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Cited by 440Long-Term Effects of COVID-19COVID-19 Clinical Research StudiesCOVID-19 and Mental Health

The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.

The landscape of cognitive function in recovered COVID-19 patients

Open access
Zhou, Hetong, Lu, Shaojia, Chen, Jingkai, Wei, Ning, Wang, Dandan, Lyu, Hailong, Shi, Chuan, Hu, Shaohua·2020·Journal of Psychiatric Research
DOI 10.1016/j.jpsychires.2020.06.022PMC PMC7324344
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Abstract

This study aims to evaluate the impacts of COVID-19 on cognitive functions in recovered patients and its relationship with inflammatory profiles. Twenty-nine patients recovered from COVID-19 as confirmed by negative nucleic tests for two consecutive times were recruited. A total of 29 age-, gender- and education-matched healthy controls were also recruited. The cognitive functions of all subjects were evaluated by the iPad-based online neuropsychological tests, including the Trail Making Test (TMT), Sign Coding Test (SCT), Continuous Performance Test (CPT), and Digital Span Test (DST). Blood samples from all patients were collected for examining inflammatory profiles, including interleukin-2 (IL-2), IL-4, IL-6, IL-10, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), and C-reactive protein (CRP). The relationship between cognitive functions and inflammatory profiles were analyzed by Pearson correlation. In results, although no significant differences were found in TMT, SCT, and DST between the two groups, patients with COVID-19 scored lower in the correct number of the second and third parts of CPT, they also scored higher in the missing number of the third part of CPT (all P < 0.05). In patients with COVID-19, there was a trend of significant difference for lower reaction time in the first and second parts of CPT (P = 0.050, and 0.051, respectively), as well as the lower correct number of the second part of CPT (P = 0.050). Correlation analysis showed that the reaction time for the first and second parts of CPT was positively correlated with the CRP levels (r = 0.557 and 0.410, P < 0.05). In conclusion, our findings indicated that cognitive impairments exist even in patients recovered from COVID-19, and might be possibly linked to the underlying inflammatory processes.

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Metadata

Authors
Zhou, H., Lu, S., Chen, J., Wei, N., Wang, D., Lyu, H., Shi, C., & Hu, S.
Affiliations
  • First Affiliated Hospital Zhejiang University (CN)
  • Peking University (CN)
Corresponding author
  • Shi, Chuan
  • Hu, Shaohua
ORCID
Venue
Journal of Psychiatric Research
Publisher
Elsevier BV
Published
2020-10
Volume
129
Pages
98-102
ISSN
0022-3956 (ISSN-L)
DOI
10.1016/j.jpsychires.2020.06.022
PMC
PMC7324344
OpenAlex
W3040367645
Cited by
440
References
35
Citations by year
2026: 10 · 2025: 37 · 2024: 55 · 2023: 82 · 2022: 137 · 2021: 109 · 2020: 8
FWCI
36.35
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Psychiatric Research (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Sci-Tech Academy, Zhejiang University
Topics
  • Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
Keywords
COVID-19 pandemic, post-COVID cognitive impairment, recovered patients, inflammatory markers, C-reactive protein, continuous performance test, reaction time, neuropsychological assessment, interleukins, TNF-α, interferon-gamma
MeSH terms
Betacoronavirus, COVID-19, SARS-CoV-2, Adult, Female, Humans, Inflammation, Male, Middle Aged, Neuropsychological Tests, Pneumonia, Viral, Survivors, Coronavirus Infections, Pandemics, Cognitive Dysfunction

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