Cited by 332Personality Disorders and PsychopathologyPosttraumatic Stress Disorder ResearchSleep and related disorders

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Comorbidity of borderline personality disorder and posttraumatic stress disorder in the U.S. population

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Pagura, Jina, Stein, Murray B., Bolton, James M., Cox, Brian J., Grant, Bridget, Sareen, Jitender·2010·Journal of Psychiatric Research

DOI 10.1016/j.jpsychires.2010.04.016PMC PMC4209725

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Abstract

While placed on different axes of the DSM classification system, borderline personality disorder (BPD) and posttraumatic stress disorder (PTSD) have important relationships with trauma, and overlap between these disorders has long been recognized. The current study is the first to examine comorbidity of PTSD and BPD in a large nationally representative sample using a reliable and valid method of assessing Axis I and II mental disorders. Data came from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) Wave II (N = 34,653; response rate 70.2%). Multiple regression models were used to examine differences in psychopathology, traumatic events and health-related quality of life across individuals with PTSD alone (n = 1820), BPD alone (n = 1290) and those with comorbid PTSD-BPD (n = 643). The lifetime prevalence of PTSD and BPD were 6.6% and 5.9%, respectively. Of individuals with BPD, 30.2% were also diagnosed with PTSD, whereas 24.2% of individuals with PTSD were also diagnosed with BPD. Individuals with comorbid PTSD-BPD had a poorer quality of life, more comorbidity with other Axis I conditions, increased odds of a lifetime suicide attempt, and a higher prevalence of repeated childhood traumatic events than individuals with either condition alone. These results show that PTSD and BPD have a high degree of lifetime co-occurrence but are not entirely overlapping. Their concurrence is associated with poorer functioning compared to either diagnosis alone, emphasizing the clinical utility of diagnosing both conditions. Future research should explore the determinants of having either or both diagnoses with an aim toward improved identification, prevention, and intervention.

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Authors: Pagura, J., Stein, M. B., Bolton, J. M., Cox, B. J., Grant, B., & Sareen, J.
Affiliations: University of Manitoba (CA)
University of California San Diego (US)
National Institutes of Health (US)
Corresponding author: Sareen, Jitender
ORCID: Stein, Murray B.
Bolton, James M.
Cox, Brian J.
Sareen, Jitender
Venue: Journal of Psychiatric Research
Publisher: Elsevier BV
Published: 2010-12
Volume: 44
Issue: 16
Pages: 1190-1198
ISSN: 0022-3956 (ISSN-L)
DOI: 10.1016/j.jpsychires.2010.04.016
PMC: PMC4209725
OpenAlex: W2111282764
Cited by: 330
References: 57
Citations by year: 2026: 14 · 2025: 20 · 2024: 22 · 2023: 38 · 2022: 34 · 2021: 25 · 2020: 23 · 2019: 18 · 2018: 15 · 2017: 16 · 2016: 19 · 2015: 20 · 2014: 23 · 2013: 19 · 2012: 15
FWCI: 14.80
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Journal of Psychiatric Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Canadian Institutes of Health Research (82894)
National Institute on Alcohol Abuse and Alcoholism (Z01AA000449)
National Institute of Mental Health (MH-64122, K24MH064122)
National Institute on Drug Abuse
Topics: Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords: borderline personality disorder, post-traumatic stress disorder, comorbidities, trauma exposure, childhood trauma, health-related quality of life, suicide attempts, lifetime prevalence, psychopathology, NESARC
MeSH terms: Adult, Aged, Borderline Personality Disorder, Data Collection, Female, Health Surveys, Humans, Longitudinal Studies, Male, Middle Aged, Psychiatric Status Rating Scales, Quality of Life, Severity of Illness Index, Stress Disorders, Post-Traumatic, Suicide, Attempted, United States, Comorbidity, Prevalence, Age of Onset, Young Adult

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Comorbidity of borderline personality disorder and posttraumatic stress disorder in the U.S. population

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