Cited by 909Nerve injury and regenerationPhysical Activity and HealthExercise and Physiological Responses

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A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor

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Szuhany, Kristin L., Bugatti, Matteo, Otto, Michael W.·2015·Journal of Psychiatric Research

DOI 10.1016/j.jpsychires.2014.10.003PMC PMC4314337

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Abstract

Consistent evidence indicates that exercise improves cognition and mood, with preliminary evidence suggesting that brain-derived neurotrophic factor (BDNF) may mediate these effects. The aim of the current meta-analysis was to provide an estimate of the strength of the association between exercise and increased BDNF levels in humans across multiple exercise paradigms. We conducted a meta-analysis of 29 studies (N = 1111 participants) examining the effect of exercise on BDNF levels in three exercise paradigms: (1) a single session of exercise, (2) a session of exercise following a program of regular exercise, and (3) resting BDNF levels following a program of regular exercise. Moderators of this effect were also examined. Results demonstrated a moderate effect size for increases in BDNF following a single session of exercise (Hedges' g = 0.46, p < 0.001). Further, regular exercise intensified the effect of a session of exercise on BDNF levels (Hedges' g = 0.59, p = 0.02). Finally, results indicated a small effect of regular exercise on resting BDNF levels (Hedges' g = 0.27, p = 0.005). When analyzing results across paradigms, sex significantly moderated the effect of exercise on BDNF levels, such that studies with more women showed less BDNF change resulting from exercise. Effect size analysis supports the role of exercise as a strategy for enhancing BDNF activity in humans, but indicates that the magnitude of these effects may be lower in females relative to males.

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Authors: Szuhany, K. L., Bugatti, M., & Otto, M. W.
Affiliations: Boston University (US)
Corresponding author: Szuhany, Kristin L.
ORCID: Szuhany, Kristin L.
Bugatti, Matteo
Otto, Michael W.
Venue: Journal of Psychiatric Research
Publisher: Elsevier BV
Published: 2015-01
Volume: 60
Pages: 56-64
ISSN: 0022-3956 (ISSN-L)
DOI: 10.1016/j.jpsychires.2014.10.003
PMC: PMC4314337
OpenAlex: W2047262956
Cited by: 909
References: 96
Citations by year: 2026: 113 · 2025: 104 · 2024: 83 · 2023: 90 · 2022: 77 · 2021: 99 · 2020: 75 · 2019: 76 · 2018: 64 · 2017: 63 · 2016: 49 · 2015: 15
FWCI: 4.84
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Psychiatric Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (F31 MH100773)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: physical activity, brain-derived neurotrophic factor, single-session exercise, regular exercise, sex differences, cognitive function, mood, neuroplasticity
MeSH terms: Adult, Age Factors, Female, Humans, Male, Motor Activity, Sex Factors, Time Factors, Exercise, Brain-Derived Neurotrophic Factor

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A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor

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