Cited by 167Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsDementia and Cognitive Impairment Research

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Altered lymphocyte distribution in Alzheimer’s disease

RICHARTZSALZBURGER, E, BATRA, A, STRANSKY, E, LASKE, C, KOHLER, N, BARTELS, M, BUCHKREMER, G, SCHOTT, K·2007·Journal of Psychiatric Research

DOI 10.1016/j.jpsychires.2006.01.010

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Abstract

The contribution of immunological factors in the etiopathogenesis of Alzheimer's disease (AD) is increasingly noted. Apart from cerebral immunological findings, peripheral changes of the immune systems have been reported including lymphocyte function and subset distribution. As data still remain inconsistent, we investigated a sample of 43 patients with AD and of 34 healthy age-matched controls. Distribution of the T-, B- and NK cell subsets was determined by flow cytometry (FACS). We found a significant decrease of CD3(+) lymphocytes as well as of CD19(+) lymphocytes. A slight increase of the CD4(+) and a decrease of the CD8(+) subpopulation could be observed, without significant change of the CD4(+)/CD8(+) ratio. CD16(+)56(+) cells were not altered. Our findings of decreased T- and B-Cell numbers in AD sustain the hypothesis of a general decline of immune activity in AD. A putative association with premature immunosenescence in AD and possible pathogenetic implications are discussed.

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Authors: RICHARTZSALZBURGER, E., BATRA, A., STRANSKY, E., LASKE, C., KOHLER, N., BARTELS, M., BUCHKREMER, G., & SCHOTT, K.
Affiliations: University of Tübingen (DE)
ORCID: BATRA, A
LASKE, C
SCHOTT, K
Venue: Journal of Psychiatric Research
Publisher: Elsevier BV
Published: 2007-01
Volume: 41
Issue: 1-2
Pages: 174-178
ISSN: 0022-3956 (ISSN-L)
DOI: 10.1016/j.jpsychires.2006.01.010
OpenAlex: W1986300349
Cited by: 167
References: 49
Citations by year: 2026: 8 · 2025: 5 · 2024: 8 · 2023: 8 · 2022: 21 · 2021: 10 · 2020: 11 · 2019: 11 · 2018: 10 · 2017: 12 · 2016: 5 · 2015: 10 · 2014: 6 · 2013: 11 · 2012: 5
FWCI: 3.29
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Psychiatric Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Alzheimer's disease, lymphocyte subsets, T cells, B cells, natural killer cells, immunosenescence, CD4/CD8 ratio, neuroinflammation
MeSH terms: Aged, Alzheimer Disease, Female, Humans, Male, Severity of Illness Index, Antigens, CD, Lymphocyte Subsets

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Altered lymphocyte distribution in Alzheimer’s disease

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