuquerque, E. X., Pereira, E. F. R., Alkondon, M., & Rogers, S. W. (2009) · Physiological Reviews · doi:10.1152/physrev.00015.2008 · Cited by 1,724 · see citing works

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

Jin, R., Yang, G., & Li, G. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.1109766 · Cited by 1,521 · see citing works

Selective Ablation of Proliferating Microglial Cells Exacerbates Ischemic Injury in the Brain

Lalancette-Hébert, M., Gowing, G., Simard, A., Weng, Y. C., & Kriz, J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5360-06.2007 · Cited by 874 · see citing works

Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease

Petzinger, G. M., Fisher, B. E., McEwen, S., Beeler, J. A., Walsh, J. P., & Jakowec, M. W. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70123-6 · Cited by 798 · see citing works

Neuronal ‘On’ and ‘Off’ signals control microglia

Biber, K., Neumann, H., Inoue, K., & Boddeke, H. W. G. M. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.08.007 · Cited by 787 · see citing works

Toll‐like receptor 4 is required for α‐synuclein dependent activation of microglia and astroglia

Fellner, L., Irschick, R., Schanda, K., Reindl, M., Klimaschewski, L., Poewe, W., Wenning, G. K., & Stefanova, N. (2013) · Glia · doi:10.1002/glia.22437 · Cited by 697 · see citing works

Neurotransmitter receptors on microglia

Pocock, J. M., & Kettenmann, H. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.07.007 · Cited by 650 · see citing works

Microglial cell dysregulation in brain aging and neurodegeneration

von Bernhardi, R., Eugenín-von Bernhardi, L., & Eugenín, J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00124 · Cited by 556 · see citing works

Microglia activation in retinal degeneration

Langmann, T. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0207114 · Cited by 496 · see citing works

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

Edison, P., Archer, H. A., Gerhard, A., Hinz, R., Pavese, N., Turkheimer, F. E., Hammers, A., Tai, Y. F., Fox, N., Kennedy, A., et al. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.08.001 · Cited by 513 · see citing works

Microglial activation correlates with severity in Huntington disease: A clinical and PET study

Pavese, N., Gerhard, A., Tai, Y. F., Ho, A. K., Turkheimer, F., Barker, R. A., Brooks, D. J., & Piccini, P. (2006) · Neurology · doi:10.1212/01.wnl.0000222734.56412.17 · Cited by 462 · see citing works

Lipopolysaccharide-induced microglial activation and neuroprotection against experimental brain injury is independent of hematogenous TLR4

Chen, Z., Jalabi, W., Shpargel, K. B., Farabaugh, K. T., Dutta, R., Yin, X., Kidd, G. J., Bergmann, C. C., Stohlman, S. A., & Trapp, B. D. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0730-12.2012 · Cited by 432 · see citing works

Microglial activation in presymptomatic Huntington's disease gene carriers

Tai, Y. F., Pavese, N., Gerhard, A., Tabrizi, S. J., Barker, R. A., Brooks, D. J., & Piccini, P. (2007) · Brain · doi:10.1093/brain/awm044 · Cited by 440 · see citing works

Microglial phenotype: is the commitment reversible?

Schwartz, M., Butovsky, O., Brück, W., & Hanisch, U.-K. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2005.12.005 · Cited by 434 · see citing works

Microglial senescence: does the brain's immune system have an expiration date?

Streit, W. J. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.07.001 · Cited by 397 · see citing works

Microglial activation precedes and predominates over macrophage infiltration in transient focal cerebral ischemia: a study in green fluorescent protein transgenic bone marrow chimeric mice

Schilling, M., Besselmann, M., Leonhard, C., Mueller, M., Ringelstein, E. B., & Kiefer, R. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00082-7 · Cited by 375 · see citing works

Microglia and Alzheimer's disease pathogenesis

Streit, W. J. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20093 · Cited by 335 · see citing works

Microglial pathology

Streit, W. J., Xue, Q.-S., Tischer, J., & Bechmann, I. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0142-6 · Cited by 317 · see citing works

Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices

Tremblay, M., Zettel, M. L., Ison, J. R., Allen, P. D., & Majewska, A. K. (2012) · Glia · doi:10.1002/glia.22287 · Cited by 309 · see citing works

Cellular senescence and the aging brain

Chinta, S. J., Woods, G., Rane, A., Demaria, M., Campisi, J., & Andersen, J. K. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2014.09.018 · Cited by 282 · see citing works

Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity

Lopes, K. O., Sparks, D. L., & Streit, W. J. (2008) · Glia · doi:10.1002/glia.20678 · Cited by 262 · see citing works

Neuroprotective function for ramified microglia in hippocampal excitotoxicity

Vinet, J., van Weering, H. R., Heinrich, A., Kälin, R. E., Wegner, A., Brouwer, N., Heppner, F. L., van Rooijen, N., Boddeke, H. W., & Biber, K. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-27 · Cited by 274 · see citing works

Evidence That Aging And Amyloid Promote Microglial Cell Senescence

Flanary, B. E., Sammons, N. W., Nguyen, C., Walker, D., & Streit, W. J. (2007) · Rejuvenation Research · doi:10.1089/rej.2006.9096 · Cited by 272 · see citing works

Neuroinflammation in Alzheimer's Disease and Parkinson's Disease: Are Microglia Pathogenic in Either Disorder?

Rogers, J., Mastroeni, D., Leonard, B., Joyce, J., & Grover, A. (2007) · International Review of Neurobiology · doi:10.1016/s0074-7742(07)82012-5 · Cited by 260 · see citing works

Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition

Bilbo, S. D., Biedenkapp, J. C., Der-Avakian, A., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1748-05.2005 · Cited by 251 · see citing works

Isolation of murine microglial cells for RNA analysis or flow cytometry

Cardona, A. E., Huang, D., Sasse, M. E., & Ransohoff, R. M. (2006) · Nature Protocols · doi:10.1038/nprot.2006.327 · Cited by 236 · see citing works

Age related macular degeneration and drusen: Neuroinflammation in the retina

Buschini, E., Piras, A., Nuzzi, R., & Vercelli, A. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.011 · Cited by 230 · see citing works

Parkinson’s disease as a result of aging

Rodriguez, M., Rodriguez‐Sabate, C., Morales, I., Sanchez, A., & Sabate, M. (2015) · Aging Cell · doi:10.1111/acel.12312 · Cited by 214 · see citing works

Serotonin stimulates secretion of exosomes from microglia cells

Glebov, K., Löchner, M., Jabs, R., Lau, T., Merkel, O., Schloss, P., Steinhäuser, C., & Walter, J. (2015) · Glia · doi:10.1002/glia.22772 · Cited by 221 · see citing works

Microglia Kv1.3 Channels Contribute to Their Ability to Kill Neurons

Fordyce, C. B., Jagasia, R., Zhu, X., & Schlichter, L. C. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1251-05.2005 · Cited by 213 · see citing works

Friends or foes: matrix metalloproteinases and their multifaceted roles in neurodegenerative diseases

Brkic, M., Balusu, S., Libert, C., & Vandenbroucke, R. E. (2015) · Mediators of Inflammation · doi:10.1155/2015/620581 · Cited by 205 · see citing works

Microglia in the healthy and degenerating retina: Insights from novel mouse models

Karlstetter, M., Ebert, S., & Langmann, T. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.05.010 · Cited by 197 · see citing works

Priming of microglia with <scp>IFN</scp> ‐γ impairs adult hippocampal neurogenesis and leads to depression‐like behaviors and cognitive defects

Zhang, J., He, H., Qiao, Y., Zhou, T., He, H., Yi, S., Zhang, L., Mo, L., Li, Y., Jiang, W., et al. (2020) · Glia · doi:10.1002/glia.23878 · Cited by 174 · see citing works

Dysregulated neuronal–microglial cross-talk during aging, stress and inflammation

Jurgens, H. A., & Johnson, R. W. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2010.11.014 · Cited by 179 · see citing works

Toll-like Receptors in Defense and Damage of the Central Nervous System

Aravalli, R. N., Peterson, P. K., & Lokensgard, J. R. (2007) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-007-9071-5 · Cited by 173 · see citing works

Altered lymphocyte distribution in Alzheimer’s disease

RICHARTZSALZBURGER, E., BATRA, A., STRANSKY, E., LASKE, C., KOHLER, N., BARTELS, M., BUCHKREMER, G., & SCHOTT, K. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.01.010 · Cited by 167 · see citing works

Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease?

Chinta, S. J., Lieu, C. A., DeMaria, M., Laberge, R. ‐., Campisi, J., & Andersen, J. K. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12029 · Cited by 165 · see citing works

Role of TGFβ signaling in the pathogenesis of Alzheimer’s disease

von Bernhardi, R., Cornejo, F., Parada, G. E., & Eugenín, J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00426 · Cited by 149 · see citing works

The Role of the Immune System in Huntington’s Disease

Ellrichmann, G., Reick, C., Saft, C., & Linker, R. A. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/541259 · Cited by 155 · see citing works

Microglial degeneration in the aging brain - bad news for neurons?

Streit, W. (2008) · Frontiers in Bioscience · doi:10.2741/2937 · Cited by 150 · see citing works

MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State

Saba, R., Gushue, S., Huzarewich, R. L. C. H., Manguiat, K., Medina, S., Robertson, C., & Booth, S. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030832 · Cited by 151 · see citing works

The kynurenine pathway and inflammation in amyotrophic lateral sclerosis

Chen, Y., Stankovic, R., Cullen, K. M., Meininger, V., Garner, B., Coggan, S., Grant, R., Brew, B. J., & Guillemin, G. J. (2010) · Neurotoxicity Research · doi:10.1007/s12640-009-9129-7 · Cited by 141 · see citing works

Gene expression changes in the hypothalamus provide evidence for regionally-selective changes in IL-1 and microglial markers after acute stress

Blandino, P., Barnum, C. J., Solomon, L. G., Larish, Y., Lankow, B. S., & Deak, T. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.04.013 · Cited by 137 · see citing works

Targeting innate immunity for neurodegenerative disorders of the central nervous system

Andreasson, K. I., Bachstetter, A. D., Colonna, M., Ginhoux, F., Holmes, C., Lamb, B., Landreth, G., Lee, D. C., Low, D., Lynch, M. A., et al. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13667 · Cited by 126 · see citing works

From cellular senescence to Alzheimer’s disease: The role of telomere shortening

Boccardi, V., Pelini, L., Ercolani, S., Ruggiero, C., & Mecocci, P. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.04.003 · Cited by 121 · see citing works

The microglia in healthy and diseased retina

Li, L., Eter, N., & Heiduschka, P. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.04.020 · Cited by 112 · see citing works

Activation of interferon signaling pathways in spinal cord astrocytes from an ALS mouse model

Wang, R., Yang, B., & Zhang, D. (2011) · Glia · doi:10.1002/glia.21167 · Cited by 115 · see citing works

Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β

Kauppinen, T. M., Suh, S., Higashi, Y., Berman, A. E., Escartin, C., Won, S., Wang, C., Cho, S.-H., Gan, L., & Swanson, R. A. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-152 · Cited by 112 · see citing works

Activity of adenosine receptors type 1 Is required for CX3CL1-mediated neuroprotection and neuromodulation in hippocampal neurons

Lauro, C., Di Angelantonio, S., Cipriani, R., Sobrero, F., Antonilli, L., Brusadin, V., Ragozzino, D., & Limatola, C. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7590 · Cited by 110 · see citing works

Natural Products as a Potential Modulator of Microglial Polarization in Neurodegenerative Diseases

Jin, X., Liu, M.-Y., Zhang, D.-F., Zhong, X., Du, K., Qian, P., Gao, H., & Wei, M.-J. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104253 · Cited by 109 · see citing works

Gene expression profiling of scrapie-infected brain tissue

Riemer, C., Neidhold, S., Burwinkel, M., Schwarz, A., Schultz, J., Krätzschmar, J., Mönning, U., & Baier, M. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.124 · Cited by 108 · see citing works

Lipopolysaccharides Upregulate Hepcidin in Neuron via Microglia and the IL-6/STAT3 Signaling Pathway

Qian, Z.-M., He, X., Liang, T., Wu, K.-C., Yan, Y.-C., Lu, L.-N., Yang, G., Luo, Q. Q., Yung, W.-H., & Ke, Y. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8671-3 · Cited by 89 · see citing works

Differential effects of neonatal handling on early life infection-induced alterations in cognition in adulthood

Bilbo, S. D., Newsum, N. J., Sprunger, D. B., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.10.005 · Cited by 88 · see citing works

Human CNS immune senescence and neurodegeneration

Streit, W. J., & Xue, Q.-S. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.05.005 · Cited by 86 · see citing works

Effect of aging on the microglial response to peripheral nerve injury

Conde, J. R., & Streit, W. J. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.07.012 · Cited by 86 · see citing works

Got worms? Perinatal exposure to helminths prevents persistent immune sensitization and cognitive dysfunction induced by early-life infection

Williamson, L. L., McKenney, E. A., Holzknecht, Z. E., Belliveau, C., Rawls, J. F., Poulton, S., Parker, W., & Bilbo, S. D. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.07.006 · Cited by 84 · see citing works

Mechanism of microglia neuroprotection: Involvement of<scp>P2X</scp>7,<scp>TNF</scp>α, and valproic acid

Masuch, A., Shieh, C., van Rooijen, N., van Calker, D., & Biber, K. (2016) · Glia · doi:10.1002/glia.22904 · Cited by 81 · see citing works

Protection of rat primary hippocampal cultures from Aβ cytotoxicity by pro-inflammatory molecules is mediated by astrocytes

Ramírez, G., Toro, R., Döbeli, H., & von Bernhardi, R. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.01.007 · Cited by 60 · see citing works

Aldose reductase inhibitors attenuate β-amyloid-induced TNF-α production in microlgia via ROS-PKC-mediated NF-κB and MAPK pathways

Song, X.-M., Yu, Q., Dong, X., Yang, H. O., Zeng, K.-W., Li, J., & Tu, P.-F. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.06.005 · Cited by 60 · see citing works

Innate Immune Response Gene Expression Profiles of N9 Microglia Are Pathogen-Type Specific

McKimmie, C. S., Roy, D., Forster, T., & Fazakerley, J. K. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.03.012 · Cited by 51 · see citing works

Transforming growth factor-β1 acts via TβR-I on microglia to protect against MPP+-induced dopaminergic neuronal loss

Liu, Z., Chen, H.-Q., Huang, Y., Qiu, Y.-H., & Peng, Y.-P. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.08.006 · Cited by 51 · see citing works

Isolation and Phenotyping of Adult Mouse Microglial Cells

Grabert, K., & McColl, B. W. (2018) · Methods in Molecular Biology · doi:10.1007/978-1-4939-7837-3_7 · Cited by 48 · see citing works

Susceptibility of juvenile and adult blood–brain barrier to endothelin-1: regulation of P-glycoprotein and breast cancer resistance protein expression and transport activity

Harati, R., Villégier, A.-S., Banks, W. A., & Mabondzo, A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-273 · Cited by 45 · see citing works

The Role of Microglial Cellular Senescence in the Aging and Alzheimer Diseased Brain

Flanary, B. (2005) · Rejuvenation Research · doi:10.1089/rej.2005.8.82 · Cited by 40 · see citing works

Galectin-3 in Microglia-Mediated Neuroinflammation: Implications for Central Nervous System Diseases

Tian, Y.-K., Ye, D.-W., Ge, M.-M., Chen, N., Zhou, Y.-Q., & Yang, H. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220201094547 · Cited by 31 · see citing works

Microglia express functional 11β‐hydroxysteroid dehydrogenase type 1

Gottfried‐Blackmore, A., Sierra, A., Mcewen, B. S., Ge, R., & Bulloch, K. (2010) · Glia · doi:10.1002/glia.21007 · Cited by 27 · see citing works

Deletion of CD38 and supplementation of NAD+ attenuate axon degeneration in a mouse facial nerve axotomy model

Takaso, Y., Noda, M., Hattori, T., Roboon, J., Hatano, M., Sugimoto, H., Brenner, C., Yamamoto, Y., Okamoto, H., Higashida, H., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-73984-3 · Cited by 17 · see citing works

Neuroprotective effects of the survival promoting peptide Y-P30

Schneeberg, J., Riek‐Burchardt, M., Braun, H., Landgraf, P., Kreutz, M. R., & Reymann, K. G. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.05.029 · Cited by 8 · see citing works

Contributions of Microglia in the Healthy and Injured Brain

Rice, R. A. (2015) · eScholarship (California Digital Library)

Neuroprotective Properties of Chitosan and Its Derivatives

Pangestuti, R., & Kim, S. (2010) · Marine Drugs · doi:10.3390/md8072117 · Cited by 173 · see citing works

Microglia in multiple sclerosis: protectors turn destroyers

Yong, V. W. (2022) · Neuron · doi:10.1016/j.neuron.2022.06.023 · Cited by 185 · see citing works

Microglia derived from the axotomized adult rat facial nucleus uptake glutamate and metabolize it to glutamine in vitro

Nakajima, K., Kanamatsu, T., Koshimoto, M., & Kohsaka, S. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.10.015 · Cited by 7 · see citing works