The effect of acute exercise on blood concentrations of brain-derived neurotrophic factor in healthy adults. A meta-analysis.

Dinoff, Adam; Herrmann, Nathan; Swardfager, Walter; Lanctôt, Krista L.

doi:10.1111/ejn.13603

Cited by 323Nerve injury and regenerationPhysical Activity and HealthExercise and Physiological Responses

The effect of acute exercise on blood concentrations of brain-derived neurotrophic factor in healthy adults. A meta-analysis.

Dinoff, Adam, Herrmann, Nathan, Swardfager, Walter, Lanctôt, Krista L.·2017·European Journal of Neuroscience

DOI 10.1111/ejn.13603

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Abstract

It has been hypothesized that one mechanism through which physical activity provides benefits to cognition and mood is via increasing brain‐derived neurotrophic factor (BDNF) concentrations. Some studies have reported immediate benefits to mood and various cognitive domains after a single session of exercise. This meta‐analysis sought to determine the effect of a single exercise session on concentrations of BDNF in peripheral blood, in order to evaluate the potential role of BDNF in mediating the beneficial effects of exercise on brain health. MEDLINE, Embase, PsycINFO, SPORTDiscus, Rehabilitation & Sports Medicine Source, and CINAHL databases were searched for original, peer‐reviewed reports of peripheral blood BDNF concentrations before and after acute exercise interventions. Risk of bias within studies was assessed using standardized criteria. Standardized mean differences (SMD s) were generated from random effects models. Risk of publication bias was assessed using a funnel plot and Egger's test. Potential sources of heterogeneity were explored in subgroup analyses. In 55 studies that met inclusion criteria, concentrations of peripheral blood BDNF were higher after exercise (SMD = 0.59, 95% CI: 0.46–0.72, P < 0.001). In meta‐regression analysis, greater duration of exercise was associated with greater increases in BDNF. Subgroup analyses revealed an effect in males but not in females, and a greater BDNF increase in plasma than serum. Acute exercise increased BDNF concentrations in the peripheral blood of healthy adults. This effect was influenced by exercise duration and may be different across genders.

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Dose is an essential factor for triggering neurobiological processes, such as release of neurotrophins including BDNF, which in turn lead to neuroplastic changes.
“Since dose is an essential factor for triggering neurobiological processes (e.g., release of neurotrophins such as BDNF; Dinoff et al., 2017), which in turn lead to neuroplastic”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Dinoff et al., 2017
Neurobiological processes triggered by exercise, such as release of neurotrophins like BDNF, lead to neuroplastic and cognitive changes.
“for triggering neurobiological processes (e.g., release of neurotrophins such as BDNF; Dinoff et al., 2017), which in turn lead to neuroplastic and cognitive changes (Cotman et al., 2007; Voss et al., 2011, 2013a; Lucas et al., 2015; Zimmer et al., 2015; Basso and Suzuki, 2017; Stimpson et al., 2018)”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Dinoff et al., 2017
Increased BDNF concentrations were observed after longer bout durations, more than 30 minutes versus less than 30 minutes, in those with higher cardiorespiratory fitness, and the findings were selective to males, although 75% of participants across studies were male.
“Findings further indicated that increased BDNF concentrations were observed following longer bout durations (>30 min relative to <30 min) in those who had higher cardiorespiratory fitness (i.e., > VO2 peak), and that the findings were selective to males (although 75% of participants across studies were male) (74).”
From Physical Activity, Cognition, and Brain Outcomes: A Review of the 2018 Physical Activity Guidelines (2019) · cites this paper as [74]
A meta-analysis indicated higher concentrations of peripheral blood BDNF after an acute bout of physical activity, for both aerobic and resistance bouts.
“However, a meta-analysis examining a blood-based biomarker has indicated higher concentrations of peripheral blood BDNF following an acute bout of PA (both aerobic and resistance bouts).”
From Physical Activity, Cognition, and Brain Outcomes: A Review of the 2018 Physical Activity Guidelines (2019) · cites this paper as [74]

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Physical activity and depression: towards understanding the antidepressant mechanisms of physical activity
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Self-citation
A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor
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996. The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-derived Neurotrophic Factor (BDNF): A Meta-analysis
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Self-citation
Changes in brain-derived neurotropic factor following aerobic exercise
Curtis, R., Blades, A., Moris, J. M., & Koh, Y. (2024) · Sport Sciences for Health · doi:10.1007/s11332-024-01244-2 · Cited by 8 · see citing works

Authors: Dinoff, A., Herrmann, N., Swardfager, W., & Lanctôt, K. L.
Affiliations: University of Toronto (CA)
Corresponding author: Lanctôt, Krista L.
ORCID: Herrmann, Nathan
Swardfager, Walter
Lanctôt, Krista L.
Venue: European Journal of Neuroscience
Publisher: Wiley
Published: 2017-06-19
Volume: 46
Issue: 1
Pages: 1635-1646
ISSN: 0953-816X (ISSN-L)
1460-9568
DOI: 10.1111/ejn.13603
OpenAlex: W2612535417
Cited by: 323
References: 151
Citations by year: 2026: 27 · 2025: 44 · 2024: 43 · 2023: 28 · 2022: 39 · 2021: 45 · 2020: 36 · 2019: 28 · 2018: 27 · 2017: 6
FWCI: 3.26
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: European Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Physiology › Physical Activity and Health
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords: acute exercise, brain-derived neurotrophic factor, exercise duration, sex differences, exercise and cognition, exercise and mood, healthy adults
MeSH terms: Humans, Exercise, Brain-Derived Neurotrophic Factor

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The effect of acute exercise on blood concentrations of brain-derived neurotrophic factor in healthy adults. A meta-analysis.

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