The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Blunted reward responsiveness in remitted depression
Open accessAbstract
Major depressive disorder has been associated with blunted responsiveness to rewards, but inconsistencies exist whether such abnormalities persist after complete remission. To address this issue, across two independent studies, 47 adults with remitted major depressive disorder (rMDD) and 37 healthy controls completed a Probabilistic Reward Task, which used a differential reinforcement schedule of social or monetary feedback to examine reward responsiveness (i.e., ability to modulate behavior as a function of reinforcement history). Relative to controls, adults with rMDD showed blunted reward responsiveness. Importantly, a history of depression predicted reduced reward learning above and beyond residual depressive (including anhedonic) symptoms and perceived stress. Findings indicate that blunted reward responsiveness endures even when adults are in remission and might be a trait-related abnormality in MDD. More research is warranted to investigate if blunted reward responsiveness may predict future depressive episodes and whether targeting reward-related deficits may prevent the re-occurrence of the disorder.
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“Second, blunted reward learning—defined as a diminished ability to modulate behavior as a function of rewards—has been observed in both individuals with current and remitted MDD (Goldstein and Klein, 2014; Pechtel et al, 2013; Pizzagalli, 2014).”
From Neural Correlates of Three Promising Endophenotypes of Depression: Evidence from the EMBARC Study (2016) · cites this paper as Pechtel et al, 2013
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Depression, Stress, and Anhedonia: Toward a Synthesis and Integrated Model
Pizzagalli, D. A. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050212-185606 · Cited by 1,155
Self-citationReward processing dysfunction in major depression, bipolar disorder and schizophrenia
Whitton, A. E., Treadway, M. T., & Pizzagalli, D. A. (2014) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000122 · Cited by 740
Self-citationAssessing anhedonia in depression: potentials and pitfalls
Rizvi, S. J., Pizzagalli, D. A., Sproule, B. A., & Kennedy, S. H. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.004 · Cited by 571
Self-citationDysfunctional reward processing in depression
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Metadata
- Authors
- Pechtel, P., Dutra, S. J., Goetz, E. L., & Pizzagalli, D. A.
- Affiliations
- Harvard University (US)
- Yale University (US)
- Corresponding author
- Pechtel, Pia
- Pizzagalli, Diego A.
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 47
- Issue
- 12
- Pages
- 1864-1869
- ISSN
- 0022-3956 (ISSN-L)
- PMC
- PMC3978009
- OpenAlex
- W2142577246
- Cited by
- 192
- References
- 42
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 6 · 2023: 15 · 2022: 17 · 2021: 17 · 2020: 25 · 2019: 13 · 2018: 15 · 2017: 16 · 2016: 11 · 2015: 22 · 2014: 8
- FWCI
- 7.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Harvard University
- Deutsche Forschungsgemeinschaft
- National Institute of Mental Health (R01MH101521, R01MH095809, R01MH068376, R21MH078979, R01 MH68376)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- remitted depression, reward learning, probabilistic reward task, differential reinforcement, anhedonia, residual depressive symptoms, perceived stress
- MeSH terms
- Adult, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Learning Disabilities, Male, Neuropsychological Tests, Probability, Psychiatric Status Rating Scales, Reaction Time, Regression Analysis, Reward, Young Adult
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