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Epidemiology of DSM-5 bipolar I disorder: Results from the National Epidemiologic Survey on Alcohol and Related Conditions – III

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Blanco, Carlos, Compton, Wilson M., Saha, Tulshi D., Goldstein, Benjamin I., Ruan, W. June, Huang, Boji, Grant, Bridget F.·2017·Journal of Psychiatric Research

DOI 10.1016/j.jpsychires.2016.10.003PMC PMC7416534

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Abstract

Background The objective of this study was to present 12-month and lifetime prevalence, correlates, comorbidity, treatment and disability of DSM-5 bipolar I disorder. Methods Nationally representative U.S. adult sample (N = 36,309), the 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions - III. Results Prevalences of 12-month and lifetime DSM-5 bipolar I disorder were 1.5% and 2.1% and did not differ between men (1.6% and 2.2%) and women (1.5% and 2.0%). Prevalences of bipolar I disorder were greater among Native Americans, and lower among Blacks, Hispanics and Asians/Pacific Islanders than whites. Rates were also lower among younger than older individuals, those previously married than currently married and with lower education and income relative to higher education and income. Bipolar I disorder was more strongly related to borderline and schizotypal personality disorders (adjusted odds ratios (AORS) = 2.2-4.7)), than to anxiety disorders (AORs = 1.3-2.9), and substance use disorders (AORs = 1.3-2.1) overall and among men and women. Quality of life was lower among individuals with bipolar I disorder relative to those without the disorder. Treatment rates among individuals with bipolar I disorder were low in the total sample (46%, SE = 2.63), among men (36.7%, SE = 3.82) and among women (55.8%, SE = 3.32). Conclusions Bipolar I disorder continues to be common disabling and highly comorbid disorder among men and women, contributing substantially to low quality of life and burden of disease in our society.

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Authors: Blanco, C., Compton, W. M., Saha, T. D., Goldstein, B. I., Ruan, W. J., Huang, B., & Grant, B. F.
Affiliations: National Institute on Drug Abuse (US)
National Institutes of Health (US)
Sunnybrook Health Science Centre (CA)
Corresponding author: Saha, Tulshi D.
ORCID: Blanco, Carlos
Compton, Wilson M.
Goldstein, Benjamin I.
Ruan, W. June
Venue: Journal of Psychiatric Research
Publisher: Elsevier BV
Published: 2017-01
Volume: 84
Pages: 310-317
ISSN: 0022-3956 (ISSN-L)
DOI: 10.1016/j.jpsychires.2016.10.003
PMC: PMC7416534
OpenAlex: W2529367653
Cited by: 149
References: 85
Citations by year: 2026: 13 · 2025: 16 · 2024: 18 · 2023: 10 · 2022: 23 · 2021: 18 · 2020: 17 · 2019: 9 · 2018: 16 · 2017: 8
FWCI: 9.77
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Psychiatric Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism
National Institute on Drug Abuse
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Keywords: bipolar I disorder, prevalence, DSM-5, comorbidities, borderline personality disorder, schizotypal personality disorder, substance use disorders, anxiety disorders, quality of life, treatment rates, disability, socioeconomic factors, racial and ethnic disparities, sex differences, NESARC
MeSH terms: Adolescent, Adult, Age Factors, Aged, Bipolar Disorder, Disability Evaluation, Female, Humans, Interview, Psychological, Male, Middle Aged, Quality of Life, Sex Factors, Socioeconomic Factors, United States, Comorbidity, Prevalence, Diagnostic and Statistical Manual of Mental Disorders, Young Adult

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Epidemiology of DSM-5 bipolar I disorder: Results from the National Epidemiologic Survey on Alcohol and Related Conditions – III

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