Association of brain-derived neurotrophic factor DNA methylation and reduced white matter integrity in the anterior corona radiata in major depression

Choi, Sunyoung; Han, Kyu-Man; Won, Eunsoo; Yoon, Bong-June; Lee, Min-Soo; Ham, Byung-Joo

doi:10.1016/j.jad.2014.09.042

Cited by 111Epigenetics and DNA MethylationTreatment of Major DepressionAdvanced Neuroimaging Techniques and Applications

Association of brain-derived neurotrophic factor DNA methylation and reduced white matter integrity in the anterior corona radiata in major depression

Choi, Sunyoung, Han, Kyu-Man, Won, Eunsoo, Yoon, Bong-June, Lee, Min-Soo, Ham, Byung-Joo·2015·Journal of Affective Disorders

DOI 10.1016/j.jad.2014.09.042

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Abstract

Considerable evidence suggests a crucial role for the epigenetic regulation of brain-derived neurotrophic factor (BDNF) in the pathophysiology of major depressive disorder (MDD). However, the relationship between BDNF DNA methylation and white matter (WM) integrity in MDD has not yet been investigated. In the current study, we examined the association between the DNA methylation status of the BDNF promoter region and WM integrity in MDD. Sixty patients with MDD and 53 healthy controls underwent T1-weighted structural magnetic resonance imaging (MRI), including diffusion tensor imaging (DTI), to assess their WM integrity. BDNF DNA methylation at 4 CpG sites of the promoter region was also measured. As compared to healthy controls, the MDD group demonstrated reduced fractional anisotropy (FA) in the bilateral anterior and posterior corona radiata (ACR and PCR), genu of the corpus callosum, and the bilateral posterior thalamic radiations. We observed a significant inverse correlation between the DNA methylation of the BDNF promoter region and the FA of the right ACR in MDD patients. Our findings demonstrate a relationship between methylation of the BDNF promoter region and the integrity of the ACR, a key structural component of the emotional and cognitive control network involved in the pathophysiology of MDD. This correlation suggests that BDNF DNA methylation may contribute to structural WM changes in MDD patients.

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Crossref · 10.1016/j.jad.2014.09.042

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The BDNF Val66Met polymorphism is associated with cognitive processes and cognitive impairment in neurodegenerative disease such as Parkinson's disease and Alzheimer's disease, and with several brain disorders including MDD, bipolar disorder, epilepsy, schizophrenia, aging and dementia, and stroke.
“More specifically, BDNF Val66Met polymorphism is associated with cognitive processes [112,123,124,125,126,127], and cognitive impairment in neurodegenerative disease, such as Parkinson’s disease (PD) [128,129] and AD [130,131], and even more with several brain disorders, including MDD and bipolar disorder [132,133,134,135,136,137], epilepsy [138,139,140], schizophrenia [125,141,142,143,144], aging”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [133]

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Background
Interactive effects of genetic polymorphisms and childhood adversity on brain morphologic changes in depression
Kim, Y., Ham, B., & Han, K.-M. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.03.009 · Cited by 50 · see citing works
“These genetic variants are involved in the shaping of brain morphology through modulating a neuronal survival, differentiation, or synaptogenesis or controlling stress-induced HPA axis responses (Choi et al., 2015; Daubert and Condron, 2010; Han et al., 2017).”
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TESC gene-regulating genetic variant (rs7294919) affects hippocampal subfield volumes and parahippocampal cingulum white matter integrity in major depressive disorder
Han, K.-M., Won, E., Kang, J., Choi, S., Kim, A., Lee, M.-S., Tae, W.-S., & Ham, B.-J. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.05.010 · Cited by 46 · see citing works
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Low Serum Levels of Brain-Derived Neurotrophic Factor Were Associated with Poor Short-Term Functional Outcome and Mortality in Acute Ischemic Stroke
Wang, J., Gao, L., Yang, Y., Li, Y., Chang, T., Man, M., Zhang, X.-Y., Guo, S., & Li, L. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0236-1 · Cited by 47 · see citing works
“Literature documented that BDNF were associated with many common and serious diseases, including diabetes [6], heart failure [7], Alzheimer’s disease [8], depression [9], dementia [10], and autism [11].”
Abnormal Brain-Derived Neurotrophic Factor Exon IX Promoter Methylation, Protein, and mRNA Levels in Patients with Major Depressive Disorder
Hsieh, M.-T., Lin, C.-C., Lee, C., & Huang, T. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050568 · Cited by 45 · see citing works
“In patients with MDD, BDNF promoter methylation level was inversely correlated with the integrity of anterior corona radiata [52].”
Background
Effects of a Polymorphism of the Neuronal Amino Acid Transporter SLC6A15 Gene on Structural Integrity of White Matter Tracts in Major Depressive Disorder
Choi, S., Han, K., Kang, J. C., Won, E., Chang, H. S., Tae, W., Son, K. R., Kim, S. J., Lee, M.-S., & Ham, B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164301 · Cited by 45 · see citing works
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Depressive disorders: Processes leading to neurogeneration and potential novel treatments
Brown, G. M., McIntyre, R. S., Rosenblat, J. D., & Hardeland, R. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.023 · Cited by 44 · see citing works
“…the left superior longitudinal fasciculus, right caudate, corona radiate, genu of the corpus callusom, posterior thalamic radiations and brain stem(Choi et al., 2015; Han et al., 2017; Lener and Iosifescu, 2015; Liao et al., 2013; Murphy and Frodl, 2011; Sexton et al., 2009; Tymofiyeva et al.,…”
Background
The BDNF Val66Met Polymorphism Affects the Vulnerability of the Brain Structural Network
Park, C.-H., Kim, J., Namgung, E., Lee, D.-W., Kim, G. H., Kim, M., Kim, N., Kim, T. D., Kim, S., Lyoo, I. K., et al. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00400 · Cited by 43 · see citing works
“…al., 2006; Montag et al., 2009), emotion (Chen et al., 2006) and even with several brain disorders including major depression (Dalby et al., 2013; Choi et al., 2015), epilepsy (Chen et al., 2016), schizophrenia (Ho et al., 2006), and stroke (Ramos-Cejudo et al., 2015) are suggested to be…”
White Matter Abnormalities in Major Depression Biotypes Identified by Diffusion Tensor Imaging
Liang, S., Wang, Q., Kong, X., Deng, W., Yang, X., Li, X., Zhang, Z., Zhang, J., Zhang, C., Li, X., et al. (2019) · Neuroscience Bulletin · doi:10.1007/s12264-019-00381-w · Cited by 41 · see citing works
White Matter Alterations in Depressive Disorder
He, E., Liu, M., Gong, S., Fu, X., Han, Y., & Deng, F. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.826812 · Cited by 44 · see citing works
Reduced fractional anisotropy in depressed patients due to childhood maltreatment rather than diagnosis
Meinert, S. L., Repple, J., Nenadić, I., Krug, A., Jansen, A., Grotegerd, D., Förster, K., Enneking, V., Dohm, K., Schmitt, S., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0472-y · Cited by 40 · see citing works
Regionconnect: Rapidly extracting standardized brain connectivity information in voxel-wise neuroimaging studies
Qi, X., & Arfanakis, K. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117462 · Cited by 39 · see citing works
“…et al., 2009; Lipton et al., 2008; Xie et al., 2006), and mostly when diffusion MRI data are available the major fiber bundles implicated may also be listed (e.g. superior longitudinal fasciculus, corona radiata) (Choi et al., 2015; Karlsgodt et al., 2008; Lee et al., 2010; Oechslin et al., 2009).”
Imaging genetics studies on monoaminergic genes in major depressive disorder
Won, E., & Ham, B. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.03.014 · Cited by 39 · see citing works
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New insights on brain‐derived neurotrophic factor epigenetics: from depression to memory extinction
Poon, C. H., Heng, B. C., & Lim, L. W. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14458 · Cited by 40 · see citing works
Brain-Derived Neurotrophic Factor ( BDNF ) Epigenomic Modifications and Brain-Related Phenotypes in Humans: A Systematic Review
Treble‐Barna, A., Heinsberg, L. W., Stec, Z., Breazeale, S., Davis, T. S., Kesbhat, A., Chattopadhyay, A., VonVille, H. M., Ketchum, A., Yeates, K. O., et al. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105078 · Cited by 37 · see citing works
White Matter Alterations Associated with Pro-inflammatory Cytokines in Patients with Major Depressive Disorder
Lim, J., Sohn, H., Kwon, M., & Kim, B. (2021) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2021.19.3.449 · Cited by 36 · see citing works
“Our re-sults are in line with a previous study published from our lab [27] and other studies reporting WM alterations in patients with MDD [44,45].”
DNA Methylation in Major Depressive Disorder
Pishva, E., Rutten, B. P. F., & van den Hove, D. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-53889-1_10 · Cited by 34 · see citing works
DNA methylations of brain-derived neurotrophic factor exon VI are associated with major depressive disorder and antidepressant-induced remission in females
Li, L., Wang, T., Chen, S., Yue, Y., Xu, Z., & Yuan, Y. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.08.016 · Cited by 27 · see citing works
Epigenetic modification impacting brain functions: Effects of physical activity, micronutrients, caffeine, toxins, and addictive substances
Mallick, R., & Duttaroy, A. K. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105627 · Cited by 26 · see citing works
Race, Socioeconomic Status, and Cerebellum Cortex Fractional Anisotropy in Pre-Adolescents
Assari, S., & Boyce, S. (2021) · Adolescents · doi:10.3390/adolescents1020007 · Cited by 22 · see citing works
Associations Between Brain Structural Alterations, Executive Dysfunction, and General Psychopathology in a Healthy and Cross-Diagnostic Adult Patient Sample
Romer, A. L., & Pizzagalli, D. A. (2021) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2021.06.002 · Cited by 22 · see citing works
“Both reduced ACR and reduced GCC FA have been identified in multiple psychiatric disorders (70,73,74), and poorer GCC FA has been associated with a higher p factor (75).”
Background
Abnormal white matter microstructures in Parkinson’s disease and comorbid depression: A whole-brain diffusion tensor imaging study
Li, Z., Liu, W., Xiao, C., Wang, X., Zhang, X., Yu, M., Hu, X., & Qian, L. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135238 · Cited by 21 · see citing works
Altered white matter microstructure in patients with post-stroke depression detected by diffusion kurtosis imaging
Shen, X., Fan, Z.-X., Wang, L., Cui, S., & Niu, J. (2019) · Neurological Sciences · doi:10.1007/s10072-019-03947-8 · Cited by 21 · see citing works
White matter microstructure changes in adults with major depressive disorder: evidence from diffusion magnetic resonance imaging
Wu, G., Mei, B., Hou, X., Wang, F., Zang, C., Zhang, X., & Zhang, Z. (2023) · BJPsych Open · doi:10.1192/bjo.2023.30 · Cited by 20 · see citing works
Neuroepigenetics of Neurotrophin Signaling: Neurobiology of Anxiety and Affective Disorders
Règue, M., Lanfumey, L., & Mongeau, R. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.03.002 · Cited by 19 · see citing works
Do Candidate Genes Affect the Brain’s White Matter Microstructure? Large-Scale Evaluation of 6,165 Diffusion MRI ScansPreprint
Jahanshad, N., Ganjgahi, H., Bralten, J., den Braber, A., Faskowitz, J., Knodt, A. R., Lemaître, H., Nir, T. M., Patel, B., Richie, S., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/107987 · Cited by 19 · see citing works
Influence of BclI C/G (rs41423247) on hippocampal shape and white matter integrity of the parahippocampal cingulum in major depressive disorder
Won, E., Kang, J. C., Kim, A., Choi, S., Han, K., Tae, W., Chang, H. S., Son, K. R., Greenberg, T., Joe, S.-H., et al. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.07.008 · Cited by 17 · see citing works
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Brain conditions mediate the association between aging and happiness
Kokubun, K., Nemoto, K., & Yamakawa, Y. (2022) · Scientific Reports · doi:10.1038/s41598-022-07748-6 · Cited by 20 · see citing works
Vesicular monoamine transporter 1 gene polymorphism and white matter integrity in major depressive disorder
Won, E., Han, K., Kang, J. C., Kim, A., Yoon, H., Chang, H. S., Park, J. Y., Lee, M.-S., Greenberg, T., Tae, W., et al. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.02.028 · Cited by 17 · see citing works
“Numerous DTI studies have reported lower FA values of the corpus callosum in patients with MDD (Choi et al., 2014), along with FA deficits associated with higher RD values (Korgaonkar et al., 2011).”
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Abnormal Regional Spontaneous Brain Activities in White Matter in Patients with Autism Spectrum Disorder
Ma, L., Liu, M., Xue, K., Ye, C., Man, W., Cheng, M., Liu, Z., Zhu, D., Liu, F., & Wang, J. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.02.022 · Cited by 19 · see citing works
Association between abnormal serum myelin-specific protein levels and white matter integrity in first-episode and drug-naïve patients with major depressive disorder
Jiang, L., Cheng, Y., Jiang, H., Xu, J., Lü, J., Shen, Z., Lü, Y., Liu, F., Li, L., & Xu, X. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.02.044 · Cited by 16 · see citing works
Shape and Volumetric Differences in the Corpus Callosum between Patients with Major Depressive Disorder and Healthy Controls
Lee, S., Pyun, S., Choi, K. W., & Tae, W. (2020) · Psychiatry Investigation · doi:10.30773/pi.2020.0157 · Cited by 16 · see citing works
Fractional anisotropy and peripheral cytokine concentrations in outpatients with depressive episode: a diffusion tensor imaging observational study
Sammer, G., Neumann, E., Blecker, C. R., & Petrozzi, B. P. (2022) · Scientific Reports · doi:10.1038/s41598-022-22437-0 · Cited by 18 · see citing works
Smartphone app for lifestyle improvement improves brain health and boosts the vitality and cognitive function of healthy middle‐aged adults
Kokubun, K., Nemoto, K., & Yamakawa, Y. (2024) · Brain and Behavior · doi:10.1002/brb3.3500 · Cited by 14 · see citing works
“The corona radiata, on the other hand, are projection fibers that connect the thalamus and the cerebral cortex (Choi et al., 2015; Mori et al., 2008) and include thalamic projections from the internal capsule to the prefrontal cortex and parietal/occipital cortex (Catani et al., 2002).”
Background
Effect of continuous esketamine infusion on brain white matter microstructure in patients with major depression: A diffusion tensor imaging study
Liu, X., Wei, Z., Li, L., Li, J., Deng, Y., Liu, Y., Li, H., Peng, D., Wan, X., & Wu, G. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.12.002 · Cited by 13 · see citing works
Tryptophan hydroxylase-2 polymorphism is associated with white matter integrity in first-episode, medication-naïve major depressive disorder patients
Ping, L., Xu, J., Zhou, C., Lü, J., Lü, Y., Shen, Z., Jiang, L., Dai, N., Xu, X., & Cheng, Y. (2019) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2019.02.002 · Cited by 13 · see citing works
Altered grey matter volume and white matter integrity in individuals with high schizo-obsessive traits, high schizotypal traits and obsessive-compulsive symptoms
Wang, Y.-M., Zhang, Y.-J., Cai, X., Yang, H., Shan, H., Cheung, E. F. C., & Chan, R. C. K. (2020) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2020.102096 · Cited by 13 · see citing works
Epigenetic aging in major depressive disorder: Clocks, mechanisms and therapeutic perspectives
Shaikh, M., & Doshi, G. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176757 · Cited by 12 · see citing works
Elevated serum neurofilament levels in young first-episode and medication-naïve major depressive disorder patients with alterative white matter integrity
Jiang, L., Shen, Z., Cheng, Y., Lü, J., He, B., Xu, J., Jiang, H., Liu, F., Li, N., Lü, Y., et al. (2021) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2021.111351 · Cited by 12 · see citing works
DNA Methylation Basis in the Effect of White Matter Integrity Deficits on Cognitive Impairments and Psychopathological Symptoms in Drug-Naive First-Episode Schizophrenia
Zong, X., Zhang, Q., He, C., Huang, X., Zhang, J., Wang, G., Lv, L., Sang, D., Zou, X., Chen, H., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.777407 · Cited by 11 · see citing works
“Recent epigenetic imaging studies revealed the associations between WM microstructural deficits and DNAm modification in major depressive disorder (20, 21), implying that impairments of WM integrity in neuropsychic disease may be epigenetically regulated, although this hypothesis remains untested in schizophrenia.”
Background
Oxytocin receptor genes moderate BDNF epigenetic methylation by childhood trauma
Lee, H. S., Kwon, A., & Lee, S. H. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.03.020 · Cited by 12 · see citing works
Per1 gene polymorphisms influence the relationship between brain white matter microstructure and depression risk
Zhao, R. Z., Sun, J., Deng, H., Chen, C., Li, X., Wang, F.-M., He, Z.-Y., Chang, M.-Y., Lu, L., Tang, C., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1022442 · Cited by 10 · see citing works
Patterns of anterior versus posterior white matter fractional anistotropy concordance in adult nonhuman primates: Effects of early life stress
Coplan, J. D., Kolavennu, V., Abdallah, C. G., Mathew, S. J., Perera, T. D., Pantol, G., Carpenter, D. M., & Tang, C. Y. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.11.049 · Cited by 9 · see citing works
“A study in major depressive disorder indicated that methylation of the BDNF promoter region was associated with reduced regional white matter integrity (Choi et al., 2015), suggesting that white matter may also be vulnerable to neurotrophic compromise.”
Background
The role of BDNF exon I region methylation in the treatment of depression with sertraline and its clinical diagnostic value
Xing, Y., Sun, T., Li, G., Xu, G., Cheng, J. R., & Gao, S. (2021) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23993 · Cited by 9 · see citing works
Effects of Uric Acid on the Alterations of White Matter Connectivity in Patients with Major Depression
Sohn, H., Kwon, M., Lee, S., Oh, J., Kim, M., Lee, S., Lee, K. S., & Kim, B. (2018) · Psychiatry Investigation · doi:10.30773/pi.2017.12.17.e1 · Cited by 9 · see citing works
Effects of Uric Acid on the Alterations of White Matter Connectivity in Patients with Major Depression
Sohn, H., Kwon, M., Lee, S., Oh, J., Kim, M. K., Lee, S., Lee, K. S., & Kim, B. (2018) · Psychiatry Investigation · doi:10.30773/pi.2017.12.17 · Cited by 7 · see citing works
Trait-like white matter abnormalities in current and remitted depression
Ming, Q., Zhang, J., Chang, C., Dong, D., Sun, X., Zhong, X. B., Chen, W., & Yao, S. (2022) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2022.111544 · Cited by 6 · see citing works
Astrocytes as Context for the Involvement of Myelin and Nodes of Ranvier in the Pathophysiology of Depression and Stress-Related Disorders
Miguel-Hidalgo, J. J. (2023) · Journal of Psychiatry and Brain Science · doi:10.20900/jpbs.20230001 · Cited by 6 · see citing works
“For example, significant correlation of neurotrophin DNA methylation and reduced WM integrity (assessed by neuroimaging methods) has been found in the WM of frontal bran regions in major depression [99].”
Background
Pharmacological mechanism of natural antidepressants: the role of epigenetic modifications
Lu, Y., Shang, R., Zhong, X., Shi, J., Zhang, G., Zhao, W., & Teng, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1616322 · Cited by 6 · see citing works
The Peripheral Epigenome Predicts White Matter Volume Contingent on Developmental Stage: An ECHO Study
Hanson, T., Spencer, S., Harker, S. A., Barry, F., Beauchemin, J., Braden, B. B., Burton, P., D’Sa, V. A., Koinis‐Mitchell, D., Mennenga, S. E., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05506-z · Cited by 5 · see citing works
“Prior research has linked peripheral DNAm to WM alterations in MDD, schizophrenia, and cognitive aging [26, 27, 29, 30].”
The brain-derived neurotrophic factor Val66Met genotype does not influence the grey or white matter structures underlying recognition memory
McKay, N. S., Moreau, D., Henare, D., & Kirk, I. J. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.03.072 · Cited by 5 · see citing works
Greater methylation of the IL-6 promoter region is associated with decreased integrity of the corpus callosum in schizophrenia
Michalczyk, A., Tyburski, E. M., Podwalski, P., Waszczuk, K., Rudkowski, K., Kucharska–Mazur, J., Mak, M., Rek-Owodziń, K., Plichta, P., Bielecki, M., et al. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.05.013 · Cited by 4 · see citing works
Microstructural Alterations in Superficial White Matter Associated With Anhedonia and Suicidal Ideation in Major Depressive Disorder
Zhang, Y., Wu, G., Witte, S. D., & Baeken, C. (2025) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2025.02.010 · Cited by 4 · see citing works
An Overview of Machine Learning Applications in Mood Disorders
Topolski, N., Jeong, S. H., & Mwangi, B. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.017 · Cited by 4 · see citing works
Epigenetics of Major Depressive Disorder
Wang, K. Z., Dada, O. O., Bani‐Fatemi, A., Tasmim, S., Monda, M., Graff, A., & Luca, V. D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-58131-8.00002-1 · Cited by 4 · see citing works
Mood Disorders
(2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018 · Cited by 3 · see citing works
Clonal haematopoiesis of indeterminate potential and risk of incident psychiatric disorders
Yu, Y., Wan, C., Li, J., Sun, Y., Yu, B., Tan, X., Wang, B., Lu, Y., & Wang, N. (2026) · BMC Medicine · doi:10.1186/s12916-026-04720-3 · Cited by 2 · see citing works
“Notably, dysfunction in some of the TET2-CHIP related brain IDPs was proved in pathological brain alterations of patients with depression [32], which provided a new perspective for understanding TET2-CHIP-related depression, while more in-depth mechanistic studies, such as knockout models, should…”
Neuroimaging Studies of Effects of Psychotherapy in Depression
Bauer, I. E., & Meyer, T. D. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.021 · Cited by 2 · see citing works
The Influence of Long-Term Opioid Administration on the Ultrastructural Organization of the White Substance of the Brain in the Experiment
Матешук-Вацеба, Л. Р., Бекесевич, А. М., Oliinyk, I. Y., & Zin’ko, А. V. (2018) · Ukraïnsʹkij žurnal medicini bìologìï ta sportu · doi:10.26693/jmbs03.06.031 · Cited by 2 · see citing works
Electrophysiological Biomarkers for Mood Disorders
Ramakrishnan, N., Murphy, N., Selvaraj, S., & Cho, R. Y. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.015 · Cited by 2 · see citing works
Lateralized white matter integrity changes across the lifespan in major depression: AES-SDM meta-analysis
Zhang, E., Hauson, A. O., Pollard, A. A., Zelman, D. C., Ulibarri, M. D., Kapalka, G. M., Fortea, L., & Raduà, J. (2025) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2025.111960 · Cited by 1 · see citing works
Brain Imaging and the Mechanisms of Antidepressant Action
Godlewska, B. R., Selvaraj, S., & Cowen, P. J. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.020 · Cited by 1 · see citing works
Effects of Lithium on Brain Structure in Bipolar Disorder
Kaur, J., Kafantaris, V., & Szeszko, P. R. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.018 · Cited by 1 · see citing works
Functional Connectome in Bipolar Disorder
Cha, J., & Anand, A. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.008 · Cited by 1 · see citing works
Maximum Credibility Voting (MCV) — An Integrative Approach for Accurate Diagnosis of Major Depressive Disorder from Clinically Readily Available Data
Shimizu, Y., Yoshimoto, J., Takamura, M., Okada, G., Matsumoto, T., Fuchikami, M., Okada, S., Morinobu, S., Okamoto, Y., Yamawaki, S., et al. (2022) · APSIPA Transactions on Signal and Information Processing · doi:10.1561/116.00000042 · Cited by 1 · see citing works
“Indeed, Choi et al. [33] have shown an inverse (cid:13)" (cid:28)(cid:25)(cid:24)$ association of BDNF DNA methylation and reduced white matter integrity in the anterior corona radiata in major depression.”
Background
Epigenetics of major depressive disorder
Braun, P., & Potash, J. (2021) · Epigenetics in Psychiatry · doi:10.1016/b978-0-12-823577-5.00002-7
Imaging Genetics Studies on Susceptibility Genes for Major Depressive Disorder, the Present and the Future
Won, E., Ham, B., & Kim, Y. (2018) · Springer eBooks · doi:10.1007/978-981-10-6580-4_2
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Structural, Functional, and Molecular Neuroimaging in Depression
Zhang, K., Huang, J., Feng, J., Zhang, H., & Tian, M. (2017) · Springer eBooks · doi:10.1007/978-981-10-6580-4_10
Imaging Genetic and Epigenetic Markers in Mood Disorders
Poletti, S., Mazza, E. A., Vai, B., & Benedetti, F. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.012
Brain Imaging of Reward Dysfunction in Unipolar and Bipolar Disorders
Kumar, P., Jiang, Y., & Whitton, A. E. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.006
Resting-State Functional Connectivity in Unipolar Depression
Chen, Z., & Gong, Q. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.007
Brain Imaging Methods in Mood Disorders
Selvaraj, S., Brambilla, P., & Soares, J. C. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.002
Magnetic Resonance Spectroscopy Investigations of Bioenergy and Mitochondrial Function in Mood Disorders
Kious, B. M., & Renshaw, P. F. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.009
Neuroimaging Brain Inflammation in Mood Disorders
Meyer, J. H. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.011
Functional Near-Infrared Spectroscopy Studies in Mood Disorders
Matsuo, K., & Matsubara, T. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.014
Neuroanatomical Findings in Unipolar Depression and the Role of the Hippocampus
Arnone, D. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.003
Neuroimaging Biomarkers in Pediatric Mood Disorders
West, M. P., Tang, W. J., & Singh, M. K. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.005
fMRI Neurofeedback as Treatment for Depression
Skottnik, L., & Linden, D. E. J. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.013
Neuroanatomical Findings in Bipolar Disorder
Tronchin, G., & McDonald, C. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.004
Imaging Glutamatergic and GABAergic Abnormalities in Mood Disorders
Scotti-Muzzi, E., Otaduy, M. C. G., Soeiro‐de‐Souza, M. G., & Machado‐Vieira, R. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.010
Molecular Imaging of Dopamine and Antipsychotics in Bipolar Disorder
Jauhar, S. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.019

Brain-derived neurotrophic factor promoter methylation and cortical thickness in recurrent major depressive disorder
Na, K.-S., Won, E., Kang, J., Chang, H. S., Yoon, H.-K., Tae, W. S., Kim, Y.-K., Lee, M.-S., Joe, S.-H., Kim, H., et al. (2016) · Scientific Reports · doi:10.1038/srep21089 · Cited by 84 · see citing works
Self-citation
Association between reduced white matter integrity in the corpus callosum and serotonin transporter gene DNA methylation in medication-naive patients with major depressive disorder
Won, E., Choi, S., Kang, J. C., Kim, A., Han, K.-M., Chang, H.-S., Tae, W., Son, K. R., Joe, S.-H., Lee, M.-S., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.137 · Cited by 97 · see citing works
Self-citation
Negative association between DNA methylation in brain-derived neurotrophic factor exon VI and left superior parietal gyrification in major depressive disorder
Li, L., Wang, T., Li, F., Yue, Y., Yin, Y., Chen, S., Hou, Z., Xu, Z., Kong, Y., & Yuan, Y. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114684 · Cited by 5 · see citing works
White matter integrity in major depressive disorder: Implications of childhood trauma, 5-HTTLPR and BDNF polymorphisms
Tatham, E. L., Ramasubbu, R., Gaxiola‐Valdez, I., Cortese, F., Clark, D., Goodyear, B. G., Foster, J. A., & Hall, G. B. (2016) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2016.04.014 · Cited by 46 · see citing works
DNA methylations of brain-derived neurotrophic factor exon VI are associated with major depressive disorder and antidepressant-induced remission in females
Li, L., Wang, T., Chen, S., Yue, Y., Xu, Z., & Yuan, Y. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.08.016 · Cited by 27 · see citing works

Authors: Choi, S., Han, K.-M., Won, E., Yoon, B.-J., Lee, M.-S., & Ham, B.-J.
Affiliations: Korea University (KR)
Corresponding author: Ham, Byung-Joo
ORCID: Han, Kyu-Man
Won, Eunsoo
Lee, Min-Soo
Ham, Byung-Joo
Venue: Journal of Affective Disorders
Publisher: Elsevier BV
Published: 2015-02
Volume: 172
Pages: 74-80
ISSN: 0165-0327 (ISSN-L)
DOI: 10.1016/j.jad.2014.09.042
OpenAlex: W2043053557
Cited by: 111
References: 50
Citations by year: 2026: 5 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 10 · 2021: 31 · 2020: 8 · 2019: 9 · 2018: 12 · 2017: 11 · 2016: 7 · 2015: 3
FWCI: 2.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Affective Disorders (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords: brain-derived neurotrophic factor, major depressive disorder, white matter integrity, fractional anisotropy, epigenetic regulation, corpus callosum, thalamic radiation
MeSH terms: Adult, Cognition, Corpus Callosum, Major Depressive Disorder, Emotions, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Thalamus, Case-Control Studies, Anisotropy, DNA Methylation, Brain-Derived Neurotrophic Factor, Epigenesis, Genetic, Diffusion Tensor Imaging, Republic of Korea, White Matter

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Association of brain-derived neurotrophic factor DNA methylation and reduced white matter integrity in the anterior corona radiata in major depression

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