Cited by 909Nerve injury and regenerationPhysical Activity and HealthExercise and Physiological Responses

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A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor

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Szuhany, Kristin L., Bugatti, Matteo, Otto, Michael W.·2015·Journal of Psychiatric Research

DOI 10.1016/j.jpsychires.2014.10.003PMC PMC4314337

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Abstract

Consistent evidence indicates that exercise improves cognition and mood, with preliminary evidence suggesting that brain-derived neurotrophic factor (BDNF) may mediate these effects. The aim of the current meta-analysis was to provide an estimate of the strength of the association between exercise and increased BDNF levels in humans across multiple exercise paradigms. We conducted a meta-analysis of 29 studies (N = 1111 participants) examining the effect of exercise on BDNF levels in three exercise paradigms: (1) a single session of exercise, (2) a session of exercise following a program of regular exercise, and (3) resting BDNF levels following a program of regular exercise. Moderators of this effect were also examined. Results demonstrated a moderate effect size for increases in BDNF following a single session of exercise (Hedges' g = 0.46, p < 0.001). Further, regular exercise intensified the effect of a session of exercise on BDNF levels (Hedges' g = 0.59, p = 0.02). Finally, results indicated a small effect of regular exercise on resting BDNF levels (Hedges' g = 0.27, p = 0.005). When analyzing results across paradigms, sex significantly moderated the effect of exercise on BDNF levels, such that studies with more women showed less BDNF change resulting from exercise. Effect size analysis supports the role of exercise as a strategy for enhancing BDNF activity in humans, but indicates that the magnitude of these effects may be lower in females relative to males.

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International physical activity questionnaire: 12-country reliability and validity
CRAIG, C. L., MARSHALL, A. L., SJ??STR??M, M., BAUMAN, A. E., BOOTH, M. L., AINSWORTH, B. E., PRATT, M., EKELUND, U., YNGVE, A., SALLIS, J. F., et al. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000078924.61453.fb · Cited by 21,619
Book Reviews: Statistical Methods for Meta-Analysis Larry V. Hedges and Ingram Olkin New York: Academic Press, 1985. xxii + 369 pp
Wasserman, S. S., Hedges, L. V., & Olkin, I. (1988) · Journal of Educational Statistics · doi:10.2307/1164953 · Cited by 10,377
Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory, Musculoskeletal, and Neuromotor Fitness in Apparently Healthy Adults
Garber, C. E., Blissmer, B., Deschenes, M. R., Franklin, B. A., Lamonte, M. J., Lee, I.-M., Nieman, D. C., & Swain, D. P. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318213fefb · Cited by 9,319 · cited 1×
“These included sex (expressed as % female), age, assay type (i.e., serum or plasma), diagnostic status, and exercise frequency (defined as greater than or equal to American College of Sports Medicine guidelines, Garber et al., 2011).”
Background
Untitled work
(2000) · Cited by 9,198
A power primer.
Cohen, J. (1992) · Psychological Bulletin · doi:10.1037//0033-2909.112.1.155 · Cited by 8,771
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
Methods of Meta-Analysis: Correcting Error and Bias in Research Findings
Schmidt, F. L., & Hunter, J. E. (2015) · doi:10.4135/9781483398105 · Cited by 5,542
Exercise training increases size of hippocampus and improves memory
Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., Kim, J. S., Heo, S., Alves, H., White, S. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015950108 · Cited by 4,855
Statistical Methods for Meta-Analysis.
Freeman, P. R., Hedges, L. V., & Olkin, I. (1986) · Biometrics · doi:10.2307/2531069 · Cited by 4,840
Meta-Analytic Procedures for Social Research
Rosenthal, R. (1991) · doi:10.4135/9781412984997 · Cited by 4,635

Show all 96 references

Research works printed but not linked: 1

Cohen, 1992, power primer, Psychol Bull, 112, 155, 10.1037/0033-2909.112.1.155 · DOI · Paper page

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Authors: Szuhany, K. L., Bugatti, M., & Otto, M. W.
Affiliations: Boston University (US)
Corresponding author: Szuhany, Kristin L.
ORCID: Szuhany, Kristin L.
Bugatti, Matteo
Otto, Michael W.
Venue: Journal of Psychiatric Research
Publisher: Elsevier BV
Published: 2015-01
Volume: 60
Pages: 56-64
ISSN: 0022-3956 (ISSN-L)
DOI: 10.1016/j.jpsychires.2014.10.003
PMC: PMC4314337
OpenAlex: W2047262956
Cited by: 909
References: 96
Citations by year: 2026: 113 · 2025: 104 · 2024: 83 · 2023: 90 · 2022: 77 · 2021: 99 · 2020: 75 · 2019: 76 · 2018: 64 · 2017: 63 · 2016: 49 · 2015: 15
FWCI: 4.84
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Psychiatric Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (F31 MH100773)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: physical activity, brain-derived neurotrophic factor, single-session exercise, regular exercise, sex differences, cognitive function, mood, neuroplasticity
MeSH terms: Adult, Age Factors, Female, Humans, Male, Motor Activity, Sex Factors, Time Factors, Exercise, Brain-Derived Neurotrophic Factor

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A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor

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