Cited by 187LGBTQ Health, Identity, and PolicyAdvanced Neuroimaging Techniques and ApplicationsSexual Differentiation and Disorders

The DOI matches its Crossref record; 51 of the 53 references it cites were found in a registry or an index.

White matter microstructure in female to male transsexuals before cross-sex hormonal treatment. A diffusion tensor imaging study

Rametti, Giuseppina, Carrillo, Beatriz, Gómez-Gil, Esther, Junque, Carme, Segovia, Santiago, Gomez, Ángel, Guillamon, Antonio·2011·Journal of Psychiatric Research

Abstract

Background Some gray and white matter regions of the brain are sexually dimorphic. The best MRI technique for identifying subtle differences in white matter is diffusion tensor imaging (DTI). The purpose of this paper is to investigate whether white matter patterns in female to male (FtM) transsexuals before commencing cross-sex hormone treatment are more similar to that of their biological sex or to that of their gender identity.Method DTI was performed in 18 FtM transsexuals and 24 male and 19 female heterosexual controls scanned with a 3 T Trio Tim Magneton. Fractional anisotropy (FA) was performed on white matter fibers of the whole brain, which was spatially analyzed using Tract-Based Spatial Statistics.Results In controls, males have significantly higher FA values than females in the medial and posterior parts of the right superior longitudinal fasciculus (SLF), the forceps minor, and the corticospinal tract. Compared to control females, FtM showed higher FA values in posterior part of the right SLF, the forceps minor and corticospinal tract. Compared to control males, FtM showed only lower FA values in the corticospinal tract.Conclusions Our results show that the white matter microstructure pattern in untreated FtM transsexuals is closer to the pattern of subjects who share their gender identity (males) than those who share their biological sex (females). Our results provide evidence for an inherent difference in the brain structure of FtM transsexuals.

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Crossref · 10.1016/j.jpsychires.2010.05.006

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Research works printed but not linked: 2

  1. Bobes, 1997, Validez del M.I.N.I. (Mini International Neuropsychiatric Interview) en tres centros de AP en España, Psiquiatría Biológica, 4, 79
  2. Gómez-Gil, 2005, Estimación de la prevalencia, incidencia y razón de sexos del transexualismo en Cataluña según la demanda asistencial, Actas Españolas de Psiquiatría, 34, 295

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Items 101–186 of 186

Metadata

Authors
Rametti, G., Carrillo, B., Gómez-Gil, E., Junque, C., Segovia, S., Gomez, Á., & Guillamon, A.
Affiliations
  • Hospital Clínic de Barcelona (ES)
  • Universitat de Barcelona (ES)
  • Universidad Nacional de Educación a Distancia (ES)
Venue
Journal of Psychiatric Research
Publisher
Elsevier BV
Published
2011-02
Volume
45
Issue
2
Pages
199-204
ISSN
0022-3956 (ISSN-L)
OpenAlex
W2103554216
Cited by
187
References
53
Citations by year
2025: 6 · 2024: 13 · 2023: 7 · 2022: 11 · 2021: 13 · 2020: 18 · 2019: 17 · 2018: 17 · 2017: 11 · 2016: 15 · 2015: 8 · 2014: 19 · 2013: 18 · 2012: 7
FWCI
13.93
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Psychiatric Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • World Health Organization
  • Emory University
Topics
  • Social Sciences › Psychology › Social Psychology › LGBTQ Health, Identity, and Policy
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords
female-to-male transsexuals, white matter microstructure, sexual dimorphism, brain structure, gender identity, superior longitudinal fasciculus, forceps minor, corticospinal tract, fractional anisotropy, sex differences in brain
MeSH terms
Adolescent, Adult, Brain, Brain Mapping, Female, Humans, Male, Nerve Fibers, Myelinated, Sex Characteristics, Transsexualism, Young Adult, Diffusion Tensor Imaging

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