Enzymes involved in the formation and transformation of steroid hormones in the fetal and placental compartments
Abstract
Human fetal and placental compartments have all the enzymatic systems necessary to produce steroid hormones. However, their activities are different and complementary: the fetus is very active in converting acetate into cholesterol, in transforming pregnanes to androstanes, various hydroxylases, sulfotransferases, whilst all these transformations are absent or very limited in the placenta. This compartment can transform cholesterol to C21-steroids, convert 5-ene to 4-ene steroids, and has a high capacity to aromatize C19 precursors and to hydrolyse sulfates. Steroid hormone receptors are present at an early stage of gestation and are functional for important physiological activities. The production rate of some steroids increases drastically with fetal evolution (e.g. estriol increases 500-1000 times in relation to non-pregnant women). We can hypothesize that the control of active steroid hormones could be carried out by fetal and placental factors, which act by stimulating or inhibiting the enzymes involved in their formation and transformation during pregnancy evolution and, consequently, limiting the high levels of the biologically active hormone.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Most progesterone in the fetal circulation comes from the placenta, which secretes progesterone directly into the fetal circulation at high levels.
“It is likely, therefore, that most progesterone in the fetal circulation comes from the placenta, which secretes progesterone directly into the fetal circulation at high levels [31,32], similar to those reported here.”
From Alternative (backdoor) androgen production and masculinization in the human fetus (2019) · cites this paper as [32]
Cites
Carcinogenicity of catechol estrogens in Syrian hamsters
Liehr, J. G., Wan-Fen, F., Sirbasku, D. A., & Ari-Ulubelen, A. (1986) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(86)90080-4 · Cited by 356 · see citing works
Brandenberger, A. W., Tee, M. K., Lee, J. Y., Chao, V. A., & Jaffe, R. B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.10.4400 · Cited by 335 · see citing works
Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis?
Zhu, B. T., & Conney, A. H. (1998) · PubMed · Cited by 282 · see citing works
The selective estrogen enzyme modulators in breast cancer: a review
Pasqualini, J. R. (2004) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2004.03.001 · Cited by 192 · see citing works
Self-citationProfiling transcript levels for steroidogenic enzymes in fetal tissues
Pezzi, V., Mathis, J. M., Rainey, W. E., & Carr, B. R. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2003.07.006 · Cited by 156 · see citing works
Osborne, M. P., Bradlow, H. L., Wong, G. Y., & TELANG, N. T. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.23.1917 · Cited by 149 · see citing works
Merriam, G. R., MacLusky, N. J., Picard, M. K., & Naftolin, F. N. (1980) · Steroids · doi:10.1016/0039-128x(80)90062-8 · Cited by 111 · see citing works
Expression and Cellular Localization of Estrogen Receptors α and β in the Human Fetus1
Takeyama, J., Suzuki, T., Inoue, S., Kaneko, C., Nagura, H., Harada, N., & Sasano, H. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7447 · Cited by 102 · see citing works
Alfaidy, N., Li, W., MacIntosh, T., Yang, K., & Challis, J. R. G. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021915 · Cited by 97 · see citing works
The effect of endogenous estradiol metabolites on the proliferation of human breast cancer cells
Lippert, C., Seeger, H., & Mueck, A. O. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02305-6 · Cited by 85 · see citing works
A Technique for Perfusion of the Previable Human Fetus
Westin, B., Nyberg, R., & Enhörning, G. (1958) · Acta Paediatrica · doi:10.1111/j.1651-2227.1958.tb07643.x · Cited by 84 · see citing works
Estradiol metabolism and malignant disease
Mueck, A. O., Seeger, H., & Lippert, T. H. (2002) · Maturitas · doi:10.1016/s0378-5122(02)00141-x · Cited by 80 · see citing works
Cholesterol Synthesis in Human Fetal Tissues*
Carr, B. R., & Simpson, E. R. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-55-3-447 · Cited by 78 · see citing works
The selective estrogen enzyme modulator (SEEM) in breast cancer
Chetrite, G. S., & Pasqualini, J. R. (2001) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(01)00046-2 · Cited by 68 · see citing works
Self-citation(2008) · CRC Press eBooks · doi:10.3109/9781420058734 · Cited by 64 · see citing works
Hormones and fetal pathophysiology
(1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90172-f · Cited by 54 · see citing works
Compartmentalization of regulatory proteins in the cell nucleus.
Hendzel, M. J., Kruhlak, M., Maclean, N. A. B., Boisvert, F., Lever, M. A., & Bazett-Jones, D. (2001) · Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(00)00153-9 · Cited by 48 · see citing works
SUMIDA, C., & Pasqualini, J. R. (1989) · Endocrinology · doi:10.1210/endo-124-2-591 · Cited by 42 · see citing works
Self-citation17 -Hydroxysteroid Dehydrogenase Type 1 and 2 Expression in the Human Fetus
Takeyama, J., SUZUKI, T. A., Hirasawa, G., Muramatsu, Y., Nagura, H., Iinuma, K., Nakamura, J., Kimura, K.-I., Yoshihama, M., Harada, N., et al. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.1.6323 · Cited by 41 · see citing works
(1991) · Elsevier eBooks · doi:10.1016/c2009-0-00786-7 · Cited by 40 · see citing works
De Novo Synthesis of Cholesterol by the Human Fetal Adrenal Gland*
Carr, B. R., & Simpson, E. R. (1981) · Endocrinology · doi:10.1210/endo-108-6-2154 · Cited by 40 · see citing works
Catechol-O-methyltransferase in human breast cancers
Assicot, M., Contesso, G., & Bohuon, C. (1977) · European Journal of Cancer (1965) · doi:10.1016/0014-2964(77)90173-6 · Cited by 38 · see citing works
Unique regulation of expression of human aromatase in the placenta
Harada, N., Yoshimura, N., & Honda, S. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00375-3 · Cited by 38 · see citing works
Regulation of cell cycle and cyclins by 16alpha-hydroxyestrone in MCF-7 breast cancer cells
Lewis, J., Thomas, T. J., Klinge, C. M., Gallo, M., & Thomas, T. (2001) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0270293 · Cited by 38 · see citing works
Paradoxical effect of estradiol: it can block its own bioformation in human breast cancer cells
Pasqualini, J. R., & Chetrite, G. S. (2001) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(01)00080-2 · Cited by 33 · see citing works
Self-citationExpression and Cellular Localization of Estrogen Receptors and in the Human Fetus
Takeyama, J. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.5.2258 · Cited by 31 · see citing works
Allfrey, V. G. (1980) · Elsevier eBooks · doi:10.1016/b978-0-12-289503-6.50015-1 · Cited by 30 · see citing works
Effects of Estradiol on the Acetylation of Histones in the Fetal Uterus of the Guinea Pig
Pasqualini, J. R., Clavreul, C., Vidali, G., & Allfrey, V. G. (1981) · Biology of Reproduction · doi:10.1095/biolreprod25.5.1035 · Cited by 28 · see citing works
Self-citationPregnanolone isomers, pregnenolone and their polar conjugates around parturition
Klak, J., Hill, M., Pařı́zek, A., Havlı́ková, H., Bičı́ková, M., Hampl, R., Fait, T., Šulcová, J., Pouzar, V., Kancheva, R. L., et al. (2003) · Physiological Research · doi:10.33549/physiolres.930317 · Cited by 27 · see citing works
Breast Cancer: Prognosis, Treatment and Prevention
(2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00195-4 · Cited by 26 · see citing works
Mathur, R. S., Archer, D. F., Wiqvist, N., & Diczfalusy, E. R. (1970) · European Journal of Endocrinology · doi:10.1530/acta.0.0650663 · Cited by 22 · see citing works
Pasqualini, J. R., Sterner, R., Bertrand, P., & Allfrey, V. G. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)91378-8 · Cited by 20 · see citing works
Self-citationNuclear type II [3H]estradiol binding sites: A histone H3–H4 complex
Shoulars, K., Rodriguez, M. A., Crowley, J. R., TURK, J. W., Thompson, T., & Markaverich, B. M. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.12.047 · Cited by 13 · see citing works
Archer, D. F., Mathur, R. S., Wiqvist, N., & Diczfalusy, E. R. (1971) · European Journal of Endocrinology · doi:10.1530/acta.0.0660666 · Cited by 12 · see citing works
AN EXPERIMENTAL STUDY OF THE PREVIABLE HUMAN FOETUS
Nyberg, R., & Westin, B. (1962) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1962.tb01291.x · Cited by 8 · see citing works
The Selective Estrogen Enzyme Modulators (SEEM) in Breast Cancer
Chetrite, G. S. (2002) · CRC Press eBooks · doi:10.1201/b14039-8 · Cited by 7 · see citing works
The Fetus, Pregnancy, and Breast Cancer
Pasqualini, J. R. (2002) · CRC Press eBooks · doi:10.3109/9780203909249-5 · Cited by 7 · see citing works
Self-citationMetabolism of 7-3H-pregnenolone in normal human placenta maintained in organ culture
Meeker, C., Cesaris, V. D., & Tulp, O. L. (1971) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(71)90497-2 · Cited by 6 · see citing works
Pasqualini, J. R., Kincl, F. A., & SUMIDA, C. (1991) · Elsevier eBooks · doi:10.1016/b978-0-08-035720-1.50006-2 · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
2 of the 41 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Weight Gain During Pregnancy: Reexamining the Guidelines
Rasmussen, K. M., & Yaktine, A. L. (2009) · Cited by 4,052 · see citing works
Endocrine Factors Modulating Immune Responses in Pregnancy
Schumacher, A., Costa, S., & Zenclussen, A. C. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00196 · Cited by 220 · see citing works
Placental steroidogenesis in pregnant women with polycystic ovary syndrome
Maliqueo, M. A., Lara, H. E., Sánchez, F., Echiburú, B., Crisosto, N., & Sir‐Petermann, T. (2012) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2012.10.015 · Cited by 223 · see citing works
Prouillac, C., & Lecoeur, S. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.033571 · Cited by 214 · see citing works
Basics of androgen synthesis and action
Elzenaty, R. N., du Toit, T., & Flück, C. E. (2022) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2022.101665 · Cited by 204 · see citing works
Alternative (backdoor) androgen production and masculinization in the human fetus
O’Shaughnessy, P. J., Antignac, J. P., Le Bizec, B., Morvan, M.-L., Svechnikov, K., Söder, O., Savchuk, I., Monteiro, A., Soffientini, U., Johnston, Z. C., et al. (2019) · PLOS Biology · doi:10.1371/journal.pbio.3000002 · Cited by 177 · see citing works
Regulation and deregulation of cholesterol homeostasis: The liver as a metabolic “power station”
Trapani, L. (2012) · World Journal of Hepatology · doi:10.4254/wjh.v4.i6.184 · Cited by 178 · see citing works
Potential significance of physiological and pharmacological glucocorticoids in early pregnancy
Michael, A. E., & Papageorghiou, A. T. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn021 · Cited by 168 · see citing works
Sex hormone metabolism in lung development and maturation
Seaborn, T., Simard, M., Provost, P. R., Piedbœuf, B., & Tremblay, Y. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.09.001 · Cited by 152 · see citing works
Steroid hormones and pregnancy
Noyola-Martínez, N., Halhali, A., & Barrera, D. (2019) · Gynecological Endocrinology · doi:10.1080/09513590.2018.1564742 · Cited by 150 · see citing works
Evolution of steroids during pregnancy: Maternal, placental and fetal synthesis
Morel, Y., Roucher, F., Plotton, I., Goursaud, C., Tardy, V., & Mallet, D. (2016) · Annales d'Endocrinologie · doi:10.1016/j.ando.2016.04.023 · Cited by 119 · see citing works
Fetal programming by maternal stress: Insights from a conflict perspective
Giudice, M. D. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.05.014 · Cited by 112 · see citing works
Steroid profiling in pregnancy: A focus on the human fetus
Hill, M., Pašková, A., Kančeva, R., Velíková, M., Kubátová, J., Kancheva, L., Adamcová, K., Mikešová, M., Žižka, Z., Koucký, M., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.03.008 · Cited by 101 · see citing works
The role of sulfated steroid hormones in reproductive processes
Geyer, J., Bakhaus, K., Bernhardt, R., Blaschka, C., Dezhkam, Y., Fietz, D., Grosser, G., Hartmann, K., Hartmann, M. F., Neunzig, J., et al. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.07.002 · Cited by 88 · see citing works
The Human Placenta Expresses CYP17 and Generates Androgens<i>De Novo</i>
Escobar, J. C., Patel, S. S., Beshay, V. E., Suzuki, T., & Carr, B. R. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2504 · Cited by 80 · see citing works
Potassium channels are involved in testosterone-induced vasorelaxation of human umbilical artery
Cairrão, E., Álvarez, E., Santos-Silva, A. J., & Verde, I. (2007) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-007-0213-3 · Cited by 76 · see citing works
Lassance, L., Haghiac, M., Minium, J., Catalano, P., & Hauguel-de Mouzon, S. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2792 · Cited by 73 · see citing works
Metabolic Pathfinding Using RPAIR Annotation
Faust, K., Croes, D., & van Helden, J. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.03.006 · Cited by 69 · see citing works
Toft, G. V., Jönsson, B., Bonde, J. P., Nørgaard‐Pedersen, B., HOUGAARD, D. M., Cohen, A. S., Lindh, C. H., Ivell, R., Anand‐Ivell, R., & Lindhard, M. S. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1409288 · Cited by 64 · see citing works
Steroid hormones specifically modify the activity of organic anion transporting polypeptides
Koenen, A., Köck, K., Keiser, M., Siegmund, W., Kroemer, H. K., & Grube, M. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.08.017 · Cited by 62 · see citing works
Saal, F. S. V., VandeVoort, C. A., Taylor, J. A., Welshons, W. V., Toutain, P., & Hunt, P. A. (2014) · Reproductive Toxicology · doi:10.1016/j.reprotox.2014.01.007 · Cited by 63 · see citing works
Vascular mechanisms of testosterone: The non-genomic point of view
Lorigo, M., Mariana, M., Lemos, M. C., & Cairrão, E. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105496 · Cited by 60 · see citing works
O’Shaughnessy, P. J., Monteiro, A., Bhattacharya, S., Fraser, M., & Fowler, P. (2012) · Molecular Human Reproduction · doi:10.1093/molehr/gas059 · Cited by 58 · see citing works
Revisiting Steroidogenic Pathways in the Human Placenta and Primary Human Trophoblast Cells
Karahoda, R., Kallol, S., Groessl, M., Ontsouka, E. C., Anderle, P., Flück, C. E., Štaud, F., & Albrecht, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041704 · Cited by 55 · see citing works
Cholesterol: From Feeding to Gene Regulation
Martini, C., & Pallottini, V. (2007) · Genes & Nutrition · doi:10.1007/s12263-007-0049-y · Cited by 53 · see citing works
Fetoplacental vasculature as a model to study human cardiovascular endocrine disruption
Lorigo, M., & Cairrão, E. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.101054 · Cited by 50 · see citing works
Dysregulation of 11beta-hydroxysteroid dehydrogenases: implications during pregnancy and beyond
Konstantakou, P., Mastorakos, G. P., Vrachnis, N., Tomlinson, J., & Valsamakis, G. (2016) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2016.1171308 · Cited by 48 · see citing works
Reproductive immunomodulatory functions of B cells in pregnancy
Dutta, S., Sengupta, P., & Haque, N. (2019) · International Reviews of Immunology · doi:10.1080/08830185.2019.1674299 · Cited by 46 · see citing works
Swart, A. C., Storbeck, K., & Swart, P. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.12.014 · Cited by 44 · see citing works
Adrenal and thyroid function in the fetus and preterm infant
Chung, H. R. (2014) · Korean Journal of Pediatrics · doi:10.3345/kjp.2014.57.10.425 · Cited by 42 · see citing works
Heterocyclic steroids: Efficient routes for annulation of pentacyclic steroidal pyrimidines
Monier, M., El‐Mekabaty, A., Abdel-Latif, D. A., Mert, B. D., & Elattar, K. M. (2019) · Steroids · doi:10.1016/j.steroids.2019.108548 · Cited by 40 · see citing works
Modulation of fetoplacental growth, development and reproductive function by endocrine disrupters
Basak, S., Varma, S., & Duttaroy, A. K. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1215353 · Cited by 39 · see citing works
Pedersen, M., Halldorsson, T. I., Mathiesen, L., Mose, T., Brouwer, A., Hedegaard, M. S., Loft, S. H., Kleinjans, J. C. S., Besselink, H. T., & Knudsen, L. E. (2010) · Environment International · doi:10.1016/j.envint.2010.02.002 · Cited by 39 · see citing works
Obesity during pregnancy affects sex steroid concentrations depending on fetal gender
Maliqueo, M. A., Cruz, G., Espina, C., Contreras, I., García, M. I., Echiburú, B., & Crisosto, N. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.159 · Cited by 36 · see citing works
Emerging roles for LXRs and LRH-1 in female reproduction
Mouzat, K., Baron, S., Marceau, G., Caira, F., Sapin, V., Volle, D. H., Lumbroso, S., & Lobaccaro, J. A. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.06.009 · Cited by 35 · see citing works
Endocrine Activity of Extraembryonic Membranes Extends beyond Placental Amniotes
Albergotti, L. C., Hamlin, H. J., McCoy, M. W., & Guillette, L. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005452 · Cited by 35 · see citing works
PKG is involved in testosterone-induced vasorelaxation of human umbilical artery
Cairrão, E., Santos-Silva, A. J., & Verde, I. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.04.025 · Cited by 34 · see citing works
Long‐ and short‐term effects of androgens in human umbilical artery smooth muscle
Saldanha, P., Cairrão, E., Maia, C. J., & Verde, I. (2012) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12047 · Cited by 34 · see citing works
Alterations of adrenal steroidomic profiles in preterm infants at birth
Travers, S. A. A., Martinerie, L., Boileau, P., Lombès, M., & Pussard, E. (2017) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2016-312457 · Cited by 33 · see citing works
Revisiting the physiological role of androgens in women
Rosato, E., Sciarra, F., Anastasiadou, E., Lenzi, A., & Venneri, M. A. (2022) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2022.2144834 · Cited by 34 · see citing works
Liu, W., Zhu, H.-L., Xiong, Y.-W., Lv, J., Huang, Y., & Wang, H. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.135668 · Cited by 31 · see citing works
Banker, M. M., Puttabyatappa, M., O’Day, P., Goodrich, J. M., Kelley, A. S., Domino, S. E., Smith, Y. R., Dolinoy, D. C., Song, P. X. ‐., Auchus, R. J., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa909 · Cited by 29 · see citing works
Immunohistochemical analysis of steroid sulfatase in human tissues
Selcer, K. W., DiFrancesca, H. M., Chandra, A. B., & Li, P. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.12.105 · Cited by 30 · see citing works
Mohareb, R. M., Abbas, N. S., & Abdelaziz, M. A. (2014) · Steroids · doi:10.1016/j.steroids.2014.04.011 · Cited by 29 · see citing works
Geranylgeraniol and Neurological Impairment: Involvement of Apoptosis and Mitochondrial Morphology
Marcuzzi, A., Piscianz, E., Zweyer, M., Bortul, R., Loganes, C., Girardelli, M., Baj, G., Monasta, L., & Celeghini, C. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030365 · Cited by 28 · see citing works
Elattar, K. M., & El‐Mekabaty, A. (2020) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.4174 · Cited by 26 · see citing works
Qin, X., Ma, Q., Yuan, J., Xinnan, H., Tan, Q., Zhang, Z., Wang, L., & Xu, X. (2018) · Toxicology Research · doi:10.1039/c7tx00257b · Cited by 23 · see citing works
Ao, Z., Li, Z., Wang, X., Zhao, C., Gan, Y., Wu, X. F., Zeng, F., Shi, J., Gu, T., Hong, L., et al. (2019) · Molecular Reproduction and Development · doi:10.1002/mrd.23102 · Cited by 23 · see citing works
Does steroid sulfatase deficiency influence postpartum psychosis risk?
Davies, W. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.03.001 · Cited by 22 · see citing works
Midzak, A. S., Akula, N., Rone, M. B., & Papadopoulos, V. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.03.023 · Cited by 20 · see citing works
Biosynthesis of estetrol in human pregnancy: Potential pathways
Stanczyk, F. Z., & Archer, D. F. (2023) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2023.106359 · Cited by 21 · see citing works
Yu, D., Liu, X., Liu, X., Cao, W., Zhang, X., Tian, H., Wang, J., Xiong, N., Wen, S., Wu, Y., et al. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16122178 · Cited by 21 · see citing works
Progesterone levels in cesarean and normal delivered term placentas
Feinshtein, V., Ben‐Zvi, Z., Sheiner, E., Amash, A., Sheizaf, B., & Holcberg, G. (2009) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-009-1125-x · Cited by 21 · see citing works
Composition and Components of Gestational Weight Gain: Physiology and Metabolism
Rasmussen, K. M., & Yaktine, A. L. (2009) · Cited by 20 · see citing works
Breast cancer and steroid metabolizing enzymes: The role of progestogens
Pasqualini, J. R. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.11.006 · Cited by 20 · see citing works
Self-citationPaitz, R. T., & Bowden, R. M. (2015) · Biology Letters · doi:10.1098/rsbl.2014.0946 · Cited by 20 · see citing works
Metabolomic Changes after Coffee Consumption: New Paths on the Block
Favari, C., Righetti, L., Tassotti, M., Gethings, L. A., Martini, D., Rosi, A., Antonini, M., Rubert, J., Manach, C., Dei, A., et al. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000875 · Cited by 20 · see citing works
Martinerie, L., Pussard, E., Méduri, G., Delezoide, A., Boileau, P., & Lombès, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031949 · Cited by 20 · see citing works
Cruze, L., Kohno, S., McCoy, M. W., & Guillette, L. J. (2012) · Biology of Reproduction · doi:10.1095/biolreprod.112.101360 · Cited by 20 · see citing works
Comparative profiling of adrenal steroids in maternal and umbilical cord blood
Travers, S. A. A., Martinerie, L., Boileau, P., Xue, Q.-Y., Lombès, M., & Pussard, E. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.11.012 · Cited by 19 · see citing works
Midzak, A. S., Rammouz, G., & Papadopoulos, V. (2012) · Steroids · doi:10.1016/j.steroids.2012.08.019 · Cited by 18 · see citing works
Zehra, M., Curry, J. C., Pillai, S. S., Lakhani, H. V., Edwards, C. E., & Sodhi, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134737 · Cited by 17 · see citing works
Guibourdenche, J., Leguy, M.-C., Pidoux, G., Hébert-Schuster, M., Laguillier, C., Anselem, O., Grangé, G., Bonnet-Serrano, F., & Tsatsaris, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087669 · Cited by 16 · see citing works
Koskivuori, J., Voutilainen, R., Storvik, M., Häkkinen, M. R., Uusitalo, L., Keski‐Nisula, L., Backman, K., Auriola, S. O. K., & Lehtonen, M. (2023) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2023.106357 · Cited by 16 · see citing works
Dawson, P. A., Pirlo, K. J., Steane, S. E., Kunzelmann, K., Chien, Y. J., & Markovich, D. (2006) · Genes & Genetic Systems · doi:10.1266/ggs.81.265 · Cited by 16 · see citing works
Miura, H., Yamazaki, T., KIKUCHI, M., & Sakaguchi, M. (2019) · Animal Science Journal · doi:10.1111/asj.13286 · Cited by 16 · see citing works
VandeVoort, C. A., Gerona, R. R. L., Saal, F. S. V., Tarantal, A. F., Hunt, P. A., Hillenweck, A., & Zalko, D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165410 · Cited by 16 · see citing works
Sex Differences in Pulmonary Anatomy and Physiology
Sathish, V., & Prakash, Y. S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802388-4.00006-9 · Cited by 15 · see citing works
Altered umbilical sex steroids in preterm infants born small for gestational age
Allvin, K., Ankarberg‐Lindgren, C., Niklasson, A., Jacobsson, B., & Dahlgren, J. (2019) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2019.1598362 · Cited by 15 · see citing works
López‐Pingarrón, L., Almeida, H., Pereboom, D., & García, J. J. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45090476 · Cited by 14 · see citing works
Hydroxylation and sulfation of sex steroid hormones in inflammatory liver
Sang, R., Seung-yeon, L., Sang-yun, K., Ryu, S., Bae-kuen, P., & Hong, E. (2017) · Journal of Biomedical Research · doi:10.7555/jbr.31.20170031 · Cited by 14 · see citing works
Evidence of steroid hormone activity in the chorioallantoic membrane of a Turtle (Pseudemys nelsoni)
Cruze, L., Hamlin, H. J., Kohno, S., McCoy, M. W., & Guillette, L. J. (2013) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2013.02.007 · Cited by 13 · see citing works
Schneuer, F. J., Bower, C. I., Holland, A. J. A., Tasevski, V., Jamieson, S., Barker, A., Lee, L., Majzoub, J. A., & Nassar, N. (2016) · Human Reproduction · doi:10.1093/humrep/dew150 · Cited by 13 · see citing works
Prenatal exposure to glycol ethers and sex steroid hormones at birth
Warembourg, C., Binter, A.-C., Giton, F., Fiet, J., Labat, L., Monfort, C., Chevrier, C., Multigner, L., Cordier, S., & Garlantézec, R. (2018) · Environment International · doi:10.1016/j.envint.2018.01.013 · Cited by 12 · see citing works
Protease Inhibitor Anti-HIV, Lopinavir, Impairs Placental Endocrine Function
Fraichard, C., Bonnet-Serrano, F., Laguillier, C., Hébert-Schuster, M., Lai–Kuen, R., Sibiude, J., Fournier, T., Cohen, M., & Guibourdenche, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020683 · Cited by 12 · see citing works
Atrazine disrupts gonadal development in a live-bearing lizard
Parsley, L. M., Wapstra, E., & Jones, S. (2015) · Endocrine Disruptors · doi:10.1080/23273747.2015.1006071 · Cited by 12 · see citing works
Expression of steroidogenic proteins in bovine placenta during the first half of gestation
Verduzco, A. R., Fecteau, G., Lefebvre, R. C., Smith, L. C., & Murphy, B. D. (2011) · Reproduction Fertility and Development · doi:10.1071/rd10303 · Cited by 11 · see citing works
Hormones, grossesse et relation materno-fætale
Gailly-Fabre, E., Kerlan, V., & Christin‐Maître, S. (2015) · Annales d Endocrinologie · doi:10.1016/s0003-4266(16)30006-3 · Cited by 11 · see citing works
Progestins in the menopause in healthy women and breast cancer patients
Pasqualini, J. R. (2009) · Maturitas · doi:10.1016/j.maturitas.2008.12.008 · Cited by 11 · see citing works
Self-citationWannowius, M., Karakuş, E., Aktürk, Z., Breuer, J., & Geyer, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129926 · Cited by 10 · see citing works
Fraichard, C., Bonnet-Serrano, F., Garnier, A., Hébert-Schuster, M., Bouzerara, A., Gerbaud, P., Ferecatu, I., Fournier, T., Hernandez, I., Trabado, S., et al. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110586 · Cited by 10 · see citing works
Turning the spotlight on the C11-oxy androgens in human fetal development
du Toit, T., & Swart, A. C. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105946 · Cited by 10 · see citing works
Fu, Y., Zhang, J., Liu, W., Zhang, Y., Zhang, S., Tan, L., Lin, Q., Ouyang, K.-W., Xiong, Y.-W., Chang, W., et al. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.113807 · Cited by 9 · see citing works
Albergotti, L. C., & Guillette, L. J. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-374930-7.10009-3 · Cited by 9 · see citing works
Chen, W., Qiu, C., Hao, J., Liao, J., Lurmann, F. W., Pavlovic, N., Habre, R., Jones, D. P., Bastain, T. M., Breton, C. V., et al. (2025) · Environmental Health · doi:10.1186/s12940-025-01162-x · Cited by 8 · see citing works
Holder, G., Makin, H. L. J., & Bradlow, H. L. (2010) · Springer eBooks · doi:10.1023/b135931_8 · Cited by 8 · see citing works
Zhang, Y., Chen, Y., Dai, B., Bai, M., Lu, S., Lin, N., Zhou, H., & Jiang, H. (2022) · Drug Metabolism and Disposition · doi:10.1124/dmd.121.000685 · Cited by 7 · see citing works
Jedynak, P., Bustamante, M., Rolland, M., Mustieles, V., Thomsen, C., Sakhi, A. K., Sabaredzovic, A., Foraster, M., Gascón, M., Gómez‐Roig, M. D., et al. (2025) · Environmental Health Perspectives · doi:10.1289/ehp15117 · Cited by 6 · see citing works
Lertsburapa, T., Vargas, D., Lambert-Messerlian, G. M., Tantravahi, U., Gündoğan, F., de la Monte, S. M., Coyle, M. G., & Paepe, M. E. D. (2014) · Pediatric and Developmental Pathology · doi:10.2350/14-05-1485-cr.1 · Cited by 6 · see citing works
Mangwiro, Y. T. M., Cuffe, J. S. M., Vickers, M. H., Reynolds, C. M., Mahizir, D., Anevska, K., Gravina, S., Romano, T., Moritz, K. M., Briffa, J. F., et al. (2020) · Placenta · doi:10.1016/j.placenta.2020.11.006 · Cited by 6 · see citing works
Lavender Essential Oil Modulates Hepatic Cholesterol Metabolism in HepG2 Cells
Martella, N., Colardo, M., Sergio, W., Petraroia, M., Varone, M., Pensabene, D., Russo, M., Bartolomeo, S. D., Ranalli, G., Saviano, G., et al. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45010026 · Cited by 6 · see citing works
Liu, J., Kandel, S. E., Lampe, J. N., & Scott, E. E. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104993 · Cited by 6 · see citing works
Silveyra, P., Fuentes, N., & Rivera, L. (2017) · InTech eBooks · doi:10.5772/intechopen.69627 · Cited by 6 · see citing works
Luo, Y., Zhu, H., Huang, B., Sun, C., Zhang, X., Wang, X., Hu, Y., Zhang, X., Xu, S., Zhou, H., et al. (2025) · Advanced Science · doi:10.1002/advs.202500924 · Cited by 5 · see citing works
Risk Factors in Fetal Ovarian Cysts for Postnatal Adverse Outcomes
Muto, M., YOSHIZATO, T., Horinouchi, T., Yokomine, M., Sakamoto, Y., Ishii, S., Kinoshita, M., Kozuma, Y., & Ushijima, K. (2022) · The Kurume Medical Journal · doi:10.2739/kurumemedj.ms6934002 · Cited by 5 · see citing works
Braun, B., & Jewgenow, K. (2016) · Reproduction in Domestic Animals · doi:10.1111/rda.12829 · Cited by 5 · see citing works
Placental Steroid Hormones in Preeclampsia: Multilayered Regulation of Endocrine Pathogenesis
Yang, Y. S., Zhang, S., Fang, X., Shao, T., Shao, X., & Wang, Y. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf039 · Cited by 4 · see citing works
Komal, Duhan, J., Dhuva, B., & Obrai, S. (2026) · ChemistrySelect · doi:10.1002/slct.202506371 · Cited by 4 · see citing works
Parsley, L. M., Wapstra, E., & Jones, S. (2014) · Reproduction Fertility and Development · doi:10.1071/rd13411 · Cited by 4 · see citing works
Parsley, L. M., Wapstra, E., & Jones, S. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.02.020 · Cited by 4 · see citing works
- Authors
- Pasqualini, J. R.
- Corresponding author
- Pasqualini, J.R.
- Venue
- The Journal of Steroid Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 97
- Issue
- 5
- Pages
- 401-415
- ISSN
- 0960-0760 (ISSN-L)
- OpenAlex
- W2063029948
- Cited by
- 141
- References
- 41
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 2 · 2023: 10 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 11 · 2018: 5 · 2017: 9 · 2016: 9 · 2015: 9 · 2014: 9 · 2013: 4 · 2012: 12
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- steroidogenesis, fetal steroidogenesis, placental steroidogenesis, steroid hydroxylase, sulfotransferase, cholesterol biosynthesis, aromatization, steroid hormone receptors, estriol, pregnancy, enzyme regulation
- MeSH terms
- Androgens, Breast Neoplasms, Cholesterol, Estriol, Estrogens, Female, Fetus, Glucocorticoids, Humans, Mineralocorticoids, Models, Biological, Placenta, Pregnancy, Progestins, Progesterone, Gonadal Steroid Hormones
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
