Cited by 115Bipolar Disorder and TreatmentTreatment of Major DepressionSchizophrenia research and treatment

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Sodium butyrate and mood stabilizers block ouabain-induced hyperlocomotion and increase BDNF, NGF and GDNF levels in brain of Wistar rats

Varela, Roger B., Valvassori, Samira S., Lopes-Borges, Jéssica, Mariot, Edemilson, Dal-Pont, Gustavo C., Amboni, Rafaela T., Bianchini, Guilherme, Quevedo, João·2015·Journal of Psychiatric Research

DOI 10.1016/j.jpsychires.2014.11.003

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Abstract

Bipolar Disorder (BD) is one of the most severe psychiatric disorders. Despite adequate treatment, patients continue to have recurrent mood episodes, residual symptoms, and functional impairment. Some preclinical studies have shown that histone deacetylase inhibitors may act on manic-like behaviors. Neurotrophins have been considered important mediators in the pathophysiology of BD. The present study aims to investigate the effects of lithium (Li), valproate (VPA), and sodium butyrate (SB), an HDAC inhibitor, on BDNF, NGF and GDNF in the brain of rats subjected to an animal model of mania induced by ouabain. Wistar rats received a single ICV injection of ouabain or artificial cerebrospinal fluid. From the day following ICV injection, the rats were treated for 6 days with intraperitoneal injections of saline, Li, VPA or SB twice a day. In the 7th day after ouabain injection, locomotor activity was measured using the open-field test. The BDNF, NGF and GDNF levels were measured in the hippocampus and frontal cortex by sandwich-ELISA. Li, VPA or SB treatments reversed ouabain-related manic-like behavior. Ouabain decreased BDNF, NGF and GDNF levels in hippocampus and frontal cortex of rats. The treatment with Li, VPA or SB reversed these impairment induced by ouabain. In addition, Li, VPA and SB per se increased NGF and GDNF levels in hippocampus of rats. Our data support the notion that neurotrophic factors play a role in BD and in the mechanisms of the action of Li, VPA and SB.

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Authors: Varela, R. B., Valvassori, S. S., Lopes-Borges, J., Mariot, E., Dal-Pont, G. C., Amboni, R. T., Bianchini, G., & Quevedo, J.
Affiliations: Universidade do Extremo Sul Catarinense (BR)
ORCID: Varela, Roger B.
Valvassori, Samira S.
Dal-Pont, Gustavo C.
Quevedo, João
Venue: Journal of Psychiatric Research
Publisher: Elsevier BV
Published: 2015-02
Volume: 61
Pages: 114-121
ISSN: 0022-3956 (ISSN-L)
DOI: 10.1016/j.jpsychires.2014.11.003
OpenAlex: W2068078801
Cited by: 115
References: 90
Citations by year: 2026: 7 · 2025: 16 · 2024: 12 · 2023: 12 · 2022: 12 · 2021: 13 · 2020: 9 · 2019: 9 · 2018: 8 · 2017: 6 · 2016: 8 · 2015: 3
FWCI: 4.33
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Psychiatric Research (publishedVersion)
PubMed (publishedVersion)
Funders: Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Universidade do Extremo Sul Catarinense
Instituto Mente e Cérebro - Neurociência
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: sodium butyrate, histone deacetylase inhibitors, bipolar disorder, mania, ouabain, hyperlocomotion, lithium, valproic acid, brain-derived neurotrophic factor, nerve growth factor, glial cell line-derived neurotrophic factor, neurotrophic factors, hippocampus, frontal cortex, mood stabilizers
MeSH terms: Affect, Animals, Bipolar Disorder, Disease Models, Animal, Hippocampus, Histamine Antagonists, Locomotion, Male, Motor Activity, Ouabain, Valproic Acid, Treatment Outcome, Rats, Wistar, Prefrontal Cortex, Lithium Compounds, Antimanic Agents, Brain-Derived Neurotrophic Factor, Butyric Acid, Nerve Growth Factor, Glial Cell Line-Derived Neurotrophic Factor, Rats

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Sodium butyrate and mood stabilizers block ouabain-induced hyperlocomotion and increase BDNF, NGF and GDNF levels in brain of Wistar rats

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