The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort
Open accessAbstract
We have performed a genome-wide association study (GWAS) of schizophrenia in a Norwegian discovery sample of 201 cases and 305 controls (TOP study) with a focused replication analysis in a larger European sample of 2663 cases and 13,780 control subjects (SGENE-plus study). Firstly, the discovery sample was genotyped with Affymetrix Genome-Wide Human SNP Array 6.0 and 572,888 markers were tested for schizophrenia association. No SNPs in the discovery sample attained genome-wide significance (P < 8.7 × 10−8). Secondly, based on the GWAS data, we selected 1000 markers with the lowest P values in the discovery TOP sample, and tested these (or HapMap-based surrogates) for association in the replication sample. Sixteen loci were associated with schizophrenia (nominal P value < 0.05 and concurring OR) in the replication sample. As a next step, we performed a combined analysis of the findings from these two studies, and the strongest evidence for association with schizophrenia was provided for markers rs7045881 on 9p21, rs433598 on 16p12 and rs10761482 on 10q21. The markers are located in PLAA, ACSM1 and ANK3, respectively. PLAA has not previously been described as a susceptibility gene, but 9p21 is implied as a schizophrenia linkage region. ACSM1 has been identified as a susceptibility gene in a previous schizophrenia GWAS study. The association of ANK3 with schizophrenia is intriguing in light of recent associations of ANK3 with bipolar disorder, thereby supporting the hypothesis of an overlap in genetic susceptibility between these psychopathological entities.
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Cites
Intraclass correlations: Uses in assessing rater reliability.
Shrout, P. E., & Fleiss, J. L. (1979) · Psychological Bulletin · doi:10.1037/0033-2909.86.2.420 · Cited by 24,532
The Global Assessment Scale: A Procedure for Measuring Overall Severity of Psychiatric Disturbance
Endicott, J. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770060086012 · Cited by 4,982 · cited 6×
“The inter-rater reliability of the investigators was good for the GAF with an intra class correlation, ICC 1.1, of 0.86 (Endicott et al., 1976; Shrout and Fleiss, 1979).”
MethodInfluentialCommon polygenic variation contributes to risk of schizophrenia and bipolar disorder
The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821
The Structured Clinical Interview for DSM-III-R (SCID): I: History, Rationale, and Description
Spitzer, R. L. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820080032005 · Cited by 4,336
Common variants conferring risk of schizophrenia
†Genetic Risk and Outcome in Psychosis (GROUP), Stefansson, H., Ophoff, R. A., Steinberg, S., Andreassen, O. A., Cichon, S., Rujescu, D., Werge, T., Pietiläinen, O. P. H., Mors, O., et al. (2009) · Nature · doi:10.1038/nature08186 · Cited by 1,677 · cited 4×
“However, despite an estimated heritability of up to 0.8 (Cardno and Gottesman, 2000; Lichtenstein et al., 2009), few common variants have been identified in schizophrenia (Owen et al., 2009; O’Donovan et al., 2008; Stefansson et al., 2009; Shi et al., 2009; Purcell et al., 2009).”
BackgroundInfluentialSelf-citationWellcome Trust Case Control Consortium, Ferreira, M. A. R., O'Donovan, M. C., Meng, Y. A., Jones, I. R., Ruderfer, D. M., Jones, L., Fan, J., Kirov, G., Perlis, R. H., et al. (2008) · Nature Genetics · doi:10.1038/ng.209 · Cited by 1,237
Self-citationIdentification of loci associated with schizophrenia by genome-wide association and follow-up
Molecular Genetics of Schizophrenia Collaboration, O'Donovan, M. C., Craddock, N., Norton, N., Williams, H., Peirce, T., Moskvina, V., Nikolov, I., Hamshere, M., Carroll, L., et al. (2008) · Nature Genetics · doi:10.1038/ng.201 · Cited by 1,070
Self-citationA HapMap harvest of insights into the genetics of common disease
Manolio, T. A., Brooks, L. D., & Collins, F. S. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34772 · Cited by 889 · cited 2×
“It is postulated to be caused by the coactions of several loci, each with a small effect (odds ratio (OR) 1.5) (Manolio et al., 2008).”
BackgroundInfluentialBaum, A. E., Akula, N., Cabanero, M., Cardona, I., Corona, W., Klemens, B., Schulze, T. G., Cichon, S., Rietschel, M., Nöthen, M. M., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002012 · Cited by 700
Self-citationTraining and quality assurance with the structured clinical interview for DSM-iV (SCID-I/P)
Ventura, J., Liberman, R. P., Green, M. F., Shaner, A., & Mintz, J. (1998) · Psychiatry Research · doi:10.1016/s0165-1781(98)00038-9 · Cited by 591 · cited 1×
“All interviewers finished a training course in SCID assessment based on a UCLA training program (Ventura et al., 1998), and participated in diagnostic evaluation meetings on regular basis led by an experienced clinical researcher in the field of diagnostics in severe mental disorder.”
Method
Cited by
(2013) · The Lancet · doi:10.1016/s0140-6736(12)62129-1 · Cited by 3,010
Variant of TREM2 Associated with the Risk of Alzheimer's Disease
Jonsson, T., Stefansson, H., Steinberg, S., Jonsdottir, I., Jonsson, P. V., Snaedal, J., Bjornsson, S., Huttenlocher, J., Levey, A. I., Lah, J. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211103 · Cited by 2,558
Self-citationNeuregulin-ERBB Signaling in the Nervous System and Neuropsychiatric Diseases
Mei, L., & Nave, K.-A. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.007 · Cited by 592
Ayalew, M., Le-Niculescu, H., Levey, D. F., Jain, N., Changala, B., Patel, S. D., Winiger, E., Breier, A., Shekhar, A., Amdur, R., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.37 · Cited by 397
Cichon, S., Mühleisen, T. W., Degenhardt, F. A., Mattheisen, M., Miró, X., Strohmaier, J., Steffens, M., Meesters, C., Herms, S., Weingarten, M., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.01.017 · Cited by 286
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Metadata
- Authors
- Athanasiu, L., Mattingsdal, M., Kähler, A. K., Brown, A., Gustafsson, O., Agartz, I., Giegling, I., Muglia, P., Cichon, S., Rietschel, M., Pietiläinen, O. P. H., Peltonen, L., Bramon, E., Collier, D., Clair, D. S., Sigurdsson, E., Petursson, H., Rujescu, D., Melle, I., Steen, V. M., Djurovic, S., & Andreassen, O. A.
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 44
- Issue
- 12
- Pages
- 748-753
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2158991820
- Cited by
- 213
- References
- 11
- FWCI
- 16.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Athanasiu, L., Mattingsdal, M., Kähler, A. K., Brown, A., Gustafsson, O., Agartz, I., Giegling, I., Muglia, P., Cichon, S., Rietschel, M., Pietiläinen, O. P. H., Peltonen, L., Bramon, E., Collier, D., Clair, D. S., Sigurdsson, E., Petursson, H., Rujescu, D., Melle, I., . . . Andreassen, O. A. (2010). Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort. Journal of Psychiatric Research. https://doi.org/10.1016/j.jpsychires.2010.02.002
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