Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder
Open accessAbstract
We conducted a genome-wide association study (GWAS) and a follow-up study of bipolar disorder (BD), a common neuropsychiatric disorder. In the GWAS, we investigated 499,494 autosomal and 12,484 X-chromosomal SNPs in 682 patients with BD and in 1300 controls. In the first follow-up step, we tested the most significant 48 SNPs in 1729 patients with BD and in 2313 controls. Eight SNPs showed nominally significant association with BD and were introduced to a meta-analysis of the GWAS and the first follow-up samples. Genetic variation in the neurocan gene (NCAN) showed genome-wide significant association with BD in 2411 patients and 3613 controls (rs1064395, p = 3.02 × 10(-8); odds ratio = 1.31). In a second follow-up step, we replicated this finding in independent samples of BD, totaling 6030 patients and 31,749 controls (p = 2.74 × 10(-4); odds ratio = 1.12). The combined analysis of all study samples yielded a p value of 2.14 × 10(-9) (odds ratio = 1.17). Our results provide evidence that rs1064395 is a common risk factor for BD. NCAN encodes neurocan, an extracellular matrix glycoprotein, which is thought to be involved in cell adhesion and migration. We found that expression in mice is localized within cortical and hippocampal areas. These areas are involved in cognition and emotion regulation and have previously been implicated in BD by neuropsychological, neuroimaging, and postmortem studies.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Genetic susceptibility for schizophrenia is associated with genes encoding PNN components, matrix-regulating molecules, and immune system factors.
“We integrate these considerations with results from recent genetic studies showing genetic susceptibility for schizophrenia associated with genes encoding for PNN components, matrix-regulating molecules and immune system factors.”
From Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia (2015) · cites this paper as Cichon et al., 2011
Several vulnerability genes for schizophrenia encode PNN components and enzymes involved in ECM remodeling.
“Our findings, together with recent findings from genetic studies showing that several vulnerability genes for SZ encode PNN components and enzymes involved in ECM remodeling (Buxbaum et al., 2008; Cichon et al., 2011; Dow et al., 2011; Groszewska et al., 2011; Ripke and Consortium, 2011; Ripke et al., 2013; Ripke and Schizophrenia Working Group of the Psychiatric Genomics, 2014; Rybakowski et al.,”
From Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia (2015) · cites this paper as Cichon et al., 2011
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089 · see citing works
A simple salting out procedure for extracting DNA from human nucleated cells
Miller, S. A., Dykes, D. D., & Polesky, H. F. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.3.1215 · Cited by 20,341 · see citing works
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442 · see citing works
Self-citationSpitzer, R. L. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770300115013 · Cited by 6,946 · see citing works
A haplotype map of the human genome
The International HapMap Consortium (2005) · Nature · doi:10.1038/nature04226 · Cited by 5,858 · see citing works
Endicott, J. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770310043002 · Cited by 5,686 · see citing works
The Structured Clinical Interview for DSM-III-R (SCID): I: History, Rationale, and Description
Spitzer, R. L. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820080032005 · Cited by 4,336 · see citing works
Howie, B. N., Donnelly, P., & Marchini, J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000529 · Cited by 3,928 · see citing works
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Saxena, R., Voight, B. F., Lyssenko, V., Burtt, N. P., de Bakker, P. I. W., Chen, H., Roix, J. J., Kathiresan, S., Hirschhorn, J. N., Daly, M. J., et al. (2007) · Science · doi:10.1126/science.1142358 · Cited by 2,843 · see citing works
The Wellcome Trust Case Control Consortium, U.K.
Mossman, K. (2008) · Scientific American · doi:10.1038/scientificamerican0108-42a · Cited by 2,714 · see citing works
Utility of a new procedure for diagnosing mental disorders in primary care. The PRIME-MD 1000 study
Spitzer, R. L. (1994) · JAMA · doi:10.1001/jama.272.22.1749 · Cited by 2,648 · see citing works
SCAN: Schedules fonr Clinical Assessment in Neuropsychiatry
Wing, J. K. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810180089012 · Cited by 2,517 · see citing works
Diagnostic Interview for Genetic Studies
Nürnberger, J. I. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950110009002 · Cited by 2,066 · see citing works
Utility of a New Procedure for Diagnosing Mental Disorders in Primary Care: The PRIME-MD 1000 Study
Spitzer, R. L. (1994) · JAMA · doi:10.1001/jama.1994.03520220043029 · Cited by 1,873 · see citing works
SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap
Johnson, A. D., Handsaker, R., Pulit, S., Nizzari, M. M., O'Donnell, C., & de Bakker, P. D. (2008) · Bioinform. · doi:10.1093/bioinformatics/btn564 · Cited by 1,530 · see citing works
Best Estimate of Lifetime Psychiatric Diagnosis
Leckman, J. F. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290080001001 · Cited by 1,418 · see citing works
Wellcome Trust Case Control Consortium, Ferreira, M. A. R., O'Donovan, M. C., Meng, Y. A., Jones, I. R., Ruderfer, D. M., Jones, L., Fan, J., Kirov, G., Perlis, R. H., et al. (2008) · Nature Genetics · doi:10.1038/ng.209 · Cited by 1,237 · see citing works
Self-citationBaum, A. E., Akula, N., Cabanero, M., Cardona, I., Corona, W., Klemens, B., Schulze, T. G., Cichon, S., Rietschel, M., Nöthen, M. M., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002012 · Cited by 700 · see citing works
Self-citationWhole-genome association study of bipolar disorder
Sklar, P. B., Smoller, J. W., Fan, J., Ferreira, M. A. R., Perlis, R. H., Chambert, K., Nimgaonkar, V. L., McQueen, M. B., Faraone, S. V., Kirby, A. W., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002151 · Cited by 691 · see citing works
Schmermund, A., Möhlenkamp, S., Stang, A., Grönemeyer, D. H. W., Seibel, R. M. M., Hirche, H., Mann, K., Siffert, W., Lauterbach, K. W., Siegrist, J., et al. (2002) · American Heart Journal · doi:10.1067/mhj.2002.123579 · Cited by 576 · see citing works
Practical aspects of imputation-driven meta-analysis of genome-wide association studies
de Bakker, P. I. W., Ferreira, M. A. R., Jia, X., Neale, B. M., Raychaudhuri, S., & Voight, B. F. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn288 · Cited by 531 · see citing works
Detection of sharing by descent, long-range phasing and haplotype imputation
Kong, A., Masson, G., Frigge, M. L., Gylfason, A., Zusmanovich, P., Thorleifsson, G., Olason, P. I., Ingason, A., Steinberg, S., Rafnar, T., et al. (2008) · Nature Genetics · doi:10.1038/ng.216 · Cited by 447 · see citing works
Self-citationKORA-gen - Resource for Population Genetics, Controls and a Broad Spectrum of Disease Phenotypes
Wichmann, H. ‐., Gieger, C., & Illig, T. (2005) · Das Gesundheitswesen · doi:10.1055/s-2005-858226 · Cited by 417 · see citing works
Self-citationSmith, E. N., Bloss, C. S., Badner, J. A., Barrett, T., Belmonte, P. L., Berrettini, W., Byerley, W., Coryell, W., Craig, D., Edenberg, H. J., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.43 · Cited by 363 · see citing works
Self-citationKrawczak, M., Nikolaus, S., von Eberstein, H., Croucher, P. J. P., Mokhtari, N. E. E., & Schreiber, S. (2006) · Public Health Genomics · doi:10.1159/000090694 · Cited by 338 · see citing works
Self-citationRauch, U., Karthikeyan, L., Maurel, P., Margolis, R. U., & Margolis, R. K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41808-x · Cited by 333 · see citing works
Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry
Scott, L. J., Muglia, P., Kong, X., Guan, W., Flickinger, M., Upmanyu, R., Tozzi, F., Li, J. Z., Burmeister, M., Absher, D., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813386106 · Cited by 314 · see citing works
Muglia, P., Tozzi, F., Galwey, N. W., Francks, C., Upmanyu, R., Kong, X., Antoniades, A., Domenici, E., Perry, J., Rothen, S., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.131 · Cited by 265 · see citing works
Self-citationCommon Variants in the Trichohyalin Gene Are Associated with Straight Hair in Europeans
Medland, S. E., Nyholt, D. R., Painter, J. N., McEvoy, B. P., McRae, A. F., Zhu, G., Gordon, S. D., Ferreira, M. A. R., Wright, M. J., Henders, A. K., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.10.009 · Cited by 261 · see citing works
Self-citationStructure of the Anaphase-Promoting Complex/Cyclosome Interacting with a Mitotic Checkpoint Complex
Herzog, F., Primorac, I., Dube, P., Lénárt, P., Sander, B. O., Mechtler, K., Stark, H., & Peters, J. (2009) · Science · doi:10.1126/science.1163300 · Cited by 238 · see citing works
Athanasiu, L., Mattingsdal, M., Kähler, A. K., Brown, A. A., Gústafsson, Ó., Agartz, I., Giegling, I., Muglia, P., Cichon, S., Rietschel, M., et al. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.02.002 · Cited by 210 · see citing works
Self-citationNeurocan Is Dispensable for Brain Development
Zhou, X.-H., Brakebusch, C., Matthies, H., Oohashi, T., Hirsch, E., Moser, M., Krug, M., Seidenbecher, C. I., Boeckers, T. M., Rauch, U., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.5970-5978.2001 · Cited by 206 · see citing works
Iwanaga, Y., Chi, Y., Miyazato, A., Sheleg, S. V., Haller, K., Péloponèse, J., Li, Y., Ward, J. M., Benezra, R., & Jeang, K. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3326 · Cited by 190 · see citing works
Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder
Schulze, T. G., Detera‐Wadleigh, S. D., Akula, N., Gupta, A. K., Kassem, L., Steele, J., Pearl, J., Strohmaier, J., Breuer, R., Schwarz, M., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.134 · Cited by 187 · see citing works
Self-citationPeters, L., & Andrews, G. (1995) · Psychological Medicine · doi:10.1017/s0033291700033237 · Cited by 179 · see citing works
The role of hippocampus in the pathophysiology of bipolar disorder
Frey, B. N., Andreazza, A. C., Nery, F. G., Martins, M. R., Quevedo, J., Soares, J. C., & Kapczinski, F. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282df3cde · Cited by 162 · see citing works
Reliability and procedural validity of UM-CIDI DSM-III-R phobic disorders
Wïttchen, H., Zhao, S., Abelson, J. M., Abelson, J. L., & Kessler, R. C. (1996) · Psychological Medicine · doi:10.1017/s0033291700035893 · Cited by 153 · see citing works
Wittchen, H. ‐., Höfler, M., Gander, F., Pfister, H., Storz, S., Üstün, B., Müller, N., & Kessler, R. C. (1999) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.57 · Cited by 149 · see citing works
(1982) · Springer eBooks · doi:10.1007/978-3-642-68405-0 · Cited by 132 · see citing works
Bipolar disorder: from genes to behavior pathways
Martinowich, K., Schloesser, R. J., & Manji, H. K. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37703 · Cited by 123 · see citing works
Djurovic, S., Gústafsson, Ó., Mattingsdal, M., Athanasiu, L., Bjella, T. D., Tesli, M., Agartz, I., Lorentzen, S., Melle, I. S., Morken, G., et al. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.04.007 · Cited by 120 · see citing works
Self-citationBaum, A. E., Hamshere, M., Green, E., Cichon, S., Rietschel, M., Nöthen, M. M., Craddock, N. J., & McMahon, F. J. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.16 · Cited by 114 · see citing works
Self-citationAnxiety with Panic Disorder Linked to Chromosome 9q in Iceland
Thorgeirsson, T. E., Óskarsson, H., Desnica, N., Kostic, J. P., Stefánsson, J. G., Kolbeinsson, H., Líndal, E., Gagunashvili, N., Frigge, M. L., Kong, A., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/375141 · Cited by 96 · see citing works
Milev, P., Monnerie, H., Popp, S., Margolis, R. K., & Margolis, R. U. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.34.21439 · Cited by 95 · see citing works
Étain, B., Dumaine, A., Mathieu, F., Chevalier, F., Henry, C., Kahn, J., Deshommes, J., Bellivier, F., Leboyer, M., & Jamain, S. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.148 · Cited by 88 · see citing works
Self-citationMitchell, P. B., Johnston, A. K., Corry, J., Ball, J. R. B., & Malhi, G. S. (2009) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670802607220 · Cited by 51 · see citing works
Self-citationMethodological Issues in Using a Polydiagnostic Approach to Define Psychotic Illness
FARMER, A. E., Wessely, S. C., Castle, D. J., & McGuffin, P. (1992) · The British Journal of Psychiatry · doi:10.1192/bjp.161.6.824 · Cited by 49 · see citing works
Miró, X., Zhou, X., Boretius, S., Michaelis, T., Kubisch, C., Álvarez-Bolado, G., & Gruß, P. (2009) · Disease Models & Mechanisms · doi:10.1242/dmm.001602 · Cited by 49 · see citing works
Self-citationWatanabe, E., Aono, S., Matsui, F., Yamada, Y., Naruse, I., & Oohira, A. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb00659.x · Cited by 44 · see citing works
Computer-Assisted Phenotype Characterization for Genetic Research in Psychiatry
Fangerau, H., Ohlraun, S., Granath, R. O., Nöthen, M. M., Rietschel, M., & Schulze, T. G. (2004) · Human Heredity · doi:10.1159/000083538 · Cited by 41 · see citing works
Self-citationMcAuley, E. Z., Blair, I. P., Liu, Z., Fullerton, J. M., Scimone, A., Herten, M. V., Evans, M. R., Kirkby, K. C., Donald, J. A., Mitchell, P. B., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002146 · Cited by 32 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
(2013) · The Lancet · doi:10.1016/s0140-6736(12)62129-1 · Cited by 3,010 · see citing works
Genome-wide association study identifies 30 loci associated with bipolar disorder
eQTLGen Consortium, Stahl, E. A., BIOS Consortium, the Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Breen, G., Forstner, A. J., McQuillin, A., Ripke, S., Trubetskoy, V., Mattheisen, M., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0397-8 · Cited by 1,519 · see citing works
Self-citationMullins, N., Forstner, A. J., O’Connell, K. S., Coombes, B., Coleman, J. R. I., Qiao, Z., Als, T. D., Bigdeli, T. B., Børte, S., Bryois, J., et al. (2021) · Nature Genetics · doi:10.1038/s41588-021-00857-4 · Cited by 1,517 · see citing works
Self-citationGenome-wide association analysis identifies 13 new risk loci for schizophrenia
Multicenter Genetic Studies of Schizophrenia Consortium, Ripke, S., Psychosis Endophenotypes International Consortium, Wellcome Trust Case Control Consortium 2, O'Dushlaine, C., Chambert, K., Moran, J. L., Kähler, A. K., Akterin, S., Bergen, S. E., et al. (2013) · Nature Genetics · doi:10.1038/ng.2742 · Cited by 1,496 · see citing works
Self-citationPsychiatric GWAS Consortium Bipolar Disorder Working Group, Sklar, P., Ripke, S., Scott, L. J., Andreassen, O. A., Cichon, S., Craddock, N., Edenberg, H. J., Nurnberger, J. I., Rietschel, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.943 · Cited by 1,344 · see citing works
Self-citationGenetic architectures of psychiatric disorders: the emerging picture and its implications
Sullivan, P. F., Daly, M. J., & O'Donovan, M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3240 · Cited by 1,177 · see citing works
Self-citationGenome-wide association study reveals two new risk loci for bipolar disorder
Mühleisen, T. W., Leber, M., Schulze, T. G., Strohmaier, J., Degenhardt, F., Treutlein, J., Mattheisen, M., Forstner, A. J., Schumacher, J., Breuer, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms4339 · Cited by 346 · see citing works
Self-citationDoherty, J. L., & Owen, M. J. (2014) · Genome Medicine · doi:10.1186/gm546 · Cited by 228 · see citing works
Self-citationSchork, A. J., Won, H., Appadurai, V., Nudel, R., Gandal, M., Delaneau, O., Revsbech Christiansen, M., Hougaard, D. M., Bækved-Hansen, M., Bybjerg-Grauholm, J., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0320-0 · Cited by 223 · see citing works
Berretta, S., Pantazopoulos, H., Markota, M., Brown, C., & Batzianouli, E. T. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2014.12.040 · Cited by 152 · see citing works
Common variant at 16p11.2 conferring risk of psychosis
Steinberg, S., de Jong, S., Mattheisen, M., Costas, J., Demontis, D., Jamain, S., Pietiläinen, O. P. H., Lin, K., Papiol, S., Huttenlocher, J., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2012.157 · Cited by 104 · see citing works
Self-citationPriebe, L., Degenhardt, F. A., Herms, S., Haenisch, B., Mattheisen, M., Nieratschker, V, Weingarten, M., Witt, S., Breuer, R., Paul, T., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.8 · Cited by 84 · see citing works
Self-citationMühleisen, T. W., Mattheisen, M., Strohmaier, J., Degenhardt, F., Priebe, L., Schultz, C. C., Breuer, R., Meier, S., Hoffmann, P., Rivandeneira, F., et al. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.03.007 · Cited by 80 · see citing works
Self-citationSchultz, C. C., Mühleisen, T. W., Nenadic, I., Koch, K., Wagner, G., Schachtzabel, C., Siedek, F., Nöthen, M. M., Rietschel, M., Deufel, T., et al. (2014) · Psychological Medicine · doi:10.1017/s0033291713001414 · Cited by 60 · see citing works
Self-citationPedroso, I., Lourdusamy, A., Rietschel, M., Nöthen, M. M., Cichon, S., McGuffin, P., Al-Chalabi, A., Barnes, M. R., & Breen, G. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.031 · Cited by 59 · see citing works
Self-citationSullivan, P., & on behalf of 96 Psychiatric Genetics Investigators* (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.94 · Cited by 59 · see citing works
Incubation of depression: ECM assembly and parvalbumin interneurons after stress
Spijker, S., Koskinen, M.-K., & Riga, D. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.015 · Cited by 55 · see citing works
Perineuronal Net Protein Neurocan Inhibits NCAM/EphA3 Repellent Signaling in GABAergic Interneurons
Sullivan, C. S., Gotthard, I., Wyatt, E. V., Bongu, S., Mohan, V., Weinberg, R. J., & Maness, P. F. (2018) · Scientific Reports · doi:10.1038/s41598-018-24272-8 · Cited by 37 · see citing works
Post‐mortem multiple sclerosis lesion pathology is influenced by single nucleotide polymorphisms
Fransen, N. L., Crusius, J. B. A., Smolders, J., Mizee, M. R., van Eden, C. G., Luchetti, S., Remmerswaal, E. B. M., Hamann, J., Mason, M. R. J., & Huitinga, I. (2020) · Brain Pathology · doi:10.1111/bpa.12760 · Cited by 37 · see citing works
- Authors
- Cichon, S., Mühleisen, T. W., Degenhardt, F. A., Mattheisen, M., Miró, X., Strohmaier, J., Steffens, M., Meesters, C., Herms, S., Weingarten, M., Priebe, L., Haenisch, B., Alexander, M., Vollmer, J., Breuer, R., Schmäl, C., Tessmann, P., Moebus, S., Wichmann, H.-E., Schreiber, S., Müller-Myhsok, B., Lucae, S., Jamain, S., Leboyer, M., Bellivier, F., Etain, B., Henry, C., Kahn, J.-P., Heath, S., Hamshere, M., O'Donovan, M. C., Owen, M. J., Craddock, N., Schwarz, M., Vedder, H., Kammerer-Ciernioch, J., Reif, A., Sasse, J., Bauer, M., Hautzinger, M., Wright, A., Mitchell, P. B., Schofield, P. R., Montgomery, G. W., Medland, S. E., Gordon, S. D., Martin, N. G., Gustafsson, O., Andreassen, O., Djurovic, S., Sigurdsson, E., Steinberg, S., Stefansson, H., Stefansson, K., Kapur-Pojskic, L., Oruc, L., Rivas, F., Mayoral, F., Chuchalin, A., Babadjanova, G., Tiganov, A. S., Pantelejeva, G., Abramova, L. I., Grigoroiu-Serbanescu, M., Diaconu, C. C., Czerski, P. M., Hauser, J., Zimmer, A., Lathrop, M., Schulze, T. G., Wienker, T. F., Schumacher, J., Maier, W., Propping, P., Rietschel, M., & Nöthen, M. M.
- Affiliations
- University of Bonn (DE)
- University of Mannheim (DE)
- University of Duisburg-Essen (DE)
- Helmholtz Munich (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- Max Planck Institute of Psychiatry (DE)
- Inserm (FR)
- Fondation FondaMental (FR)
- Cardiff University (GB)
- University of Würzburg (DE)
- University Hospital Carl Gustav Carus (DE)
- University of Tübingen (DE)
- Black Dog Institute (AU)
- UNSW Sydney (AU)
- QIMR Berghofer Medical Research Institute (AU)
- Oslo University Hospital (NO)
- deCODE Genetics (Iceland) (IS)
- Clinical Center University of Sarajevo (BA)
- Pirogov Russian National Research Medical University (RU)
- Mental Health Research Center of Russian Academy of Medical Sciences (RU)
- Romanian Academy (RO)
- Poznan University of Medical Sciences (PL)
- Universitätsmedizin Göttingen (DE)
- Corresponding author
- Cichon, Sven
- ORCID
- Cichon, Sven
- Mühleisen, Thomas W.
- Degenhardt, Franziska A.
- Mattheisen, Manuel
- Strohmaier, Jana
- Steffens, Michael
- Meesters, Christian
- Herms, Stefan
- Moebus, Susanne
- Wichmann, H.-Erich
- Schreiber, Stefan
- Lucae, Susanne
- Jamain, Stéphane
- Leboyer, Marion
- Bellivier, Frank
- Henry, Chantal
- Kahn, Jean-Pierre
- Heath, Simon
- Hamshere, Marian
- Owen, Michael J.
- Craddock, Nick
- Schwarz, Markus
- Vedder, Helmut
- Reif, Andreas
- Bauer, Michael
- Hautzinger, Martin
- Mitchell, Philip B.
- Schofield, Peter R.
- Montgomery, Grant W.
- Medland, Sarah E.
- Gordon, Scott D.
- Martin, Nicholas G.
- Andreassen, Ole
- Djurovic, Srdjan
- Steinberg, Stacy
- Mayoral, Fermín
- Diaconu, Carmen C.
- Czerski, Piotr M.
- Hauser, Joanna
- Zimmer, Andreas
- Lathrop, Mark
- Schulze, Thomas G.
- Schumacher, Johannes
- Rietschel, Marcella
- Nöthen, Markus M.
- Venue
- The American Journal of Human Genetics
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 88
- Issue
- 3
- Pages
- 372-381
- ISSN
- 0002-9297 (ISSN-L)
- PMC
- PMC3059436
- OpenAlex
- W2058335733
- Cited by
- 286
- References
- 52
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 12 · 2023: 5 · 2022: 14 · 2021: 9 · 2020: 20 · 2019: 20 · 2018: 23 · 2017: 24 · 2016: 20 · 2015: 25 · 2014: 26 · 2013: 28 · 2012: 38
- FWCI
- 22.54
- Type
- journal article
- Language
- en
- Update notices
- erratum (2011-03-11)
- Open access
- bronze
- doi.org
- Licence
- Locations
- The American Journal of Human Genetics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- JuSER (Forschungszentrum Jülich) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- bipolar disorder, neurocan, genetic susceptibility, single nucleotide polymorphisms, extracellular matrix glycoprotein, extracellular matrix genes, hippocampus, cortex, cell adhesion, cell migration, neuropsychiatric disorders
- MeSH terms
- Animals, Bipolar Disorder, Brain, Follow-Up Studies, Humans, Genetic Variation, Reproducibility of Results, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Mice, Genome-Wide Association Study, Neurocan
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
