Cited by 192Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

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Blunted reward responsiveness in remitted depression

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Pechtel, Pia, Dutra, Sunny J., Goetz, Elena L., Pizzagalli, Diego A.·2013·Journal of Psychiatric Research

DOI 10.1016/j.jpsychires.2013.08.011PMC PMC3978009

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Abstract

Major depressive disorder has been associated with blunted responsiveness to rewards, but inconsistencies exist whether such abnormalities persist after complete remission. To address this issue, across two independent studies, 47 adults with remitted major depressive disorder (rMDD) and 37 healthy controls completed a Probabilistic Reward Task, which used a differential reinforcement schedule of social or monetary feedback to examine reward responsiveness (i.e., ability to modulate behavior as a function of reinforcement history). Relative to controls, adults with rMDD showed blunted reward responsiveness. Importantly, a history of depression predicted reduced reward learning above and beyond residual depressive (including anhedonic) symptoms and perceived stress. Findings indicate that blunted reward responsiveness endures even when adults are in remission and might be a trait-related abnormality in MDD. More research is warranted to investigate if blunted reward responsiveness may predict future depressive episodes and whether targeting reward-related deficits may prevent the re-occurrence of the disorder.

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Authors: Pechtel, P., Dutra, S. J., Goetz, E. L., & Pizzagalli, D. A.
Affiliations: Harvard University (US)
Yale University (US)
Corresponding author: Pechtel, Pia
Pizzagalli, Diego A.
ORCID: Pechtel, Pia
Dutra, Sunny J.
Pizzagalli, Diego A.
Venue: Journal of Psychiatric Research
Publisher: Elsevier BV
Published: 2013-12
Volume: 47
Issue: 12
Pages: 1864-1869
ISSN: 0022-3956 (ISSN-L)
DOI: 10.1016/j.jpsychires.2013.08.011
PMC: PMC3978009
OpenAlex: W2142577246
Cited by: 192
References: 42
Citations by year: 2026: 14 · 2025: 13 · 2024: 6 · 2023: 15 · 2022: 17 · 2021: 17 · 2020: 25 · 2019: 13 · 2018: 15 · 2017: 16 · 2016: 11 · 2015: 22 · 2014: 8
FWCI: 7.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Psychiatric Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Harvard University
Deutsche Forschungsgemeinschaft
National Institute of Mental Health (R01MH101521, R01MH095809, R01MH068376, R21MH078979, R01 MH68376)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: remitted depression, reward learning, probabilistic reward task, differential reinforcement, anhedonia, residual depressive symptoms, perceived stress
MeSH terms: Adult, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Learning Disabilities, Male, Neuropsychological Tests, Probability, Psychiatric Status Rating Scales, Reaction Time, Regression Analysis, Reward, Young Adult

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Blunted reward responsiveness in remitted depression

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