Cited by 17Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNerve injury and regeneration

Clinical and Environmental Correlates of Serum BDNF: A Descriptive Study with Plausible Implications for AD Research

Open access
Weinstein, Galit, Preis, Sarah R., Beiser, Alexa S., Kaess, Bernhard, Chen, Tai C., Satizabal, Claudia, Rahman, Faisal, Benjamin, Emelia J. +2 more·2017·Current Alzheimer Research

Abstract

BACKGROUND: Brain derived neurotrophic factor (BDNF) may play a central role in the pathogenesis of Alzheimer's disease (AD) through neurotrophic effects on basal cholinergic neurons. Reduced serum levels of BDND are observed among AD patients and may predict AD risk. Nevertheless, knowledge about factors associated with its levels in blood is lacking. OBJECTIVE: To identify clinical and demographic correlates of serum BDNF levels. METHODS: BDNF was measured from serum collected between 1992-1996 and 1998-2001 in participants from the Original and Offspring cohorts of the Framingham Study, respectively. A cross-sectional analysis was done to evaluate the relationship between clinical measures and BDNF levels using standard linear regression and stepwise models. Analyses were conducted in the total sample and separately in each cohort, and were adjusted for age and sex. RESULTS: BDNF was measured in 3,689 participants (mean age 65 years, 56% women; 82% Offspring). Cigarette smoking and high total cholesterol were associated with elevated BDNF levels, and history of atrial fibrillation was associated with decreased levels. Elevated BDNF levels were related to greater physical activity and lower Tumor Necrosis Factor-α levels in Offspring. Stepwise models also revealed associations with statin use, alcohol consumption and Apolipoprotein Eε4 genotype. CONCLUSION: Serum BDNF correlates with various metabolic, inflammatory and life-style measures which in turn have been linked with risk of AD. Future studies of serum BDNF should adjust for these correlates and are needed to further explore the underlying interplay between BDNF and other factors in the pathophysiology of cognitive impairment and AD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.2174/1567205014666170203094520

Cites

85 of 85 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Weinstein, G., Preis, S. R., Beiser, A. S., Kaess, B., Chen, T. C., Satizabal, C., Rahman, F., Benjamin, E. J., Vasan, R. S., & Seshadri, S.
Affiliations
  • University of Haifa (IL)
  • Framingham Heart Study (US)
  • Boston University (US)
Corresponding author
Weinstein, Galit
Venue
Current Alzheimer Research
Published
2017-06-19
Volume
14
Issue
7
Pages
722-730
ISSN
1567-2050 (ISSN-L)
OpenAlex
W2589444584
Cited by
17
References
85
Citations by year
2026: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 1
FWCI
1.35
Type
journal article
Language
en
Open access
Locations
  • Current Alzheimer Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (n01hc25195-41-0-1)
  • National Institute on Aging (P30AG010129, U01AG049505, R01AG031287, U01AG052409, R01AG054076, R01AG049607, R01AG033040, R01AG033193, R01AG008122)
  • National Heart, Lung, and Blood Institute (R01HL128914, N01-HC-025195, R01HL092577)
  • National Institute of Neurological Disorders and Stroke (UH2NS100605, R01NS017950)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
brain-derived neurotrophic factor, serum BDNF, Alzheimer's disease, Framingham Offspring cohort, cigarette smoking, total cholesterol, atrial fibrillation, physical activity, TNF-α, statin use, alcohol consumption, APOE ε4, biomarkers, cholinergic neurons, inflammation, lifestyle factors
MeSH terms
Adult, Alzheimer Disease, C-Reactive Protein, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Female, Homocysteine, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Tumor Necrosis Factor-alpha, Cohort Studies, Linear Models, Brain-Derived Neurotrophic Factor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review