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Cited by 110Coffee research and impactsSports Performance and TrainingMuscle metabolism and nutrition

Improvements on neuromuscular performance with caffeine ingestion depend on the time-of-day

Mora-Rodríguez, Ricardo, Pallarés, Jesús G., López-Gullón, José María, López-Samanes, Álvaro, Fernández-Elías, Valentín E., Ortega, Juan F.·2015·Journal of science and medicine in sport
DOI 10.1016/j.jsams.2014.04.010
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Abstract

Objectives To determine whether the ergogenic effects of caffeine ingestion on neuromuscular performance are similar when ingestion takes place in the morning and in the afternoon.Design Double blind, cross-over, randomized, placebo controlled design.Methods Thirteen resistance-trained males carried out bench press and full squat exercises against four incremental loads (25%, 50%, 75% and 90% 1RM), at maximal velocity. Trials took place 60 min after ingesting either 6 mg kg(-1) of caffeine or placebo. Two trials took place in the morning (AMPLAC and AMCAFF) and two in the afternoon (PMPLAC and PMCAFF), all separated by 36-48 h. Tympanic temperature, plasma caffeine concentration and side-effects were measured.Results Plasma caffeine increased similarly during AMCAFF and PMCAFF. Tympanic temperature was lower in the mornings without caffeine effects (36.7±0.4 vs. 37.0±0.5°C for AM vs. PM; p<0.05). AMCAFF increased propulsive velocity above AMPLAC to levels similar to those found in the PM trials for the 25%, 50%, 75% 1RM loads in the SQ exercise (5.4-8.1%; p<0.05). However, in the PM trials, caffeine ingestion did not improve propulsive velocity at any load during BP or SQ. The negative side effects of caffeine were more prevalent in the afternoon trials (13 vs. 26%).Conclusions The ingestion of a moderate dose of caffeine counteracts the muscle contraction velocity declines observed in the morning against a wide range of loads. Caffeine effects are more evident in the lower body musculature. Evening caffeine ingestion not only has little effect on neuromuscular performance, but increases the rate of negative side-effects reported.

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  • Muscle velocity and muscle power assessment require optimal neuromuscular conditions, and studies analyzing supplement effects on muscular velocity and power selected a maximum of two repetitions with a submaximal load, with recovery periods of 2−5 min.

    “Muscle velocity and muscle power assessment require optimal neuromuscular conditions and, as such, studies analyzing the effect of different supplements on muscular velocity and power selected a maximum of two repetitions with a submaximal load, with recovery periods of 2−5 min [117,118,119,120,121,122].”

    From Effects of Dietary Nitrate Supplementation on Weightlifting Exercise Performance in Healthy Adults: A Systematic Review (2020) · cites this paper as [118]

  • NaNO2 administration can increase cytosolic [Ca2+] without altering force production at a supraphysiological PO2, or lower cytosolic [Ca2+] concomitant with lower submaximal, but not maximal, force at a physiological PO2, during single evoked isometric contractions in isolated mouse muscle fibers.

    “There is also previous evidence indicating that NaNO2 administration can increase cytosolic [Ca2+] without altering force production at a supraphysiological PO2 [134], or lower cytosolic [Ca2+] concomitant with lower submaximal, but not maximal, force at a physiological PO2 [118], during single evoked isometric contractions in isolated mouse muscle fibers.”

    From Effects of Dietary Nitrate Supplementation on Weightlifting Exercise Performance in Healthy Adults: A Systematic Review (2020) · cites this paper as [118]

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Authors
Mora-Rodríguez, R., Pallarés, J. G., López-Gullón, J. M., López-Samanes, Á., Fernández-Elías, V. E., & Ortega, J. F.
Affiliations
University of Castilla-La Mancha (ES)
ORCID
Venue
Journal of science and medicine in sport
Publisher
Elsevier BV
Published
2015-05
Volume
18
Issue
3
Pages
338-342
ISSN
1440-2440 (ISSN-L)
DOI
10.1016/j.jsams.2014.04.010
OpenAlex
W2048545473
Cited by
110
References
30
Citations by year
2026: 7 · 2025: 6 · 2024: 10 · 2023: 5 · 2022: 14 · 2021: 15 · 2020: 15 · 2019: 13 · 2018: 4 · 2017: 4 · 2016: 11 · 2015: 4 · 2014: 2
FWCI
5.09
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of science and medicine in sport (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
caffeine ingestion, neuromuscular performance, time of day, ergogenic aids, resistance training, squatting, bench press, propulsive velocity, plasma caffeine concentration, tympanic temperature, caffeine side effects
MeSH terms
Central Nervous System Stimulants, Body Temperature, Caffeine, Double-Blind Method, Exercise Test, Humans, Male, Muscle Contraction, Time Factors, Weight Lifting, Muscle, Skeletal, Cross-Over Studies, Muscle Strength, Young Adult

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