Cited by 46Treatment of Major DepressionGenetic Associations and EpidemiologyNeurotransmitter Receptor Influence on Behavior

TESC gene-regulating genetic variant (rs7294919) affects hippocampal subfield volumes and parahippocampal cingulum white matter integrity in major depressive disorder

Han, Kyu-Man, Won, Eunsoo, Kang, June, Choi, Sunyoung, Kim, Aram, Lee, Min-Soo, Tae, Woo-Suk, Ham, Byung-Joo·2017·Journal of Psychiatric Research

Abstract

Two recent genome-wide association studies have suggested that rs7294919 is associated with changes in hippocampal volume. rs7294919 regulates the transcriptional products of the TESC gene, which is involved in neuronal proliferation and differentiation. We investigated the interactive effect of rs7294919 and major depressive disorder (MDD) on the volume of the hippocampal subfields and the integrity of the parahippocampal cingulum (PHC). We also investigated the correlation of these structural changes with the DNA methylation status of rs7294919. A total of 105 patients with MDD and 85 healthy control subjects underwent T1-weighted structural magnetic resonance imaging and diffusion tensor imaging. The rs7294919 was genotyped and its DNA methylation status was assessed in all the participants. We analyzed the hippocampal subfield volumes and PHC integrity using FreeSurfer and the Tracts Constrained by Underlying Anatomy (TRACULA) respectively. Significant interactive effects of rs7294919 and MDD were observed in the volumes of the dentate gyrus and CA4. The patients with MDD had increased methylation in two of the three CpG loci of rs7294919, and the methylation of CpG3 was significantly correlated with right PHC integrity in the MDD group. Our results provide neurobiological evidence for the association of rs7294919 with brain structural changes in MDD.

Integrity signals

Registry

Crossref · 10.1016/j.jpsychires.2017.05.010

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Han, K.-M., Won, E., Kang, J., Choi, S., Kim, A., Lee, M.-S., Tae, W.-S., & Ham, B.-J.
Affiliations
  • Korea University (KR)
  • Korea University Anam Hospital (KR)
Corresponding author
  • Tae, Woo-Suk
  • Ham, Byung-Joo
Venue
Journal of Psychiatric Research
Publisher
Elsevier BV
Published
2017-10
Volume
93
Pages
20-29
ISSN
0022-3956 (ISSN-L)
OpenAlex
W2619926897
Cited by
46
References
66
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 25 · 2020: 4 · 2019: 3 · 2018: 2
FWCI
1.72
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Psychiatric Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Bio & Medical Technology Development Program of the National Research Foundation (NRF) (NRF-2016M3A9A7916996)
  • Ministry of Science, ICT and Future Planning (2016M3A9A7916996)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
major depressive disorder, hippocampal subfields, dentate gyrus, CA4, white matter integrity, DNA methylation, gene-disease interaction, CpG methylation, hippocampal volume
MeSH terms
Adult, Aged, Analysis of Variance, Calcium-Binding Proteins, Major Depressive Disorder, Female, Genotype, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, DNA Methylation, Parahippocampal Gyrus, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Young Adult, Diffusion Tensor Imaging, White Matter

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review